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Gene: Gab1 (GRB2-associated binding protein 1) Rattus norvegicus

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Symbol:

Gab1

Name:

GRB2-associated binding protein 1

RGD ID:

1311085

Description:

Predicted to enable signaling adaptor activity. Involved in response to hepatocyte growth factor. Predicted to be located in cell-cell junction. Predicted to be active in cell cortex. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 26. Orthologous to human GAB1 (GRB2 associated binding protein 1); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; fibroblast growth factor signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; amphetamine; atrazine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

GRB2-associated binding protein 1 long isoform; GRB2-associated-binding protein 1; growth factor receptor bound protein 2-associated protein 1; LOC361388

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GAB1 (GRB2 associated binding protein 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Gab1 (growth factor receptor bound protein 2-associated protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gab1 (GRB2 associated binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GAB1 (GRB2 associated binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GAB1 (GRB2 associated binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gab1 (GRB2 associated binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GAB1 (GRB2 associated binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GAB1 (GRB2 associated binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gab1 (GRB2 associated binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Gab1 (GRB2 associated binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GAB1 (GRB2 associated binding protein 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gab1 (growth factor receptor bound protein 2-associated protein 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gab1 (GRB2-associated binding protein 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	dos	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	dos	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	gab1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gab1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	44,035,693 - 44,143,617 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	44,035,063 - 44,143,617 (+)	Ensembl				GRCr8
mRatBN7.2	19	27,131,262 - 27,239,236 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	27,131,262 - 27,239,236 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	33,982,820 - 34,090,922 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	34,636,884 - 34,744,979 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	36,863,071 - 36,971,252 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	30,794,290 - 30,903,819 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	30,794,571 - 30,902,008 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	41,699,636 - 41,808,268 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	28,980,284 - 29,088,877 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	26,648,689 - 26,756,049 (+)	NCBI		Celera
RGSC_v3.1	19	28,977,650 - 29,091,892 (+)	NCBI
Cytogenetic Map	19	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive nonsyndromic deafness 26 (ISO)

Experimental Liver Cirrhosis (ISO)

Helicobacter Infections (ISO)

polycystic ovary syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Brodifacoum (EXP)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

calcitriol (ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

cyclosporin A (ISO)

cylindrospermopsin (ISO)

DDE (ISO)

Dibutyl phosphate (ISO)

diclofenac (ISO)

diethyl maleate (ISO)

dioxygen (ISO)

disodium selenite (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

epoxiconazole (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

fenthion (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

gentamycin (EXP)

glafenine (EXP)

hyaluronic acid (ISO)

hydrogen cyanide (ISO)

lipopolysaccharide (ISO)

lutein (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

melphalan (ISO)

metam (ISO)

methidathion (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

nicotine (ISO)

ozone (EXP,ISO)

p-menthan-3-ol (ISO)

paracetamol (ISO)

paraquat (ISO)

perfluorohexanesulfonic acid (ISO)

permethrin (ISO)

PhIP (ISO)

potassium chromate (ISO)

propiconazole (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

resveratrol (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

troglitazone (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

angiogenesis (ISO)

cellular response to vascular endothelial growth factor stimulus (ISO)

endothelial cell chemotaxis (ISO)

epidermal growth factor receptor signaling pathway (ISO)

epidermis development (ISO)

heart development (ISO)

interleukin-6-mediated signaling pathway (ISO)

labyrinthine layer development (ISO)

platelet-derived growth factor receptor signaling pathway (ISO)

positive regulation of angiogenesis (ISO)

positive regulation of blood vessel endothelial cell migration (ISO)

positive regulation of MAP kinase activity (ISO)

positive regulation of MAPK cascade (ISO)

regulation of cell migration (ISO)

response to hepatocyte growth factor (IPI)

response to oxidative stress (ISO)

signal transduction (IBA,IEA,ISO)

vascular endothelial growth factor signaling pathway (ISO)

Cellular Component

cell cortex (ISO)

cell-cell junction (ISO)

cytoplasm (IBA,ISO)

