Pcna (proliferating cell nuclear antigen) - Rat Genome Database

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Gene: Pcna (proliferating cell nuclear antigen) Rattus norvegicus
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Symbol: Pcna
Name: proliferating cell nuclear antigen
RGD ID: 3269
Description: Enables nuclear estrogen receptor binding activity. Involved in several processes, including cellular response to hydrogen peroxide; estrous cycle; and liver regeneration. Located in nucleus. Biomarker of several diseases, including brain ischemia (multiple); liver cancer (multiple); mucositis; obstructive jaundice; and sciatic neuropathy. Human ortholog(s) of this gene implicated in ataxia-telangiectasia-like disorder-2. Orthologous to human PCNA (proliferating cell nuclear antigen); PARTICIPATES IN mismatch repair pathway; nucleotide excision repair pathway; base excision repair pathway; INTERACTS WITH (+)-pilocarpine; (+)-taxifolin; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cyclin; Pcna/cyclin; PCNAR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83139,951,948 - 139,955,820 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3139,951,941 - 139,955,901 (-)EnsemblGRCr8
mRatBN7.23119,499,039 - 119,502,911 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3119,498,810 - 119,502,995 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3123,402,795 - 123,406,667 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03131,989,995 - 131,993,868 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03129,658,899 - 129,662,771 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03124,880,698 - 124,884,570 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3124,880,698 - 124,884,570 (-)Ensemblrn6Rnor6.0
Rnor_5.03131,376,235 - 131,380,108 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43120,008,715 - 120,012,589 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3118,296,567 - 118,300,439 (-)NCBICelera
RGSC_v3.13119,914,289 - 119,918,243 (-)NCBI
RH 3.4 Map31023.4RGD
Cytogenetic Map3q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-taxifolin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(-)-quinic acid  (ISO)
(R)-adrenaline  (ISO)
(R)-lipoic acid  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
(Z)-3-butylidenephthalide  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichlorobenzene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-thiazolidine-2,4-dione  (ISO)
1,4-benzoquinone  (ISO)
1,4-dichlorobenzene  (EXP)
1,4-dioxane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,2':5',2''-terthiophene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-D  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetamidofluorene  (EXP)
2-bromohexadecanoic acid  (ISO)
2-deoxy-D-glucose  (ISO)
2-nitrofluorene  (EXP)
2-tert-butylhydroquinone  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5,5'-tetraiodothyroacetic acid  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid  (EXP)
3-aminobenzamide  (EXP)
3-BROMO-7-NITROINDAZOLE  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
4-nonylphenol  (EXP,ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (EXP)
5-fluorouracil  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5-methyltetrahydrofolic acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (EXP,ISO)
acetamide  (EXP)
acetic acid  (EXP)
acetylsalicylic acid  (EXP)
acrylamide  (EXP)
actinomycin D  (EXP,ISO)
adenosine  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alpha-amanitin  (ISO)
alpha-hexachlorocyclohexane  (EXP)
aluminium atom  (ISO)
aluminium(0)  (ISO)
alvocidib  (ISO)
amifostine  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amoxicillin  (ISO)
amphibole asbestos  (ISO)
andrographolide  (ISO)
aniline  (EXP,ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony(0)  (EXP)
apigenin  (ISO)
apocynin  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite ion  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (EXP)
asiatic acid  (EXP)
astragaloside IV  (ISO)
atrazine  (ISO)
atropine  (ISO)
avobenzone  (ISO)
azadirachtin A  (ISO)
azathioprine  (ISO)
azithromycin  (ISO)
Azoxymethane  (EXP,ISO)
azoxystrobin  (ISO)
bafilomycin A1  (ISO)
baicalein  (ISO)
bathocuproine disulfonic acid  (ISO)
benazepril  (EXP)
benzamide  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Besigomsin  (ISO)
beta-aminopropionitrile  (ISO)
