Aqp1 (aquaporin 1) - Rat Genome Database

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Gene: Aqp1 (aquaporin 1) Rattus norvegicus
Analyze
Symbol: Aqp1
Name: aquaporin 1
RGD ID: 2141
Description: Enables glycerol transmembrane transporter activity and water channel activity. Involved in several processes, including glycerol transmembrane transport; lateral ventricle development; and positive regulation of lamellipodium assembly. Located in several cellular components, including basolateral plasma membrane; brush border; and neuronal cell body membrane. Biomarker of several diseases, including autosomal recessive polycystic kidney disease; brain disease (multiple); hypertension; retinal vein occlusion; and uveitis. Orthologous to human AQP1 (aquaporin 1 (Colton blood group)); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH 17beta-estradiol; 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AQP-1; Aquaporin 1 (aquaporin channel forming integral protein 28 (CHIP)); aquaporin 1 (Colton blood group); aquaporin-1; aquaporin-CHIP; CHIP28; water channel protein for red blood cells and kidney proximal tubule
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SD
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8485,812,784 - 85,824,964 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl485,812,784 - 85,830,504 (+)EnsemblGRCr8
mRatBN7.2484,482,512 - 84,494,690 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl484,482,512 - 84,494,690 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx489,700,946 - 89,713,083 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0485,476,356 - 85,488,493 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0483,882,115 - 83,894,263 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0485,551,503 - 85,563,683 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl485,551,502 - 85,569,360 (+)Ensemblrn6Rnor6.0
Rnor_5.04150,203,461 - 150,215,641 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4484,098,346 - 84,110,524 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera479,349,727 - 79,361,905 (+)NCBICelera
RGSC_v3.1484,384,810 - 84,396,991 (+)NCBI
Cytogenetic Map4q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-naringenin  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-methoxy-17beta-estradiol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetazolamide  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
adenine  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP)
allopurinol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
Azoxymethane  (ISO)
benazepril  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
Calphostin C  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chlorogenic acid  (ISO)
chlorpyrifos  (ISO)
ciglitazone  (EXP)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corticosterone  (EXP)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cytarabine  (ISO)
D-glucose  (EXP)
Deoxycorticosterone acetate  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diiodine  (ISO)
dimethyl sulfoxide  (EXP)
dioxygen  (EXP,ISO)
diprotium oxide  (EXP,ISO)
diquat  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
etoposide  (ISO)
eugenol  (EXP)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folpet  (ISO)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (EXP)
glycidol  (EXP)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
iodide salt  (EXP)
kojic acid  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
lycopene  (ISO)
mercaptoethanol  (ISO)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
morphine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
naringin  (ISO)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
Osajin  (ISO)
oxaliplatin  (EXP)
oxybenzone  (EXP,ISO)
ozone  (EXP,ISO)
p-chloromercuribenzenesulfonic acid  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (ISO)
peptidoglycan  (ISO)
perchlorate  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
Pomiferin  (ISO)
potassium chloride  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
propiconazole  (ISO)
prostaglandin E2  (ISO)
puerarin  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
roflumilast  (ISO)
Rosavin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP)
sulindac  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tebuconazole  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraethylammonium  (ISO)
