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Gene: Folh1 (folate hydrolase 1) Rattus norvegicus

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Symbol:

Folh1

Name:

folate hydrolase 1

RGD ID:

70963

Description:

Predicted to enable Ac-Asp-Glu binding activity; exopeptidase activity; and tetrahydrofolyl-poly(glutamate) polymer binding activity. Involved in positive regulation of apoptotic process and protein catabolic process. Predicted to be located in cell surface and membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and cerebral infarction. Orthologous to several human genes including FOLH1 (folate hydrolase 1); PARTICIPATES IN folate cycle metabolic pathway; folate metabolic pathway; folate mediated one-carbon metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

FGCP; folate hydrolase; folylpoly-gamma-glutamate carboxypeptidase; GCPII; glutamate carboxypeptidase 2; glutamate carboxypeptidase II; membrane glutamate carboxypeptidase; mGCP; N-acetylated alpha-linked acidic dipeptidase; N-acetylated-alpha-linked acidic dipeptidase I; Naalad; NAALADase I; prostate-specific membrane antigen homolog; pteroylpoly-gamma-glutamate carboxypeptidase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FOLH1 (folate hydrolase 1)	HGNC	EggNOG, Ensembl, Inparanoid, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Folh1 (folate hydrolase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FOLH1B (folate hydrolase 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FOLH1B (folate hydrolase 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FOLH1 (folate hydrolase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	FOLH1B (folate hydrolase 1B (pseudogene))	HGNC	NCBI, OrthoDB
Homo sapiens (human):	NAALAD2 (N-acetylated alpha-linked acidic dipeptidase 2)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	FOLH1 (folate hydrolase 1)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Folh1 (folate hydrolase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	FOLH1B (folate hydrolase 1B (pseudogene))	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Danio rerio (zebrafish):	naalad2 (N-acetylated alpha-linked acidic dipeptidase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	naalad2 (N-acetylated alpha-linked acidic dipeptidase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	gcp-2.1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gcp-2.1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TRE1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	VPS70	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	VPS70	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gcp-2.2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TRE2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	folh1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	149,828,286 - 149,914,313 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	149,840,760 - 149,914,035 (-)	Ensembl				GRCr8
mRatBN7.2	1	140,428,101 - 140,501,563 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	140,428,101 - 140,501,379 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	148,335,238 - 148,426,869 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	155,505,880 - 155,597,520 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	148,379,807 - 148,471,432 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	150,323,768 - 150,395,415 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	150,323,768 - 150,395,415 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	156,631,301 - 156,702,948 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	142,936,379 - 143,010,358 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	138,771,206 - 138,844,472 (-)	NCBI		Celera
RGSC_v3.1	1	143,014,784 - 143,088,764 (-)	NCBI
RH 3.4 Map	1	1111.7	RGD
Cytogenetic Map	1	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

abdominal aortic aneurysm (ISO)

amyotrophic lateral sclerosis type 1 (ISO)

cerebral infarction (ISO)

Prostatic Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-chloropropane-1,2-diol (EXP)

4-hydroxyphenyl retinamide (ISO)

6-aminohexanoate (ISO)

6-aminohexanoic acid (ISO)

6-propyl-2-thiouracil (EXP)

Ac-Asp-Glu (ISO)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

calcitriol (ISO)

cefaloridine (EXP)

CGP 52608 (ISO)

copper atom (ISO)

copper(0) (ISO)

cyanocob(III)alamin (ISO)

cyclosporin A (ISO)

DDE (ISO)

DDT (ISO)

difenoconazole (ISO)

dioxygen (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

endosulfan (ISO)

ethanol (ISO)

eugenol (EXP)

fentin acetate (ISO)

folic acid (ISO)

lead diacetate (EXP)

methoxychlor (EXP)

