Syt1 (synaptotagmin 1) - Rat Genome Database

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Gene: Syt1 (synaptotagmin 1) Rattus norvegicus
Analyze
Symbol: Syt1
Name: synaptotagmin 1
RGD ID: 3803
Description: Enables several functions, including calcium ion sensor activity; phospholipid binding activity; and syntaxin binding activity. Involved in several processes, including detection of calcium ion; regulation of secretion by cell; and regulation of vesicle-mediated transport. Located in several cellular components, including excitatory synapse; neuron projection terminus; and secretory vesicle. Is active in several cellular components, including hippocampal mossy fiber to CA3 synapse; postsynaptic cytosol; and presynaptic cytosol. Orthologous to human SYT1 (synaptotagmin 1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: P65; synaptotagmin I; synaptotagmin-1; sytI
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8745,699,649 - 46,244,460 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl745,702,228 - 46,244,213 (-)EnsemblGRCr8
mRatBN7.2743,813,204 - 44,358,020 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl743,815,785 - 44,357,803 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx745,726,193 - 46,271,079 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0747,929,286 - 48,474,187 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0747,707,065 - 48,251,959 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0750,084,063 - 50,638,996 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl750,084,060 - 50,638,798 (-)Ensemblrn6Rnor6.0
Rnor_5.0750,097,034 - 50,289,950 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4747,243,375 - 47,795,496 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera740,680,324 - 41,216,966 (-)NCBICelera
RGSC_v3.1747,261,066 - 47,815,950 (-)NCBI
RH 3.4 Map7348.01RGD
Cytogenetic Map7q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcidiol  (EXP)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
Cuprizon  (EXP)
D-glucose  (EXP)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
diallyl disulfide  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenthion  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glucose  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
heroin  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
inulin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phloretin  (ISO)
pirinixic acid  (ISO)
Ptaquiloside  (ISO)
sarin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium activated phospholipid scrambling  (IMP)
calcium ion-regulated exocytosis of neurotransmitter  (ISO)
calcium-dependent activation of synaptic vesicle fusion  (IBA,IEA,ISO)
calcium-ion regulated exocytosis  (TAS)
cell differentiation  (IEA)
cellular response to calcium ion  (IMP)
detection of calcium ion  (IC,IDA)
fast, calcium ion-dependent exocytosis of neurotransmitter  (IEA,ISO,ISS)
inhibitory postsynaptic potential  (IMP)
membraneless organelle assembly  (IDA)
negative regulation of neurotransmitter secretion  (IMP)
neurotransmitter secretion  (ISO)
positive regulation of calcium ion-dependent exocytosis  (IDA)
positive regulation of calcium ion-dependent exocytosis of neurotransmitter  (IEA,ISO,ISS)
positive regulation of dendrite extension  (IEA,ISO)
positive regulation of dopamine secretion  (IMP)
positive regulation of synaptic transmission  (IEA,ISO,ISS)
positive regulation of vesicle fusion  (IDA)
protein heterooligomerization  (IPI)
protein insertion into membrane  (IMP)
regulated exocytosis  (IEA)
regulation of calcium ion-dependent exocytosis  (IBA,IEA,IMP,ISO)
regulation of calcium-dependent activation of synaptic vesicle fusion  (IMP)
regulation of dopamine secretion  (IEA,ISO)
regulation of endocytosis  (IMP)
regulation of regulated secretory pathway  (IMP)
regulation of synaptic transmission, glutamatergic  (IEA,ISO,ISS)
regulation of synaptic vesicle exocytosis  (IBA,IDA)
regulation of vesicle fusion  (IMP)
response to calcium ion  (IDA)
spontaneous neurotransmitter secretion  (ISO)
synaptic vesicle exocytosis  (ISO,TAS)
synaptic vesicle recycling  (IMP)
synchronous neurotransmitter secretion  (ISO)
vesicle docking  (IDA,IMP)
vesicle fusion  (IDA,IMP)
vesicle organization  (IEA,ISO)
vesicle targeting  (IDA)
vesicle-mediated transport  (IBA)
xenobiotic transmembrane transport  (IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles. Bacaj T, etal., PLoS Biol. 2015 Oct 5;13(10):e1002267. doi: 10.1371/journal.pbio.1002267. eCollection 2015 Oct.
2. C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I. Bai J, etal., Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1665-70. doi: 10.1073/pnas.032541099. Epub 2002 Jan 22.