tetrathiomolybdate(2-)  (ISO)
thallium atom  (EXP)
thallium sulfate  (EXP)
thioacetamide  (EXP)
thiourea  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
triclosan  (ISO)
Triptolide  (EXP)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
verapamil  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
water  (EXP,ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ammonium transmembrane transport  (ISO,ISS)
camera-type eye morphogenesis  (ISO)
carbon dioxide transmembrane transport  (IBA,ISO,ISS)
carbon dioxide transport  (ISO,ISS)
cell volume homeostasis  (ISO,ISS)
cellular homeostasis  (ISO,ISS)
cellular hyperosmotic response  (ISO,ISS)
cellular response to cAMP  (ISO,ISS)
cellular response to copper ion  (ISO,ISS)
cellular response to dexamethasone stimulus  (ISO,ISS)
cellular response to hydrogen peroxide  (ISO,ISS)
cellular response to hypoxia  (ISO,ISS)
cellular response to mechanical stimulus  (ISO,ISS)
cellular response to mercury ion  (ISO,ISS)
cellular response to nitric oxide  (ISO)
cellular response to retinoic acid  (ISO,ISS)
cellular response to salt stress  (ISO,ISS)
cellular response to UV  (ISO,ISS)
cerebrospinal fluid secretion  (ISO)
corticotropin secretion  (ISO)
defense response to Gram-negative bacterium  (IEA,ISO)
establishment or maintenance of actin cytoskeleton polarity  (ISO,ISS)
glomerular filtration  (ISO)
glycerol transmembrane transport  (IDA,ISO)
hydrogen peroxide transmembrane transport  (IEA)
hyperosmotic response  (IBA,IEP)
intracellular water homeostasis  (ISO,ISS)
lateral ventricle development  (IEA,IEP,ISO)
lipid digestion  (ISO)
metanephric descending thin limb development  (IEA,ISO)
metanephric glomerulus vasculature development  (IEA,ISO)
metanephric proximal convoluted tubule segment 2 development  (IEA,ISO)
metanephric proximal straight tubule development  (IEA,ISO)
metanephric proximal tubule development  (IEA,IEP)
monoatomic cation transmembrane transport  (IEA)
multicellular organismal-level water homeostasis  (ISO)
negative regulation of apoptotic process  (ISO,ISS)
nitric oxide transport  (ISO,ISS)
odontogenesis  (ISO)
pancreatic juice secretion  (ISO)
positive regulation of angiogenesis  (ISO,ISS)
positive regulation of cell migration  (ISO)
positive regulation of epithelial cell migration  (IMP)
positive regulation of fibroblast proliferation  (ISO,ISS)
positive regulation of lamellipodium assembly  (IMP)
positive regulation of saliva secretion  (ISO,ISS)
potassium ion transmembrane transport  (IEA)
potassium ion transport  (IEA,ISO)
renal water absorption  (ISO)
renal water transport  (IBA,ISO,ISS)
response to estrogen  (IEP)
response to hormone  (IEP)
secretion by cell  (ISO)
secretory granule organization  (ISO)
sensory perception of pain  (ISO)
transepithelial water transport  (ISO,ISS)
transmembrane transport  (IEA)
water transport  (IEA,IMP,ISO)
wound healing  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Evidence for a glycerol pathway through aquaporin 1 (CHIP28) channels. Abrami L, etal., Pflugers Arch. 1995 Jul;430(3):447-58.
2. Expression and regulation of aquaporins 1, 8, and 9 in the testis, efferent ducts, and epididymis of adult rats and during postnatal development. Badran HH and Hermo LS, J Androl 2002 May-Jun;23(3):358-73.
3. Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease. Banales JM, etal., Am J Pathol. 2008 Dec;173(6):1637-46. Epub 2008 Nov 6.
4. Angiotensin II and hypertonicity modulate proximal tubular aquaporin 1 expression. Bouley R, etal., Am J Physiol Renal Physiol. 2009 Dec;297(6):F1575-86. Epub 2009 Sep 23.
5. Isolation of a cDNA for rat CHIP28 water channel: high mRNA expression in kidney cortex and inner medulla. Deen PM, etal., Biochem Biophys Res Commun 1992 Nov 16;188(3):1267-73.
6. Human neuronal changes in brain edema and increased intracranial pressure. Faragó N, etal., Acta Neuropathol Commun. 2016 Aug 4;4(1):78. doi: 10.1186/s40478-016-0356-x.
7. Altered expression of aquaporins 1 and 4 coincides with neurodegenerative events in retinas of spontaneously diabetic Torii rats. Fukuda M, etal., Exp Eye Res. 2010 Jan;90(1):17-25. Epub 2009 Sep 11.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Involvement of aquaporin-1 in gastric epithelial cell migration during wound repair. Hayashi S, etal., Biochem Biophys Res Commun. 2009 Aug 28;386(3):483-7. Epub 2009 Jun 17.
