FOLH1B (folate hydrolase 1B) - Rat Genome Database

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Gene: FOLH1B (folate hydrolase 1B) Canis lupus familiaris
Analyze
Symbol: FOLH1B
Name: folate hydrolase 1B
RGD ID: 12158275
Description: ENCODES a protein that exhibits Ac-Asp-Glu binding (ortholog); metallocarboxypeptidase activity (ortholog); peptidase activity (ortholog); INVOLVED IN folic acid-containing compound metabolic process (ortholog); positive regulation of apoptotic process (ortholog); protein catabolic process (ortholog); PARTICIPATES IN folate cycle metabolic pathway; folate mediated one-carbon metabolic pathway; folate metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); cerebral infarction (ortholog); FOUND IN cell surface (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: folate hydrolase (prostate-specific membrane antigen) 1; folate hydrolase 1; FOLH1; glutamate carboxypeptidase 2; prostate-specific membrane antigen; PSMA; putative N-acetylated-alpha-linked acidic dipeptidase
RGD Orthologs
Human
Mouse
Rat
Pig
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12110,401,129 - 10,466,162 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2110,203,492 - 10,466,161 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2110,252,624 - 10,317,104 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02110,582,575 - 10,647,371 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2110,581,865 - 10,647,452 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12110,371,141 - 10,435,721 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02110,429,798 - 10,494,435 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02110,486,267 - 10,550,766 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16221666   PMID:18196537   PMID:23359458   PMID:30032202   PMID:30601866  


Genomics

Comparative Map Data
FOLH1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12110,401,129 - 10,466,162 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2110,203,492 - 10,466,161 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2110,252,624 - 10,317,104 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02110,582,575 - 10,647,371 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2110,581,865 - 10,647,452 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12110,371,141 - 10,435,721 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02110,429,798 - 10,494,435 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02110,486,267 - 10,550,766 (-)NCBIUU_Cfam_GSD_1.0
FOLH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381149,145,092 - 49,208,602 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1149,145,092 - 49,208,638 (-)EnsemblGRCh38hg38GRCh38
GRCh371149,166,644 - 49,230,154 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361149,124,763 - 49,186,798 (-)NCBINCBI36Build 36hg18NCBI36
Build 341149,124,763 - 49,186,798NCBI
Celera1149,319,516 - 49,381,546 (-)NCBICelera
Cytogenetic Map11p11.12NCBI
HuRef1148,886,315 - 48,948,370 (-)NCBIHuRef
CHM1_11149,166,592 - 49,228,610 (-)NCBICHM1_1
T2T-CHM13v2.01149,322,228 - 49,385,778 (-)NCBIT2T-CHM13v2.0
Folh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39786,365,733 - 86,425,171 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl786,368,185 - 86,425,151 (-)EnsemblGRCm39 Ensembl
GRCm38786,716,525 - 86,776,053 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl786,718,977 - 86,775,943 (-)EnsemblGRCm38mm10GRCm38
MGSCv37793,867,486 - 93,924,374 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36786,594,748 - 86,651,592 (-)NCBIMGSCv36mm8
Celera784,090,600 - 84,151,262 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map748.51NCBI
Folh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81149,828,286 - 149,914,313 (-)NCBIGRCr8
mRatBN7.21140,428,101 - 140,501,563 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1140,428,101 - 140,501,379 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1148,335,238 - 148,426,869 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01155,505,880 - 155,597,520 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01148,379,807 - 148,471,432 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01150,323,768 - 150,395,415 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1150,323,768 - 150,395,415 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01156,631,301 - 156,702,948 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41142,936,379 - 143,010,358 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11143,014,784 - 143,088,764 (-)NCBI
Celera1138,771,206 - 138,844,472 (-)NCBICelera
RH 3.4 Map11111.7RGD
Cytogenetic Map1q32NCBI
FOLH1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl922,903,979 - 22,963,472 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1922,903,997 - 22,960,648 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2925,630,162 - 25,687,739 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in FOLH1B
896 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 6 1 1 8 6 6
Low 4 5 16 6 6 6 5 6 11 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000006940   ⟹   ENSCAFP00000006423
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2110,203,492 - 10,464,318 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000068616   ⟹   ENSCAFP00000051462
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2110,203,492 - 10,466,161 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000069975   ⟹   ENSCAFP00000063250
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2110,401,844 - 10,466,128 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000093161   ⟹   ENSCAFP00000048211
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2110,203,492 - 10,466,128 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845044871   ⟹   ENSCAFP00845035166
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2110,581,865 - 10,647,452 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845044938   ⟹   ENSCAFP00845035216
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2110,581,865 - 10,647,452 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845045090   ⟹   ENSCAFP00845035349
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2110,582,473 - 10,647,452 (-)Ensembl
RefSeq Acc Id: NM_001271778   ⟹   NP_001258707
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12110,401,844 - 10,466,143 (-)NCBI
Dog10K_Boxer_Tasha2110,252,624 - 10,317,104 (-)NCBI
ROS_Cfam_1.02110,582,575 - 10,647,371 (-)NCBI
UMICH_Zoey_3.12110,371,141 - 10,435,721 (-)NCBI
UNSW_CanFamBas_1.02110,429,798 - 10,494,435 (-)NCBI
UU_Cfam_GSD_1.02110,486,267 - 10,550,766 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001258707   ⟸   NM_001271778
- UniProtKB: A0A8C0KTI3 (UniProtKB/TrEMBL),   A0A8C0N3B8 (UniProtKB/TrEMBL),   A0A8I3PUM6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000063250   ⟸   ENSCAFT00000069975
RefSeq Acc Id: ENSCAFP00000048211   ⟸   ENSCAFT00000093161
RefSeq Acc Id: ENSCAFP00000051462   ⟸   ENSCAFT00000068616
RefSeq Acc Id: ENSCAFP00000006423   ⟸   ENSCAFT00000006940
RefSeq Acc Id: ENSCAFP00845035349   ⟸   ENSCAFT00845045090
RefSeq Acc Id: ENSCAFP00845035166   ⟸   ENSCAFT00845044871
RefSeq Acc Id: ENSCAFP00845035216   ⟸   ENSCAFT00845044938
Protein Domains
B box-type   B30.2/SPRY   PA   Peptidase M28   RING-type   Transferrin receptor-like dimerisation