3. Identification of a human synaptotagmin-1 mutation that perturbs synaptic vesicle cycling. Baker K, etal., J Clin Invest. 2015 Apr;125(4):1670-8. doi: 10.1172/JCI79765. Epub 2015 Feb 23.
4. Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. Bakkaloglu B, etal., Am J Hum Genet. 2008 Jan;82(1):165-73. doi: 10.1016/j.ajhg.2007.09.017.
5. Analysis of the synaptotagmin family during reconstituted membrane fusion. Uncovering a class of inhibitory isoforms. Bhalla A, etal., J Biol Chem. 2008 Aug 1;283(31):21799-807. doi: 10.1074/jbc.M709628200. Epub 2008 May 28.
6. Synaptotagmin: a calcium sensor on the synaptic vesicle surface. Brose N, etal., Science. 1992 May 15;256(5059):1021-5. doi: 10.1126/science.1589771.
7. A novel function for the second C2 domain of synaptotagmin. Ca2+-triggered dimerization. Chapman ER, etal., J Biol Chem. 1996 Mar 8;271(10):5844-9. doi: 10.1074/jbc.271.10.5844.
8. Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin. Chapman ER, etal., J Biol Chem. 1998 Dec 4;273(49):32966-72.
9. Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha1A subunit of the P/Q-type calcium channel. Charvin N, etal., EMBO J. 1997 Aug 1;16(15):4591-6.
10. Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain. Cheng Y, etal., Protein Sci. 2004 Oct;13(10):2665-72. Epub 2004 Aug 31.
11. Single-molecule FRET-derived model of the synaptotagmin 1-SNARE fusion complex. Choi UB, etal., Nat Struct Mol Biol. 2010 Mar;17(3):318-24. doi: 10.1038/nsmb.1763. Epub 2010 Feb 21.
12. Direct interaction of the rab3 effector rim with ca2+ channels, snap-25, and synaptotagmin. Coppola T, etal., J Biol Chem 2001 Aug 31;276(35):32756-62.
13. Rab3A Inhibition of Ca2+ -Dependent Dopamine Release From PC12 Cells Involves Interaction With Synaptotagmin I. Dai Z, etal., J Cell Biochem. 2017 Nov;118(11):3696-3705. doi: 10.1002/jcb.26016. Epub 2017 May 16.
14. A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding. Davletov BA and Sudhof TC, J Biol Chem. 1993 Dec 15;268(35):26386-90.
15. Stonin 2 is an AP-2-dependent endocytic sorting adaptor for synaptotagmin internalization and recycling. Diril MK, etal., Dev Cell. 2006 Feb;10(2):233-44. doi: 10.1016/j.devcel.2005.12.011.
16. Phosphorylation-dependent interaction of the synaptic vesicle proteins cysteine string protein and synaptotagmin I. Evans GJ and Morgan A, Biochem J 2002 Jun 1;364(Pt 2):343-7.
17. RNA interference-mediated silencing of synaptotagmin IX, but not synaptotagmin I, inhibits dense-core vesicle exocytosis in PC12 cells. Fukuda M Biochem J. 2004 Jun 15;380(Pt 3):875-9.
18. Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells. Fukuda M, etal., J Biol Chem. 2002 Feb 15;277(7):4601-4. Epub 2001 Dec 21.
19. The V0 sector of the V-ATPase, synaptobrevin, and synaptophysin are associated on synaptic vesicles in a Triton X-100-resistant, freeze-thawing sensitive, complex. Galli T, etal., J Biol Chem. 1996 Jan 26;271(4):2193-8.
20. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
21. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
22. N-glycosylation is essential for vesicular targeting of synaptotagmin 1. Han W, etal., Neuron. 2004 Jan 8;41(1):85-99. doi: 10.1016/s0896-6273(03)00820-1.
23. Nadrin, a novel neuron-specific GTPase-activating protein involved in regulated exocytosis. Harada A, etal., J Biol Chem 2000 Nov 24;275(47):36885-91.
24. Subcellular localization and putative role of VPS13A/chorein in dopaminergic neuronal cells. Hayashi T, etal., Biochem Biophys Res Commun. 2012 Mar 16;419(3):511-6. doi: 10.1016/j.bbrc.2012.02.047. Epub 2012 Feb 15.
25. The calcium sensor synaptotagmin 1 is expressed and regulated in hippocampal postsynaptic spines. Hussain S, etal., Hippocampus. 2017 Nov;27(11):1168-1177. doi: 10.1002/hipo.22761. Epub 2017 Jul 24.