10. The potential role of caveolin-1 in inhibition of aquaporins during the AVD. Jablonski EM and Hughes FM Jr, Biol Cell. 2006 Jan;98(1):33-42.
11. Aquaporin-1 in the choroid plexuses of developing mammalian brain. Johansson PA, etal., Cell Tissue Res. 2005 Dec;322(3):353-64. Epub 2005 Aug 26.
12. Differential expressions of aquaporin subtypes in astroglia in the hippocampus of chronic epileptic rats. Kim JE, etal., Neuroscience. 2009 Oct 20;163(3):781-9. Epub 2009 Jul 18.
13. Aquaporins in rat pancreatic interlobular ducts. Ko SB, etal., Am J Physiol Gastrointest Liver Physiol 2002 Feb;282(2):G324-31.
14. Aquaporins in the kidney. Kwon TH, etal., Handb Exp Pharmacol. 2009;(190):95-132. doi: 10.1007/978-3-540-79885-9_5.
15. Evidence for the presence of a Hg-inhibitable water-permeability pathway and aquaporin 1 in A5 salivary epithelial cells. Lazowski KW, etal., J Cell Physiol. 1995 Sep;164(3):613-9.
16. Downregulation of renal aquaporins in response to unilateral ureteral obstruction. Li C, etal., Am J Physiol Renal Physiol 2003 May;284(5):F1066-79.
17. Examination of rat salivary glands for the presence of the aquaporin CHIP. Li J, etal., Pflugers Arch 1994 Oct;428(5-6):455-60.
18. Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. Ma T, etal., J Biol Chem 1998 Feb 20;273(8):4296-9.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Renogenic characterization and in vitro differentiation of rat amniotic fluid stem cells into renal proximal tubular- and juxtaglomerular-like cells. Minocha E, etal., In Vitro Cell Dev Biol Anim. 2019 Feb;55(2):138-147. doi: 10.1007/s11626-018-00315-2. Epub 2019 Jan 15.
21. Aquaporin expression in blood-retinal barrier cells during experimental autoimmune uveitis. Motulsky E, etal., Mol Vis. 2010 Apr 3;16:602-10.
22. Aquaporin 1 immunoreactive enteric neurons in the rat ileum. Nagahama M, etal., Neurosci Lett. 2006 Mar 13;395(3):206-10. Epub 2005 Nov 23.
23. Immunolocalization of aquaporin-1 in the mechanoreceptive Ruffini endings in the periodontal ligament. Nandasena BG, etal., Brain Res. 2007 Jul 9;1157:32-40. Epub 2007 Apr 19.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Compensatory increase in AQP2, p-AQP2, and AQP3 expression in rats with diabetes mellitus. Nejsum LN, etal., Am J Physiol Renal Physiol 2001 Apr;280(4):F715-26.
26. Functional requirement of aquaporin-5 in plasma membranes of sweat glands. Nejsum LN, etal., Proc Natl Acad Sci U S A 2002 Jan 8;99(1):511-516.
27. Aquaporin 1 - a novel player in spinal cord injury. Nesic O, etal., J Neurochem. 2008 May;105(3):628-40. Epub 2008 Jan 28.
28. Expression of aquaporin 1 and 4 in a congenital hydrocephalus rat model. Paul L, etal., Neurosurgery. 2011 Feb;68(2):462-73.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
31. Evidence of aquaporin involvement in human central pontine myelinolysis. Popescu BF, etal., Acta Neuropathol Commun. 2013 Jul 25;1(1):40. doi: 10.1186/2051-5960-1-40.
32. High-salt loading exacerbates increased retinal content of aquaporins AQP1 and AQP4 in rats with diabetic retinopathy. Qin Y, etal., Exp Eye Res. 2009 Nov;89(5):741-7. Epub 2009 Jul 9.