beta-naphthoflavone  (EXP,ISO)
beta-tocopherol  (EXP)
betulinic acid  (EXP,ISO)
bezafibrate  (EXP,ISO)
bicalutamide  (ISO)
biochanin A  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
Bisphenol B  (EXP)
bisphenol F  (EXP)
boric acid  (EXP)
boron atom  (EXP)
brexpiprazole  (ISO)
bromocriptine  (EXP)
bromodichloromethane  (EXP,ISO)
bromoform  (ISO)
brucine  (EXP)
budesonide  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
C.I. Natural Red 20  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcidiol  (ISO)
calcitriol  (EXP,ISO)
calcium silicate  (ISO)
camostat  (ISO)
cannabidiol  (ISO)
capmatinib  (ISO)
captafol  (EXP)
carbamate ester  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP,ISO)
cefaloridine  (EXP)
celastrol  (ISO)
celecoxib  (ISO)
cerium trichloride  (ISO)
chelerythrine  (EXP)
Chlorodibromomethane  (ISO)
chloroethene  (ISO)
chloroform  (ISO)
chlorogenic acid  (ISO)
chlorophyllin  (ISO)
chloroprocaine  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
cholic acid  (ISO)
chromium(6+)  (EXP,ISO)
chrysin  (EXP)
chrysophanol  (ISO)
cilostazol  (ISO)
Cinobufagin  (ISO)
cisplatin  (EXP,ISO)
citral  (EXP)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
coenzyme Q10  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
cortisol  (ISO)
costunolide  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (EXP,ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyanidin cation  (ISO)
cycloastragenol  (ISO)
cyclohexanols  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (EXP)
cyhalothrin  (EXP)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
cyprodinil  (ISO)
D-aspartic acid  (ISO)
D-glucose  (EXP,ISO)
daidzein  (EXP,ISO)
dapoxetine  (EXP)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
delta-tocopherol  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
Di-n-octyl phthalate  (EXP)
Diallyl sulfide  (EXP)
diallyl trisulfide  (ISO)
diamminedichloroplatinum  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dicyclanil  (ISO)
dieckol  (ISO)
dieldrin  (EXP)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP,ISO)
diheptyl phthalate  (EXP)
dihydroxyacetone  (ISO)
dimethomorph  (EXP)
dimethylarsinic acid  (EXP)
diminazene diaceturate  (ISO)
diosmin  (EXP)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
disodium selenite  (ISO)
diuron  (ISO)
dodecanoic acid  (ISO)
doxorubicin  (EXP,ISO)
elemental boron  (EXP)
elemental selenium  (ISO)
ellagic acid  (ISO)
embelin  (ISO)
emodin  (EXP)
endosulfan  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
enzacamene  (ISO)
enzyme inhibitor  (ISO)
eriocitrin  (ISO)
estragole  (EXP)
ethanol  (EXP,ISO)
eugenol  (EXP,ISO)
eumelanin  (ISO)
Evodiamine  (ISO)
famotidine  (EXP)
fenhexamid  (ISO)
fenofibrate  (ISO)
fenvalerate  (EXP)
finasteride  (EXP)
fipronil  (EXP)
fludioxonil  (ISO)
flufenoxuron  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
gallic acid  (EXP)
gamma-linolenic acid  (ISO)
gamma-tocopherol  (EXP)
gefitinib  (ISO)
gemfibrozil  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
geranial  (EXP)
geraniol  (EXP,ISO)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glycitein  (ISO)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
GSK-J4  (ISO)
hesperetin  (EXP,ISO)
hesperidin  (EXP)
hexachlorobenzene  (EXP,ISO)
histamine  (ISO)
hydralazine  (EXP)
hydrochlorothiazide  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
imidacloprid  (EXP)
imiquimod  (ISO)
indometacin  (EXP,ISO)
Inotodiol  (EXP)
irinotecan  (EXP)
iron atom  (EXP)
iron dextran  (EXP)
iron(0)  (EXP)
iron(III) nitrilotriacetate  (EXP)
isoflavones  (EXP)
ivermectin  (ISO)
juglone  (ISO)
kaempferol  (EXP)
ketoconazole  (EXP)
kojic acid  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (EXP)
L-glutamine  (ISO)
lanthanum trichloride  (ISO)
lapatinib  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
limonene  (EXP)
linsidomine  (ISO)
linuron  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
lupeol  (ISO)
LY294002  (EXP,ISO)
lycopene  (EXP)
mabuterol  (EXP)
malachite green cation  (EXP)
malathion  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
masoprocol  (ISO)
Mecamylamine  (ISO)
mechlorethamine  (EXP)
melatonin  (EXP,ISO)
meloxicam  (ISO)
menadione  (ISO)
methapyrilene  (EXP)
methimazole  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP)
methylseleninic acid  (ISO)
methyltestosterone  (EXP)
mevalonic acid  (ISO)