26. The AP2 binding site of synaptotagmin 1 is not an internalization signal but a regulator of endocytosis. Jarousse N and Kelly RB, J Cell Biol. 2001 Aug 20;154(4):857-66. Epub 2001 Aug 13.
27. Molecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2. Jung N, etal., J Cell Biol. 2007 Dec 31;179(7):1497-510. doi: 10.1083/jcb.200708107.
28. Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. Ko J, etal., EMBO J. 2009 Oct 21;28(20):3244-55. doi: 10.1038/emboj.2009.249. Epub 2009 Sep 3.
29. The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. Krapivinsky G, etal., Neuron. 2006 Nov 9;52(3):485-96.
30. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
31. Synaptotagmin 1 modulates lipid acyl chain order in lipid bilayers by demixing phosphatidylserine. Lai AL, etal., J Biol Chem. 2011 Jul 15;286(28):25291-300. doi: 10.1074/jbc.M111.258848. Epub 2011 May 24.
32. The importance of an asymmetric distribution of acidic lipids for synaptotagmin 1 function as a Ca2+ sensor. Lai Y and Shin YK, Biochem J. 2012 Apr 1;443(1):223-9. doi: 10.1042/BJ20112044.
33. The synaptotagmin 1 linker may function as an electrostatic zipper that opens for docking but closes for fusion pore opening. Lai Y, etal., Biochem J. 2013 Nov 15;456(1):25-33. doi: 10.1042/BJ20130949.
34. Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins. Li C, etal., Nature 1995 Jun 15;375(6532):594-9.
35. A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Li H, etal., Nat Cell Biol. 2013 Jul;15(7):773-85. doi: 10.1038/ncb2791. Epub 2013 Jun 23.
36. The juxtamembrane linker of full-length synaptotagmin 1 controls oligomerization and calcium-dependent membrane binding. Lu B, etal., J Biol Chem. 2014 Aug 8;289(32):22161-71. doi: 10.1074/jbc.M114.569327. Epub 2014 Jun 27.
37. A plethora of presynaptic proteins associated with ATP-storing organelles in cultured astrocytes. Maienschein V, etal., Glia. 1999 May;26(3):233-44.
38. Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue. Matthew WD, etal., J Cell Biol. 1981 Oct;91(1):257-69.
39. Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release. Maximov A, etal., J Cell Biol. 2007 Jan 1;176(1):113-24. Epub 2006 Dec 26.
40. The juxtamembrane region of synaptotagmin 1 interacts with dynamin 1 and regulates vesicle fission during compensatory endocytosis in endocrine cells. McAdam RL, etal., J Cell Sci. 2015 Jun 15;128(12):2229-35. doi: 10.1242/jcs.161505. Epub 2015 May 11.
41. The juxtamembrane linker of synaptotagmin 1 regulates Ca2+ binding via liquid-liquid phase separation. Mehta N, etal., Nat Commun. 2024 Jan 4;15(1):262. doi: 10.1038/s41467-023-44414-5.
42. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
43. JNK phosphorylates synaptotagmin-4 and enhances Ca2+-evoked release. Mori Y, etal., EMBO J. 2008 Jan 9;27(1):76-87. Epub 2007 Nov 29.
44. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
45. Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C. Perin MS, etal., Nature 1990 May 17;345(6272):260-3.
46. GOA pipeline RGD automated data pipeline
47. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
48. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
49. Direct interaction between synaptotagmin and the intracellular loop I-II of neuronal voltage-sensitive sodium channels. Sampo B, etal., Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3666-71.
50. Isoform-specific, calcium-regulated interaction of the synaptic vesicle proteins SV2 and synaptotagmin. Schivell AE, etal., J Biol Chem. 1996 Nov 1;271(44):27770-5.
51. SV2A and SV2C contain a unique synaptotagmin-binding site. Schivell AE, etal., Mol Cell Neurosci. 2005 May;29(1):56-64. doi: 10.1016/j.mcn.2004.12.011.
52. Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions. Shin OH, etal., Neuron. 2003 Jan 9;37(1):99-108.
53. Synaptotagmin-1-, Munc18-1-, and Munc13-1-dependent liposome fusion with a few neuronal SNAREs. Stepien KP and Rizo J, Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2019314118. doi: 10.1073/pnas.2019314118.