33. Effects of intravitreal triamcinolone acetonide on retinal gene expression in a rat model of central retinal vein occlusion. Rehak M, etal., Graefes Arch Clin Exp Ophthalmol. 2011 Aug;249(8):1175-83. Epub 2011 Apr 13.
34. GOA pipeline RGD automated data pipeline
35. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Isolation of gene markers of differentiated and proliferating vascular smooth muscle cells. Shanahan CM, etal., Circ Res 1993 Jul;73(1):193-204.
38. Hydrocephalus in a rat model of Meckel Gruber syndrome with a TMEM67 mutation. Shim JW, etal., Sci Rep. 2019 Jan 31;9(1):1069. doi: 10.1038/s41598-018-37620-5.
39. Expression, localization, and regulation of aquaporin-1 to -3 in rat urothelia. Spector DA, etal., Am J Physiol Renal Physiol 2002 Jun;282(6):F1034-42.
40. [Changes of VEGF and AQPs gene and protein expression in rat brain tissue during hypoxic encephaledema]. Tian YM, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2011 Feb;27(1):7-11.
41. Expression of aquaporins 1 and 4 in the brain of spontaneously hypertensive rats. Tomassoni D, etal., Brain Res. 2010 Apr 14;1325:155-63. Epub 2010 Feb 12.
42. 2-Methoxyestradiol inhibits the up-regulation of AQP4 and AQP1 expression after spinal cord injury. Wang YF, etal., Brain Res. 2011 Jan 25;1370:220-6. Epub 2010 Nov 16.
43. Cloning, functional analysis and cell localization of a kidney proximal tubule water transporter homologous to CHIP28. Zhang R, etal., J Cell Biol 1993 Jan;120(2):359-69.
44. Induction stage-dependent expression of vascular endothelial growth factor and aquaporin-1 in diethylstilbestrol-treated rat pituitary. Zhao W, etal., Eur J Histochem. 2009 Jan-Mar;53(1):53-60.
Additional References at PubMed
PMID:1373524   PMID:1510932   PMID:7521540   PMID:7530250   PMID:8576117   PMID:8584435   PMID:9013443   PMID:9096382   PMID:9321919   PMID:9369468   PMID:9405233   PMID:9806845  
PMID:9829975   PMID:9886922   PMID:10021457   PMID:10021464   PMID:10318966   PMID:10510269   PMID:10564231   PMID:10613915   PMID:10642600   PMID:10644730   PMID:10662735   PMID:10724035  
PMID:10795927   PMID:10836992   PMID:10839360   PMID:11001937   PMID:11034202   PMID:11035042   PMID:11076974   PMID:11078688   PMID:11121384   PMID:11573934   PMID:11891232   PMID:11914159  
PMID:11922632   PMID:12002613   PMID:12012207   PMID:12034763   PMID:12051745   PMID:12084581   PMID:12133842   PMID:12137589   PMID:12172703   PMID:12181190   PMID:12468529   PMID:12477932  
PMID:12522663   PMID:12676067   PMID:12745312   PMID:12766090   PMID:12801959   PMID:12855358   PMID:14521551   PMID:14527167   PMID:14561230   PMID:14637313   PMID:14644770   PMID:14675051  
PMID:14701836   PMID:15135660   PMID:15283758   PMID:15326289   PMID:15624322   PMID:15647389   PMID:15727941   PMID:15844003   PMID:15850448   PMID:15857386   PMID:15948717   PMID:15952169  
PMID:15998844   PMID:16008975   PMID:16179736   PMID:16407156   PMID:16476579   PMID:16508653   PMID:16525162   PMID:16565507   PMID:16574458   PMID:16596446   PMID:16646408   PMID:16682607  
PMID:16711029   PMID:16814974   PMID:16936111   PMID:16997459   PMID:17012249   PMID:17074307   PMID:17178220   PMID:17229677   PMID:17257750   PMID:17371871   PMID:17377981   PMID:17409744  
PMID:17566653   PMID:17628981   PMID:17632520   PMID:17636236   PMID:17638014   PMID:17645239   PMID:17673462   PMID:17700641   PMID:17876668   PMID:17890385   PMID:17898873   PMID:17936693  
PMID:17981899   PMID:18202181   PMID:18275976   PMID:18392839   PMID:18471415   PMID:18501347   PMID:18509662   PMID:18511455   PMID:18511498   PMID:18538351   PMID:18617525   PMID:18618131  
PMID:18665841   PMID:18762715   PMID:18795320   PMID:19056867   PMID:19179619   PMID:19268465   PMID:19273840   PMID:19298815   PMID:19424603   PMID:19537242   PMID:19545896   PMID:19584911  
PMID:19610096   PMID:19628672   PMID:19640902   PMID:19724054   PMID:20177708   PMID:20340000   PMID:20423836   PMID:20501409   PMID:20663307   PMID:20958229   PMID:21038658   PMID:21092464  