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000024888 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030012888 UniProtKB/TrEMBL
  ENSCAFG00040019953 UniProtKB/TrEMBL
  ENSCAFG00845025397 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000006940.5 UniProtKB/TrEMBL
  ENSCAFT00000068616.2 UniProtKB/TrEMBL
  ENSCAFT00000069975.2 UniProtKB/TrEMBL
  ENSCAFT00000093161.2 UniProtKB/TrEMBL
  ENSCAFT00030024019.1 UniProtKB/TrEMBL
  ENSCAFT00030024207.1 UniProtKB/TrEMBL
  ENSCAFT00030024414.1 UniProtKB/TrEMBL
  ENSCAFT00030024558.1 UniProtKB/TrEMBL
  ENSCAFT00040037247.1 UniProtKB/TrEMBL
  ENSCAFT00040037432.1 UniProtKB/TrEMBL
  ENSCAFT00040037568.1 UniProtKB/TrEMBL
  ENSCAFT00040037680.1 UniProtKB/TrEMBL
  ENSCAFT00040037790.1 UniProtKB/TrEMBL
  ENSCAFT00845044871 ENTREZGENE
  ENSCAFT00845044871.1 UniProtKB/TrEMBL
  ENSCAFT00845044938.1 UniProtKB/TrEMBL
  ENSCAFT00845045090.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.930.40 UniProtKB/TrEMBL
  2.60.120.920 UniProtKB/TrEMBL
  3.50.30.30 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
  Zinc/RING finger domain, C3HC4 (zinc finger) UniProtKB/TrEMBL
  Zn peptidases UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/TrEMBL
  Butyrophylin_SPRY UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/TrEMBL
  PA_dom_sf UniProtKB/TrEMBL
  PA_domain UniProtKB/TrEMBL
  Peptidase_M28 UniProtKB/TrEMBL
  Peptidase_M28B UniProtKB/TrEMBL
  SPRY_dom UniProtKB/TrEMBL
  TFR-like_dimer_dom UniProtKB/TrEMBL
  TFR-like_dimer_dom_sf UniProtKB/TrEMBL
  Znf_B-box UniProtKB/TrEMBL
  Znf_C3HC4_RING-type UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
KEGG Report cfa:476775 UniProtKB/TrEMBL
NCBI Gene FOLH1 ENTREZGENE
PANTHER GLUTAMATE CARBOXYPEPTIDASE 2 UniProtKB/TrEMBL
  PTHR10404 UniProtKB/TrEMBL
Pfam Peptidase_M28 UniProtKB/TrEMBL
  PF02225 UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
  TFR_dimer UniProtKB/TrEMBL
  zf-C3HC4 UniProtKB/TrEMBL
PRINTS BUTYPHLNCDUF UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/TrEMBL
  ZF_BBOX UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
SMART RING UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
Superfamily-SCOP B-box zinc-binding domain UniProtKB/TrEMBL
  Concanavalin A-like lectins/glucanases UniProtKB/TrEMBL
  PA domain UniProtKB/TrEMBL
  RING/U-box UniProtKB/TrEMBL
  SSF47672 UniProtKB/TrEMBL
  Zn-dependent exopeptidases UniProtKB/TrEMBL
UniProt A0A8C0KTI3 ENTREZGENE
  A0A8C0N3B8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0N499_CANLF UniProtKB/TrEMBL
  A0A8C0N9T7_CANLF UniProtKB/TrEMBL
  A0A8C0RJ37_CANLF UniProtKB/TrEMBL
  A0A8C0T8C8_CANLF UniProtKB/TrEMBL
  A0A8C0T948_CANLF UniProtKB/TrEMBL
  A0A8C0T9M8_CANLF UniProtKB/TrEMBL
  A0A8C0T9S7_CANLF UniProtKB/TrEMBL
  A0A8C0Z308_CANLF UniProtKB/TrEMBL
  A0A8I3PQ13_CANLF UniProtKB/TrEMBL
  A0A8I3PUM6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PV00_CANLF UniProtKB/TrEMBL
  A0A8P0P159_CANLF UniProtKB/TrEMBL
  A0A8P0S9X8_CANLF UniProtKB/TrEMBL
  A0A8P0T182_CANLF UniProtKB/TrEMBL
  A0A8P0TEY1_CANLF UniProtKB/TrEMBL
  I4IY07_CANLF UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-12 FOLH1B  folate hydrolase 1B  FOLH1  folate hydrolase (prostate-specific membrane antigen) 1  Symbol and/or name change 5135510 APPROVED