miconazole  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
Morroniside  (ISO)
myricitrin  (ISO)
N'-Nitrosonornicotine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-bis(2-hydroxypropyl)nitrosamine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-ethyl-N-nitrosourea  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
NCX-4040  (ISO)
nefazodone  (ISO)
nelfinavir  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
nitrates  (ISO)
nitrofen  (EXP,ISO)
nitrogen dioxide  (ISO)
NMN zwitterion  (ISO)
NORCANTHARIDIN  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
olaparib  (ISO)
oleanolic acid  (EXP,ISO)
omeprazole  (EXP,ISO)
orlistat  (ISO)
ouabain  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
pantoprazole  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
PD 0325901  (ISO)
pentachlorophenol  (ISO)
perfluorobutyric acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
piclamilast  (EXP)
picoxystrobin  (ISO)
pifithrin-alpha hydrobromide  (EXP)
pinosylvin  (ISO)
piperonyl butoxide  (EXP,ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
poly(propylene imine) macromolecule  (ISO)
potassium dichromate  (EXP)
potassium iodide  (EXP)
potassium nitrate  (ISO)
prednisone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
probucol  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
propofol  (ISO)
pterostilbene  (EXP)
pyrethrins  (EXP)
pyrithione  (ISO)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
raloxifene  (EXP,ISO)
Rebamipide  (EXP)
reparixin  (ISO)
reserpine  (EXP)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
rotenone  (EXP)
roxadustat  (ISO)
royal jelly  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
SB 203580  (ISO)
SB 431542  (ISO)
scutellarin  (ISO)
selenium atom  (ISO)
selenomethionine  (ISO)
serpentine asbestos  (EXP,ISO)
shikimic acid  (ISO)
Shikonin  (EXP)
SHP099  (ISO)
sildenafil citrate  (EXP)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (EXP)
Soman  (EXP)
spiromesifen  (ISO)
stattic  (ISO)
stavudine  (EXP,ISO)
sterigmatocystin  (EXP)
streptozocin  (EXP,ISO)
sucrose  (ISO)
sulfadimethoxine  (EXP)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulindac  (EXP,ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (EXP)
Swertiamarin  (EXP)
T-2 toxin  (EXP)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
taurine  (EXP)
terephthalic acid  (EXP)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
tetrachlorohydroquinone  (ISO)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP,ISO)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
thymoquinone  (EXP,ISO)
titanium dioxide  (ISO)
tocopherol  (EXP)
tolcapone  (EXP)
toluene 2,4-diisocyanate  (ISO)
Tomentosin  (ISO)
topotecan  (ISO)
trans-pinosylvin  (ISO)
transplatin  (ISO)
trichloroacetic acid  (EXP,ISO)
trichloroethene  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
trimethylarsine oxide  (EXP)
triphenylstannane  (EXP)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
uranium atom  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vancomycin  (ISO)
vinyl carbamate  (ISO)
vitamin D  (ISO)
vitamin E  (ISO)
Y-27632  (ISO)
zerumbone  (EXP)
zidovudine  (ISO)
zinc atom  (ISO)
zinc dichloride  (EXP)
zinc sulfate  (EXP)
zinc(0)  (ISO)
zingerone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IEA,ISO)
chromatin  (IEA,ISO,ISS)
cyclin-dependent protein kinase holoenzyme complex  (IEA,ISO)
nuclear lamina  (IEA,ISO)
nuclear replication fork  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IDA,IEA,ISO)
PCNA complex  (IBA,IEA,ISO,ISS)
PCNA-p21 complex  (IEA,ISO,ISS)
replication fork  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Proliferating cell nuclear antigen and epidermal growth factor receptor (EGFr) status in renal cell carcinoma patients with polysomy of chromosome 7. Amare Kadam PS, etal., Cancer Genet Cytogenet. 2001 Mar;125(2):139-46.
2. Cardiac myocyte hypertrophy and proliferating cell nuclear antigen expression in Wistar rats infected with Trypanosoma cruzi. Arnaiz MR, etal., J Parasitol. 2002 Oct;88(5):919-25.
3. Distribution patterns of PCNA and ANP in perinatal stages of the developing rat heart. Cayli S, etal., Acta Histochem 2002;104(3):271-7.
4. Hepatic apoptosis and proliferation in male and female rats fed alcohol: role of cytokines. Colantoni A, etal., Alcohol Clin Exp Res. 2003 Jul;27(7):1184-9. doi: 10.1097/01.ALC.0000075834.52279.F9.
