Trpc4 (transient receptor potential cation channel, subfamily C, member 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Trpc4 (transient receptor potential cation channel, subfamily C, member 4) Rattus norvegicus
Analyze
Symbol: Trpc4
Name: transient receptor potential cation channel, subfamily C, member 4
RGD ID: 621276
Description: Enables calcium channel activity. Involved in calcium ion transport; positive regulation of store-operated calcium entry; and regulation of action potential firing rate. Predicted to be located in several cellular components, including basolateral plasma membrane; caveola; and cortical cytoskeleton. Predicted to be part of calcium channel complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human TRPC4 (transient receptor potential cation channel subfamily C member 4); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: capacitative calcium entry channel 1; CCE1; short transient receptor potential channel 4; transient receptor potential 4; transient receptor potential channel 4; transient receptor potential protein 4; transient receptor protein 4; Trp4; Trrp4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Trpc4_v1 ; Trpc4_v2 ; Trpc4Tn(sb-T2/Bart3)2.192Mcwi ; Trpc4Tn(sb)Tngen
Genetic Models: F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi ; F344-Trpc4Tn(sb)1Bni
Candidate Gene For: Cm49
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82140,457,841 - 140,629,556 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2140,458,296 - 140,626,969 (+)EnsemblGRCr8
mRatBN7.22138,307,676 - 138,476,856 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2138,308,084 - 138,476,768 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2144,918,944 - 145,044,642 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02143,030,992 - 143,156,703 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02137,662,818 - 137,788,527 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd2139,583,568 - 139,709,136 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive2139,902,958 - 140,028,528 (+)NCBILyon_Normotensive
Lyon_Hypertensive2139,506,552 - 139,632,113 (+)NCBILyon_Hypertensive
F344_StmMcwi2139,342,565 - 139,461,109 (+)NCBIF344_StmMcwi
Rnor_6.02143,433,102 - 143,605,757 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2143,475,323 - 143,604,972 (+)Ensemblrn6Rnor6.0
Rnor_5.02163,115,873 - 163,282,223 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42143,350,286 - 143,485,716 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2132,835,300 - 132,958,908 (+)NCBICelera
RGSC_v3.12143,254,891 - 143,435,776 (+)NCBI
Cytogenetic Map2q26NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,2-dichloroethane  (ISO)
1-Oleoyl-2-acetyl-sn-glycerol  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
barium(0)  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbachol  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dexamethasone  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
fenvalerate  (EXP)
folic acid  (ISO)
indometacin  (ISO)
lead diacetate  (EXP)
malaoxon  (EXP)
malathion  (EXP,ISO)
maneb  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Muscarine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
okadaic acid  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
Ptaquiloside  (ISO)
pyrethrins  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
strontium atom  (ISO)
sunitinib  (ISO)
testosterone  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. TRPC4 inactivation confers a survival benefit in severe pulmonary arterial hypertension. Alzoubi A, etal., Am J Pathol. 2013 Dec;183(6):1779-1788. doi: 10.1016/j.ajpath.2013.08.016. Epub 2013 Oct 8.
2. Cloning and expression localization of cDNA for rat homolog of TRP protein, a possible store-operated calcium (Ca2+) channel. Funayama M, etal., Brain Res Mol Brain Res 1996 Dec 31;43(1-2):259-66.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Loss of the trpc4 gene is associated with a reduction in cocaine self-administration and reduced spontaneous ventral tegmental area dopamine neuronal activity, without deficits in learning for natural rewards. Klipec WD, etal., Behav Brain Res. 2016 Jun 1;306:117-27. doi: 10.1016/j.bbr.2016.03.027. Epub 2016 Mar 14.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Cocaine self-administration in rats lacking a functional trpc4 gene. Rasmus KC, etal., F1000Res. 2013 Apr 17;2:110. doi: 10.12688/f1000research.2-110.v1. eCollection 2013.
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Cloning and functional expression of a novel splice variant of rat TRPC4. Satoh E, etal., Circ J 2002 Oct;66(10):954-8.
13. Functional differences between TRPC4 splice variants. Schaefer M, etal., J Biol Chem 2002 Feb 1;277(5):3752-9.
14. Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. Tang Y, etal., J Biol Chem 2000 Dec 1;275(48):37559-64.
15. A rat knockout model implicates TRPC4 in visceral pain sensation. Westlund KN, etal., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3.
16. Identification of TRPCs genetic variants that modify risk for lung cancer based on the pathway and two-stage study. Zhang Z, etal., Meta Gene. 2016 Jul 8;9:191-6. doi: 10.1016/j.mgene.2016.07.005. eCollection 2016 Sep.
