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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3269 Species: Rattus norvegicus RGD Object: Gene Symbol: Pcna Name: proliferating cell nuclear antigen

Acc ID: CHEBI:3750 Term: clofibrate Definition: A propanoate ester that has formula C12H15ClO3. CasRN: 637-07-0 Chemical ID: MESH:D002994

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	EXP		6480464	CTD	Clofibrate results in decreased expression of PCNA mRNA	PMID:19224547
increases expression	EXP		6480464	CTD	Clofibrate results in increased expression of PCNA protein	PMID:9007043 PMID:12851107
increases expression	EXP		6480464	CTD	Clofibrate results in increased expression of PCNA protein	PMID:12851107 PMID:9007043