54. Molecular anatomy of a trafficking organelle. Takamori S, etal., Cell. 2006 Nov 17;127(4):831-46.
55. Localization of Rab3A-binding site on C2A domain of synaptotagmin I to reveal its regulatory mechanism. Tang X, etal., Int J Biol Macromol. 2017 Mar;96:736-742. doi: 10.1016/j.ijbiomac.2016.12.074. Epub 2017 Jan 3.
56. Synaptotagmin 1-mediated cell membrane penetration and dopamine release enhancement by latroeggtoxin-VI. Tang X, etal., Int J Biol Macromol. 2022 Sep 1;216:906-915. doi: 10.1016/j.ijbiomac.2022.07.208. Epub 2022 Jul 30.
57. Functional analysis of the C2A domain of synaptotagmin 1: implications for calcium-regulated secretion. Thomas DM and Elferink LA, J Neurosci. 1998 May 15;18(10):3511-20. doi: 10.1523/JNEUROSCI.18-10-03511.1998.
58. Functional and biochemical analysis of the C2 domains of synaptotagmin IV. Thomas DM, etal., Mol Biol Cell. 1999 Jul;10(7):2285-95.
59. Two synaptotagmin genes, Syt1 and Syt4, are differentially regulated in adult brain and during postnatal development following kainic acid-induced seizures. Tocco G, etal., Brain Res Mol Brain Res 1996 Sep 1;40(2):229-39.
60. Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1. Tokumaru H, etal., Brain Cell Biol. 2008 Dec;36(5-6):173-89. doi: 10.1007/s11068-008-9032-9. Epub 2009 Jan 9.
61. Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells. Tucker WC, etal., J Cell Biol. 2003 Jul 21;162(2):199-209. Epub 2003 Jul 14.
62. Phosphatidylinositol 4,5-bisphosphate increases Ca2+ affinity of synaptotagmin-1 by 40-fold. van den Bogaart G, etal., J Biol Chem. 2012 May 11;287(20):16447-53. doi: 10.1074/jbc.M112.343418. Epub 2012 Mar 23.
63. Cis- and trans-membrane interactions of synaptotagmin-1. Vennekate W, etal., Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):11037-42. doi: 10.1073/pnas.1116326109. Epub 2012 Jun 18.
64. Human stoned B interacts with AP-2 and synaptotagmin and facilitates clathrin-coated vesicle uncoating. Walther K, etal., EMBO Rep. 2001 Jul;2(7):634-40. Epub 2001 Jul 3.
65. Synaptotagmin-1 C2B domain interacts simultaneously with SNAREs and membranes to promote membrane fusion. Wang S, etal., Elife. 2016 Apr 15;5:e14211. doi: 10.7554/eLife.14211.
66. Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion. Wang Z and Chapman ER, J Biol Chem. 2010 Oct 1;285(40):30759-66. doi: 10.1074/jbc.M110.137745. Epub 2010 Aug 5.
67. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
68. Identification of a novel protein complex containing annexin A4, rabphilin and synaptotagmin. Willshaw A, etal., FEBS Lett. 2004 Feb 13;559(1-3):13-21.
69. Polybasic Patches in Both C2 Domains of Synaptotagmin-1 Are Required for Evoked Neurotransmitter Release. Wu Z, etal., J Neurosci. 2022 Jul 27;42(30):5816-5829. doi: 10.1523/JNEUROSCI.1385-21.2022. Epub 2022 Jun 14.
70. The synaptotagmins: calcium sensors for vesicular trafficking. Yoshihara M and Montana ES, Neuroscientist. 2004 Dec;10(6):566-74.
71. LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25. Yun HJ, etal., Exp Mol Med. 2013 Aug 16;45:e36. doi: 10.1038/emm.2013.68.
72. Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells. Zhang Z, etal., Mol Biol Cell. 2011 Jul 1;22(13):2324-36. doi: 10.1091/mbc.E11-02-0159. Epub 2011 May 5.
73. Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis. Zhou Q, etal., Nature. 2015 Sep 3;525(7567):62-7. doi: 10.1038/nature14975. Epub 2015 Aug 17.
74. Synaptotagmin I and IX function redundantly in controlling fusion pore of large dense core vesicles. Zhu D, etal., Biochem Biophys Res Commun. 2007 Oct 5;361(4):922-7. Epub 2007 Jul 25.