N-nitrosodiethylamine (ISO)

nickel atom (ISO)

ozone (ISO)

pentobarbital (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

pirinixic acid (EXP)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

Soman (EXP)

tetramethrin (ISO)

trichloroethene (EXP)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

folic acid-containing compound metabolic process (ISO)

glutamate biosynthetic process (ISO)

intestinal folate absorption (ISO)

positive regulation of apoptotic process (IMP)

positive regulation of glutamate receptor signaling pathway (ISO)

protein catabolic process (IDA)

proteolysis (IEA,ISO)

Cellular Component

cell surface (ISO)

membrane (IEA,ISO)

plasma membrane (IBA,IEA,ISO)

Molecular Function

Ac-Asp-Glu binding (ISO)

carboxypeptidase activity (IBA,IEA,ISO)

catalytic activity (IEA)

dipeptidase activity (IEA,ISO)

hydrolase activity (IEA)

metal ion binding (IEA)

metallocarboxypeptidase activity (IEA,ISO)

metallopeptidase activity (IEA)

peptidase activity (IEA,ISO)

protein binding (ISO)

tetrahydrofolyl-poly(glutamate) polymer binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

folate cycle metabolic pathway (ISO)

folate mediated one-carbon metabolic pathway (TAS)

folate metabolic pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects.	Blom HJ and Smulders Y, J Inherit Metab Dis. 2011 Feb;34(1):75-81. doi: 10.1007/s10545-010-9177-4. Epub 2010 Sep 4.
2.	Molecular cloning of a peptidase against N-acetylaspartylglutamate from a rat hippocampal cDNA library.	Bzdega T, etal., J Neurochem 1997 Dec;69(6):2270-7.
3.	Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase.	Carter RE, etal., Proc Natl Acad Sci U S A 1996 Jan 23;93(2):749-53.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models.	Ghadge GD, etal., Proc Natl Acad Sci U S A 2003 Aug 5;100(16):9554-9. Epub 2003 Jul 22.
6.	Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm.	Giusti B, etal., J Med Genet. 2008 Nov;45(11):721-30. doi: 10.1136/jmg.2008.057851. Epub 2008 Jul 17.
7.	Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism.	Giusti B, etal., Thromb Haemost. 2010 Aug;104(2):231-42. doi: 10.1160/TH09-11-0748. Epub 2010 May 10.
8.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
9.	Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen.	Israeli RS, etal., Cancer Res 1993 Jan 15;53(2):227-30.
10.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
11.	Isolation and expression of a rat brain cDNA encoding glutamate carboxypeptidase II.	Luthi-Carter R, etal., Proc Natl Acad Sci U S A 1998 Mar 17;95(6):3215-20.
12.	Gene Data Set	MGD Curation, June 12, 2002
13.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
14.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
15.	Prostate-specific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells.	Pinto JT, etal., Clin Cancer Res. 1996 Sep;2(9):1445-51.
16.	GOA pipeline	RGD automated data pipeline
17.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
19.	Gamma-glutamyl hydrolase and drug resistance.	Schneider E and Ryan TJ, Clin Chim Acta. 2006 Dec;374(1-2):25-32. Epub 2006 Jun 10.

Additional References at PubMed

PMID:11210180	PMID:12949938	PMID:15019832	PMID:15030392	PMID:17241121	PMID:18076021	PMID:21908619	PMID:22570482	PMID:23533145	PMID:24863754	PMID:30113208

Genomics

Comparative Map Data

Folh1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	149,828,286 - 149,914,313 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	149,840,760 - 149,914,035 (-)	Ensembl				GRCr8
mRatBN7.2	1	140,428,101 - 140,501,563 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	140,428,101 - 140,501,379 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	148,335,238 - 148,426,869 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	155,505,880 - 155,597,520 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	148,379,807 - 148,471,432 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	150,323,768 - 150,395,415 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	150,323,768 - 150,395,415 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	156,631,301 - 156,702,948 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	142,936,379 - 143,010,358 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	138,771,206 - 138,844,472 (-)	NCBI		Celera
RGSC_v3.1	1	143,014,784 - 143,088,764 (-)	NCBI
RH 3.4 Map	1	1111.7	RGD
Cytogenetic Map	1	q32	NCBI