PMID:21118806   PMID:21197617   PMID:21215257   PMID:21244858   PMID:21251984   PMID:21500577   PMID:21677414   PMID:21705333   PMID:22028046   PMID:22166655   PMID:22334691   PMID:22419034  
PMID:22581383   PMID:22587908   PMID:22610042   PMID:22683574   PMID:22921298   PMID:22975633   PMID:22997161   PMID:23029347   PMID:23164158   PMID:23199524   PMID:23238222   PMID:23376485  
PMID:23533145   PMID:23942196   PMID:23962074   PMID:24328827   PMID:24364558   PMID:24570172   PMID:24777974   PMID:25184686   PMID:25341953   PMID:25416956   PMID:25441658   PMID:25451277  
PMID:25489856   PMID:25592135   PMID:25656365   PMID:25659484   PMID:26281310   PMID:26315345   PMID:26317897   PMID:26554235   PMID:26724476   PMID:27181510   PMID:27229103   PMID:27261598  
PMID:27424549   PMID:27779640   PMID:28344346   PMID:28525373   PMID:28733452   PMID:28798257   PMID:29303021   PMID:29357442   PMID:29956781   PMID:30060820   PMID:30864707   PMID:31063681  
PMID:31529146   PMID:31556577   PMID:31790718   PMID:31995798   PMID:32179955   PMID:32188840   PMID:33358303   PMID:33506920   PMID:36293145   PMID:38375595   PMID:39238634  


Genomics

Comparative Map Data
Aqp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8485,812,784 - 85,824,964 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl485,812,784 - 85,830,504 (+)EnsemblGRCr8
mRatBN7.2484,482,512 - 84,494,690 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl484,482,512 - 84,494,690 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx489,700,946 - 89,713,083 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0485,476,356 - 85,488,493 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0483,882,115 - 83,894,263 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0485,551,503 - 85,563,683 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl485,551,502 - 85,569,360 (+)Ensemblrn6Rnor6.0
Rnor_5.04150,203,461 - 150,215,641 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4484,098,346 - 84,110,524 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera479,349,727 - 79,361,905 (+)NCBICelera
RGSC_v3.1484,384,810 - 84,396,991 (+)NCBI
Cytogenetic Map4q24NCBI
AQP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38730,911,853 - 30,925,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl730,911,720 - 30,925,517 (+)Ensemblhg38GRCh38
GRCh37730,951,468 - 30,965,131 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36730,917,993 - 30,931,656 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34730,724,707 - 30,738,371NCBI
Celera730,940,621 - 30,954,337 (+)NCBICelera
Cytogenetic Map7p14.3NCBI
HuRef730,833,637 - 30,847,351 (+)NCBIHuRef
CHM1_1730,951,350 - 30,965,064 (+)NCBICHM1_1
T2T-CHM13v2.0731,049,501 - 31,063,163 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2731,000,921 - 31,014,637 (+)NCBI
Aqp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39655,313,284 - 55,325,540 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl655,313,417 - 55,325,540 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38655,336,299 - 55,348,555 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl655,336,432 - 55,348,555 (+)Ensemblmm10GRCm38
MGSCv37655,286,293 - 55,298,549 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36655,266,010 - 55,278,133 (+)NCBIMGSCv36mm8
Celera655,870,108 - 55,882,362 (+)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.38NCBI
Aqp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541032,066,196 - 32,078,717 (+)Ensembl
ChiLan1.0NW_00495541032,066,196 - 32,078,661 (+)NCBIChiLan1.0ChiLan1.0
AQP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2635,722,747 - 35,736,555 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1784,047,527 - 84,061,283 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0731,524,933 - 31,538,602 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1731,644,331 - 31,658,141 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl731,644,331 - 31,658,141 (+)EnsemblpanPan2panpan1.1
AQP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11443,592,266 - 43,603,903 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1443,578,721 - 43,605,720 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1443,024,519 - 43,036,159 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01443,532,873 - 43,544,517 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1443,532,714 - 43,546,331 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11443,648,522 - 43,660,154 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01443,325,031 - 43,336,701 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01443,686,308 - 43,697,947 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aqp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511887,935,407 - 87,948,638 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364787,147,027 - 7,160,401 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364787,146,997 - 7,160,369 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AQP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1842,063,485 - 42,076,746 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11842,063,482 - 42,076,741 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AQP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12127,456,553 - 27,473,196 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2127,456,259 - 27,470,728 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604277,234,082 - 77,247,886 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aqp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624783164,609 - 177,766 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624783164,615 - 177,317 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Aqp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1685,726,131 - 85,738,471 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Aqp1
66 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:684
Count of miRNA genes:282
Interacting mature miRNAs:358
Transcripts:ENSRNOT00000015692
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)480216705104243248Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
2306794Ean2Experimental allergic neuritis QTL 26.4nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)48279077797183061Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46390045888813920Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat

Markers in Region
RH127574  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2484,494,282 - 84,494,479 (+)MAPPERmRatBN7.2
Rnor_6.0485,563,276 - 85,563,472NCBIRnor6.0
Rnor_5.04150,215,234 - 150,215,430UniSTSRnor5.0
RGSC_v3.4484,110,117 - 84,110,313UniSTSRGSC3.4
Celera479,361,498 - 79,361,694UniSTS
RH 3.4 Map4526.6UniSTS
Cytogenetic Map4q24UniSTS
Aqp1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2484,492,064 - 84,493,114 (+)MAPPERmRatBN7.2
Rnor_6.0485,561,058 - 85,562,107NCBIRnor6.0
Rnor_5.04150,213,016 - 150,214,065UniSTSRnor5.0
Celera479,359,280 - 79,360,329UniSTS
Cytogenetic Map4q24UniSTS


Related Rat Strains
The following Strains have been annotated to Aqp1
SD    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 154 91 90 59 88 59 6 352 188 11 132 81 92 31 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000015692   ⟹   ENSRNOP00000015692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl485,812,784 - 85,824,964 (+)Ensembl
mRatBN7.2 Ensembl484,482,512 - 84,494,690 (+)Ensembl
Rnor_6.0 Ensembl485,551,503 - 85,563,683 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087191   ⟹   ENSRNOP00000072600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl485,551,502 - 85,569,360 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000123840   ⟹   ENSRNOP00000099404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl485,812,784 - 85,830,504 (+)Ensembl
RefSeq Acc Id: NM_012778   ⟹   NP_036910
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8485,812,784 - 85,824,964 (+)NCBI
mRatBN7.2484,482,512 - 84,494,690 (+)NCBI
Rnor_6.0485,551,503 - 85,563,683 (+)NCBI
Rnor_5.04150,203,461 - 150,215,641 (+)NCBI
RGSC_v3.4484,098,346 - 84,110,524 (+)RGD
Celera479,349,727 - 79,361,905 (+)RGD
Sequence:
RefSeq Acc Id: NP_036910   ⟸   NM_012778
- UniProtKB: Q5EB50 (UniProtKB/Swiss-Prot),   Q7TN36 (UniProtKB/Swiss-Prot),   P29975 (UniProtKB/Swiss-Prot),   A6K0X8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072600   ⟸   ENSRNOT00000087191
Ensembl Acc Id: ENSRNOP00000015692   ⟸   ENSRNOT00000015692
Ensembl Acc Id: ENSRNOP00000099404   ⟸   ENSRNOT00000123840

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29975-F1-model_v2 AlphaFold P29975 1-269 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693081
Promoter ID:EPDNEW_R3598
Type:single initiation site
Name:Aqp1_1
Description:aquaporin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0485,551,503 - 85,551,563EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2141 AgrOrtholog
BioCyc Gene G2FUF-44733 BioCyc
Ensembl Genes ENSRNOG00000011648 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015692 ENTREZGENE
  ENSRNOT00000015692.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1080.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7190406 IMAGE-MGC_LOAD
InterPro Aquaporin-like UniProtKB/Swiss-Prot
  Aquaporin_1 UniProtKB/Swiss-Prot
  Aquaporin_transptr UniProtKB/Swiss-Prot
  MIP UniProtKB/Swiss-Prot
  MIP_CS UniProtKB/Swiss-Prot
KEGG Report rno:25240 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93653 IMAGE-MGC_LOAD
NCBI Gene 25240 ENTREZGENE
PANTHER AQUAPORIN-1 UniProtKB/Swiss-Prot
  PTHR19139 UniProtKB/Swiss-Prot
Pfam MIP UniProtKB/Swiss-Prot
PhenoGen Aqp1 PhenoGen
PRINTS AQUAPORIN1 UniProtKB/Swiss-Prot
  MINTRINSICP UniProtKB/Swiss-Prot
PROSITE MIP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011648 RatGTEx
Superfamily-SCOP SSF81338 UniProtKB/Swiss-Prot
UniProt A0ABK0LD92_RAT UniProtKB/TrEMBL
  A6K0X8 ENTREZGENE, UniProtKB/TrEMBL
  AQP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5EB50 ENTREZGENE
  Q7TN36 ENTREZGENE
UniProt Secondary Q5EB50 UniProtKB/Swiss-Prot
  Q7TN36 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-11 Aqp1  aquaporin 1  Aqp1  aquaporin 1 (Colton blood group)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-03-27 Aqp1  aquaporin 1 (Colton blood group)  Aqp1  aquaporin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Aqp1  aquaporin 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to basolateral and luminal membranes 70596
gene_drugs basolateral and luminal application of isotonic HEPES-buffered solution containing HgCl2 induced concentration-dependent inhibition of osmotic water permeability of the ducts, preincubation with DMSO [500mM] inhibits the water permeability 70596
gene_expression expressed in renal proximal tubules and paw capillary endothelial cells 70240
gene_expression expressed in interlobular duct cells of pancreas 70596
gene_expression expressed in capillary and arteriole endothelial cells 70596
gene_expression expressed in kidney with highest expression in renal inner medulla 1298548
gene_expression expressed in epithelial cells in proximal tubule and thin descending limb of Henle 1298577
gene_expression expressed in salivary glands 1298674
gene_function water channel protein 67997
gene_function appears to be the main water channel in pancreatic interlobular ducts 70596
gene_function mercury-sensitive, water channel protein 70596
gene_function fluid transport molecule 1298548
gene_function major water transport protein in the kidney proximal tubule 1298577
gene_function water channel in kidney and red blood cells 1298674
gene_process plays a critical role in urinary concentration 67997
gene_process regulates the epithelial cell volume and responsible for bulk water movement across the urothelia 70596
gene_process responsible for approximately 90% of the water transport into the pancreatic duct lumen 70596
gene_process responsible for nephron water transport 70596
gene_process may induce water permeability in salivary gland capillary beds 1298674
gene_protein 29 kDa protein 70596
gene_protein 28kDa protein 1298577