5. Expression of PCNA and Ki-67 in the rat submandibular gland after one year cadmium intoxication--a preliminary study. Czykier E and Dzieciol J, Rocz Akad Med Bialymst. 2004;49 Suppl 1:172-4.
6. Changes in CLIP3 expression after sciatic nerve injury in adult rats. Deng X, etal., J Mol Histol. 2012 Dec;43(6):669-79. doi: 10.1007/s10735-012-9450-y. Epub 2012 Sep 27.
7. Mitofusin 2 Downregulation Triggers Pulmonary Artery Smooth Muscle Cell Proliferation and Apoptosis Imbalance in Rats With Hypoxic Pulmonary Hypertension Via the PI3K/Akt and Mitochondrial Apoptosis Pathways. Fang X, etal., J Cardiovasc Pharmacol. 2016 Feb;67(2):164-74. doi: 10.1097/FJC.0000000000000333.
8. Immunohistochemical analysis of proliferating cell nuclear antigen (PCNA) in infiltrating ductal carcinomas: comparison with clinical and pathologic variables. Frierson HF Jr Mod Pathol. 1993 May;6(3):290-4.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Trans-cellular proliferating cell nuclear antigen gene activation in cerebral vascular smooth muscle by endothelial oxidative injury in vivo. Gerzanich V, etal., Arterioscler Thromb Vasc Biol. 2003 Nov 1;23(11):2048-54. Epub 2003 Sep 11.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Towards non-surgical therapy for uterine fibroids: catechol-O-methyl transferase inhibitor shrinks uterine fibroid lesions in the Eker rat model. Hassan MH, etal., Hum Reprod. 2011 Nov;26(11):3008-18. doi: 10.1093/humrep/der280. Epub 2011 Sep 6.
13. Replication clamps and clamp loaders. Hedglin M, etal., Cold Spring Harb Perspect Biol. 2013 Apr 1;5(4):a010165. doi: 10.1101/cshperspect.a010165.
14. Hepatic expression of polymerase beta, Ref-1, PCNA, and Bax in WY 14,643-exposed rats and hamsters. Holmes EW, etal., Exp Mol Pathol 2002 Dec;73(3):209-19.
15. Contribution of cell proliferative activity to malignancy potential in testicular seminoma. Hori K, etal., Pathol Int. 1997 May;47(5):282-7.
16. Specific expression of the cell cycle regulation proteins, GADD34 and PCNA, in the peri-infarct zone after focal cerebral ischaemia in the rat. Imai H, etal., Eur J Neurosci 2002 Jun;15(12):1929-36.
17. Neurogenic marker abnormalities in the hippocampus in dementia with Lewy bodies. Johnson M, etal., Hippocampus. 2011 Oct;21(10):1126-36. doi: 10.1002/hipo.20826. Epub 2010 Jul 21.
18. IQGAP1 translocates to the nucleus in early S-phase and contributes to cell cycle progression after DNA replication arrest. Johnson M, etal., Int J Biochem Cell Biol. 2011 Jan;43(1):65-73. doi: 10.1016/j.biocel.2010.09.014. Epub 2010 Sep 29.
19. Expression of proliferative and preapoptotic molecules in human myometrium and leiomyoma throughout the menstrual cycle. Kayisli UA, etal., Reprod Sci. 2007 Oct;14(7):678-86.
20. cDNA microarray analysis of gene expression in rat alveolar macrophages in response to organic extract of diesel exhaust particles. Koike E, etal., Toxicol Sci 2002 Jun;67(2):241-6.
21. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
22. Expression of proliferating cell nuclear antigen in luminal epithelium during the growth and regression of rat uterus. Lai MD, etal., J Endocrinol. 2000 Jul;166(1):87-93.
23. Nuclear recruitment of A1p145 subunit of replication factor C in the early G1 phase of the cell cycle in Faza 567 hepatoma cell line and hepatocyte primary cultures. Levavasseur F, etal., FEBS Lett. 1995 Apr 17;363(1-2):132-6.
24. Mechanisms and functions of DNA mismatch repair. Li GM Cell Res. 2008 Jan;18(1):85-98.
25. Expression and prognostic significance of proliferating cell nuclear antigen and Ki-67 in malignant ovarian germ cell tumors. Liu FS, etal., Zhonghua Yi Xue Za Zhi (Taipei). 1999 Oct;62(10):695-702.
