Zap70 (zeta chain of T cell receptor associated protein kinase 70) - Rat Genome Database

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Gene: Zap70 (zeta chain of T cell receptor associated protein kinase 70) Rattus norvegicus
Analyze
Symbol: Zap70
Name: zeta chain of T cell receptor associated protein kinase 70
RGD ID: 3983
Description: Predicted to enable ATP binding activity; non-membrane spanning protein tyrosine kinase activity; and phosphotyrosine residue binding activity. Predicted to be involved in immune response. Predicted to act upstream of or within several processes, including T cell selection; positive regulation of alpha-beta T cell activation; and positive regulation of intracellular signal transduction. Predicted to be located in several cellular components, including cell-cell junction; immunological synapse; and membrane raft. Predicted to be part of T cell receptor complex. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 48 and severe combined immunodeficiency. Orthologous to human ZAP70 (zeta chain of T cell receptor associated protein kinase 70); PARTICIPATES IN phosphatidylinositol 3-kinase class I signaling pathway; primary immunodeficiency pathway; T cell receptor signaling pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC108902; Srk; syk-related protein tyrosine kinase; tyrosine-protein kinase ZAP-70; Zap70_mapped; zeta-chain (TCR) associated protein kinase; zeta-chain (TCR) associated protein kinase 70; zeta-chain (TCR) associated protein kinase 70 (mapped); zeta-chain (TCR) associated protein kinase 70kDa
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8946,485,605 - 46,507,552 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl946,485,598 - 46,509,062 (+)EnsemblGRCr8
mRatBN7.2938,989,750 - 39,011,701 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl938,989,750 - 39,011,700 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx947,492,671 - 47,514,535 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0952,608,543 - 52,630,495 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0950,890,437 - 50,912,386 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0943,331,149 - 43,353,097 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl943,331,155 - 43,353,113 (+)Ensemblrn6Rnor6.0
Rnor_5.0942,980,050 - 43,002,015 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4935,693,089 - 35,715,071 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera936,755,106 - 36,777,088 (+)NCBICelera
Cytogenetic Map9q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-amino-4,6-dinitrotoluene  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
alpha-amanitin  (ISO)
alpha-Zearalanol  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium dichloride  (EXP)
calciol  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
disodium selenite  (ISO)
entinostat  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (ISO)
GSK-J4  (ISO)
inulin  (ISO)
lead diacetate  (ISO)
methylarsonic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nevirapine  (EXP)
nickel atom  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
pirinixic acid  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell-cell junction  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
immunological synapse  (IEA,ISO)
membrane  (IEA,ISO)
membrane raft  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO)
T cell receptor complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase. Arpaia E, etal., Cell. 1994 Mar 11;76(5):947-58.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:1423621   PMID:7630421   PMID:8176201   PMID:8196616   PMID:8798454   PMID:9169414   PMID:9182527   PMID:9208839   PMID:9275205   PMID:12051764   PMID:12150984   PMID:12447358  
PMID:12477932   PMID:14738763   PMID:15599401   PMID:17028588   PMID:21354221   PMID:22732588   PMID:23620790   PMID:23793062   PMID:38263783  


Genomics

Comparative Map Data
Zap70
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8946,485,605 - 46,507,552 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl946,485,598 - 46,509,062 (+)EnsemblGRCr8
mRatBN7.2938,989,750 - 39,011,701 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl938,989,750 - 39,011,700 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx947,492,671 - 47,514,535 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0952,608,543 - 52,630,495 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0950,890,437 - 50,912,386 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0943,331,149 - 43,353,097 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl943,331,155 - 43,353,113 (+)Ensemblrn6Rnor6.0
Rnor_5.0942,980,050 - 43,002,015 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4935,693,089 - 35,715,071 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera936,755,106 - 36,777,088 (+)NCBICelera
Cytogenetic Map9q21NCBI
ZAP70
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38297,713,576 - 97,756,364 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl297,713,576 - 97,744,327 (+)Ensemblhg38GRCh38
