G6pc1 (glucose-6-phosphatase catalytic subunit 1) - Rat Genome Database

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Gene: G6pc1 (glucose-6-phosphatase catalytic subunit 1) Rattus norvegicus
Analyze
Symbol: G6pc1 (Ensembl: Psme3)
Name: glucose-6-phosphatase catalytic subunit 1 (Ensembl:proteasome activator subunit 3)
RGD ID: 2644
Description: Enables glucose-6-phosphatase activity. Involved in several processes, including cellular response to insulin stimulus; gluconeogenesis; and response to resveratrol. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum and membrane. Used to study type 2 diabetes mellitus. Biomarker of steatotic liver disease. Human ortholog(s) of this gene implicated in glycogen storage disease Ia and hepatocellular carcinoma. Orthologous to human G6PC1 (glucose-6-phosphatase catalytic subunit 1); PARTICIPATES IN altered galactose metabolic pathway; gluconeogenesis pathway; Fanconi syndrome pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1,2-dimethylhydrazine; 1-benzylpiperazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AC123346.1; G-6-Pase; G6PASE; G6pc; Glucose-6-phosphatase; glucose-6-phosphatase, catalytic; glucose-6-phosphatase, catalytic subunit; MGC93613; proteasome activator subunit 3; Psme3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,807,659 - 86,819,023 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1086,757,899 - 86,818,033 (+)EnsemblGRCr8
mRatBN7.21086,307,400 - 86,318,766 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,257,668 - 86,333,804 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1091,345,012 - 91,356,309 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,819,762 - 90,831,058 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,213,072 - 86,224,369 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,286,009 - 89,296,213 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,285,855 - 89,296,213 (+)Ensemblrn6Rnor6.0
Rnor_5.01089,084,064 - 89,094,265 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41090,393,531 - 90,403,485 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1085,025,492 - 85,036,580 (+)NCBICelera
RGSC_v3.11090,407,938 - 90,417,855 (+)NCBI
RH 3.4 Map10837.1RGD
Cytogenetic Map10q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(aminooxy)acetic acid  (ISO)
(E)-thiamethoxam  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (ISO)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-(4-hydroxyphenyl)ethanol  (EXP)
2-acetamidofluorene  (EXP)
3',5'-cyclic AMP  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside  (ISO)
4-nitrophenol  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
acephate  (EXP)
acetyl-CoA  (ISO)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (EXP,ISO)
alloxan  (EXP)
aluminium phosphide  (EXP)
AM-251  (ISO)
ammonium chloride  (EXP)
anthracen-2-amine  (EXP)
arachidonyl-2'-chloroethylamide  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
Azoxymethane  (ISO)
azoxystrobin  (ISO)
bacitracin  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
betulin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bosentan  (ISO)
bucladesine  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
carbamazepine  (EXP)
carbendazim  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chenodeoxycholic acid  (ISO)
chloroacetic acid  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
citronellol  (EXP)
clemizole  (ISO)
clofibrate  (EXP,ISO)
clopidogrel  (ISO)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cyprodinil  (ISO)
D-glucopyranose 6-phosphate  (ISO)
D-glucose  (EXP,ISO)
dehydroepiandrosterone  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dicyclanil  (ISO)
diethyl maleate  (ISO)
difenoconazole  (ISO)
digoxigenin  (ISO)
dihydroouabain  (ISO)
dimethomorph  (ISO)
Diosbulbin B  (ISO)
diphenyl diselenide  (EXP)
disodium selenite  (EXP,ISO)
doramapimod  (ISO)
drometrizole  (ISO)
duvoglustat  (ISO)
ebselen  (EXP)
endosulfan  (ISO)
enilconazole  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
esculetin  (ISO)
ethanol  (EXP,ISO)