FOLH1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	49,145,092 - 49,208,602 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	49,145,092 - 49,208,640 (-)	Ensembl			hg38	GRCh38
GRCh37	11	49,166,644 - 49,230,154 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	49,124,763 - 49,186,798 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	11	49,124,763 - 49,186,798	NCBI
Celera	11	49,319,516 - 49,381,546 (-)	NCBI		Celera
Cytogenetic Map	11	p11.12	NCBI
HuRef	11	48,886,315 - 48,948,370 (-)	NCBI		HuRef
CHM1_1	11	49,166,592 - 49,228,610 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	49,322,228 - 49,385,778 (-)	NCBI		T2T-CHM13v2.0

Folh1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	86,365,733 - 86,425,171 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	86,368,185 - 86,425,151 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	86,716,525 - 86,776,053 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	86,718,977 - 86,775,943 (-)	Ensembl			mm10	GRCm38
MGSCv37	7	93,867,486 - 93,924,374 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	86,594,748 - 86,651,592 (-)	NCBI		MGSCv36	mm8
Celera	7	84,090,600 - 84,151,262 (-)	NCBI		Celera
Cytogenetic Map	7	D3	NCBI
cM Map	7	48.51	NCBI

FOLH1B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	10,401,129 - 10,466,162 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	10,203,492 - 10,466,161 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	10,252,624 - 10,317,104 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	10,582,575 - 10,647,371 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	10,581,865 - 10,647,452 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	10,371,141 - 10,435,721 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	10,429,798 - 10,494,435 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	10,486,267 - 10,550,766 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