GRCh37298,330,039 - 98,356,323 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36297,696,463 - 97,722,755 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34297,809,386 - 97,814,841NCBI
Celera292,533,995 - 92,560,286 (+)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef292,095,689 - 92,121,947 (+)NCBIHuRef
CHM1_1298,334,370 - 98,360,661 (+)NCBICHM1_1
T2T-CHM13v2.0298,171,200 - 98,202,543 (+)NCBIT2T-CHM13v2.0
Zap70
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39136,800,912 - 36,821,899 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl136,800,879 - 36,821,899 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38136,761,798 - 36,782,821 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl136,761,798 - 36,782,818 (+)Ensemblmm10GRCm38
MGSCv37136,818,706 - 36,839,661 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36136,706,407 - 36,727,362 (+)NCBIMGSCv36mm8
Celera136,542,193 - 36,563,340 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map115.41NCBI
Zap70
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554704,386,311 - 4,396,419 (+)Ensembl
ChiLan1.0NW_0049554704,379,260 - 4,397,851 (+)NCBIChiLan1.0ChiLan1.0
LOC100971372
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21230,715,251 - 30,745,868 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A30,718,013 - 30,748,630 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A101,582,567 - 101,613,175 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A98,613,740 - 98,639,742 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A98,613,740 - 98,639,088 (+)EnsemblpanPan2panpan1.1
ZAP70
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11044,887,416 - 44,913,845 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1044,887,433 - 44,900,071 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1044,814,558 - 44,845,740 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01045,763,554 - 45,794,709 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1045,763,556 - 45,786,952 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11045,475,442 - 45,506,585 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01045,761,536 - 45,792,714 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01045,944,828 - 45,975,965 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101971458
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629283,747,123 - 83,759,795 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367441,000,105 - 1,012,433 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367441,000,105 - 1,012,712 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZAP70
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl356,515,449 - 56,541,740 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1356,515,446 - 56,541,806 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2359,135,457 - 59,151,701 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZAP70
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1141,403,294 - 1,430,205 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl141,404,325 - 1,431,015 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041168,846,354 - 168,873,240 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101716577
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247492,893,601 - 2,901,035 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247492,893,601 - 2,901,256 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
LOC116898139
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14112,980,216 - 112,992,784 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Zap70
133 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:36
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000023036
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat

Markers in Region
RH132636  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2939,011,462 - 39,011,645 (+)MAPPERmRatBN7.2
Rnor_6.0943,352,859 - 43,353,041NCBIRnor6.0
Rnor_5.0943,001,777 - 43,001,959UniSTSRnor5.0
RGSC_v3.4935,714,833 - 35,715,015UniSTSRGSC3.4
Celera936,776,850 - 36,777,032UniSTS
RH 3.4 Map9366.6UniSTS
Cytogenetic Map9q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 65 148 89 88 57 92 57 6 352 190 11 119 81 92 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000023036   ⟹   ENSRNOP00000023036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl946,488,529 - 46,507,683 (+)Ensembl
mRatBN7.2 Ensembl938,989,750 - 39,011,700 (+)Ensembl
Rnor_6.0 Ensembl943,331,155 - 43,353,113 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110442   ⟹   ENSRNOP00000092439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl946,485,598 - 46,509,062 (+)Ensembl
mRatBN7.2 Ensembl938,998,730 - 39,011,700 (+)Ensembl
RefSeq Acc Id: NM_001012002   ⟹   NP_001012002
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8946,485,605 - 46,507,552 (+)NCBI
mRatBN7.2938,989,750 - 39,011,701 (+)NCBI
Rnor_6.0943,331,149 - 43,353,097 (+)NCBI
Rnor_5.0942,980,050 - 43,002,015 (+)NCBI