Additional References at PubMed
PMID:10998353   PMID:11301024   PMID:11897792   PMID:14505576   PMID:14668438   PMID:15044151   PMID:15199065   PMID:16254212   PMID:17141310   PMID:17416589   PMID:17593972   PMID:17928298  
PMID:18261457   PMID:18538797   PMID:19139271   PMID:19996314   PMID:20164195   PMID:20662729   PMID:22534489   PMID:22611033   PMID:23526217   PMID:23677990   PMID:23922735   PMID:24352411  
PMID:25049082   PMID:27083517   PMID:27129253   PMID:27641617   PMID:28697491   PMID:29634917   PMID:31904090   PMID:31996247   PMID:38636714  


Genomics

Comparative Map Data
Trpc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82140,457,841 - 140,629,556 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2140,458,296 - 140,626,969 (+)EnsemblGRCr8
mRatBN7.22138,307,676 - 138,476,856 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2138,308,084 - 138,476,768 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2144,918,944 - 145,044,642 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02143,030,992 - 143,156,703 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02137,662,818 - 137,788,527 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd2139,583,568 - 139,709,136 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive2139,902,958 - 140,028,528 (+)NCBILyon_Normotensive
Lyon_Hypertensive2139,506,552 - 139,632,113 (+)NCBILyon_Hypertensive
F344_StmMcwi2139,342,565 - 139,461,109 (+)NCBIF344_StmMcwi
Rnor_6.02143,433,102 - 143,605,757 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2143,475,323 - 143,604,972 (+)Ensemblrn6Rnor6.0
Rnor_5.02163,115,873 - 163,282,223 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42143,350,286 - 143,485,716 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2132,835,300 - 132,958,908 (+)NCBICelera
RGSC_v3.12143,254,891 - 143,435,776 (+)NCBI
Cytogenetic Map2q26NCBI
TRPC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381337,632,063 - 37,869,772 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1337,632,063 - 37,870,204 (-)Ensemblhg38GRCh38
GRCh371338,206,200 - 38,443,909 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361337,108,795 - 37,341,935 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341337,108,794 - 37,341,935NCBI
Celera1319,264,388 - 19,497,682 (-)NCBICelera
Cytogenetic Map13q13.3NCBI
HuRef1319,010,251 - 19,243,495 (-)NCBIHuRef
CHM1_11338,178,367 - 38,411,614 (-)NCBICHM1_1
T2T-CHM13v2.01336,851,454 - 37,089,250 (-)NCBIT2T-CHM13v2.0
Trpc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39354,063,441 - 54,225,892 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl354,063,456 - 54,225,892 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38354,155,584 - 54,318,471 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl354,156,035 - 54,318,471 (+)Ensemblmm10GRCm38
MGSCv37353,960,026 - 54,122,389 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36354,244,033 - 54,406,396 (+)NCBIMGSCv36mm8
Celera353,878,360 - 54,040,521 (+)NCBICelera
Cytogenetic Map3CNCBI
cM Map325.43NCBI
Trpc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554318,282,812 - 8,479,944 (+)Ensembl
ChiLan1.0NW_0049554318,283,585 - 8,479,524 (+)NCBIChiLan1.0ChiLan1.0
TRPC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21437,165,899 - 37,395,117 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11328,272,271 - 28,501,184 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01318,852,991 - 19,081,790 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11337,445,015 - 37,673,783 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1337,445,015 - 37,592,115 (-)EnsemblpanPan2panpan1.1
TRPC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1252,927,347 - 3,133,935 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl252,981,518 - 3,132,829 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha253,022,599 - 3,229,148 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0253,025,824 - 3,232,420 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl253,025,926 - 3,231,292 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1252,930,561 - 3,136,488 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0252,920,321 - 3,126,347 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0252,990,669 - 3,197,659 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Trpc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945164,042,735 - 164,240,721 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647231,711,040 - 31,843,876 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647231,710,873 - 31,909,106 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1113,298,992 - 13,517,502 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11113,300,288 - 13,519,001 