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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3269 Species: Rattus norvegicus RGD Object: Gene Symbol: Pcna Name: proliferating cell nuclear antigen

Acc ID: CHEBI:31355 Term: carboplatin Definition: A platinum coordination entity that has formula C6H12N2O4Pt. CasRN: 41575-94-4 Chemical ID: MESH:D016190

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:732094	6480464	CTD	PCNA mRNA affects the reaction [DPYD mRNA affects the susceptibility to Carboplatin] PCNA mRNA affects the reaction [TYMS mRNA affects the susceptibility to Carboplatin]	PMID:16685392
increases expression	EXP		6480464	CTD	Carboplatin results in increased expression of PCNA mRNA	PMID:18172885