26. Gene expression of PCNA/cyclin in adult tissues and the R3230AC mammary tumor of rat. Liu YC and Bambara RA, Biochem Biophys Res Commun. 1989 Jun 15;161(2):873-82.
27. Localization of proliferating cell nuclear antigen in the developing and mature rat heart cell. Marino TA, etal., Anat Rec. 1996 Aug;245(4):677-84.
28. Molecular cloning of cDNA coding for rat proliferating cell nuclear antigen (PCNA)/cyclin. Matsumoto K, etal., EMBO J 1987 Mar;6(3):637-42.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. PCNA, the maestro of the replication fork. Moldovan GL, etal., Cell. 2007 May 18;129(4):665-79.
31. Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. Morishita R, etal., Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8474-8.
32. In vitro proliferation of axotomized rat facial nucleus-derived activated microglia in an autocrine fashion. Nakajima K, etal., J Neurosci Res. 2006 Aug 1;84(2):348-59. doi: 10.1002/jnr.20882.
33. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. Zhonghua bing li xue za zhi Chinese journal of pathology Niu Y, etal., Zhonghua Bing Li Xue Za Zhi. 1997 Dec;26(6):337-9.
35. Nihon Hinyokika Gakkai zasshi. The japanese journal of urology Ohyama C, etal., Nippon Hinyokika Gakkai Zasshi. 1995 Oct;86(10):1543-51.
36. Proliferating cell nuclear antigen in neurones: induction by u.v. irradiation. Okada M, etal., Neuroreport. 1996 Jul 29;7(11):1770-2.
37. Potential role of estrogen in regulation of the insulin-like growth factor2-H19 locus in the rat testis. Pathak S, etal., Mol Cell Endocrinol. 2010 Jan 15;314(1):110-7. doi: 10.1016/j.mce.2009.08.005. Epub 2009 Aug 14.
38. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
39. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
40. GOA pipeline RGD automated data pipeline
41. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. Induction of p21Cip1-mediated G2/M arrest in H2O2-treated lens epithelial cells. Seomun Y, etal., Mol Vis. 2005 Sep 16;11:764-74.
44. Obstructive jaundice alters proliferating cell nuclear antigen expression in rat small intestine. Sheen-Chen SM, etal., World J Surg. 2003 Oct;27(10):1161-4. Epub 2003 Aug 18.
45. Prognostic value of proliferating cell nuclear antigen in Wilms' tumour in children. Skotnicka-Klonowicz G, etal., Eur J Surg Oncol. 2002 Feb;28(1):67-71.
46. Dietary olive oil and corn oil differentially affect experimental breast cancer through distinct modulation of the p21ras signaling and the proliferation-apoptosis balance. Solanas M, etal., Carcinogenesis. 2009 Oct 13.
47. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
48. Glucocorticoid impairs growth of kidney outer medulla and accelerates loop of Henle differentiation and urinary concentrating capacity in rat kidney development. Stubbe J, etal., Am J Physiol Renal Physiol. 2006 Oct;291(4):F812-22. Epub 2006 Apr 25.
49. Enhanced sequential expression of G1/S cyclins during experimental epatocarcinogenesis and tyrosine phosphorylation. Sundarrajan M, etal., J Environ Pathol Toxicol Oncol. 2001;20(3):189-97.
50. Prediction of early relapse and shortened survival in patients with breast cancer by proliferating cell nuclear antigen score. Tahan SR, etal., Cancer. 1993 Jun 1;71(11):3552-9.
51. Protective mechanism of glutamine on the expression of proliferating cell nuclear antigen after cisplatin-induced intestinal mucosal injury. Tazuke Y, etal., Pediatr Surg Int. 2011 Feb;27(2):151-8. doi: 10.1007/s00383-010-2798-8.
52. Proliferating cell nuclear antigen (PCNA) expression in regenerating rat liver after partial hepatectomy. Theocharis SE, etal., Dig Dis Sci. 1994 Feb;39(2):245-52.
53. Changes in proliferating cell nuclear antigen, a protein involved in DNA repair, in vulnerable hippocampal neurons following global cerebral ischemia. Tomasevic G, etal., Brain Res Mol Brain Res. 1998 Oct 1;60(2):168-76.
54. Proliferating cell nuclear antigen as a molecular biomarker for spermatogenesis in PTU-induced hypothyroidism of rats. Tousson E, etal., Reprod Sci. 2011 Jul;18(7):679-86. doi: 10.1177/1933719110395401. Epub 2011 Jan 27.