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21113,275,420 - 13,336,168 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21113,401,850 - 13,486,078 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRPC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1316,135,822 - 16,358,902 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605727,929,460 - 28,150,311 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trpc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624920641,917 - 903,171 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624920641,931 - 903,229 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Trpc4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13100,101,101 - 100,256,387 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Trpc4
1021 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:114
Count of miRNA genes:79
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000015437, ENSRNOT00000044028
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2124103798154505346Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2120039407159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2120039407151869825Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2114032149150226270Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
RH134901  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22138,476,449 - 138,476,634 (+)MAPPERmRatBN7.2
Rnor_6.02143,604,778 - 143,604,962NCBIRnor6.0
Rnor_5.02163,281,870 - 163,282,054UniSTSRnor5.0
RGSC_v3.42143,485,522 - 143,485,706UniSTSRGSC3.4
Celera2132,958,714 - 132,958,898UniSTS
RH 3.4 Map2860.6UniSTS
Cytogenetic Map2q26UniSTS
Trpc4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22138,475,745 - 138,476,511 (+)MAPPERmRatBN7.2
Rnor_6.02143,604,074 - 143,604,839NCBIRnor6.0
Rnor_5.02163,281,166 - 163,281,931UniSTSRnor5.0
RGSC_v3.42143,484,818 - 143,485,583UniSTSRGSC3.4
Celera2132,958,010 - 132,958,775UniSTS
Cytogenetic Map2q26UniSTS
Trpc4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22138,476,205 - 138,476,314 (+)MAPPERmRatBN7.2
Rnor_6.02143,604,534 - 143,604,642NCBIRnor6.0
Rnor_5.02163,281,626 - 163,281,734UniSTSRnor5.0
Celera2132,958,470 - 132,958,578UniSTS
Cytogenetic Map2q26UniSTS


Genetic Models
This gene Trpc4 is modified in the following models/strains:
F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi     F344-Trpc4Tn(sb)1Bni    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 11 55 144 50 49 18 32 18 5 228 119 10 117 69 91 31 12 12

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001083115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_080396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB008889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC118066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF288407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF288408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF421363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF421364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF421365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF421366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF421367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF421368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000015437   ⟹   ENSRNOP00000015437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2140,501,296 - 140,626,845 (+)Ensembl
mRatBN7.2 Ensembl2138,351,086 - 138,476,644 (+)Ensembl
Rnor_6.0 Ensembl2143,475,323 - 143,604,972 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000044028   ⟹   ENSRNOP00000042886
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2140,458,296 - 140,626,969 (+)Ensembl
mRatBN7.2 Ensembl2138,308,084 - 138,476,768 (+)Ensembl
Rnor_6.0 Ensembl2143,475,323 - 143,604,972 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101369   ⟹   ENSRNOP00000094229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2140,458,296 - 140,626,969 (+)Ensembl
mRatBN7.2 Ensembl2138,308,084 - 138,427,689 (+)Ensembl
RefSeq Acc Id: NM_001083115   ⟹   NP_001076584
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82140,501,296 - 140,626,845 (+)NCBI
mRatBN7.22138,351,086 - 138,476,644 (+)NCBI
Dahl_SR_JrHsd2139,583,568 - 139,709,136 (+)NCBI
Lyon_Normotensive2139,902,958 - 140,028,528 (+)NCBI
Lyon_Hypertensive2139,506,552 - 139,632,113 (+)NCBI
F344_StmMcwi2139,342,565 - 139,461,109 (+)NCBI
Rnor_6.02143,475,323 - 143,604,972 (+)NCBI
Rnor_5.02163,115,873 - 163,282,223 (+)NCBI
RGSC_v3.42143,350,286 - 143,485,716 (+)RGD
Celera2132,835,300 - 132,958,908 (+)RGD
Sequence:
RefSeq Acc Id: NM_080396   ⟹   NP_536321
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82140,501,296 - 140,626,845 (+)NCBI
mRatBN7.22138,351,086 - 138,476,644 (+)NCBI
