Crp (C-reactive protein) - Rat Genome Database

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Gene: Crp (C-reactive protein) Rattus norvegicus
Analyze
Symbol: Crp
Name: C-reactive protein
RGD ID: 2411
Description: Enables cholesterol binding activity; identical protein binding activity; and low-density lipoprotein particle binding activity. Involved in several processes, including cellular response to nitric oxide; complement activation, classical pathway; and negative regulation of superoxide anion generation. Located in extracellular space; filopodium; and growth cone. Used to study rheumatoid arthritis. Biomarker of several diseases, including artery disease (multiple); iron deficiency anemia; metabolic dysfunction and alcohol associated liver disease; obesity; and status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; antiphospholipid syndrome; macular degeneration (multiple); middle cerebral artery infarction; and nephritis (multiple). Orthologous to human CRP (C-reactive protein); PARTICIPATES IN classical complement pathway; interleukin-6 signaling pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (R)-lipoic acid; 1,1-dichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Aa1249; Ab1-341; Ab2-196; Ac1-114; Ac1262; Ac2-069; Ba2-693; C-reactive protein member of the pentraxin family; C-reactive protein, member of the pentraxin family; C-reactive protein, pentraxin-related; C-reactive protein, petaxin related
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81387,694,062 - 87,695,978 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1387,657,317 - 87,707,514 (+)EnsemblGRCr8
mRatBN7.21385,135,384 - 85,175,178 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1385,124,977 - 85,175,178 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1387,664,967 - 87,666,915 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01389,065,246 - 89,067,190 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01386,249,976 - 86,251,928 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01391,080,448 - 91,081,358 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1391,054,974 - 91,093,713 (+)Ensemblrn6Rnor6.0
Rnor_5.01395,599,418 - 95,600,328 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41388,702,243 - 88,703,153 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1384,770,843 - 84,771,753 (+)NCBICelera
RGSC_v3.11388,891,058 - 88,892,928 (+)NCBI
Cytogenetic Map13q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Coronary Syndrome  (ISO)
acute kidney failure  (IEP,ISO)
acute stress disorder  (ISO)
Acute Uveitis  (IEP,ISO)
aggressive periodontitis  (ISO)
Albuminuria  (ISO)
alcoholic liver cirrhosis  (ISO)
Alzheimer's disease  (ISO)
ankylosing spondylitis  (ISO)
antiphospholipid syndrome  (ISO)
anxiety disorder  (ISO)
Arsenic Poisoning  (ISO)
arthritis  (ISO)
aspergillosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Bacteremia  (ISO)
bacterial infectious disease  (ISO)
bacterial meningitis  (ISO)
Behcet's disease  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
bronchiolitis  (ISO)
Burns  (IEP)
Cardiac Arrhythmias  (ISO)
cardiovascular system disease  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon cancer  (IEP)
congestive heart failure  (ISO)
Contrast-Induced Nephropathy  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
depressive disorder  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
disease by infectious agent  (ISO)
disease of metabolism  (ISO)
Drug Hypersensitivity Syndrome  (ISO)
end stage renal disease  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (IDA,ISO)
Experimental Liver Cirrhosis  (IEP)
familial hyperlipidemia  (IEP)
Fever of Unknown Origin  (ISO)
heart disease  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
hypertension  (IEP,ISO)
hypertensive retinopathy  (ISO)
Hypertriglyceridemia  (ISO)
Hypoxia  (ISO)
Inflammation  (IEP,ISO)
inflammatory bowel disease  (ISO)
intermediate coronary syndrome  (ISO)
interstitial cystitis  (ISO)
interstitial nephritis  (ISO)
Intestinal Reperfusion Injury  (IEP)
iron deficiency anemia  (IEP)
juvenile rheumatoid arthritis  (ISO)
Kawasaki disease  (ISO)
kidney failure  (ISO)
Kuhnt-Junius degeneration  (ISO)
Left Ventricular Hypertrophy  (ISO)
leishmaniasis  (ISO)
liver cirrhosis  (ISO)
low tension glaucoma  (ISO)
Lung Neoplasms  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
lymphopenia  (ISO)
macular degeneration  (ISO)
malaria  (ISO)
mastoiditis  (ISO)
meningitis  (ISO)
metabolic dysfunction and alcohol associated liver disease  (IEP)
Metabolic Syndrome  (ISO)
mevalonic aciduria  (ISO)
middle cerebral artery infarction  (ISO)
mouth disease  (IEP)
Mycoplasma pneumoniae pneumonia  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Ischemia  (IEP,ISO)
Myocardial Reperfusion Injury  (IEP)
myocarditis  (ISO)
Neonatal Sepsis  (IEP)
non-arteritic anterior ischemic optic neuropathy  (ISO)
obesity  (IEP,ISO)
obstructive sleep apnea  (ISO)
opiate dependence  (ISO)
otitis externa  (ISO)
otitis media  (ISO)
overactive bladder syndrome  (ISO)
Parkinson's disease  (ISO)
Pasteurellaceae Infections  (ISO)
pelvic inflammatory disease  (ISO)
periodontitis  (ISO)
pharyngoconjunctival fever  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
polymyalgia rheumatica  (ISO)
Polypoidal Choroidal Vasculopathy  (ISO)
Postoperative Atrial Fibrillation  (ISO)
Pseudomonas Infections  (IEP,ISO)
psoriasis  (ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
pyelonephritis  (IEP)
renal cell carcinoma  (ISO)
Renal Colic  (ISO)
renal fibrosis  (ISO)
renal hypertension  (IEP)
retinal vein occlusion  (ISO)
rheumatoid arthritis  (IDA,ISO)
secondary hyperparathyroidism  (ISO)
Sepsis  (IEP,ISO)
Serositis  (ISO)
Sjogren's syndrome  (ISO)
Spinal Cord Injuries  (IDA)
status epilepticus  (IEP)
Stevens-Johnson syndrome  (ISO)
systemic lupus erythematosus  (ISO)
temporal arteritis  (ISO)
thrombosis  (ISO)
Tubulointerstitial Nephritis and Uveitis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urticaria  (ISO)
uveal melanoma  (ISO)
vestibular neuronitis  (ISO)
visceral leishmaniasis  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid  (ISO)
(R)-lipoic acid  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
1,1-dichloroethene  (EXP)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
7,12-dimethyltetraphene  (ISO)
abacavir  (ISO)
acalabrutinib  (ISO)
acetamide  (EXP)
acetic acid  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
alclofenac  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiodarone  (ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
apigenin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP)
atorvastatin calcium  (EXP,ISO)
benidipine  (EXP)
benzbromarone  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzylpenicillin  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bivalirudin  (ISO)
boron atom  (EXP)
Botulinum toxin type A  (EXP)
Bromperidol  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
calcitriol  (ISO)
candesartan  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carnosine  (EXP,ISO)
carrageenan  (EXP)
carvedilol  (EXP,ISO)
celecoxib  (ISO)
ceruletide  (EXP)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
colesevelam hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
cyproterone acetate  (ISO)
D-penicillamine  (ISO)
daidzein  (ISO)
delta-tocotrienol  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP)
desogestrel  (ISO)
dexamethasone  (EXP,ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
dienogest  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethoate  (EXP)
disodium selenite  (EXP,ISO)
doxazosin  (ISO)
elemental boron  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
eptifibatide  (ISO)
erythromycin A  (ISO)
ethanol  (EXP,ISO)
ezetimibe  (ISO)
fenofibrate  (ISO)
flucloxacillin  (ISO)
flunitrazepam  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fosfomycin  (ISO)
fructose  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP)
gamma-tocopherol  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
geraniol  (EXP)
gestodene  (ISO)
ginsenoside Re  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
gossypin  (EXP)
heparin  (ISO)
indinavir  (ISO)
indometacin  (EXP)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) citrate  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
kaempferol  (ISO)
L-arginine  (EXP)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
lead nitrate  (ISO)
lead(0)  (ISO)
levonorgestrel  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP)
lovastatin  (EXP)
lupeol  (EXP)
medroxyprogesterone acetate  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
Mesaconitine  (EXP)
metformin  (EXP,ISO)
methotrexate  (ISO)
mevalonic acid  (ISO)
milrinone  (ISO)
mono(2-ethyl-5-hydroxyhexyl) phthalate  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
morphine  (ISO)
myricitrin  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
neoechinulin A  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotinic acid  (ISO)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
nomegestrol  (ISO)
nomegestrol acetate  (ISO)
Nonidet P-40  (ISO)
norgestimate  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
olmesartan  (ISO)
Olmesartan medoxomil  (EXP)
olsalazine  (ISO)
ozone  (EXP)
p-menthan-3-ol  (EXP)
pamidronate  (ISO)
paracetamol  (EXP,ISO)
Pentoxifylline  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphatidylcholine  (ISO)
pioglitazone  (EXP,ISO)
pirinixic acid  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
pterostilbene  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
rifampicin  (ISO)
rifamycin SV  (ISO)
rivastigmine  (EXP)
rosmarinic acid  (EXP)
rosuvastatin calcium  (ISO)
rotenone  (ISO)
salvianolic acid B  (EXP,ISO)
SB 203580  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium nitrite  (EXP)
sterigmatocystin  (ISO)
streptozocin  (ISO)
Sunset Yellow FCF  (ISO)
superoxide  (EXP)
telmisartan  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
tibolone  (ISO)
titanium dioxide  (ISO)
TMC-120A  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
Triptolide  (EXP,ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vitamin E  (ISO)
withaferin A  (EXP)
wortmannin  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Postoperative atrial fibrillation is not correlated to C-reactive protein. Ahlsson AJ, etal., Ann Thorac Surg. 2007 Apr;83(4):1332-7.
2. Hospitalised patients with Influenza A (H1N1) in the Royal Hospital, Oman: Experience of a tertiary care hospital, July-December 2009. Al-Lawati J, etal., Sultan Qaboos Univ Med J. 2010 Dec;10(3):326-34. Epub 2010 Nov 14.
3. Plasma oxidative and inflammatory markers in patients with idiopathic Parkinson's disease. Andican G, etal., Acta Neurol Belg. 2012 Feb 9.
4. The value of C-reactive protein determination in patients with renal colic to decide urgent urinary diversion. Angulo JC, etal., Urology. 2010 Aug;76(2):301-6. Epub 2010 Mar 5.
5. The effectiveness of Echinacea extract or composite glucosamine, chondroitin and methyl sulfonyl methane supplements on acute and chronic rheumatoid arthritis rat model. Arafa NM, etal., Toxicol Ind Health. 2011 Dec 15.
6. Atheroma plaque, metabolic syndrome and inflammation in patients with psoriasis. Arias-Santiago S, etal., Eur J Dermatol. 2012 Apr 16.
7. C-reactive protein (CRP): An important diagnostic and prognostic tool in nursing-home-associated pneumonia. Arinzon Z, etal., Arch Gerontol Geriatr. 2011 Mar 23.
8. Long-term outcome of tumor necrosis factor alpha antagonist's treatment in pediatric Crohn's disease. Assa A, etal., J Crohns Colitis. 2012 Apr 4.
9. Association between C-reactive protein and generalized anxiety disorder in stable coronary heart disease patients. Bankier B, etal., Eur Heart J. 2008 Sep;29(18):2212-7. doi: 10.1093/eurheartj/ehn326. Epub 2008 Jul 4.
10. Prolonged C1 inhibitor administration improves local healing of burn wounds and reduces myocardial inflammation in a rat burn wound model. Begieneman MP, etal., J Burn Care Res. 2012 Jul;33(4):544-51.
11. The effects of melatonin on burn-induced inflammatory responses and coagulation disorders in rats. Bekyarova G, etal., Methods Find Exp Clin Pharmacol. 2010 Jun;32(5):299-303.
12. Promotion of beta-amyloid production by C-reactive protein and its implications in the early pathogenesis of Alzheimer's disease. Bi BT, etal., Neurochem Int. 2012 Feb;60(3):257-66. Epub 2011 Dec 19.
13. Platelet count, mean platelet volume and smoking status in stable chronic obstructive pulmonary disease. Biljak VR, etal., Platelets. 2011 Apr 20.
14. Relationship between inflammatory markers, oxidant-antioxidant status and intima-media thickness in prepubertal children with juvenile idiopathic arthritis. Breda L, etal., Clin Res Cardiol. 2012 Aug 11.
15. Effects of topical indomethacin, bromfenac and nepafenac on lipopolysaccharide-induced ocular inflammation. Bucolo C, etal., J Pharm Pharmacol. 2014 Jul;66(7):954-60. doi: 10.1111/jphp.12224. Epub 2014 Feb 12.
16. Synergistic effects of aminoglycosides and fosfomycin on Pseudomonas aeruginosa in vitro and biofilm infections in a rat model. Cai Y, etal., J Antimicrob Chemother. 2009 Sep;64(3):563-6. Epub 2009 Jun 26.
17. Accuracy of white blood cell count, C-reactive protein, interleukin-6 and tumor necrosis factor alpha for diagnosing late neonatal sepsis. Caldas JP, etal., J Pediatr (Rio J). 2008 Nov-Dec;84(6):536-42. doi: doi:10.2223/JPED.1838.
18. Lack of effect of a single injection of human C-reactive protein on murine lupus or nephrotoxic nephritis. Carlucci F, etal., Arthritis Rheum. 2010 Jan;62(1):245-9.
19. Early proinflammatory cytokines and C-reactive protein trends as predictors of outcome in invasive Aspergillosis. Chai L, etal., J Infect Dis. 2010 Nov 1;202(9):1454-62. doi: 10.1086/656527.
20. Significant elevation of plasma pentraxin 3 in patients with pelvic inflammatory disease. Chang CC, etal., Clin Chem Lab Med. 2011 Oct;49(10):1655-60. doi: 10.1515/CCLM.2011.650. Epub 2011 Jun 17.
21. Augmented nitric oxide generation in neutrophils: oxidative and pro-inflammatory implications in hypertension. Chatterjee M, etal., Free Radic Res. 2009 Dec;43(12):1195-204.
22. [Promoting effect of granulocyto-colony stimulating factor on neovascularization in rats with myocardial infarction]. Chen T, etal., Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2010 Oct;24(10):1239-43.
23. Molecular and clinical characteristics of adenoviral infections in Taiwanese children in 2004-2005. Cheng CC, etal., Eur J Pediatr. 2008 Jun;167(6):633-40. Epub 2007 Sep 18.
24. Inflammatory gene polymorphisms and susceptibility to kawasaki disease and its arterial sequelae. Cheung YF, etal., Pediatrics. 2008 Sep;122(3):e608-14. doi: 10.1542/peds.2008-0646. Epub 2008 Aug 18.
25. Mastoiditis diagnosed by clinical symptoms and imaging studies in children: disease spectrum and evolving diagnostic challenges. Chien JH, etal., J Microbiol Immunol Infect. 2012 Oct;45(5):377-81. doi: 10.1016/j.jmii.2011.12.008. Epub 2012 May 9.
26. Malignant otitis externa: an Australian case series. Chin R, etal., Surgeon. 2012 Oct;10(5):273-7. doi: 10.1016/j.surge.2011.09.004. Epub 2011 Oct 26.
27. C-reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillation. Chung MK, etal., Circulation. 2001 Dec 11;104(24):2886-91.
28. Elevation of serum c-reactive protein in patients with OAB and IC/BPS implies chronic inflammation in the urinary bladder. Chung SD, etal., Neurourol Urodyn. 2011 Mar;30(3):417-20. doi: 10.1002/nau.20938. Epub 2011 Jan 31.
29. NP1 regulates neuronal activity-dependent accumulation of BAX in mitochondria and mitochondrial dynamics. Clayton KB, etal., J Neurosci. 2012 Jan 25;32(4):1453-66.
30. The association of low-grade systemic inflammation with hypertensive retinopathy. Coban E, etal., Clin Exp Hypertens. 2010;32(8):528-31. doi: 10.3109/10641963.2010.496519.
31. Inflammation reduces HDL protection against primary cardiac risk. Corsetti JP, etal., Eur J Clin Invest. 2010 Jun;40(6):483-9. doi: 10.1111/j.1365-2362.2010.02287.x. Epub 2010 Apr 14.
32. Role of thrombocytosis in diagnosis of giant cell arteritis and differentiation of arteritic from non-arteritic anterior ischemic optic neuropathy. Costello F, etal., Eur J Ophthalmol. 2004 May-Jun;14(3):245-57.
33. Complement activation in patients with COVID-19: A novel therapeutic target. Cugno M, etal., J Allergy Clin Immunol. 2020 May 14. pii: S0091-6749(20)30650-3. doi: 10.1016/j.jaci.2020.05.006.
34. [Assess the impact of concentrations of inflammatory markers IL-6, CRP in the presence of albuminuria in patients with type 2 diabetes]. Czyzewska J, etal., Pol Merkur Lekarski. 2012 Feb;32(188):98-102.
35. Exercise Training and Antioxidants: Effects on Rat Heart Tissue Exposed to Lead Acetate. Dabidi Roshan V, etal., Int J Toxicol. 2011 Mar 4.
36. C-reactive protein and atrial fibrillation in idiopathic dilated cardiomyopathy. Dai S, etal., Clin Cardiol. 2009 Sep;32(9):E45-50. doi: 10.1002/clc.20430.
37. Isolation and characterization of C-reactive protein and serum amyloid P component in the rat. de Beer FC, etal., Immunology. 1982 Jan;45(1):55-70.
38. Selection of Symptomatic Patients With Crohn's Disease for Abdominopelvic Computed Tomography: Role of Serum C-Reactive Protein. Desmond AN, etal., Can Assoc Radiol J. 2012 Mar 14.
39. Rat C-reactive protein activates the autologous complement system. Diaz Padilla N, etal., Immunology. 2003 Aug;109(4):564-71.
40. Retinal vein occlusion: C-reactive protein and arterial hypertension. Dodson PM and Shine B, Acta Ophthalmol (Copenh). 1984 Feb;62(1):123-30.
41. Iron deficiency and renal development in the newborn rat. Drake KA, etal., Pediatr Res. 2009 Dec;66(6):619-24.
42. Cytokine activation during attacks of the hyperimmunoglobulinemia D and periodic fever syndrome. Drenth JP, etal., Blood. 1995 Jun 15;85(12):3586-93.
43. Decreased autoantibody levels and enhanced survival of (NZB x NZW) F1 mice treated with C-reactive protein. Du Clos TW, etal., Clin Immunol Immunopathol. 1994 Jan;70(1):22-7.
44. Risk factors for recurrence of diabetic foot ulcers: prospective follow-up analysis of a Eurodiale subgroup. Dubsky M, etal., Int Wound J. 2012 Jun 19. doi: 10.1111/j.1742-481X.2012.01022.x.
45. Periodontitis in humans and non-human primates: oral-systemic linkage inducing acute phase proteins. Ebersole JL, etal., Ann Periodontol. 2002 Dec;7(1):102-11.
46. Correlation of oxidative stress and inflammatory markers with the severity of sickle cell nephropathy. Emokpae MA, etal., Ann Afr Med. 2010 Jul-Sep;9(3):141-6.
47. Risk factors for contrast induced nephropathy: A study among Italian patients. Evola S, etal., Indian Heart J. 2012 Sep-Oct;64(5):484-91. doi: 10.1016/j.ihj.2012.07.007. Epub 2012 Jul 27.
48. Role of quercetin and arginine in ameliorating nano zinc oxide-induced nephrotoxicity in rats. Faddah LM, etal., BMC Complement Altern Med. 2012 May 2;12:60.
49. Nitric oxide-induced expression of C-reactive protein in islet cells as a very early marker for islet stress in the rat pancreas. Fehsel K, etal., Nitric Oxide. 1997 Jun;1(3):254-62.
50. Complement factor H Y402H and C-reactive protein polymorphism and photodynamic therapy response in age-related macular degeneration. Feng X, etal., Ophthalmology. 2009 Oct;116(10):1908-12.e1. doi: 10.1016/j.ophtha.2009.03.011. Epub 2009 Aug 18.
51. Autoantibodies against C-reactive protein: clinical associations in systemic lupus erythematosus and primary antiphospholipid syndrome. Figueredo MA, etal., J Rheumatol. 2006 Oct;33(10):1980-6.
52. C-reactive protein is released in the coronary circulation and causes endothelial dysfunction in patients with acute coronary syndromes. Forte L, etal., Int J Cardiol. 2011 Oct 6;152(1):7-12. doi: 10.1016/j.ijcard.2011.05.062. Epub 2011 Jul 26.
53. Effect of antibacterial cathelicidin peptide CAP18/LL-37 on sepsis in neonatal rats. Fukumoto K, etal., Pediatr Surg Int. 2005 Jan;21(1):20-4. doi: 10.1007/s00383-004-1256-x.
54. Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19. Gao Y, etal., J Med Virol. 2020 Jul;92(7):791-796. doi: 10.1002/jmv.25770. Epub 2020 Apr 10.
55. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
56. Serum markers of inflammation and oxidative stress in chronic opium (Taryak) smokers. Ghazavi A, etal., Immunol Lett. 2013 Jun;153(1-2):22-6. doi: 10.1016/j.imlet.2013.07.001. Epub 2013 Jul 12.
57. Effect of a high-fat diet on the hepatic expression of nuclear receptors and their target genes: relevance to drug disposition. Ghoneim RH, etal., Br J Nutr. 2015 Feb 14;113(3):507-16. doi: 10.1017/S0007114514003717. Epub 2015 Jan 23.
58. Human C-reactive protein increases cerebral infarct size after middle cerebral artery occlusion in adult rats. Gill R, etal., J Cereb Blood Flow Metab. 2004 Nov;24(11):1214-8.
59. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
60. C-reactive protein levels do not correlate with retinal artery occlusion but with atherosclerosis. Goldenberg-Cohen N, etal., Eye (Lond). 2009 Apr;23(4):785-90. doi: 10.1038/eye.2008.159. Epub 2008 Jun 6.
61. Serum biomarkers of aging in the Brown Norway rat. Gordon CJ, etal., Exp Gerontol. 2011 Nov;46(11):953-7. Epub 2011 Jul 28.
62. Adeno-associated virus-mediated human C-reactive protein gene delivery causes endothelial dysfunction and hypertension in rats. Guan H, etal., Clin Chem. 2009 Feb;55(2):274-84. doi: 10.1373/clinchem.2008.115857. Epub 2008 Dec 4.
63. Docosahexaenoic acid, but not eicosapentaenoic acid, reduces the early inflammatory response following compression spinal cord injury in the rat. Hall JC, etal., J Neurochem. 2012 Jun;121(5):738-50. doi: 10.1111/j.1471-4159.2012.07726.x. Epub 2012 Apr 12.
64. Inhibition of classical complement activation attenuates liver ischaemia and reperfusion injury in a rat model. Heijnen BH, etal., Clin Exp Immunol. 2006 Jan;143(1):15-23.
65. Blood plasma inflammation markers during epileptogenesis in post-status epilepticus rat model for temporal lobe epilepsy. Holtman L, etal., Epilepsia. 2013 Apr;54(4):589-95. doi: 10.1111/epi.12112. Epub 2013 Feb 8.
66. Using IL-2R/lymphocytes for predicting the clinical progression of patients with COVID-19. Hou H, etal., Clin Exp Immunol. 2020 Jul;201(1):76-84. doi: 10.1111/cei.13450. Epub 2020 May 15.
67. Systemic inflammation and innate immune response in patients with previous anterior uveitis. Huhtinen M, etal., Br J Ophthalmol. 2002 Apr;86(4):412-7.
68. C-reactive protein and uric Acid levels in patients with psoriasis. Isha, etal., Indian J Clin Biochem. 2011 Jul;26(3):309-11. doi: 10.1007/s12291-011-0132-4. Epub 2011 May 4.
69. [The relationship between inflammatory mediators and pulmonary hypertension in patients with chronic obstructive pulmonary disease]. Jiang YW, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2011 Dec;34(12):904-8.
70. Association of serum glycated albumin, C-reactive protein and ICAM-1 levels with diffuse coronary artery disease in patients with type 2 diabetes mellitus. Jin C, etal., Clin Chim Acta. 2009 Oct;408(1-2):45-9. Epub 2009 Jul 15.
71. Association between SLE nephritis and polymorphic variants of the CRP and FcgammaRIIIa genes. Jonsen A, etal., Rheumatology (Oxford). 2007 Sep;46(9):1417-21. Epub 2007 Jun 27.
72. Acute phase inflammatory markers in patients with non-steroidal anti-inflammatory drugs (NSAIDs)-induced acute urticaria/angioedema and after aspirin challenge. Kasperska-Zajac A, etal., J Eur Acad Dermatol Venereol. 2012 Feb 21. doi: 10.1111/j.1468-3083.2012.04486.x.
73. Elevated C-reactive protein levels in patients with polypoidal choroidal vasculopathy and patients with neovascular age-related macular degeneration. Kikuchi M, etal., Ophthalmology. 2007 Sep;114(9):1722-7. Epub 2007 Apr 2.
74. Human C-reactive protein enhances vulnerability of immature rats to hypoxic-ischemic brain damage: a preliminary study. Kinugasa-Taniguchi Y, etal., Reprod Sci. 2010 May;17(5):419-25. doi: 10.1177/1933719110361379. Epub 2010 Mar 10.
75. Value of serum C-reactive protein concentrations in febrile children without apparent focus. Kohli V, etal., Ann Trop Paediatr. 1993;13(4):373-8.
76. Long-term prognostic value of baseline C-reactive protein in predicting recurrence of atrial fibrillation after electrical cardioversion. Korantzopoulos P, etal., Pacing Clin Electrophysiol. 2008 Oct;31(10):1272-6. doi: 10.1111/j.1540-8159.2008.01177.x.
77. Lipid peroxidation and erythrocyte antioxidant enzymes in patients with Behcet's disease. Kose K, etal., Tohoku J Exp Med. 2002 May;197(1):9-16.
78. Value of procalcitonin, C-reactive protein, and neopterin in exacerbations of chronic obstructive pulmonary disease. Lacoma A, etal., Int J Chron Obstruct Pulmon Dis. 2011;6:157-69. Epub 2011 Feb 28.
79. Acute-phase proteins and serum immunoglobulins in ankylosing spondylitis. Laurent MR and Panayi GS, Ann Rheum Dis. 1983 Oct;42(5):524-8.
80. Microalbuminuria in non-diabetic stemi: An independent predictor for acute kidney injury. Lazzeri C, etal., Scand Cardiovasc J. 2012 Jul 10.
81. Pre-ART Levels of Inflammation and Coagulation Markers Are Strong Predictors of Death in a South African Cohort with Advanced HIV Disease. Ledwaba L, etal., PLoS One. 2012;7(3):e24243. Epub 2012 Mar 20.
82. Severity of obstructive sleep apnea syndrome and high-sensitivity C-reactive protein reduced after relocation pharyngoplasty. Lee LA, etal., Otolaryngol Head Neck Surg. 2011 Apr;144(4):632-8. Epub 2011 Feb 10.
83. Analysis of systemic endothelin-1, matrix metalloproteinase-9, macrophage chemoattractant protein-1, and high-sensitivity C-reactive protein in normal-tension glaucoma. Lee NY, etal., Curr Eye Res. 2012 Dec;37(12):1121-6. doi: 10.3109/02713683.2012.725798. Epub 2012 Sep 11.
84. C-reactive protein levels in normal tension glaucoma. Leibovitch I, etal., J Glaucoma. 2005 Oct;14(5):384-6.
85. Cardiovascular disease potentially contributes to the progression and poor prognosis of COVID-19. Li M, etal., Nutr Metab Cardiovasc Dis. 2020 Jun 25;30(7):1061-1067. doi: 10.1016/j.numecd.2020.04.013. Epub 2020 Apr 18.
86. Clinical and pathological investigation of severe COVID-19 patients. Li S, etal., JCI Insight. 2020 May 19. pii: 138070. doi: 10.1172/jci.insight.138070.
87. C-reactive protein promotes acute renal inflammation and fibrosis in unilateral ureteral obstructive nephropathy in mice. Li ZI, etal., Lab Invest. 2011 Jun;91(6):837-51. Epub 2011 Mar 7.
88. Discovery of serum biomarkers of alcoholic fatty liver in a rodent model: C-reactive protein. Liu SL, etal., J Biomed Sci. 2011 Aug 1;18:52. doi: 10.1186/1423-0127-18-52.
89. CRP1, a protein localized in filopodia of growth cones, is involved in dendritic growth. Ma L, etal., J Neurosci. 2011 Nov 16;31(46):16781-91.
90. Cardiovascular disease in U.S. patients with metabolic syndrome, diabetes, and elevated C-reactive protein. Malik S, etal., Diabetes Care. 2005 Mar;28(3):690-3.
91. Serum C-reactive protein in polymyalgia rheumatica. A prospective serial study. Mallya RK, etal., Arthritis Rheum. 1985 Apr;28(4):383-7.
92. Iron-binding proteins and C-reactive protein in Nipple Aspirate Fluids: role of Iron-driven inflammation in breast cancer microenvironment? Mannello F, etal., Am J Transl Res. 2010 Oct 30;3(1):100-13.
93. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
94. Lipoprotein (a) and acute-phase response in patients with vestibular neuronitis. Milionis HJ, etal., Eur J Clin Invest. 2003 Dec;33(12):1045-50.
95. C-Reactive protein levels but not CRP dynamics predict mortality in patients with pneumococcal pneumonia. Mooiweer E, etal., J Infect. 2011 Apr;62(4):314-6. Epub 2011 Jan 31.
96. Rat C-reactive protein causes a charge modification of LDL and stimulates its degradation by macrophages. Mookerjea S, etal., Arterioscler Thromb. 1994 Feb;14(2):282-7.
97. High-sensitivity C-reactive protein levels predict survival and are related to haemodynamics in alcoholic cirrhosis. Mortensen C, etal., Eur J Gastroenterol Hepatol. 2012 Mar 20.
98. Cardiorenal syndrome in hypertensive rats: microalbuminuria, inflammation and ventricular hypertrophy. Moubarak M, etal., Physiol Res. 2012 Mar 6;61(1):13-24. Epub 2011 Dec 20.
99. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
100. Diagnostic markers of serious bacterial infections in febrile infants younger than 90 days old. Nosrati A, etal., Pediatr Int. 2014 Feb;56(1):47-52. doi: 10.1111/ped.12191.
101. Is inflammation a new risk factor of depression in haemodialysis patients? Nowak L, etal., Int Urol Nephrol. 2012 Sep 13.
102. Antioxidant potential, paraoxonase 1, ceruloplasmin activity and C-reactive protein concentration in diabetic retinopathy. Nowak M, etal., Clin Exp Med. 2010 Sep;10(3):185-92. doi: 10.1007/s10238-009-0084-7. Epub 2009 Dec 11.
103. C-reactive protein in rat: in development, pregnancy and effect of sex hormones. Nunomura W Comp Biochem Physiol A Comp Physiol. 1990;96(4):489-93.
104. Changes in serum concentration and mRNA level of rat C-reactive protein. Nunomura W, etal., Biochim Biophys Acta. 1994 Oct 21;1227(1-2):74-8.
105. Serum amyloid A and C-reactive protein levels may predict microalbuminuria and macroalbuminuria in newly diagnosed type 1 diabetic patients. Overgaard AJ, etal., J Diabetes Complications. 2012 Aug 10.
106. C-reactive protein and natural IgM antibodies are activators of complement in a rat model of intestinal ischemia and reperfusion. Padilla ND, etal., Surgery. 2007 Nov;142(5):722-33.
107. Chronic infections & coronary artery disease with special reference to Chalmydia pneumoniae. Padmavati S, etal., Indian J Med Res. 2012 Feb;135(2):228-32.
108. Incidence and predisposing factors for severe disease in previously healthy term infants experiencing their first episode of bronchiolitis. Papoff P, etal., Acta Paediatr. 2011 Feb 1. doi: 10.1111/j.1651-2227.2011.02181.x.
109. Long-term dietary antioxidant cocktail supplementation effectively reduces renal inflammation in diabetic mice. Park NY, etal., Br J Nutr. 2011 Nov;106(10):1514-21. Epub 2011 Jun 3.
110. C-reactive protein levels are elevated in asthma and asthma-like conditions. Pellizzaro AM and Heuertz RM, Clin Lab Sci. 2010 Fall;23(4):223-7.
111. C-reactive protein for rapid monitoring of infections of the central nervous system. Peltola HO Lancet. 1982 May 1;1(8279):980-2.
112. Epigallocatechin-3-gallate inhibits interleukin-6- and angiotensin II-induced production of C-reactive protein in vascular smooth muscle cells. Peng N, etal., Life Sci. 2010 Mar 13;86(11-12):410-5. doi: 10.1016/j.lfs.2010.01.010. Epub 2010 Jan 25.
113. Systemic exposure to Pseudomonal bacteria: a potential link between type 1 diabetes and chronic inflammation. Peraneva L, etal., Acta Diabetol. 2012 Aug 5.
114. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
115. Effects of human C-reactive protein on pathogenesis of features of the metabolic syndrome. Pravenec M, etal., Hypertension. 2011 Apr;57(4):731-7. Epub 2011 Feb 28.
116. Serum procalcitonin in pulmonary tuberculosis. Rasmussen TA, etal., Int J Tuberc Lung Dis. 2011 Feb;15(2):251-6, i.
117. Derivation of the amino acid sequence of rat C-reactive protein from cDNA cloning with additional studies on the nature of its dimeric component. Rassouli M, etal., J Biol Chem 1992 Feb 15;267(5):2947-54.
118. The regulation of superoxide generation and nitric oxide synthesis by C-reactive protein. Ratnam S and Mookerjea S, Immunology. 1998 Aug;94(4):560-8.
119. Incremental prognostic value of serum levels of troponin T and C-reactive protein on admission in patients with unstable angina pectoris. Rebuzzi AG, etal., Am J Cardiol. 1998 Sep 15;82(6):715-9.
120. GOA pipeline RGD automated data pipeline
121. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
122. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
123. Comprehensive gene review and curation RGD comprehensive gene curation
124. Experimental alveolitis in rats: microbiological, acute phase response and histometric characterization of delayed alveolar healing. Rodrigues MT, etal., J Appl Oral Sci. 2011 May-Jun;19(3):260-8.
125. Reversal of ongoing proteinuria in autoimmune mice by treatment with C-reactive protein. Rodriguez W, etal., Arthritis Rheum. 2005 Feb;52(2):642-50.
126. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Ruan Q, etal., Intensive Care Med. 2020 May;46(5):846-848. doi: 10.1007/s00134-020-05991-x. Epub 2020 Mar 3.
127. Chemopreventive efficacy of green tea drinking against 1,2-dimethyl hydrazine-induced rat colon carcinogenesis. Sadik NA Cell Biochem Funct. 2012 Sep 24. doi: 10.1002/cbf.2873.
128. Inhibition of the binding of low density lipoproteins to liver membrane receptors by rat serum phosphorylcholine binding protein. Saxena U, etal., Biochem Biophys Res Commun. 1986 Nov 26;141(1):151-7.
129. Pretherapeutic laboratory findings, extent of metastasis and choice of treatment as prognostic markers in ocular melanoma- a single centre experience. Schicher N, etal., J Eur Acad Dermatol Venereol. 2013 Mar;27(3):e394-9. doi: 10.1111/jdv.12006. Epub 2012 Oct 12.
130. Modulation of Neuronal Pentraxin 1 Expression in Rat Pancreatic beta-Cells Submitted to Chronic Glucotoxic Stress. Schvartz D, etal., Mol Cell Proteomics. 2012 Aug;11(8):244-54. Epub 2012 Mar 16.
131. C-reactive protein and CFH, ARMS2/HTRA1 gene variants are independently associated with risk of macular degeneration. Seddon JM, etal., Ophthalmology. 2010 Aug;117(8):1560-6. doi: 10.1016/j.ophtha.2009.11.020. Epub 2010 Mar 26.
132. Role of gender in the associations of microalbuminuria with inflammatory markers in hypertensive subjects: a cross-sectional study. Shantha GP, etal., Kidney Blood Press Res. 2009;32(6):434-9. Epub 2009 Dec 17.
133. C reactive protein (CRP) as a predictor for true bacteremia in children. Shaoul R, etal., Med Sci Monit. 2008 May;14(5):CR255-261.
134. Progressive Increase of Inflammatory Biomarkers in Chronic Kidney Disease and End-Stage Renal Disease. Sharain K, etal., Clin Appl Thromb Hemost. 2012 Aug 3.
135. Up-regulation of PPARgamma, heat shock protein-27 and -72 by naringin attenuates insulin resistance, beta-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes. Sharma AK, etal., Br J Nutr. 2011 Dec;106(11):1713-23. Epub 2011 Jun 21.
136. High-sensitivity C-reactive protein: an independent risk factor for left ventricular hypertrophy in patients with lupus nephritis. Shi B, etal., J Biomed Biotechnol. 2010;2010:373426. Epub 2010 Nov 7.
137. [Effects of chronic intermittent hypobaric hypoxia on immune function in rat]. Shi M, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2009 Nov;25(4):433-8.
138. Long-term ethanol consumption initiates atherosclerosis in rat aorta through inflammatory stress and endothelial dysfunction. Shirpoor A, etal., Vascul Pharmacol. 2012 Sep;57(2-4):72-7. Epub 2012 Apr 12.
139. Serum levels of autoantibodies against monomeric C-reactive protein are correlated with disease activity in systemic lupus erythematosus. Sjowall C, etal., Arthritis Res Ther. 2004;6(2):R87-94. Epub 2003 Dec 5.
140. High prevalence of autoantibodies to C-reactive protein in patients with chronic hepatitis C infection: association with liver fibrosis and portal inflammation. Sjowall C, etal., Hum Immunol. 2012 Apr;73(4):382-8. Epub 2012 Feb 1.
141. Association of posttraumatic stress disorder with low-grade elevation of C-reactive protein: evidence from the general population. Spitzer C, etal., J Psychiatr Res. 2010 Jan;44(1):15-21. doi: 10.1016/j.jpsychires.2009.06.002. Epub 2009 Jul 22.
142. Validation of CRP as prognostic marker for renal cell carcinoma in a large series of patients. Steffens S, etal., BMC Cancer. 2012 Sep 8;12(1):399.
143. Elevated C-reactive protein levels may be a predictor of persistent unfavourable symptoms in patients with mild traumatic brain injury: a preliminary study. Su SH, etal., Brain Behav Immun. 2014 May;38:111-7. doi: 10.1016/j.bbi.2014.01.009. Epub 2014 Jan 21.
144. The effects of C-reactive protein, interleukin-6, and tumor necrosis factor-alpha in rat allograft adventitial inflammation and allograft arteriosclerosis. Sun H, etal., Transplant Proc. 2009 Nov;41(9):3909-12.
145. C-reactive protein predicts response to infliximab in patients with chronic sarcoidosis. Sweiss NJ, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2010 Jul;27(1):49-56.
146. Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene. Szalai AJ, etal., Genes Immun. 2002 Feb;3(1):14-9.
147. Modified C-reactive protein might be a target autoantigen of TINU syndrome. Tan Y, etal., Clin J Am Soc Nephrol. 2011 Jan;6(1):93-100. Epub 2010 Sep 2.
148. Autoantibodies against monomeric C-reactive protein in sera from patients with lupus nephritis are associated with disease activity and renal tubulointerstitial lesions. Tan Y, etal., Hum Immunol. 2008 Dec;69(12):840-4. Epub 2008 Oct 11.
149. A model of experimental acute hematogenous pyelonephritis in the rat. Tancheva S, etal., Folia Med (Plovdiv). 2011 Apr-Jun;53(2):63-8.
150. Ampicillin/sulbactam for children hospitalized with community-acquired pneumonia. Tapisiz A, etal., J Infect Chemother. 2011 Jan 22.
151. C-reactive protein binds to the 3beta-OH group of cholesterol in LDL particles. Taskinen S, etal., Biochem Biophys Res Commun. 2005 Apr 22;329(4):1208-16.
152. Use of C-reactive protein in differentiation between acute bacterial and viral otitis media. Tejani NR, etal., Pediatrics. 1995 May;95(5):664-9.
153. Evaluation of the potential for lymph node metastasis using CRP 1846C>T genetic polymorphism in invasive breast cancer. Terata K, etal., Tumour Biol. 2014 Jun;35(6):5931-5. doi: 10.1007/s13277-014-1786-3. Epub 2014 Mar 16.
154. The levels of soluble CD40 ligand and C-reactive protein in normal weight, overweight and obese people. Unek IT, etal., Clin Med Res. 2010 Jul;8(2):89-95.
155. Biomarkers of cardiovascular disease as risk factors for age-related macular degeneration. Vine AK, etal., Ophthalmology. 2005 Dec;112(12):2076-80. Epub 2005 Oct 12.
156. Clinical features and treatment of COVID-19 patients in northeast Chongqing. Wan S, etal., J Med Virol. 2020 Jul;92(7):797-806. doi: 10.1002/jmv.25783. Epub 2020 Apr 1.
157. Reduced serum levels of autoantibodies against monomeric C-reactive protein (CRP) in patients with acute coronary syndrome. Wettero J, etal., Clin Chim Acta. 2009 Feb;400(1-2):128-31. Epub 2008 Oct 17.
158. The time-averaged inflammatory disease activity estimates the progression of erosions in MRI of the sacroiliac joints in ankylosing spondylitis. Wick MC, etal., Clin Rheumatol. 2012 Mar 16.
159. Antiretroviral treatment-associated tuberculosis in a prospective cohort of HIV-infected patients starting ART. Worodria W, etal., Clin Dev Immunol. 2011;2011:758350. Epub 2010 Dec 8.
160. [Preliminary investigation of the changes and mechanism of Leptin after myocardial ischemia/reperfusion injury]. Xue H, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2010 Nov;22(11):680-3.
161. Clinical characteristics and outcomes of patients with severe covid-19 with diabetes. Yan Y, etal., BMJ Open Diabetes Res Care. 2020 Apr;8(1). pii: 8/1/e001343. doi: 10.1136/bmjdrc-2020-001343.
162. [Effect of electroacupuncture intervention on blood-lipid, high-sensitivity C-reactive protein and adiponectin levels in hyperlipidemia rats]. Yan ZK, etal., Zhen Ci Yan Jiu. 2013 Oct;38(5):365-8, 385.
163. Leptin, triglycerides, and interleukin 6 are independently associated with C-reactive protein in Japanese type 2 diabetic patients. Yanagawa T, etal., Diabetes Res Clin Pract. 2007 Jan;75(1):2-6. Epub 2006 Jun 9.
164. Factors Associated with Hypoxemia in Children Infected with Pandemic H1N1 2009 Influenza Virus. Yeom JS, etal., Pediatr Int. 2010 Dec 30. doi: 10.1111/j.1442-200X.2010.03319.x.
165. Proteomic analysis of aortic smooth muscle cell secretions reveals an association of myosin heavy chain 11 with abdominal aortic aneurysm. Yokoyama U, etal., Am J Physiol Heart Circ Physiol. 2018 Jul 13. doi: 10.1152/ajpheart.00329.2018.
166. Raised C-reactive protein response in rheumatoid arthritis patients with secondary Sjogren's syndrome. Youinou P, etal., Rheumatol Int. 1990;10(1):39-41.
167. The correlation between viral clearance and biochemical outcomes of 94 COVID-19 infected discharged patients. Yuan J, etal., Inflamm Res. 2020 Jun;69(6):599-606. doi: 10.1007/s00011-020-01342-0. Epub 2020 Mar 29.
168. [Assessment of changes in levels of interleukin 6 and C reactive protein in patients with breast tumors]. Zakrzewska I, etal., Pol Merkur Lekarski. 2003 Aug;15(86):115-7.
169. Viral and host factors related to the clinical outcome of COVID-19. Zhang X, etal., Nature. 2020 May 20. pii: 10.1038/s41586-020-2355-0. doi: 10.1038/s41586-020-2355-0.
170. The clinical characteristics and outcomes of patients with diabetes and secondary hyperglycaemia with coronavirus disease 2019: A single-centre, retrospective, observational study in Wuhan. Zhang Y, etal., Diabetes Obes Metab. 2020 May 14. doi: 10.1111/dom.14086.
171. [Value of fluorescence quantitative PCR assay of bronchoalveolar lavage fluid samples in the diagnosis of Mycoplasma pneumoniae pneumonia in children.] Zhong LL, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2011 Mar;13(3):191-194.
Additional References at PubMed
PMID:12477932   PMID:16642000   PMID:17279354   PMID:17574226   PMID:17660720   PMID:18254451   PMID:18322245   PMID:18621373   PMID:18786923   PMID:19084272   PMID:19246692   PMID:19263040  
PMID:19680263   PMID:19748488   PMID:19850925   PMID:20332628   PMID:21037097   PMID:21323571   PMID:21633874   PMID:21840509   PMID:21856781   PMID:22201020   PMID:22301267   PMID:22306119  
PMID:22807607   PMID:23376485   PMID:23544079   PMID:24141169   PMID:24642533   PMID:24982116   PMID:25016361   PMID:25109280   PMID:25242580   PMID:25536316   PMID:25708190   PMID:26741265  
PMID:27443845   PMID:27492718   PMID:27989594   PMID:28295592   PMID:29202702   PMID:29330688   PMID:29476059   PMID:29768263   PMID:29849871   PMID:30794428   PMID:33382068   PMID:33385735  
PMID:33544171   PMID:35503088   PMID:36765308   PMID:37515488  


Genomics

Comparative Map Data
Crp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81387,694,062 - 87,695,978 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1387,657,317 - 87,707,514 (+)EnsemblGRCr8
mRatBN7.21385,135,384 - 85,175,178 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1385,124,977 - 85,175,178 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1387,664,967 - 87,666,915 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01389,065,246 - 89,067,190 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01386,249,976 - 86,251,928 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01391,080,448 - 91,081,358 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1391,054,974 - 91,093,713 (+)Ensemblrn6Rnor6.0
Rnor_5.01395,599,418 - 95,600,328 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41388,702,243 - 88,703,153 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1384,770,843 - 84,771,753 (+)NCBICelera
RGSC_v3.11388,891,058 - 88,892,928 (+)NCBI
Cytogenetic Map13q24NCBI
CRP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381159,712,289 - 159,714,589 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1159,712,289 - 159,714,589 (-)Ensemblhg38GRCh38
GRCh371159,682,079 - 159,684,379 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361157,948,703 - 157,951,003 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341156,495,152 - 156,497,452NCBI
Celera1132,750,525 - 132,752,817 (-)NCBICelera
Cytogenetic Map1q23.2NCBI
HuRef1131,038,539 - 131,040,831 (-)NCBIHuRef
CHM1_11161,076,594 - 161,078,894 (-)NCBICHM1_1
T2T-CHM13v2.01158,849,333 - 158,851,633 (-)NCBIT2T-CHM13v2.0
Crp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,525,623 - 172,527,533 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,525,622 - 172,660,598 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381172,698,056 - 172,699,966 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,698,055 - 172,833,031 (+)Ensemblmm10GRCm38
MGSCv371174,628,187 - 174,630,097 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361174,534,741 - 174,536,635 (+)NCBIMGSCv36mm8
Celera1175,548,254 - 175,550,142 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map180.13NCBI
CRP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2190,140,428 - 90,143,900 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1189,880,463 - 89,883,937 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01135,062,102 - 135,064,402 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11138,858,353 - 138,860,652 (-)NCBIPanPan1.1PanPan1.1panPan2
CRP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13822,396,787 - 22,398,180 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3822,396,263 - 22,399,166 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3822,473,724 - 22,475,116 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03822,519,785 - 22,521,176 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3822,519,714 - 22,522,146 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13822,286,369 - 22,287,757 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03822,818,770 - 22,820,163 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03823,230,160 - 23,231,548 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Crp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050585,866,551 - 5,870,192 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936740883,272 - 890,606 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936740885,855 - 888,854 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl490,793,350 - 90,805,218 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1490,793,361 - 90,801,020 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2498,764,964 - 98,772,727 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1204,232,262 - 4,235,826 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl204,232,913 - 4,235,377 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660383,340,251 - 3,342,511 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247941,531,571 - 1,533,804 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247941,531,555 - 1,533,804 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Crp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11051,808,394 - 51,810,193 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Crp
16 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:74
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000000058
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
Crp  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21385,162,863 - 85,163,015 (+)MAPPERmRatBN7.2
Rnor_6.01391,081,476 - 91,081,627NCBIRnor6.0
Rnor_5.01395,600,446 - 95,600,597UniSTSRnor5.0
RGSC_v3.41388,703,271 - 88,703,422UniSTSRGSC3.4
Celera1384,771,871 - 84,772,022UniSTS
Cytogenetic Map13q24UniSTS
AU048742  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14q11UniSTS
Cytogenetic Map13q27UniSTS
Cytogenetic Map13q24UniSTS
Cytogenetic Map20q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 12 54 126 91 90 59 44 59 6 271 129 9 99 61 92 31 6 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY310153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY318961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY321318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY321324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY325196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY325218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY325232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC091157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HH755429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI986631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M83176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000000058   ⟹   ENSRNOP00000000058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1387,674,808 - 87,695,978 (+)Ensembl
mRatBN7.2 Ensembl1385,124,977 - 85,163,634 (+)Ensembl
Rnor_6.0 Ensembl1391,080,341 - 91,081,629 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091089   ⟹   ENSRNOP00000074751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1387,667,741 - 87,707,514 (+)Ensembl
mRatBN7.2 Ensembl1385,135,399 - 85,175,178 (+)Ensembl
Rnor_6.0 Ensembl1391,054,974 - 91,093,713 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000136839   ⟹   ENSRNOP00000102651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1387,657,317 - 87,697,340 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000157946   ⟹   ENSRNOP00000110904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1387,694,062 - 87,695,064 (+)Ensembl
RefSeq Acc Id: NM_017096   ⟹   NP_058792
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81387,694,062 - 87,695,978 (+)NCBI
mRatBN7.21385,161,724 - 85,163,640 (+)NCBI
Rnor_6.01391,080,448 - 91,081,358 (+)NCBI
Rnor_5.01395,599,418 - 95,600,328 (+)NCBI
RGSC_v3.41388,702,243 - 88,703,153 (+)RGD
Celera1384,770,843 - 84,771,753 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058792 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40964 (Get FASTA)   NCBI Sequence Viewer  
  AAH91157 (Get FASTA)   NCBI Sequence Viewer  
  AAP78761 (Get FASTA)   NCBI Sequence Viewer  
  AAP85372 (Get FASTA)   NCBI Sequence Viewer  
  AAP86250 (Get FASTA)   NCBI Sequence Viewer  
  AAP86256 (Get FASTA)   NCBI Sequence Viewer  
  AAP92597 (Get FASTA)   NCBI Sequence Viewer  
  AAP92619 (Get FASTA)   NCBI Sequence Viewer  
  AAP92633 (Get FASTA)   NCBI Sequence Viewer  
  AFA37850 (Get FASTA)   NCBI Sequence Viewer  
  AFA37851 (Get FASTA)   NCBI Sequence Viewer  
  AFA37852 (Get FASTA)   NCBI Sequence Viewer  
  AFA37853 (Get FASTA)   NCBI Sequence Viewer  
  AFA37854 (Get FASTA)   NCBI Sequence Viewer  
  AFA37855 (Get FASTA)   NCBI Sequence Viewer  
  AFA37856 (Get FASTA)   NCBI Sequence Viewer  
  AFA37857 (Get FASTA)   NCBI Sequence Viewer  
  AFA37858 (Get FASTA)   NCBI Sequence Viewer  
  AFA37859 (Get FASTA)   NCBI Sequence Viewer  
  AFA37860 (Get FASTA)   NCBI Sequence Viewer  
  AFA37861 (Get FASTA)   NCBI Sequence Viewer  
  AFA37862 (Get FASTA)   NCBI Sequence Viewer  
  AFA37863 (Get FASTA)   NCBI Sequence Viewer  
  AFA37864 (Get FASTA)   NCBI Sequence Viewer  
  AFA37865 (Get FASTA)   NCBI Sequence Viewer  
  AFA37866 (Get FASTA)   NCBI Sequence Viewer  
  AFA37867 (Get FASTA)   NCBI Sequence Viewer  
  AFA37868 (Get FASTA)   NCBI Sequence Viewer  
  AFA37869 (Get FASTA)   NCBI Sequence Viewer  
  CBW53726 (Get FASTA)   NCBI Sequence Viewer  
  CBY88722 (Get FASTA)   NCBI Sequence Viewer  
  EDL94725 (Get FASTA)   NCBI Sequence Viewer  
  P48199 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058792   ⟸   NM_017096
- Peptide Label: precursor
- UniProtKB: Q5BK94 (UniProtKB/Swiss-Prot),   P48199 (UniProtKB/Swiss-Prot),   H6X2W5 (UniProtKB/TrEMBL),   H6X2V1 (UniProtKB/TrEMBL),   H6X2V8 (UniProtKB/TrEMBL),   H6X2W3 (UniProtKB/TrEMBL),   H6X2W4 (UniProtKB/TrEMBL),   H6X2X0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000058   ⟸   ENSRNOT00000000058
Ensembl Acc Id: ENSRNOP00000074751   ⟸   ENSRNOT00000091089
Ensembl Acc Id: ENSRNOP00000110904   ⟸   ENSRNOT00000157946
Ensembl Acc Id: ENSRNOP00000102651   ⟸   ENSRNOT00000136839
Protein Domains
Pentraxin (PTX)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48199-F1-model_v2 AlphaFold P48199 1-230 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699031
Promoter ID:EPDNEW_R9556
Type:multiple initiation site
Name:Crp_1
Description:C-reactive protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01391,080,367 - 91,080,427EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2411 AgrOrtholog
BioCyc Gene G2FUF-17296 BioCyc
Ensembl Genes ENSRNOG00000000053 Ensembl
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7368286 IMAGE-MGC_LOAD
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot
  Pentaxin_CS UniProtKB/Swiss-Prot
  Pentraxin-related UniProtKB/Swiss-Prot
  Pentraxin_domain UniProtKB/Swiss-Prot
KEGG Report rno:25419 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108726 IMAGE-MGC_LOAD
NCBI Gene 25419 ENTREZGENE
PANTHER C-REACTIVE PROTEIN UniProtKB/Swiss-Prot
  C-REACTIVE PROTEIN-RELATED UniProtKB/Swiss-Prot
Pfam Pentaxin UniProtKB/Swiss-Prot
PharmGKB CRP RGD
PhenoGen Crp PhenoGen
PRINTS PENTAXIN UniProtKB/Swiss-Prot
PROSITE PTX_1 UniProtKB/Swiss-Prot
  PTX_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000053 RatGTEx
SMART PTX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot
UniProt A0A8L2PYP2_RAT UniProtKB/TrEMBL
  A0ABK0LJ09_RAT UniProtKB/TrEMBL
  A0ABK0LNK7_RAT UniProtKB/TrEMBL
  CRP_RAT UniProtKB/Swiss-Prot
  H6X2V1 ENTREZGENE, UniProtKB/TrEMBL
  H6X2V2_RAT UniProtKB/TrEMBL
  H6X2V3_RAT UniProtKB/TrEMBL
  H6X2V4_RAT UniProtKB/TrEMBL
  H6X2V7_RAT UniProtKB/TrEMBL
  H6X2V8 ENTREZGENE, UniProtKB/TrEMBL
  H6X2V9_RAT UniProtKB/TrEMBL
  H6X2W0_RAT UniProtKB/TrEMBL
  H6X2W1_RAT UniProtKB/TrEMBL
  H6X2W2_RAT UniProtKB/TrEMBL
  H6X2W3 ENTREZGENE, UniProtKB/TrEMBL
  H6X2W4 ENTREZGENE, UniProtKB/TrEMBL
  H6X2W5 ENTREZGENE, UniProtKB/TrEMBL
  H6X2W6_RAT UniProtKB/TrEMBL
  H6X2W7_RAT UniProtKB/TrEMBL
  H6X2X0 ENTREZGENE, UniProtKB/TrEMBL
  P48199 ENTREZGENE
  Q5BK94 ENTREZGENE
  Q63133_RAT UniProtKB/TrEMBL
  Q7TMA9_RAT UniProtKB/TrEMBL
UniProt Secondary Q5BK94 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-24 Crp  C-reactive protein  Crp  C-reactive protein, pentraxin-related  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Crp  C-reactive protein, pentraxin-related      Name updated 1299863 APPROVED
2002-06-10 Crp  C-reactive protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein glycoprotein that exists as a covalently-linked dimer 1298812