55. Silencing of FGFR4 could influence the biological features of gastric cancer cells and its therapeutic value in gastric cancer. Ye Y, etal., Tumour Biol. 2016 Mar;37(3):3185-95. doi: 10.1007/s13277-015-4100-0. Epub 2015 Oct 2.
56. Proliferation and differentiation of osteoblasts from the mandible of osteoporotic rats. Yu SJ, etal., Exp Biol Med (Maywood). 2012 Apr;237(4):395-406. doi: 10.1258/ebm.2011.011217.
57. Boron inhibits the proliferating cell nuclear antigen index, molybdenum containing proteins and ameliorates oxidative stress in hepatocellular carcinoma. Zafar H and Ali S, Arch Biochem Biophys. 2013 Jan 15;529(2):66-74. doi: 10.1016/j.abb.2012.11.008. Epub 2012 Dec 3.
58. Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway. Zhang CL, etal., Int J Biol Sci. 2015 Apr 25;11(6):643-51. doi: 10.7150/ijbs.10785. eCollection 2015.
59. Cloning of two rat PDIP1 related genes and their interactions with proliferating cell nuclear antigen. Zhou J, etal., J Exp Zoolog A Comp Exp Biol 2005 Mar 1;303(3):227-40.
60. Mindin regulates vascular smooth muscle cell phenotype and prevents neointima formation. Zhu LH, etal., Clin Sci (Lond). 2015 Jul;129(2):129-45. doi: 10.1042/CS20140679.
Additional References at PubMed
PMID:9774970   PMID:10079221   PMID:10888872   PMID:11005803   PMID:11595739   PMID:11934988   PMID:11942627   PMID:11981756   PMID:12040017   PMID:12203718   PMID:12638230   PMID:12857463  
PMID:12970760   PMID:14703996   PMID:15177179   PMID:15489334   PMID:15494374   PMID:15543136   PMID:15569628   PMID:15606305   PMID:15805117   PMID:15818741   PMID:15982757   PMID:16099430  
PMID:16489008   PMID:17031671   PMID:17115032   PMID:17456401   PMID:18331714   PMID:18377963   PMID:18390212   PMID:18467674   PMID:18664354   PMID:18692037   PMID:18704299   PMID:18794347  
PMID:19016366   PMID:19023449   PMID:19032457   PMID:19135898   PMID:19443450   PMID:19734146   PMID:19995904   PMID:20129063   PMID:20458337   PMID:20529819   PMID:20531390   PMID:20605140  
PMID:20972911   PMID:21383955   PMID:21492153   PMID:22330348   PMID:22477723   PMID:23277426   PMID:23284756   PMID:23976951   PMID:24115439   PMID:24625528   PMID:24726645   PMID:24939902  
PMID:25416956   PMID:25596037   PMID:26030842   PMID:26130252   PMID:26677001   PMID:27665784   PMID:29333769   PMID:29476059   PMID:29569173   PMID:29748930   PMID:31515488   PMID:33450132  
PMID:33510839   PMID:35352799  


Genomics

Comparative Map Data
Pcna
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83139,951,948 - 139,955,820 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3139,951,941 - 139,955,901 (-)EnsemblGRCr8
mRatBN7.23119,499,039 - 119,502,911 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3119,498,810 - 119,502,995 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3123,402,795 - 123,406,667 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03131,989,995 - 131,993,868 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03129,658,899 - 129,662,771 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03124,880,698 - 124,884,570 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3124,880,698 - 124,884,570 (-)Ensemblrn6Rnor6.0
Rnor_5.03131,376,235 - 131,380,108 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43120,008,715 - 120,012,589 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3118,296,567 - 118,300,439 (-)NCBICelera
RGSC_v3.13119,914,289 - 119,918,243 (-)NCBI
RH 3.4 Map31023.4RGD
Cytogenetic Map3q36NCBI
PCNA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38205,114,953 - 5,126,622 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl205,114,953 - 5,126,626 (-)Ensemblhg38GRCh38
GRCh37205,095,599 - 5,107,268 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36205,043,599 - 5,055,268 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34205,043,598 - 5,048,647NCBI
Celera205,165,620 - 5,177,289 (-)NCBICelera
Cytogenetic Map20p12.3NCBI
HuRef205,049,534 - 5,061,197 (-)NCBIHuRef
CHM1_1205,096,983 - 5,108,646 (-)NCBICHM1_1
T2T-CHM13v2.0205,154,376 - 5,166,040 (-)NCBIT2T-CHM13v2.0
Pcna
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392132,091,206 - 132,095,100 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2132,091,082 - 132,095,234 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382132,249,286 - 132,253,180 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2132,249,162 - 132,253,314 (-)Ensemblmm10GRCm38