Molecular Function

protein binding (IPI,ISO)

signaling adaptor activity (IBA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

epidermal growth factor/neuregulin signaling pathway (IEA,ISO)

erythropoietin signaling pathway (ISO)

fibroblast growth factor signaling pathway (ISO)

interleukin-6 signaling pathway (ISO)

neurotrophic factor signaling pathway (IEA)

platelet-derived growth factor signaling pathway (ISO)

renal cell carcinoma pathway (IEA)

scatter factor/hepatocyte growth factor signaling pathway (ISO)

vascular endothelial growth factor signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Adapter protein CRKII signaling is involved in the rat pancreatic acini response to reactive oxygen species.	Andreolotti AG, etal., J Cell Biochem. 2006 Feb 1;97(2):359-67.
2.	Met, metastasis, motility and more.	Birchmeier C, etal., Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	The Met tyrosine kinase receptor in development and cancer.	Gentile A, etal., Cancer Metastasis Rev. 2008 Mar;27(1):85-94.
5.	Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy.	Goto Y, etal., Int J Med Sci. 2006 Nov 1;4(1):1-6. doi: 10.7150/ijms.4.1.
6.	Loss of Gab1 adaptor protein in hepatocytes aggravates experimental liver fibrosis in mice.	Kizu T, etal., Am J Physiol Gastrointest Liver Physiol. 2015 Apr 1;308(7):G613-24. doi: 10.1152/ajpgi.00289.2014. Epub 2015 Jan 23.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10779359	PMID:11146548	PMID:11940581	PMID:12218049	PMID:12808090	PMID:14551245	PMID:15736129	PMID:16166380	PMID:16185843	PMID:17178724	PMID:19359598	PMID:24126105
PMID:25217442	PMID:26090437	PMID:26706435	PMID:28738535	PMID:35591810

Genomics

Comparative Map Data

Gab1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	44,035,693 - 44,143,617 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	44,035,063 - 44,143,617 (+)	Ensembl				GRCr8
mRatBN7.2	19	27,131,262 - 27,239,236 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	27,131,262 - 27,239,236 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	33,982,820 - 34,090,922 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	34,636,884 - 34,744,979 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	36,863,071 - 36,971,252 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	30,794,290 - 30,903,819 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	30,794,571 - 30,902,008 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	41,699,636 - 41,808,268 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	28,980,284 - 29,088,877 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	26,648,689 - 26,756,049 (+)	NCBI		Celera
RGSC_v3.1	19	28,977,650 - 29,091,892 (+)	NCBI
Cytogenetic Map	19	q11	NCBI

GAB1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	143,336,876 - 143,474,565 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	143,336,402 - 143,474,565 (+)	Ensembl			hg38	GRCh38
GRCh37	4	144,258,029 - 144,395,718 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	144,477,500 - 144,610,729 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	4	141,587,895 - 141,725,726 (+)	NCBI		Celera
Cytogenetic Map	4	q31.21	NCBI
HuRef	4	139,987,709 - 140,125,505 (+)	NCBI		HuRef
CHM1_1	4	144,235,244 - 144,372,935 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	146,654,097 - 146,791,778 (+)	NCBI		T2T-CHM13v2.0

Gab1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	81,491,060 - 81,607,151 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	81,491,063 - 81,607,148 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	80,764,431 - 80,880,519 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	80,764,438 - 80,880,519 (-)	Ensembl			mm10	GRCm38
MGSCv37	8	83,288,333 - 83,404,378 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	83,660,180 - 83,776,225 (-)	NCBI		MGSCv36	mm8
Celera	8	85,038,223 - 85,155,227 (-)	NCBI		Celera
Cytogenetic Map	8	C2	NCBI
cM Map	8	38.47	NCBI

Gab1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955471	61,120 - 191,175 (-)	Ensembl
ChiLan1.0	NW_004955471	61,580 - 191,175 (-)	NCBI	ChiLan1.0	ChiLan1.0

GAB1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	141,213,273 - 141,349,862 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	141,601,058 - 141,736,803 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	135,697,939 - 135,834,755 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	146,996,936 - 147,134,576 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	146,996,936 - 147,133,672 (+)	Ensembl			panPan2	panpan1.1