Dahl_SR_JrHsd2139,583,568 - 139,709,136 (+)NCBI
Lyon_Normotensive2139,902,958 - 140,028,528 (+)NCBI
Lyon_Hypertensive2139,506,552 - 139,632,113 (+)NCBI
F344_StmMcwi2139,342,565 - 139,461,109 (+)NCBI
Rnor_6.02143,475,323 - 143,604,972 (+)NCBI
Rnor_5.02163,115,873 - 163,282,223 (+)NCBI
RGSC_v3.42143,350,286 - 143,485,716 (+)RGD
Celera2132,835,300 - 132,958,908 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232356   ⟹   XP_006232418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82140,458,011 - 140,629,556 (+)NCBI
mRatBN7.22138,307,679 - 138,476,856 (+)NCBI
Rnor_6.02143,433,104 - 143,605,757 (+)NCBI
Rnor_5.02163,115,873 - 163,282,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591143   ⟹   XP_017446632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82140,457,842 - 140,629,556 (+)NCBI
mRatBN7.22138,307,677 - 138,476,856 (+)NCBI
Rnor_6.02143,433,115 - 143,605,757 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103271   ⟹   XP_038959199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82140,457,841 - 140,629,556 (+)NCBI
mRatBN7.22138,307,676 - 138,476,856 (+)NCBI
RefSeq Acc Id: XM_039103272   ⟹   XP_038959200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82140,576,724 - 140,629,556 (+)NCBI
mRatBN7.22138,426,515 - 138,476,856 (+)NCBI
RefSeq Acc Id: NP_536321   ⟸   NM_080396
- Peptide Label: isoform alpha
- UniProtKB: Q91ZL9 (UniProtKB/Swiss-Prot),   Q9EQ75 (UniProtKB/Swiss-Prot),   Q9EQ74 (UniProtKB/Swiss-Prot),   O35119 (UniProtKB/Swiss-Prot),   Q91ZM1 (UniProtKB/TrEMBL),   F7FEC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001076584   ⟸   NM_001083115
- Peptide Label: isoform beta
- UniProtKB: Q91ZL9 (UniProtKB/Swiss-Prot),   Q9EQ75 (UniProtKB/Swiss-Prot),   Q9EQ74 (UniProtKB/Swiss-Prot),   O35119 (UniProtKB/Swiss-Prot),   Q91ZM0 (UniProtKB/TrEMBL),   A6JVB2 (UniProtKB/TrEMBL),   F7F3R3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232418   ⟸   XM_006232356
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017446632   ⟸   XM_017591143
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000042886   ⟸   ENSRNOT00000044028
Ensembl Acc Id: ENSRNOP00000015437   ⟸   ENSRNOT00000015437
RefSeq Acc Id: XP_038959199   ⟸   XM_039103271
- Peptide Label: isoform X3
- UniProtKB: Q9EQ75 (UniProtKB/Swiss-Prot),   Q9EQ74 (UniProtKB/Swiss-Prot),   O35119 (UniProtKB/Swiss-Prot),   Q91ZL9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959200   ⟸   XM_039103272
- Peptide Label: isoform X4
- UniProtKB: A6JVB3 (UniProtKB/TrEMBL),   A6JVB4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094229   ⟸   ENSRNOT00000101369
Protein Domains
Ion transport   Transient receptor ion channel

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35119-F1-model_v2 AlphaFold O35119 1-977 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621276 AgrOrtholog
BioCyc Gene G2FUF-53083 BioCyc
Ensembl Genes ENSRNOG00000011133 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000015437 ENTREZGENE
  ENSRNOT00000044028 ENTREZGENE
  ENSRNOT00000101369 ENTREZGENE
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  TRP_dom UniProtKB/Swiss-Prot
  TRPC4_channel UniProtKB/Swiss-Prot
  TRPC_channel UniProtKB/Swiss-Prot
NCBI Gene 84494 ENTREZGENE
PANTHER PTHR10117 UniProtKB/Swiss-Prot
  PTHR10117:SF25 UniProtKB/Swiss-Prot
Pfam Ank UniProtKB/Swiss-Prot
  Ank_2 UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
  TRP_2 UniProtKB/Swiss-Prot
PhenoGen Trpc4 PhenoGen
PRINTS TRNSRECEPTRP UniProtKB/Swiss-Prot
  TRPCHANNEL4 UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011133 RatGTEx
SMART ANK UniProtKB/Swiss-Prot
  TRP_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot
UniProt A0A8I6APN9_RAT UniProtKB/TrEMBL
  A6JVB2 ENTREZGENE, UniProtKB/TrEMBL
  A6JVB3 ENTREZGENE, UniProtKB/TrEMBL
  A6JVB4 ENTREZGENE, UniProtKB/TrEMBL
  F7F3R3 ENTREZGENE, UniProtKB/TrEMBL
  F7FEC4 ENTREZGENE, UniProtKB/TrEMBL
  O35119 ENTREZGENE
  Q91ZL6_RAT UniProtKB/TrEMBL
  Q91ZL7_RAT UniProtKB/TrEMBL
  Q91ZL8_RAT UniProtKB/TrEMBL
  Q91ZL9 ENTREZGENE
  Q91ZM0 ENTREZGENE
  Q91ZM1 ENTREZGENE, UniProtKB/TrEMBL
  Q9EQ74 ENTREZGENE
  Q9EQ75 ENTREZGENE
  TRPC4_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q91ZL9 UniProtKB/Swiss-Prot
  Q9EQ74 UniProtKB/Swiss-Prot
  Q9EQ75 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Trpc4  transient receptor potential cation channel, subfamily C, member 4    transient receptor protein 4  Name updated 1299863 APPROVED
2002-08-07 Trpc4  transient receptor protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_transcript splice variant Trpc4beta forms a homomultimeric cation channel 625475
gene_transcript splice variants Trpc4alpha and Trpc4beta display receptor mediated activation of calcium transport activity 625475