RGD Reference Report - Influence of sesame oil on blood glucose, lipid peroxidation, and antioxidant status in streptozotocin diabetic rats. - Rat Genome Database

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Influence of sesame oil on blood glucose, lipid peroxidation, and antioxidant status in streptozotocin diabetic rats.

Authors: Ramesh, B  Saravanan, R  Pugalendi, KV 
Citation: Ramesh B, etal., J Med Food. 2005 Fall;8(3):377-81.
RGD ID: 2315960
Pubmed: PMID:16176150   (View Abstract at PubMed)
DOI: DOI:10.1089/jmf.2005.8.377   (Journal Full-text)

The present study was carried out to assess the influence of sesame oil on blood glucose, lipid peroxidation, and status of antioxidants in normal and streptozotocin (STZ) diabetic rats. Diabetes was induced in adult female albino Wistar rats weighing 180-200 g by administration of STZ (40 mg/kg of body weight) intraperitonially. Both normal and diabetic rats were fed with a commercial diet containing 2% oil supplemented with 6% sesame oil for 42 days. Diabetic rats had elevated levels of blood glucose (322.61 +/- 9.49 mg/dL), glycosylated hemoglobin, vitamin E, thiobarbituric acid-reactive substances (TBARS), and lipid hydroperoxides and decreased levels of hemoglobin, vitamin C, and reduced glutathione (GSH). An increase in glucose-6-phosphatase and fructose-1,6-bisphosphatase activities and a decrease in hexokinase activity were observed in liver and kidney tissues. When diabetic rats fed with sesame oil were compared with diabetic rats, a significant reduction in levels of blood glucose (222.02 +/- 8.27 mg/dL), glycosylated hemoglobin, TBARS, and lipid hydroperoxides and glucose-6-phosphatase and fructose-1,6-bisphosphatase activities and an elevation in hemoglobin, vitamin E, and GSH levels and hexokinase activity were observed. Thus, sesame oil consumption influences beneficially the blood glucose, glycosylated hemoglobin, lipid peroxidation, and antioxidant levels in diabetic rats.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Diabetes Mellitus  ISOG6pc1 (Rattus norvegicus)2315960; 2315960protein:increased activity:liver and kidneyRGD 
Experimental Diabetes Mellitus  IEP 2315960protein:increased activity:liver and kidneyRGD 

Objects Annotated

Genes (Rattus norvegicus)
G6pc1  (glucose-6-phosphatase catalytic subunit 1)

Genes (Mus musculus)
G6pc1  (glucose-6-phosphatase catalytic subunit 1)

Genes (Homo sapiens)
G6PC1  (glucose-6-phosphatase catalytic subunit 1)


Additional Information