ethoprophos  (ISO)
eugenol  (EXP)
felbamate  (EXP)
fenofibrate  (ISO)
fenpyroximate  (ISO)
fipronil  (ISO)
fludioxonil  (ISO)
fluoxetine  (ISO)
flusilazole  (ISO)
flutamide  (EXP)
fluvastatin  (ISO)
fluxapyroxad  (ISO)
folic acid  (ISO)
folpet  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
gabapentin  (EXP)
gentamycin  (EXP)
ginsenoside Re  (ISO)
glafenine  (EXP)
glucagon  (EXP,ISO)
glucose  (EXP,ISO)
glyburide  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GW 4064  (ISO)
hexadecanoic acid  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
ketoconazole  (EXP)
L-methionine  (ISO)
lamivudine  (ISO)
Lasiocarpine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
MeIQ  (ISO)
MeIQx  (ISO)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methoxyacetic acid  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
Muraglitazar  (EXP)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naringin  (ISO)
nefazodone  (EXP)
nickel dichloride  (EXP)
nicotinamide  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
ozone  (EXP,ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
penconazole  (ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenytoin  (EXP)
PhIP  (ISO)
phlorizin  (EXP)
pirinixic acid  (ISO)
plumbagin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
strophanthidin  (ISO)
sucrose  (EXP)
sulconazole  (ISO)
tartrazine  (ISO)
taurine  (ISO)
tauroursodeoxycholic acid  (EXP)
tebuconazole  (ISO)
teriflunomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thiamethoxam  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP,ISO)
trichloroethene  (EXP)
triphenyl phosphate  (EXP,ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
tungstate  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (EXP,ISO)
vanillic acid  (ISO)
vanillin  (ISO)
withaferin A  (ISO)
wortmannin  (ISO)
xanthosine  (EXP)
xylitol  (ISO)
zidovudine  (ISO)
zinc dichloride  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Fermented rice bran supplementation mitigates metabolic syndrome in stroke-prone spontaneously hypertensive rats. Alauddin M, etal., BMC Complement Altern Med. 2016 Nov 8;16(1):442. doi: 10.1186/s12906-016-1427-z.
2. Liver glyconeogenesis: a pathway to cope with postprandial amino acid excess in high-protein fed rats? Azzout-Marniche D, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Apr;292(4):R1400-7. doi: 10.1152/ajpregu.00566.2006. Epub 2006 Dec 7.
3. Gossypol ameliorates liver fibrosis in diabetic rats induced by high-fat diet and streptozocin. Chen G, etal., Life Sci. 2016 Mar 15;149:58-64. doi: 10.1016/j.lfs.2016.02.044. Epub 2016 Feb 13.
4. Targeted deletion of kidney glucose-6 phosphatase leads to nephropathy. Clar J, etal., Kidney Int. 2014 Oct;86(4):747-56. doi: 10.1038/ki.2014.102. Epub 2014 Apr 9.
5. Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes. Clore JN, etal., Diabetes. 2000 Jun;49(6):969-74.
6. Intrinsic gluconeogenesis is enhanced in renal proximal tubules of Zucker diabetic fatty rats. Eid A, etal., J Am Soc Nephrol. 2006 Feb;17(2):398-405. Epub 2006 Jan 5.
7. Defect in glucokinase translocation in Zucker diabetic fatty rats. Fujimoto Y, etal., Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E414-23. Epub 2004 May 11.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Fasting for 3 days during the suckling-weaning transient period in male rats induces metabolic abnormalities in the liver and is associated with impaired glucose tolerance in adulthood. Ikeda M, etal., Eur J Nutr. 2016 Apr;55(3):1059-67. doi: 10.1007/s00394-015-0919-9. Epub 2015 May 6.
11. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
12. Kinetic properties of the glucose 6-phosphatase of the liver from arthritic rats. Kelmer-Bracht AM, etal., Biochim Biophys Acta. 2003 May 20;1638(1):50-6.
13. Glycogen storage disease type Ia mice with less than 2% of normal hepatic glucose-6-phosphatase-α activity restored are at risk of developing hepatic tumors. Kim GY, etal., Mol Genet Metab. 2017 Mar;120(3):229-234. doi: 10.1016/j.ymgme.2017.01.003. Epub 2017 Jan 10.