Additional References at PubMed
PMID:7553862   PMID:7697723   PMID:7954835   PMID:7993622   PMID:8132583   PMID:8626542   PMID:8889548   PMID:9194562   PMID:9819203   PMID:10715114   PMID:11242035   PMID:11562488  
PMID:11754837   PMID:12145198   PMID:12220627   PMID:12496247   PMID:12645522   PMID:12782290   PMID:12873386   PMID:12963743   PMID:14504267   PMID:14622145   PMID:14709554   PMID:14718921  
PMID:14983047   PMID:15016962   PMID:15044754   PMID:15046725   PMID:15071120   PMID:15082773   PMID:15197251   PMID:15238157   PMID:15350218   PMID:15561725   PMID:15628842   PMID:15774481  
PMID:16262243   PMID:16293646   PMID:16407767   PMID:16477143   PMID:16491093   PMID:16612384   PMID:16808897   PMID:16893168   PMID:17183698   PMID:17264148   PMID:17360631   PMID:17478680  
PMID:17913838   PMID:18058942   PMID:18410172   PMID:18468511   PMID:18585366   PMID:18622390   PMID:18703708   PMID:18799625   PMID:18956883   PMID:19302798   PMID:19501597   PMID:19608642  
PMID:19632983   PMID:19723500   PMID:20448186   PMID:20573977   PMID:20735850   PMID:20824061   PMID:20978127   PMID:21040848   PMID:21087613   PMID:21287204   PMID:21307259   PMID:21320440  
PMID:21322640   PMID:21344950   PMID:21456023   PMID:21521611   PMID:21576241   PMID:21646859   PMID:21928778   PMID:22008253   PMID:22398727   PMID:22609930   PMID:22810233   PMID:22871113  
PMID:22960622   PMID:23091625   PMID:23300284   PMID:23321072   PMID:23617808   PMID:23665582   PMID:23884218   PMID:23954480   PMID:23999003   PMID:24327345   PMID:24423395   PMID:24472545  
PMID:25716318   PMID:25716321   PMID:26030874   PMID:26202512   PMID:26389740   PMID:26400647   PMID:26667128   PMID:26792839   PMID:27001899   PMID:27791979   PMID:28111077   PMID:28131823  
PMID:28515322   PMID:29115943   PMID:29476059   PMID:30964765   PMID:31160571   PMID:31301806   PMID:31431523   PMID:31932584   PMID:32024024   PMID:32401194   PMID:32808925   PMID:33160605  
PMID:33536412   PMID:35537054  


Genomics

Comparative Map Data
Syt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8745,699,649 - 46,244,460 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl745,702,228 - 46,244,213 (-)EnsemblGRCr8
mRatBN7.2743,813,204 - 44,358,020 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl743,815,785 - 44,357,803 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx745,726,193 - 46,271,079 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0747,929,286 - 48,474,187 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0747,707,065 - 48,251,959 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0750,084,063 - 50,638,996 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl750,084,060 - 50,638,798 (-)Ensemblrn6Rnor6.0
Rnor_5.0750,097,034 - 50,289,950 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4747,243,375 - 47,795,496 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera740,680,324 - 41,216,966 (-)NCBICelera
RGSC_v3.1747,261,066 - 47,815,950 (-)NCBI
RH 3.4 Map7348.01RGD
Cytogenetic Map7q21NCBI
SYT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381278,863,982 - 79,452,008 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1278,863,650 - 79,452,009 (+)Ensemblhg38GRCh38
GRCh371279,257,762 - 79,845,788 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361278,135,414 - 78,368,974 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341278,113,750 - 78,347,311NCBI
Celera1278,924,230 - 79,512,467 (+)NCBICelera
Cytogenetic Map12q21.2NCBI
HuRef1276,312,006 - 76,901,927 (+)NCBIHuRef
CHM1_11279,224,059 - 79,812,179 (+)NCBICHM1_1
T2T-CHM13v2.01278,842,458 - 79,430,647 (+)NCBIT2T-CHM13v2.0
Syt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910108,333,511 - 108,846,852 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10108,333,511 - 108,846,843 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3810108,497,650 - 109,010,980 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10108,497,650 - 109,010,982 (-)Ensemblmm10GRCm38
MGSCv3710107,935,305 - 108,447,675 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610107,902,359 - 108,414,729 (-)NCBIMGSCv36mm8
Celera10110,439,113 - 110,956,164 (-)NCBICelera
Cytogenetic Map10D1NCBI
cM Map1056.52NCBI
Syt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540517,839,884 - 18,372,566 (+)Ensembl
ChiLan1.0NW_00495540517,840,012 - 18,372,156 (+)NCBIChiLan1.0ChiLan1.0