FOLH1B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	22,903,979 - 22,963,472 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	22,903,997 - 22,960,648 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	25,630,162 - 25,687,739 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FOLH1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	80,800,069 - 80,868,176 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	80,802,676 - 80,869,782 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666043	44,874,371 - 44,939,977 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Folh1
760 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	42
Count of miRNA genes:	38
Interacting mature miRNAs:	40
Transcripts:	ENSRNOT00000018592
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61442	Strs1	Sensitivity to stroke QTL 1	7.4		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	1	131179947	176179947	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	137611478	182611478	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
1598866	Bp287	Blood pressure QTL 287	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	130419227	175419227	Rat
1578770	Stresp23	Stress response QTL 23			kidney sympathetic nerve activity (VT:0004050)	stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)	1	132760429	191848948	Rat
631684	Bp117	Blood pressure QTL 117	8.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	120082258	165082258	Rat
9590300	Scort16	Serum corticosterone level QTL 16	4.39	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	1	112521556	157521556	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
631199	Cm23	Cardiac mass QTL 23	4.6	0.0004	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	142582336	182383862	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
1598850	Bp297	Blood pressure QTL 297	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	130419227	175419227	Rat
631570	Bp94	Blood pressure QTL 94		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	132889797	152403053	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	132966869	252856240	Rat
61341	Bp26	Blood pressure QTL 26			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	139442053	223964440	Rat
152025232	Bw192	Body weight QTL 192	3.93		body mass (VT:0001259)		1	127329268	206393015	Rat
724521	Uae1	Urinary albumin excretion QTL 1	3.8	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	99645382	182701046	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	99645382	221502378	Rat
61346	Rf2	Renal disease susceptibility QTL 2	3.7		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	1	142582180	153680016	Rat
8655649	Arrd1	Age-related retinal degeneration QTL 1	4.89		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	109493780	193400781	Rat
2317833	Alcrsp19	Alcohol response QTL 19	12.4	0.001	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	1	110389869	155389869	Rat
1300153	Bp171	Blood pressure QTL 171	3.37		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	124975316	152612788	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	146080545	243492863	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	103779152	223964440	Rat
631202	Gluco13	Glucose level QTL 13		0.0001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	141173126	169168317	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	98879955	208479939	Rat
631206	Niddm40	Non-insulin dependent diabetes mellitus QTL 40			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	140833106	185833106	Rat
1641897	Alcrsp1	Alcohol response QTL 1			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	1	110389869	155389869	Rat
1331751	Bp199	Blood pressure QTL 199	3.60022		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	116099376	191260518	Rat
2293140	Bp313	Blood pressure QTL 313			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	131243790	176243790	Rat
724529	Cm16	Cardiac mass QTL 16	2.7		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	1	96717367	160111531	Rat
737974	Bp161	Blood pressure QTL 161		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	129182274	174182274	Rat
1641895	Bp298	Blood pressure QTL 298			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	132760429	191848948	Rat
631496	Bp97	Blood pressure QTL 97	3.08		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	115183611	176289080	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1331793	Bp200	Blood pressure QTL 200	3.71601		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	102780511	182384005	Rat
6893347	Bw98	Body weight QTL 98	0.2	0.53	body mass (VT:0001259)	body weight (CMO:0000012)	1	143092939	188092939	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	111949780	210707719	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	128019551	173019551	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	93903998	191260518	Rat
61399	Tcat1	Tongue tumor resistance QTL 1	3.3		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)	1	108680016	153680016	Rat
6893361	Bw104	Body weight QTL 104	0.59	0.27	body mass (VT:0001259)	body weight (CMO:0000012)	1	143092939	188092939	Rat
724562	Rends1	Renal damage susceptibility QTL 1		0.05	kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	1	139442053	223964440	Rat
724567	Tcas6	Tongue tumor susceptibility QTL 6	6.85		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	1	102359314	153680016	Rat
738006	Anxrr14	Anxiety related response QTL 14	4	0.00035	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	140048073	185048073	Rat
1558645	Bw55	Body weight QTL 55	3.2	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	1	143092939	188092939	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	111949780	210707719	Rat
634348	Bp138	Blood pressure QTL 138			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	135021436	178317588	Rat
8694370	Bw154	Body weight QTL 154	8.91	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	1	112521556	157521556	Rat
738028	Anxrr12	Anxiety related response QTL 12	4.9	0.00001	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	140048073	185048073	Rat
1354623	Rf46	Renal function QTL 46	3.8		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	1	111949780	160574007	Rat
631654	Bp107	Blood pressure QTL 107			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	135021436	180021436	Rat
631544	Bp84	Blood pressure QTL 84	5.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	132760429	191190115	Rat
152025212	Bw190	Body weight QTL 190	5.7		body mass (VT:0001259)		1	132966869	206393015	Rat
631549	Bp89	Blood pressure QTL 89	5.7		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	132760429	152404087	Rat
631548	Bp88	Blood pressure QTL 88	5	0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	140915717	185915717	Rat
1358189	Cstrr1	Cold stress response QTL 1		0.0001	catecholamine amount (VT:0010543)	urine norepinephrine level (CMO:0001629)	1	132760429	191848948	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	111949780	228180370	Rat

Markers in Region

AU014956

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	140,483,312 - 140,483,539 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	150,377,349 - 150,377,575	NCBI	Rnor6.0
Rnor_5.0	1	156,684,882 - 156,685,108	UniSTS	Rnor5.0
RGSC_v3.4	1	142,992,292 - 142,992,518	UniSTS	RGSC3.4
Celera	1	138,826,406 - 138,826,632	UniSTS
Cytogenetic Map	1	q32	UniSTS

Folh1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	140,434,040 - 140,434,160 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	150,329,708 - 150,329,827	NCBI	Rnor6.0
Rnor_5.0	1	156,637,241 - 156,637,360	UniSTS	Rnor5.0
RGSC_v3.4	1	142,942,319 - 142,942,438	UniSTS	RGSC3.4
Celera	1	138,777,146 - 138,777,265	UniSTS
RH 3.4 Map	1	1111.7	UniSTS
Cytogenetic Map	1	q32	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
7	10	55	146	86	85	55	25	55	6	251	103	2	133	78	73	30	14	14