14. Tangshen formula attenuates hepatic steatosis by inhibiting hepatic lipogenesis and augmenting fatty acid oxidation in db/db mice. Kong Q, etal., Int J Mol Med. 2016 Dec;38(6):1715-1726. doi: 10.3892/ijmm.2016.2799. Epub 2016 Nov 10.
15. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
16. Isolation of a cDNA for the catalytic subunit of rat liver glucose-6-phosphatase: regulation of gene expression in FAO hepatoma cells by insulin, dexamethasone and cAMP. Lange AJ, etal., Biochem Biophys Res Commun 1994 May 30;201(1):302-9.
17. Saccharin Increases Fasting Blood Glucose but Not Liver Insulin Resistance in Comparison to a High Fructose-Fed Rat Model. Leibowitz A, etal., Nutrients. 2018 Mar 12;10(3). pii: nu10030341. doi: 10.3390/nu10030341.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Intracellular lipids are an independent cause of liver injury and chronic kidney disease in non alcoholic fatty liver disease-like context. Monteillet L, etal., Mol Metab. 2018 Oct;16:100-115. doi: 10.1016/j.molmet.2018.07.006. Epub 2018 Aug 1.
20. Regulation of glucose-6-phosphatase gene expression by insulin and metformin. Mues C, etal., Horm Metab Res. 2009 Oct;41(10):730-5. doi: 10.1055/s-0029-1225360. Epub 2009 Jul 3.
21. Glucose-6-phosphatase gene mutations in 20 adult Japanese patients with glycogen storage disease type 1a with reference to hepatic tumors. Nakamura T, etal., J Gastroenterol Hepatol. 2001 Dec;16(12):1402-8.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease. Nishikawa T, etal., J Hepatol. 2014 Jun;60(6):1203-11. doi: 10.1016/j.jhep.2014.02.014. Epub 2014 Feb 26.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
26. Enhanced trimethylation of histone h3 mediates impaired expression of hepatic glucose 6-phosphatase expression in offspring from rat dams exposed to hypoxia during pregnancy. Osumek JE, etal., Reprod Sci. 2014 Jan;21(1):112-21. doi: 10.1177/1933719113492212. Epub 2013 Jun 6.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
29. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
30. Polyunsaturated fatty acyl coenzyme A suppress the glucose-6-phosphatase promoter activity by modulating the DNA binding of hepatocyte nuclear factor 4 alpha. Rajas F, etal., J Biol Chem 2002 May 3;277(18):15736-44.
31. Influence of sesame oil on blood glucose, lipid peroxidation, and antioxidant status in streptozotocin diabetic rats. Ramesh B, etal., J Med Food. 2005 Fall;8(3):377-81.
32. GOA pipeline RGD automated data pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Expression and distribution of glucose-6-phosphatase catalytic subunit messenger RNA and its changes in the diabetic state. Shingu R, etal., Res Commun Mol Pathol Pharmacol 1996 Jul;93(1):13-24.
36. Mechanism of fat-induced hepatic gluconeogenesis: effect of metformin. Song S, etal., Am J Physiol Endocrinol Metab. 2001 Aug;281(2):E275-82.
37. Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats. Trinh KY, etal., J Biol Chem. 1998 Nov 20;273(47):31615-20.
38. DYRK1 is a co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression. von Groote-Bidlingmaier F, etal., Biochem Biophys Res Commun 2003 Jan 17;300(3):764-9.
39. Hepatic insulin resistance precedes the development of diabetes in a model of intrauterine growth retardation. Vuguin P, etal., Diabetes. 2004 Oct;53(10):2617-22.
40. 1,2-Dichloroethane impairs glucose and lipid homeostasis in the livers of NIH Swiss mice. Wang T, etal., Toxicology. 2017 Apr 1;380:38-49. doi: 10.1016/j.tox.2017.02.005. Epub 2017 Feb 8.
41. An acute increase in fructose concentration increases hepatic glucose-6-phosphatase mRNA via mechanisms that are independent of glycogen synthase kinase-3 in rats. Wei Y, etal., J Nutr. 2004 Mar;134(3):545-51.