SYT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21086,913,025 - 87,501,651 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11286,909,416 - 87,498,045 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01276,392,955 - 76,981,800 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11279,240,646 - 79,829,923 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1279,595,704 - 79,829,923 (+)EnsemblpanPan2panpan1.1
SYT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11521,629,061 - 22,042,734 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1521,834,763 - 22,042,732 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1521,934,859 - 22,469,519 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01521,856,608 - 22,392,551 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1521,856,444 - 22,390,979 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11521,446,653 - 21,981,053 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01521,507,116 - 22,042,283 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01521,747,161 - 22,282,182 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Syt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494538,336,962 - 38,847,320 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936698377,179 - 575,802 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493669865,210 - 575,538 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SYT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl5101,871,314 - 102,215,581 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.15101,871,313 - 102,394,310 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25106,815,507 - 107,335,980 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SYT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11174,442,890 - 75,032,756 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1174,795,207 - 75,032,915 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037170,421,409 - 171,012,159 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Syt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475018,774,570 - 18,989,659 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475018,774,670 - 19,313,932 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Syt1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11186,712,361 - 187,053,245 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Syt1
3671 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:134
Interacting mature miRNAs:147
Transcripts:ENSRNOT00000048880
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)72154197751639954Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)72154197751639954Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74299622658678836Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
D7Rat106  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8745,796,969 - 45,797,116 (+)Marker Load Pipeline
mRatBN7.2743,910,536 - 43,910,683 (+)MAPPERmRatBN7.2
Rnor_6.0750,181,371 - 50,181,517NCBIRnor6.0
Rnor_5.0750,191,794 - 50,191,940UniSTSRnor5.0
RGSC_v3.4747,338,134 - 47,338,281RGDRGSC3.4
RGSC_v3.4747,338,135 - 47,338,281UniSTSRGSC3.4
Celera740,774,551 - 40,774,698UniSTS
RGSC_v3.1747,358,406 - 47,358,552RGD
RH 3.4 Map7349.8UniSTS
RH 3.4 Map7349.8RGD
RH 2.0 Map7332.8RGD
SHRSP x BN Map727.21RGD
Cytogenetic Map7q21UniSTS
D7Got157  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8745,994,533 - 45,994,782 (+)Marker Load Pipeline
mRatBN7.2744,108,104 - 44,108,355 (+)MAPPERmRatBN7.2
Rnor_6.0750,382,631 - 50,382,881NCBIRnor6.0
Rnor_5.0750,393,982 - 50,394,232UniSTSRnor5.0
RGSC_v3.4747,540,916 - 47,541,167RGDRGSC3.4
RGSC_v3.4747,540,917 - 47,541,167UniSTSRGSC3.4
Celera740,971,474 - 40,971,722UniSTS
RGSC_v3.1747,561,188 - 47,561,438RGD
RH 3.4 Map7347.9RGD
RH 3.4 Map7347.9UniSTS
RH 2.0 Map7341.3RGD
Cytogenetic Map7q21UniSTS
D37792  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2743,815,731 - 43,815,891 (+)MAPPERmRatBN7.2
Rnor_6.0750,086,591 - 50,086,750NCBIRnor6.0
Rnor_5.0750,096,981 - 50,097,140UniSTSRnor5.0
RGSC_v3.4747,243,322 - 47,243,481UniSTSRGSC3.4
Celera740,680,271 - 40,680,430UniSTS
Cytogenetic Map7q21UniSTS
AW530700  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2744,089,767 - 44,089,943 (+)MAPPERmRatBN7.2
Rnor_6.0750,364,292 - 50,364,467NCBIRnor6.0
Rnor_5.0750,375,643 - 50,375,818UniSTSRnor5.0
RGSC_v3.4747,522,578 - 47,522,753UniSTSRGSC3.4