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_057185	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092938	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063275902	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063275904	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063275907	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063275908	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063275909	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF039707	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF040256	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF513486	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U75973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000018592 ⟹ ENSRNOP00000018592

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	149,840,760 - 149,914,035 (-)	Ensembl
mRatBN7.2 Ensembl	1	140,428,101 - 140,501,379 (-)	Ensembl
Rnor_6.0 Ensembl	1	150,323,768 - 150,395,415 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103049 ⟹ ENSRNOP00000088905

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	149,840,760 - 149,914,035 (-)	Ensembl
mRatBN7.2 Ensembl	1	140,428,101 - 140,501,379 (-)	Ensembl

RefSeq Acc Id:

NM_057185 ⟹ NP_476533

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	149,840,760 - 149,914,035 (-)	NCBI
mRatBN7.2	1	140,428,101 - 140,501,379 (-)	NCBI
Rnor_6.0	1	150,323,768 - 150,395,415 (-)	NCBI
Rnor_5.0	1	156,631,301 - 156,702,948 (-)	NCBI
RGSC_v3.4	1	142,936,379 - 143,010,358 (-)	RGD
Celera	1	138,771,206 - 138,844,472 (-)	RGD

Sequence:

show sequence

TAGGCTGCAGACTCTCTGCAGTAGAGCCGCAGTAGAACTGCTGAGAAAGACCAAAGTTGCCAGA
GATGTGGAACGCTCAGCAGGACAGCGACTCCGCGGAGGCCCTGGGACGCCGCCAACGCTGGTTC
TGTGCTGGAACACTGGTGCTGGCTTTCACTGGAACCTTCATCATTGGCTTCCTCTTTGGGTGGT
TTATAAAACCCTCCAATGATTCTACTAGCAGTGTTTCCTATCCTGGCATGAAGAAGGCATTTTT
GCAAGAATTGAAGGCTGAGAACATCAAAAAATTTTTATACAATTTCACACGGACACCACATTTG
GCAGGGACACAACACAATTTTGAGCTTGCAAAGCAAATTCATGCCCAGTGGAAAGAATTTGGCC
TGGATTTGGTTGAGTTATCTGATTATGATGTCCTGTTGTCCTACCCAAATAAGACCCATCCCAA
CTATATCTCAATAATTAATGAAGATGGAAATGAGATTTTCAAAACATCATTAGCTGAACTGTCA
CCCCCGGGATATGAGAACATATCAGATGTAGTGCCACCATACAGTGCCTTCTCTCCACAAGGGA
CACCAGAGGGGGATCTAGTATATGTTAACTATGCACGAACTGAAGACTTCTTTAAACTGGAACG
GGTCATGAAGATCAATTGTTCTGGGAAGATTGTCATCGCCAGATATGGGCAAGTGTTCAGAGGA
AATAAGGTTAAAAATGCTCAGCTGGCAGGTGCAAAAGGAATCATTCTGTACTCAGACCCTGCTG