42. Induction and suppression of the key enzymes of glycolysis and gluconeogenesis in isolated perfused rat liver in response to glucose, fructose and lactate. Wimhurst JM and Manchester KL, Biochem J. 1973 May;134(1):143-56.
43. Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Lepr(db/+) mice. Yamashita H, etal., Pediatr Res. 2003 Mar;53(3):411-8.
44. Complete normalization of hepatic G6PC deficiency in murine glycogen storage disease type Ia using gene therapy. Yiu WH, etal., Mol Ther. 2010 Jun;18(6):1076-84. doi: 10.1038/mt.2010.64. Epub 2010 Apr 13.
45. Resveratrol improves glycemic control in insulin-treated diabetic rats: participation of the hepatic territory. Yonamine CY, etal., Nutr Metab (Lond). 2016 Jun 29;13:44. doi: 10.1186/s12986-016-0103-0. eCollection 2016.
46. Gluconeogenesis in developing rat kidney cortex. Zorzoli A, etal., Biochem J. 1969 Jan;111(2):181-5.
Additional References at PubMed
PMID:7860767   PMID:8211187   PMID:8407995   PMID:8640227   PMID:8866562   PMID:10318794   PMID:10625614   PMID:10787428   PMID:11121425   PMID:11882511   PMID:12093795   PMID:12477932  
PMID:12902328   PMID:12915406   PMID:14759518   PMID:15087461   PMID:15302872   PMID:15388792   PMID:15661744   PMID:15682487   PMID:15735652   PMID:16256938   PMID:16893891   PMID:17106062  
PMID:17160355   PMID:17211624   PMID:17588937   PMID:17931592   PMID:18304430   PMID:18717264   PMID:21402051   PMID:22214556   PMID:31904090  


Genomics

Comparative Map Data
G6pc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,807,659 - 86,819,023 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1086,757,899 - 86,818,033 (+)EnsemblGRCr8
mRatBN7.21086,307,400 - 86,318,766 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,257,668 - 86,333,804 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1091,345,012 - 91,356,309 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,819,762 - 90,831,058 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,213,072 - 86,224,369 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,286,009 - 89,296,213 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,285,855 - 89,296,213 (+)Ensemblrn6Rnor6.0
Rnor_5.01089,084,064 - 89,094,265 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41090,393,531 - 90,403,485 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1085,025,492 - 85,036,580 (+)NCBICelera
RGSC_v3.11090,407,938 - 90,417,855 (+)NCBI
RH 3.4 Map10837.1RGD
Cytogenetic Map10q31NCBI
G6PC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,900,799 - 42,914,438 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,900,797 - 42,914,438 (+)Ensemblhg38GRCh38
GRCh371741,052,816 - 41,066,455 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,306,341 - 38,318,912 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341738,306,340 - 38,318,912NCBI
Celera1737,708,948 - 37,721,525 (+)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1736,817,624 - 36,831,212 (+)NCBIHuRef
CHM1_11741,288,425 - 41,302,053 (+)NCBICHM1_1
T2T-CHM13v2.01743,757,942 - 43,771,581 (+)NCBIT2T-CHM13v2.0
G6pc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,258,542 - 101,268,729 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,258,387 - 101,268,729 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811101,367,716 - 101,377,903 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,367,561 - 101,377,903 (+)Ensemblmm10GRCm38
MGSCv3711101,229,044 - 101,239,217 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611101,183,820 - 101,193,993 (+)NCBIMGSCv36mm8
MGSCv3611102,147,317 - 102,157,491 (+)NCBIMGSCv36mm8
Cytogenetic Map11DNCBI
cM Map1164.83NCBI
G6pc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,672,979 - 16,680,001 (+)Ensembl
ChiLan1.0NW_00495545116,672,512 - 16,680,001 (+)NCBIChiLan1.0ChiLan1.0
G6PC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,072,152 - 22,087,542 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11723,961,401 - 23,976,773 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,407,355 - 14,419,660 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,635,667 - 14,646,674 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,635,667 - 14,646,674 (-)EnsemblpanPan2panpan1.1