MGSCv372132,075,022 - 132,078,916 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362131,940,727 - 131,944,621 (-)NCBIMGSCv36mm8
Celera2133,472,471 - 133,476,365 (-)NCBICelera
Cytogenetic Map2F2NCBI
cM Map264.15NCBI
Pcna
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541515,744,601 - 15,749,673 (-)Ensembl
ChiLan1.0NW_00495541515,744,601 - 15,748,910 (-)NCBIChiLan1.0ChiLan1.0
PCNA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2216,062,480 - 6,074,144 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1206,059,299 - 6,070,967 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0205,134,930 - 5,146,603 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1204,927,731 - 4,939,440 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl204,927,731 - 4,939,440 (-)EnsemblpanPan2panpan1.1
PCNA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12416,478,774 - 16,485,992 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2416,478,769 - 16,484,992 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2416,301,671 - 16,308,866 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02416,892,157 - 16,899,336 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2416,892,161 - 16,899,332 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12416,489,199 - 16,496,352 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02416,596,221 - 16,603,283 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02416,929,896 - 16,937,077 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pcna
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640165,334,861 - 165,339,851 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648513,766,077 - 13,771,382 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648513,766,221 - 13,771,215 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCNA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1714,136,886 - 14,142,744 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11714,137,746 - 14,142,584 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21715,127,978 - 15,132,806 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PCNA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1232,936,600 - 32,953,635 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl232,948,196 - 32,953,991 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607111,581,432 - 11,598,250 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcna
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247416,143,332 - 6,148,898 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247416,143,584 - 6,148,055 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pcna
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15111,963,794 - 111,967,807 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pcna
12 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:225
Count of miRNA genes:159
Interacting mature miRNAs:169
Transcripts:ENSRNOT00000028887
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3136091420155634702Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
RH94484  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23119,499,113 - 119,499,312 (+)MAPPERmRatBN7.2
Rnor_6.03124,880,773 - 124,880,971NCBIRnor6.0
Rnor_5.03131,376,310 - 131,376,508UniSTSRnor5.0
RGSC_v3.43120,008,790 - 120,008,988UniSTSRGSC3.4
Celera3118,296,642 - 118,296,840UniSTS
RH 3.4 Map31023.4UniSTS
Cytogenetic Map3q36UniSTS
RH128612  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23119,499,080 - 119,499,300 (+)MAPPERmRatBN7.2
mRatBN7.2147,465,010 - 7,465,236 (+)MAPPERmRatBN7.2
Rnor_6.0149,023,281 - 9,023,506NCBIRnor6.0
Rnor_6.03124,880,740 - 124,880,959NCBIRnor6.0
Rnor_5.0148,992,219 - 8,992,444UniSTSRnor5.0
Rnor_5.03131,376,277 - 131,376,496UniSTSRnor5.0
RGSC_v3.43120,008,757 - 120,008,976UniSTSRGSC3.4
RGSC_v3.4148,712,241 - 8,712,466UniSTSRGSC3.4
Celera147,588,856 - 7,589,081UniSTS
Celera3118,296,609 - 118,296,828UniSTS
Cytogenetic Map3q36UniSTS
Cytogenetic Map14p22UniSTS
PMC133987P4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23119,503,077 - 119,503,437 (+)MAPPERmRatBN7.2
Rnor_6.03124,884,737 - 124,885,096NCBIRnor6.0
Rnor_5.03131,380,275 - 131,380,634UniSTSRnor5.0
RGSC_v3.43120,012,756 - 120,013,115UniSTSRGSC3.4
Celera3118,300,606 - 118,300,965UniSTS
Cytogenetic Map3q36UniSTS
GDB:450240  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83139,952,269 - 139,952,507 (+)Marker Load Pipeline