ATTACTTTGTTCCTGGGGTGAAGTCCTATCCAGATGGTTGGAACCTCCCTGGAGGTGGTGTTCA
GCGTGGAAATGTCTTAAATCTTAATGGTGCAGGTGATCCCCTCACACCAGGTTATCCAGCAAAT
GAATATGCCTACAGGCATGAATTCACAGAAGCTGTCGGTCTTCCAAGTATTCCTGTCCATCCAA
TTGGATATGATGATGCACAGAAACTATTAGAACATATGGGTGGCTCCGCACCCCCTGACAGCAG
CTGGAAGGGAGGACTAAAAGTGCCTTACAACGTGGGACCTGGCTTTGCTGGAAACTTTTCAAAA
CAAAAGGTCAAGCTGCATATTCACTCCTACAATAAAGTGACAAGAATCTACAATGTTATTGGTA
CCCTCAAAGGAGCTGTGGAACCAGACAGATATGTTATTCTTGGAGGGCACAGAGATGCTTGGGT
GTTTGGTGGCATTGACCCTCAGAGTGGAGCAGCTGTTGTTCATGAAATTGTCAGGACCTTTGGA
ACTCTGAAGAAGAAAGGTTGGAGGCCTAGAAGAACTATTTTGTTTGCAAGCTGGGATGCTGAAG
AATTTGGCCTTCTTGGTTCTACTGAGTGGGCAGAGGAACATTCAAGACTCTTACAAGAACGTGG
TGTGGCTTATATCAACGCTGATTCTTCCATAGAAGGAAACTACACTCTCAGAGTTGATTGCACA
CCACTGATGCACAGCTTAGTATACAACCTAACAAAAGAGCTGCCAAGCCCGGATGAAGGCTTTG
AAGGCAAATCTCTTTATGACAGCTGGAAAGAAAAAAGTCCTTCAACTGAGTTCATTGGAATGCC
AAGGATTAGCAAGCTGGGGTCTGGCAATGATTTTGAAGTGTTTTTCCAAAGACTTGGAATTGCT
TCAGGCAGAGCCCGGTATACTAAAAATTGGAAAAACAACAAAGTCAGCAGCTATCCTCTCTATC
ACAGTGTCTATGAAACATACGAATTGGTAGAAAAATTCTATGATCCGACATTTAAATATCACCT
CACTGTGGCCCAGGTTCGAGGAGCAATGGTATTTGAATTGGCCAATTCTATAGTGCTTCCCTTT
GACTGCCAAAGTTATGCTGTAGCTCTGAAGAAACATGCTGAGACTATCTACAACATTTCAATGA
ATCATCCACAGGAGATGAAGGCGTACATGATATCATTTGATTCGCTGTTTTCTGCAGTAAATAA
TTTTACAGATGTTGCATCCAAGTTCAATCAGAGACTGCAAGACTTAGACAAGAGCAACCCCATA
TTACTGAGAATTTTGAATGATCAGCTAATGTATCTGGAACGTGCATTCATTGATCCTTTAGGAT
TACCAGGAAGGCCTTTCTACAGGCATATCATCTATGCTCCAAGCAGCCACAACAAGTATGCAGG
AGAATCATTCCCAGGGATTTATGATGCCCTTTTTGATATTAATAACAAAGTCGACACTTCTAAG
GCCTGGAGAGAAGTGAAGAGACAGATTTCTATTGCAGCCTTCACAGTGCAAGCTGCAGCAGAGA
CTCTGAGAGAAGTAGACTAAGCAGTCTTTACAGAATTCATAAAAAACTGATTTGTGGATCAAAA
GACAAAAGTGAATAATTTCATAATGACTTATAATTTTGGCATGTATTACTAAAATTTAAAATTC
AATAGGTATTAAAACTAATGTAAACAGCCTAATAAAATGACACATTTGACAGTATTAGATAATT
ATCCGAAATCTAATACACCCTTCCCAAATCTACCCTGTAGTTTTACTTCATTATGGAATACATC
TTGGATAGTTCACAATTCTGCTCTACCTGGGGGCCTATATGCTCTCTGGTCACCAAAGGCTGGG
AGGATCATTATAGTCACCCTAGCAGACGAGTTCTAATTTATTCTCTCTTCTTGTAAACCTAATT
CCTCTTTATTGAAAAGTTTAAGTATATAGGCCAAGGTCTTGTCTGTGGCTCCCTATGGAGGATC
CTGATAAAAAGCGGCAGTCCATGGTTTTAAGGTATTTATGATCTAAAACTCTATAAATTGTAAA
AGTACAACTACTAATTAACATCTATAGTCTCAGTAACTGAACTTCTGAACAAATGCATTATTTA
TATGAAATATAATCATGGTCTTGAATTTTATGTTTATAATGTCTCTTTTTATATAGAATTACAT
GTGTTTTATATTCATTACATGTCTTGAAATATATGTAATTTTCTATTTTTCATTGTTATCTTCT
ATT

hide sequence

RefSeq Acc Id:

XM_039092938 ⟹ XP_038948866

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	149,828,286 - 149,910,893 (-)	NCBI
mRatBN7.2	1	140,428,770 - 140,498,237 (-)	NCBI

RefSeq Acc Id:

XM_063275902 ⟹ XP_063131972

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	149,828,286 - 149,914,133 (-)	NCBI

RefSeq Acc Id:

XM_063275904 ⟹ XP_063131974

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	149,828,286 - 149,914,084 (-)	NCBI

RefSeq Acc Id:

XM_063275907 ⟹ XP_063131977

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	149,849,317 - 149,914,088 (-)	NCBI

RefSeq Acc Id:

XM_063275908 ⟹ XP_063131978

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	149,853,409 - 149,914,095 (-)	NCBI

RefSeq Acc Id:

XM_063275909 ⟹ XP_063131979

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	149,849,317 - 149,914,313 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_476533	(Get FASTA)	NCBI Sequence Viewer
	XP_038948866	(Get FASTA)	NCBI Sequence Viewer
	XP_063131972	(Get FASTA)	NCBI Sequence Viewer
	XP_063131974	(Get FASTA)	NCBI Sequence Viewer
	XP_063131977	(Get FASTA)	NCBI Sequence Viewer
	XP_063131978	(Get FASTA)	NCBI Sequence Viewer
	XP_063131979	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB96759	(Get FASTA)	NCBI Sequence Viewer
	AAC40067	(Get FASTA)	NCBI Sequence Viewer
	AAC53423	(Get FASTA)	NCBI Sequence Viewer
	AAM47015	(Get FASTA)	NCBI Sequence Viewer
	EDM18599	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000018592
GenBank Protein	P70627	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_476533 ⟸ NM_057185

- UniProtKB:

Q547B6 (UniProtKB/Swiss-Prot), P70627 (UniProtKB/Swiss-Prot), G3V7S0 (UniProtKB/TrEMBL), A6I5Y1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MWNAQQDSDSAEALGRRQRWFCAGTLVLAFTGTFIIGFLFGWFIKPSNDSTSSVSYPGMKKAFL
QELKAENIKKFLYNFTRTPHLAGTQHNFELAKQIHAQWKEFGLDLVELSDYDVLLSYPNKTHPN
YISIINEDGNEIFKTSLAELSPPGYENISDVVPPYSAFSPQGTPEGDLVYVNYARTEDFFKLER
VMKINCSGKIVIARYGQVFRGNKVKNAQLAGAKGIILYSDPADYFVPGVKSYPDGWNLPGGGVQ
RGNVLNLNGAGDPLTPGYPANEYAYRHEFTEAVGLPSIPVHPIGYDDAQKLLEHMGGSAPPDSS
WKGGLKVPYNVGPGFAGNFSKQKVKLHIHSYNKVTRIYNVIGTLKGAVEPDRYVILGGHRDAWV
FGGIDPQSGAAVVHEIVRTFGTLKKKGWRPRRTILFASWDAEEFGLLGSTEWAEEHSRLLQERG
VAYINADSSIEGNYTLRVDCTPLMHSLVYNLTKELPSPDEGFEGKSLYDSWKEKSPSTEFIGMP
RISKLGSGNDFEVFFQRLGIASGRARYTKNWKNNKVSSYPLYHSVYETYELVEKFYDPTFKYHL
TVAQVRGAMVFELANSIVLPFDCQSYAVALKKHAETIYNISMNHPQEMKAYMISFDSLFSAVNN
FTDVASKFNQRLQDLDKSNPILLRILNDQLMYLERAFIDPLGLPGRPFYRHIIYAPSSHNKYAG
ESFPGIYDALFDINNKVDTSKAWREVKRQISIAAFTVQAAAETLREVD

hide sequence

Ensembl Acc Id:

ENSRNOP00000018592 ⟸ ENSRNOT00000018592

RefSeq Acc Id:	XP_038948866 ⟸ XM_039092938
- Peptide Label:	isoform X2
- UniProtKB:	Q547B6 (UniProtKB/Swiss-Prot), P70627 (UniProtKB/Swiss-Prot)

Ensembl Acc Id:

ENSRNOP00000088905 ⟸ ENSRNOT00000103049

RefSeq Acc Id:	XP_063131972 ⟸ XM_063275902
- Peptide Label:	isoform X1
- UniProtKB:	Q547B6 (UniProtKB/Swiss-Prot), P70627 (UniProtKB/Swiss-Prot), A6I5Y1 (UniProtKB/TrEMBL), G3V7S0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063131974 ⟸ XM_063275904
- Peptide Label:	isoform X1
- UniProtKB:	Q547B6 (UniProtKB/Swiss-Prot), P70627 (UniProtKB/Swiss-Prot), A6I5Y1 (UniProtKB/TrEMBL), G3V7S0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063131979 ⟸ XM_063275909
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063131977 ⟸ XM_063275907
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063131978 ⟸ XM_063275908
- Peptide Label:	isoform X4

Protein Domains

PA Peptidase M28 Transferrin receptor-like dimerisation

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P70627-F1-model_v2	AlphaFold	P70627	1-752	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690175

Promoter ID:

EPDNEW_R700

Type:

single initiation site

Name:

Folh1_1

Description:

folate hydrolase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	150,395,421 - 150,395,481	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:70963	AgrOrtholog
BioCyc Gene	G2FUF-58597	BioCyc
Ensembl Genes	ENSRNOG00000013770	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000018592	ENTREZGENE
Gene3D-CATH	1.20.930.40	UniProtKB/Swiss-Prot
	3.50.30.30	UniProtKB/Swiss-Prot
	Zn peptidases	UniProtKB/Swiss-Prot
InterPro	PA_dom_sf	UniProtKB/Swiss-Prot
	PA_domain	UniProtKB/Swiss-Prot
	Peptidase_M28	UniProtKB/Swiss-Prot
	Peptidase_M28B	UniProtKB/Swiss-Prot
	TFR-like_dimer_dom	UniProtKB/Swiss-Prot
	TFR-like_dimer_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:85309	UniProtKB/Swiss-Prot
NCBI Gene	85309	ENTREZGENE
PANTHER	GLUTAMATE CARBOXYPEPTIDASE 2	UniProtKB/Swiss-Prot
	PTHR10404	UniProtKB/Swiss-Prot
Pfam	Peptidase_M28	UniProtKB/Swiss-Prot
	PF02225	UniProtKB/Swiss-Prot
	TFR_dimer	UniProtKB/Swiss-Prot
PhenoGen	Folh1	PhenoGen
RatGTEx	ENSRNOG00000013770	RatGTEx
Superfamily-SCOP	PA domain	UniProtKB/Swiss-Prot
	SSF47672	UniProtKB/Swiss-Prot
	Zn-dependent exopeptidases	UniProtKB/Swiss-Prot
UniProt	A0A8I6ABM7_RAT	UniProtKB/TrEMBL
	A6I5Y1	ENTREZGENE, UniProtKB/TrEMBL
	FOLH1_RAT	UniProtKB/Swiss-Prot
	G3V7S0	ENTREZGENE, UniProtKB/TrEMBL
	P70627	ENTREZGENE
	Q547B6	ENTREZGENE
UniProt Secondary	Q547B6	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2009-12-15	Folh1	folate hydrolase 1	Folh1	folate hydrolase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-07-09	Folh1	folate hydrolase			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in astrocytes	728645

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - CTD

RGD Manual Annotations