G6PC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,132,973 - 20,143,642 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,132,978 - 20,143,642 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha919,594,513 - 19,605,089 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0920,851,596 - 20,862,184 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,852,175 - 20,862,060 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,636,449 - 19,647,026 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0919,902,743 - 19,913,338 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,005,407 - 20,015,994 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
G6pc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,459,203 - 19,469,287 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,605,865 - 17,615,145 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,605,865 - 17,614,754 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
G6PC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1219,965,330 - 19,975,857 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11219,965,885 - 19,975,783 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
G6PC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,380,921 - 63,392,122 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,381,382 - 63,391,540 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607734,170,149 - 34,181,234 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
G6pc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,331,601 - 1,339,580 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247951,331,592 - 1,339,575 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
G6pc1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1960,665,700 - 60,677,140 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in G6pc1
109 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH129533  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,318,480 - 86,318,677 (+)MAPPERmRatBN7.2
Rnor_6.01089,295,928 - 89,296,124NCBIRnor6.0
Rnor_5.01089,093,980 - 89,094,176UniSTSRnor5.0
RH 3.4 Map10838.0UniSTS
Cytogenetic Map10q32.1UniSTS
RH94788  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,317,643 - 86,317,842 (+)MAPPERmRatBN7.2
Rnor_6.01089,295,091 - 89,295,289NCBIRnor6.0
Rnor_5.01089,093,143 - 89,093,341UniSTSRnor5.0
RGSC_v3.41090,403,147 - 90,403,345UniSTSRGSC3.4
Celera1085,035,807 - 85,036,005UniSTS
RH 3.4 Map10837.1UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
9 9 34 64 84 84 53 80 53 6 286 140 8 40 76 83 31

Sequence


Ensembl Acc Id: ENSRNOT00000027957   ⟹   ENSRNOP00000027957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1086,757,899 - 86,765,715 (+)Ensembl
mRatBN7.2 Ensembl1086,257,668 - 86,265,444 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000028033   ⟹   ENSRNOP00000028033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1086,807,648 - 86,818,033 (+)Ensembl
mRatBN7.2 Ensembl1086,307,438 - 86,318,420 (+)Ensembl
Rnor_6.0 Ensembl1089,285,855 - 89,296,213 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1089,286,061 - 89,288,641 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076727   ⟹   ENSRNOP00000068494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,257,694 - 86,265,460 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076820   ⟹   ENSRNOP00000068449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,257,872 - 86,333,804 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077603   ⟹   ENSRNOP00000070071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,257,872 - 86,317,581 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085831   ⟹   ENSRNOP00000071453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1086,807,648 - 86,818,033 (+)Ensembl
mRatBN7.2 Ensembl1086,307,438 - 86,318,420 (+)Ensembl