mRatBN7.23119,499,360 - 119,499,598 (+)MAPPERmRatBN7.2
Rnor_6.03124,881,020 - 124,881,257NCBIRnor6.0
Rnor_5.03131,376,557 - 131,376,794UniSTSRnor5.0
RGSC_v3.43120,009,037 - 120,009,274UniSTSRGSC3.4
Celera3118,296,889 - 118,297,126UniSTS
Cytogenetic Map3q36UniSTS
Pcna-ps2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23119,499,612 - 119,501,278 (+)MAPPERmRatBN7.2
Rnor_6.03124,881,272 - 124,882,937NCBIRnor6.0
Rnor_5.03131,376,809 - 131,378,475UniSTSRnor5.0
RGSC_v3.43120,009,289 - 120,010,956UniSTSRGSC3.4
Celera3118,297,141 - 118,298,806UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC103170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000028887   ⟹   ENSRNOP00000028887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3139,951,941 - 139,955,901 (-)Ensembl
mRatBN7.2 Ensembl3119,498,810 - 119,502,995 (-)Ensembl
Rnor_6.0 Ensembl3124,880,698 - 124,884,570 (-)Ensembl
RefSeq Acc Id: NM_022381   ⟹   NP_071776
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83139,951,948 - 139,955,820 (-)NCBI
mRatBN7.23119,499,039 - 119,502,911 (-)NCBI
Rnor_6.03124,880,698 - 124,884,570 (-)NCBI
Rnor_5.03131,376,235 - 131,380,108 (-)NCBI
RGSC_v3.43120,008,715 - 120,012,589 (-)RGD
Celera3118,296,567 - 118,300,439 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_071776 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH60570 (Get FASTA)   NCBI Sequence Viewer  
  CAA68261 (Get FASTA)   NCBI Sequence Viewer  
  EDL80259 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028887
  ENSRNOP00000028887.4
GenBank Protein P04961 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071776   ⟸   NM_022381
- UniProtKB: P04961 (UniProtKB/Swiss-Prot),   A6HQF8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028887   ⟸   ENSRNOT00000028887
Protein Domains
Proliferating cell nuclear antigen PCNA C-terminal   Proliferating cell nuclear antigen PCNA N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04961-F1-model_v2 AlphaFold P04961 1-261 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692454
Promoter ID:EPDNEW_R2978
Type:initiation region
Name:Pcna_1
Description:proliferating cell nuclear antigen
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03124,884,651 - 124,884,711EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3269 AgrOrtholog
BioCyc Gene G2FUF-47781 BioCyc
Ensembl Genes ENSRNOG00000021264 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028887 ENTREZGENE
  ENSRNOT00000028887.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.70.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6891516 IMAGE-MGC_LOAD
InterPro DNA_clamp_sf UniProtKB/Swiss-Prot
  Pr_cel_nuc_antig UniProtKB/Swiss-Prot
  Pr_cel_nuc_antig_C UniProtKB/Swiss-Prot
  Pr_cel_nuc_antig_CS UniProtKB/Swiss-Prot
  Pr_cel_nuc_antig_N UniProtKB/Swiss-Prot
KEGG Report rno:25737 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72837 IMAGE-MGC_LOAD
NCBI Gene 25737 ENTREZGENE
PANTHER PROLIFERATING CELL NUCLEAR ANTIGEN UniProtKB/Swiss-Prot
  PROLIFERATING CELL NUCLEAR ANTIGEN UniProtKB/Swiss-Prot
Pfam PCNA_C UniProtKB/Swiss-Prot
  PCNA_N UniProtKB/Swiss-Prot
PhenoGen Pcna PhenoGen
PRINTS PCNACYCLIN UniProtKB/Swiss-Prot
PROSITE PCNA_1 UniProtKB/Swiss-Prot
  PCNA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021264 RatGTEx
Superfamily-SCOP DNA clamp UniProtKB/Swiss-Prot
UniProt A6HQF8 ENTREZGENE, UniProtKB/TrEMBL
  P04961 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Pcna  Proliferating cell nuclear antigen      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression protein expression is prominent in mitochondria-enriched particulate liver subfractions after exposure to oxidative stress-inducing agent WY 14,643 633642
gene_expression expressed in perinatal trabecular myocytes 1299002
gene_expression expressed in peri-infarct zone at 24 hours post focal cerebral ischaemia and in the adjacent cortex and contralateral cingulate cortex 729592
gene_function may contribute to the repair of DNA damage and to cell proliferation caused by exposure to pulmonary toxicants 727372
gene_function cell cycle protein with the potential to influence cell survival in ischaemically compromised tissue 729592
gene_function non-histone acidic nuclear protein 1299001
gene_function marker of oxidative stress 633642
gene_process operates at the G1/S boundary in the cell cycle 1299001