Celera740,953,342 - 40,953,517UniSTS
RH 3.4 Map7350.6UniSTS
Cytogenetic Map7q21UniSTS
RH78549  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2743,813,382 - 43,813,545 (+)MAPPERmRatBN7.2
Rnor_6.0750,084,242 - 50,084,404NCBIRnor6.0
Rnor_5.0750,094,632 - 50,094,794UniSTSRnor5.0
RGSC_v3.4747,240,973 - 47,241,135UniSTSRGSC3.4
Celera740,677,923 - 40,678,085UniSTS
Cytogenetic Map7q21UniSTS
RH94645  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2743,813,276 - 43,813,458 (+)MAPPERmRatBN7.2
Rnor_6.0750,084,136 - 50,084,317NCBIRnor6.0
Rnor_5.0750,094,526 - 50,094,707UniSTSRnor5.0
RGSC_v3.4747,240,867 - 47,241,048UniSTSRGSC3.4
Celera740,677,817 - 40,677,998UniSTS
RH 3.4 Map7348.01UniSTS
Cytogenetic Map7q21UniSTS
BE107999  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2743,947,624 - 43,947,774 (+)MAPPERmRatBN7.2
Rnor_6.0750,218,457 - 50,218,606NCBIRnor6.0
Rnor_5.0750,229,566 - 50,229,715UniSTSRnor5.0
RGSC_v3.4747,375,907 - 47,376,056UniSTSRGSC3.4
Celera740,811,608 - 40,811,757UniSTS
RH 3.4 Map7351.92UniSTS
Cytogenetic Map7q21UniSTS
RH137968  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2744,206,754 - 44,206,956 (+)MAPPERmRatBN7.2
Rnor_6.0750,485,630 - 50,485,831NCBIRnor6.0
Rnor_5.0750,496,981 - 50,497,182UniSTSRnor5.0
RGSC_v3.4747,642,642 - 47,642,843UniSTSRGSC3.4
Celera741,066,296 - 41,066,497UniSTS
RH 3.4 Map7348.0UniSTS
Cytogenetic Map7q21UniSTS
RH138239  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2744,323,779 - 44,323,950 (+)MAPPERmRatBN7.2
Rnor_6.0750,603,557 - 50,603,727NCBIRnor6.0
Rnor_5.0750,616,068 - 50,616,238UniSTSRnor5.0
RGSC_v3.4747,762,240 - 47,762,410UniSTSRGSC3.4
Celera741,182,950 - 41,183,120UniSTS
RH 3.4 Map7379.1UniSTS
Cytogenetic Map7q21UniSTS
RH140034  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2743,815,871 - 43,816,058 (+)MAPPERmRatBN7.2
Rnor_6.0750,086,731 - 50,086,917NCBIRnor6.0
Rnor_5.0750,097,121 - 50,097,307UniSTSRnor5.0
RGSC_v3.4747,243,462 - 47,243,648UniSTSRGSC3.4
Celera740,680,411 - 40,680,597UniSTS
RH 3.4 Map7350.91UniSTS
Cytogenetic Map7q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 9 66 155 85 84 53 33 53 6 275 124 6 135 74 93 31 18 18

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001033680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA924659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ617616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ617617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ617618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ617619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ617620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ617621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ617622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB615786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB731032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO398869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ181550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000048880   ⟹   ENSRNOP00000049624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl745,702,228 - 46,244,213 (-)Ensembl
mRatBN7.2 Ensembl743,815,785 - 44,357,803 (-)Ensembl
Rnor_6.0 Ensembl750,086,644 - 50,638,798 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088950   ⟹   ENSRNOP00000069194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl745,702,228 - 46,244,213 (-)Ensembl
mRatBN7.2 Ensembl743,815,785 - 44,357,803 (-)Ensembl
Rnor_6.0 Ensembl750,084,060 - 50,278,842 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000160614   ⟹   ENSRNOP00000107328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl745,702,228 - 45,890,803 (-)Ensembl
RefSeq Acc Id: NM_001033680   ⟹   NP_001028852
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8745,702,228 - 46,244,213 (-)NCBI
mRatBN7.2743,815,785 - 44,357,803 (-)NCBI
Rnor_6.0750,086,644 - 50,638,798 (-)NCBI
Rnor_5.0750,097,034 - 50,289,950 (-)NCBI
RGSC_v3.4747,243,375 - 47,795,496 (-)RGD
Celera740,680,324 - 41,216,966 (-)RGD
Sequence:
RefSeq Acc Id: XM_008765353   ⟹   XP_008763575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8745,699,649 - 46,244,460 (-)NCBI
mRatBN7.2743,813,204 - 44,358,020 (-)NCBI
Rnor_6.0750,084,063 - 50,638,996 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594679   ⟹   XP_017450168
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8745,699,649 - 46,244,435 (-)NCBI
mRatBN7.2743,813,204 - 44,358,019 (-)NCBI
Rnor_6.0750,084,063 - 50,638,996 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078497   ⟹   XP_038934425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8745,699,649 - 46,244,428 (-)NCBI
mRatBN7.2743,813,204 - 44,358,019 (-)NCBI
RefSeq Acc Id: XM_063263062   ⟹   XP_063119132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8745,699,649 - 46,244,428 (-)NCBI
RefSeq Acc Id: XM_063263063   ⟹   XP_063119133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8745,699,649 - 46,244,428 (-)NCBI
RefSeq Acc Id: XM_063263064   ⟹   XP_063119134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8745,699,649 - 45,904,463 (-)NCBI
RefSeq Acc Id: XM_063263065   ⟹   XP_063119135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8745,699,649 - 46,244,455 (-)NCBI
RefSeq Acc Id: NP_001028852   ⟸   NM_001033680
- UniProtKB: Q3S2E6 (UniProtKB/Swiss-Prot),   Q707P5 (UniProtKB/Swiss-Prot),   P21707 (UniProtKB/Swiss-Prot),   A6IGE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763575   ⟸   XM_008765353
- Peptide Label: isoform X2
- UniProtKB: A6IGE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450168   ⟸   XM_017594679
- Peptide Label: isoform X1
- UniProtKB: Q3S2E6 (UniProtKB/Swiss-Prot),   Q707P5 (UniProtKB/Swiss-Prot),   P21707 (UniProtKB/Swiss-Prot),   A6IGE2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000049624   ⟸   ENSRNOT00000048880
Ensembl Acc Id: ENSRNOP00000069194   ⟸   ENSRNOT00000088950
RefSeq Acc Id: XP_038934425   ⟸   XM_039078497
- Peptide Label: isoform X1
- UniProtKB: Q3S2E6 (UniProtKB/Swiss-Prot),   P21707 (UniProtKB/Swiss-Prot),   Q707P5 (UniProtKB/Swiss-Prot),   A6IGE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119135   ⟸   XM_063263065
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063119133   ⟸   XM_063263063
- Peptide Label: isoform X2
- UniProtKB: A6IGE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119132   ⟸   XM_063263062
- Peptide Label: isoform X2
- UniProtKB: A6IGE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119134   ⟸   XM_063263064
- Peptide Label: isoform X2
- UniProtKB: A6IGE2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000107328   ⟸   ENSRNOT00000160614
Protein Domains
C2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21707-F1-model_v2 AlphaFold P21707 1-421 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3803 AgrOrtholog
BIND 130539
  130591
  130592
  130593
  130594
  130901
  130902
  130903
BioCyc Gene G2FUF-34157 BioCyc
Ensembl Genes ENSRNOG00000006426 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000048880 ENTREZGENE
  ENSRNOT00000048880.3 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot
InterPro C2_dom UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  Synaptotagmin UniProtKB/Swiss-Prot
KEGG Report rno:25716 UniProtKB/Swiss-Prot
NCBI Gene 25716 ENTREZGENE
PANTHER PTHR10024:SF239 UniProtKB/Swiss-Prot
  SYNAPTOTAGMIN UniProtKB/Swiss-Prot
Pfam PF00168 UniProtKB/Swiss-Prot
PhenoGen Syt1 PhenoGen
PRINTS C2DOMAIN UniProtKB/Swiss-Prot
  SYNAPTOTAGMN UniProtKB/Swiss-Prot
PROSITE PS50004 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006426 RatGTEx
SMART SM00239 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot
UniProt A0A8L2R1E5_RAT UniProtKB/TrEMBL
  A0ABK0L9Y7_RAT UniProtKB/TrEMBL
  A6IGE2 ENTREZGENE, UniProtKB/TrEMBL
  P21707 ENTREZGENE
  Q3S2E6 ENTREZGENE
  Q707P0_RAT UniProtKB/TrEMBL
  Q707P1_RAT UniProtKB/TrEMBL
  Q707P2_RAT UniProtKB/TrEMBL
  Q707P4_RAT UniProtKB/TrEMBL
  Q707P5 ENTREZGENE
  SYT1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q3S2E6 UniProtKB/Swiss-Prot
  Q707P5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Syt1  synaptotagmin 1  Syt1  synaptotagmin I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Syt1  synaptotagmin I    synaptotagmin 1  Name updated 1299863 APPROVED
2002-06-10 Syt1  synaptotagmin 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression localized on synaptic vesicles 68912
gene_physical_interaction binds to syntaxin-1 68912
gene_physical_interaction binds calmodulin; binds calcium; binds acidic phospholipids with a specificity similar to protein kinase C 729959
gene_process involved in the fast calcium dependent component of neurotransmitter release 68912
gene_regulation binding to syntaxin-1 is stronger in the presence of calcium 68912