Rnor_6.0 Ensembl1089,286,047 - 89,295,867 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101325   ⟹   ENSRNOP00000091678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,257,694 - 86,265,460 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117234   ⟹   ENSRNOP00000080141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1086,758,313 - 86,764,223 (+)Ensembl
mRatBN7.2 Ensembl1086,258,383 - 86,265,460 (+)Ensembl
RefSeq Acc Id: NM_013098   ⟹   NP_037230
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,807,659 - 86,819,023 (+)NCBI
mRatBN7.21086,307,400 - 86,318,766 (+)NCBI
Rnor_6.01089,286,009 - 89,296,213 (+)NCBI
Rnor_5.01089,084,064 - 89,094,265 (+)NCBI
RGSC_v3.41090,393,531 - 90,403,485 (+)RGD
Celera1085,025,492 - 85,036,580 (+)RGD
Sequence:
RefSeq Acc Id: NP_037230   ⟸   NM_013098
- UniProtKB: Q5FVC9 (UniProtKB/Swiss-Prot),   P43428 (UniProtKB/Swiss-Prot),   A6HJB1 (UniProtKB/TrEMBL),   A0A8L2QF08 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028033   ⟸   ENSRNOT00000028033
Ensembl Acc Id: ENSRNOP00000071453   ⟸   ENSRNOT00000085831
Ensembl Acc Id: ENSRNOP00000068494   ⟸   ENSRNOT00000076727
Ensembl Acc Id: ENSRNOP00000091678   ⟸   ENSRNOT00000101325
Ensembl Acc Id: ENSRNOP00000070071   ⟸   ENSRNOT00000077603
Ensembl Acc Id: ENSRNOP00000068449   ⟸   ENSRNOT00000076820
Ensembl Acc Id: ENSRNOP00000080141   ⟸   ENSRNOT00000117234
Ensembl Acc Id: ENSRNOP00000027957   ⟸   ENSRNOT00000027957
Protein Domains
Phosphatidic acid phosphatase type 2/haloperoxidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43428-F1-model_v2 AlphaFold P43428 1-357 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697756
Promoter ID:EPDNEW_R8281
Type:single initiation site
Name:G6pc_1
Description:glucose-6-phosphatase, catalytic subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01089,285,998 - 89,286,058EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2644 AgrOrtholog
BioCyc Gene G2FUF-23176 BioCyc
BioCyc Pathway PWY66-399 [gluconeogenesis III] BioCyc
BioCyc Pathway Image PWY66-399 BioCyc
Ensembl Genes ENSRNOG00000051171 Ensembl
  ENSRNOG00000053448 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000085831 ENTREZGENE
  ENSRNOT00000085831.2 UniProtKB/Swiss-Prot
Gene3D-CATH Phosphatidic acid phosphatase type 2/haloperoxidase UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109006 IMAGE-MGC_LOAD
InterPro Glucose-6-phosphatase UniProtKB/Swiss-Prot
  P_Acid_Pase_2/haloperoxi_sf UniProtKB/Swiss-Prot
  P_Acid_Pase_2/haloperoxidase UniProtKB/Swiss-Prot
KEGG Report rno:25634 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93613 IMAGE-MGC_LOAD
NCBI Gene 25634 ENTREZGENE
PANTHER GLUCOSE-6-PHOSPHATASE UniProtKB/Swiss-Prot
  GLUCOSE-6-PHOSPHATASE CATALYTIC SUBUNIT 1 UniProtKB/Swiss-Prot
Pfam PAP2 UniProtKB/Swiss-Prot
PhenoGen G6pc1 PhenoGen
PIRSF Glucose-6-phosphatase UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000051171 RatGTEx
  ENSRNOG00000053448 RatGTEx
SMART acidPPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48317 UniProtKB/Swiss-Prot
UniProt A0A8I5ZP59_RAT UniProtKB/TrEMBL
  A0A8L2QF08 ENTREZGENE, UniProtKB/TrEMBL
  A6HJB1 ENTREZGENE, UniProtKB/TrEMBL
  G6PC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5FVC9 ENTREZGENE
UniProt Secondary Q5FVC9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 G6pc1  glucose-6-phosphatase catalytic subunit 1  AC123346.1    Data merged from RGD:15007920 737654 PROVISIONAL
2021-09-02 AC123346.1    Psme3  proteasome activator subunit 3  Symbol and/or name change 19259462 PROVISIONAL
2021-08-09 Psme3  proteasome activator subunit 3  AC123346.1    Symbol and/or name change 19259462 PROVISIONAL
2020-11-12 G6pc1  glucose-6-phosphatase catalytic subunit 1  G6pc  glucose-6-phosphatase, catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-11-08 AC123346.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2008-09-18 G6pc  glucose-6-phosphatase, catalytic subunit  G6pc  glucose-6-phosphatase, catalytic  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 G6pc  glucose-6-phosphatase, catalytic    Glucose-6-phosphatase  Name updated 625702 APPROVED
2002-06-10 G6pc  Glucose-6-phosphatase      Symbol and Name status set to approved 70586 APPROVED