RGSC_v3.4935,693,089 - 35,715,071 (+)RGD
Celera936,755,106 - 36,777,088 (+)RGD
Sequence:
RefSeq Acc Id: XM_006244761   ⟹   XP_006244823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8946,488,316 - 46,507,552 (+)NCBI
mRatBN7.2938,992,452 - 39,011,701 (+)NCBI
Rnor_6.0943,332,969 - 43,353,097 (+)NCBI
Rnor_5.0942,980,050 - 43,002,015 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063266894   ⟹   XP_063122964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8946,495,613 - 46,507,552 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001012002 (Get FASTA)   NCBI Sequence Viewer  
  XP_006244823 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122964 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH89855 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023036
  ENSRNOP00000023036.6
  ENSRNOP00000092439
  ENSRNOP00000092439.2
RefSeq Acc Id: NP_001012002   ⟸   NM_001012002
- UniProtKB: A0A0R4J8U1 (UniProtKB/TrEMBL),   A6INF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244823   ⟸   XM_006244761
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AHV6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023036   ⟸   ENSRNOT00000023036
Ensembl Acc Id: ENSRNOP00000092439   ⟸   ENSRNOT00000110442
RefSeq Acc Id: XP_063122964   ⟸   XM_063266894
- Peptide Label: isoform X2
Protein Domains
Protein kinase   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0R4J8U1-F1-model_v2 AlphaFold A0A0R4J8U1 1-614 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696610
Promoter ID:EPDNEW_R7135
Type:single initiation site
Name:Zap70_1
Description:zeta chain of T cell receptor associated protein kinase 70
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0943,331,158 - 43,331,218EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3983 AgrOrtholog
BioCyc Gene G2FUF-27797 BioCyc
Ensembl Genes ENSRNOG00000016995 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023036 ENTREZGENE
  ENSRNOT00000023036.9 UniProtKB/TrEMBL
  ENSRNOT00000110442 ENTREZGENE
  ENSRNOT00000110442.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Syk Kinase, Chain A, domain 2 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7380367 IMAGE-MGC_LOAD
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Kinase_SYK/ZAP-70_inter-SH2 UniProtKB/TrEMBL
  Non-receptor_tyrosine_kinases UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SYK/ZAP-70_N_SH2 UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_SYK/ZAP70 UniProtKB/TrEMBL
  Tyr_Pkinase_cat_dom UniProtKB/TrEMBL
  Tyr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:301348 UniProtKB/TrEMBL
MGC_CLONE MGC:108902 IMAGE-MGC_LOAD
NCBI Gene Zap70 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase_Tyr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PhenoGen Zap70 PhenoGen
PIRSF TyrPK_SYK UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016995 RatGTEx
SMART SH2 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A0R4J8U1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AHV6 ENTREZGENE, UniProtKB/TrEMBL
  A6INF5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 Zap70  zeta chain of T cell receptor associated protein kinase 70  Zap70  zeta-chain (TCR) associated protein kinase 70  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-03-06 Zap70  zeta-chain (TCR) associated protein kinase 70  Zap70  zeta-chain (TCR) associated protein kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-27 Zap70  zeta-chain (TCR) associated protein kinase  Zap70  zeta-chain (TCR) associated protein kinase 70  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-02-20 Zap70  zeta-chain (TCR) associated protein kinase 70  Zap70_mapped  zeta-chain (TCR) associated protein kinase 70 (mapped)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 PROVISIONAL
2007-02-20 Zap70_mapped  zeta-chain (TCR) associated protein kinase 70 (mapped)  Zap70_retired  zeta-chain (TCR) associated protein kinase 70 (mapped)  Data merged from RGD:1586178 737654 PROVISIONAL
2007-02-20 Zap70_retired    Zap70  zeta-chain (TCR) associated protein kinase 70 (mapped)  Symbol updated 1299863 PROVISIONAL
2006-11-19 Zap70  zeta-chain (TCR) associated protein kinase 70 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Zap70_mapped  zeta-chain (TCR) associated protein kinase 70 (mapped)  Zap70  zeta-chain (TCR) associated protein kinase 70kDa  Symbol and Name updated 1556543 APPROVED
2003-04-09 Zap70  zeta-chain (TCR) associated protein kinase 70kDa      Name updated 629478 APPROVED
2003-03-11   zeta-chain (TCR) associated protein kinase 70kDa  Zap70  zeta-chain (TCR) associated protein kinase  Name updated to reflect Human and Mouse nomenclature 61478 PROVISIONAL
2002-06-10 Zap70  zeta-chain (TCR) associated protein kinase      Name updated 70584 APPROVED
2001-07-09 Zap70  zeta-chain (TCR) associated protein kinase (70kD)      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-07-09 Zap70  Syk-related protein tyrosine kinase      Name withdrawn 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference