RGD Reference Report - C-reactive protein levels are elevated in asthma and asthma-like conditions. - Rat Genome Database

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C-reactive protein levels are elevated in asthma and asthma-like conditions.

Authors: Pellizzaro, AM  Heuertz, RM 
Citation: Pellizzaro AM and Heuertz RM, Clin Lab Sci. 2010 Fall;23(4):223-7.
RGD ID: 5131288
Pubmed: PMID:21140796   (View Abstract at PubMed)

OBJECTIVE: Asthma is a chronic disease involving airway hyperresponsiveness. It was proposed that asthma/chronic shortness of breath elicit chronic systemic inflammation even in the absence of episodic events. DESIGN: Volunteers completed questionnaires relevant to asthma and/or dyspnea and consented to C-reactive protein (CRP) quantitation. Subject groups were: control (no reported dyspnea) and asthma/shortness of breath [dyspnea] group. SETTING: Studies were performed in the Saint Louis metropolitan area. PARTICIPANTS: Participants consisted of volunteers aged 18-57. Inclusion criteria were good health, not pregnant, weight > 110 pounds and absence of antiinflammatory medicine use. RESULTS: Serum CRP ranged from undetectable to 22,013 ng/mL. Mean results for asthmatic/dyspnea (n = 22) and control (n = 27) groups were 4,203 +/- 1,323 ng/mL and 1,741 +/- 467 ng/mL (p < 0.05) respectively. CONCLUSION: Individuals with asthma/asthma-like symptoms have chronic low levels of systemic inflammation despite the absence of episodic pulmonary events. Understanding chronic systemic inflammation relevant to asthma/asthma-like conditions may lead to design of targeted therapeutics.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
asthma  IEP 5131288protein:increased expression:serum RGD 
asthma  ISOCRP (Homo sapiens)5131288; 5131288protein:increased expression:serum RGD 

Objects Annotated

Genes (Rattus norvegicus)
Crp  (C-reactive protein)

Genes (Mus musculus)
Crp  (C-reactive protein, pentraxin-related)

Genes (Homo sapiens)
CRP  (C-reactive protein)


Additional Information