GAB1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	10,269 - 117,808 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	12,616 - 156,694 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	260,188 - 375,446 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	33,411 - 148,702 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	33,413 - 149,200 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	13,780 - 129,344 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	370,970 - 486,927 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	720,877 - 842,755 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Gab1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	47,497,408 - 47,611,336 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936535	4,932,261 - 5,048,693 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936535	4,934,743 - 5,048,698 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GAB1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	84,257,965 - 84,391,914 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	8	84,257,958 - 84,391,511 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	89,408,945 - 89,540,504 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GAB1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	90,197,374 - 90,323,024 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	90,197,620 - 90,322,077 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	69,798,419 - 69,923,554 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gab1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624853	2,639,891 - 2,765,144 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624853	2,639,882 - 2,763,195 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Gab1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	17	19,201,705 - 19,310,560 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Gab1
970 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	196
Count of miRNA genes:	144
Interacting mature miRNAs:	175
Transcripts:	ENSRNOT00000024390
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61447	Tcas1	Tongue tumor susceptibility QTL 1	6.08		tongue integrity trait (VT:0010553)	squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)	19	19220689	64220689	Rat
9590298	Uminl5	Urine mineral level QTL 5	3.59	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	19	7997750	52997750	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	36289	74246245	Rat
61328	Eae8	Experimental allergic encephalomyelitis QTL 8	4		nervous system integrity trait (VT:0010566)	percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)	19	41720609	49971820	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	32539615	74246245	Rat
1558656	Prcs1	Prostate cancer susceptibility QTL 1	5		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	19	31287532	51431640	Rat
1331788	Rf45	Renal function QTL 45	2.818		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	19	31777888	74246245	Rat
9590090	Insglur8	Insulin/glucose ratio QTL 8	10.81	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	19	7997750	52997750	Rat
1554318	Bmd5	Bone mineral density QTL 5	12.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	19	23188586	68188586	Rat
1549835	Tcas7	Tongue tumor susceptibility QTL 7		0.001	tongue integrity trait (VT:0010553)	squamous cell carcinoma of the head and neck tumor number (CMO:0001876)	19	41722546	74246245	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2194317	74246245	Rat
1354633	Bw28	Body weight QTL 28	6.04		body mass (VT:0001259)	body weight (CMO:0000012)	19	40727092	54856850	Rat
61407	Scl12	Serum cholesterol level QTL 12		0.001	blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	19	30099383	47207961	Rat
8552935	Pigfal10	Plasma insulin-like growth factor 1 level QTL 10	5.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	19	7997750	52997750	Rat
631840	Niddm38	Non-insulin dependent diabetes mellitus QTL 38	3.86		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	19	10329076	74246245	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	19	5748064	50748064	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	32365311	74246245	Rat
724518	Uae19	Urinary albumin excretion QTL 19	5.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	24093973	69093973	Rat
2303628	Vencon9	Ventilatory control QTL 9		0.005	respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	19	23188586	68188586	Rat
61423	Cia14	Collagen induced arthritis QTL 14	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	19	10833618	74246245	Rat
9590250	Scort11	Serum corticosterone level QTL 11	23.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	7997750	52997750	Rat
1354607	Gmadr1	Adrenal mass QTL 1	5.83		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	19	40727092	54856850	Rat
2317848	Alcrsp21	Alcohol response QTL 21	1.899999976158142	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	19	20109306	65109306	Rat
1354600	Salc2	Saline consumption QTL 2	9.91	0.001	drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	19	40727092	54856850	Rat
7247442	Uae39	Urinary albumin excretion QTL 39			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	2194317	74246245	Rat

Markers in Region

RH127625

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	27,238,743 - 27,238,947 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	30,903,327 - 30,903,530	NCBI	Rnor6.0
Rnor_5.0	19	41,807,776 - 41,807,979	UniSTS	Rnor5.0
RGSC_v3.4	19	29,088,385 - 29,088,588	UniSTS	RGSC3.4
Celera	19	26,755,557 - 26,755,760	UniSTS
Cytogenetic Map	19	q11	UniSTS

RH135107

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	27,161,680 - 27,161,880 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	30,824,649 - 30,824,848	NCBI	Rnor6.0
Rnor_5.0	19	41,729,988 - 41,730,187	UniSTS	Rnor5.0
RGSC_v3.4	19	29,010,998 - 29,011,197	UniSTS	RGSC3.4
Celera	19	26,678,736 - 26,678,935	UniSTS
Cytogenetic Map	19	q11	UniSTS

BF390263

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	27,165,309 - 27,165,462 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	30,828,284 - 30,828,434	NCBI	Rnor6.0
Rnor_6.0	19	30,828,284 - 30,828,395	NCBI	Rnor6.0
Rnor_5.0	19	41,733,623 - 41,733,773	UniSTS	Rnor5.0
Rnor_5.0	19	41,733,623 - 41,733,734	UniSTS	Rnor5.0
RGSC_v3.4	19	29,014,633 - 29,014,744	UniSTS	RGSC3.4
RGSC_v3.4	19	29,014,633 - 29,014,783	UniSTS	RGSC3.4
Celera	19	26,682,371 - 26,682,521	UniSTS
Celera	19	26,682,371 - 26,682,482	UniSTS
Cytogenetic Map	19	q11	UniSTS

UniSTS:235942

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	27,163,960 - 27,164,201 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	30,826,928 - 30,827,168	NCBI	Rnor6.0
Rnor_5.0	19	41,732,267 - 41,732,507	UniSTS	Rnor5.0
RGSC_v3.4	19	29,013,277 - 29,013,517	UniSTS	RGSC3.4
Celera	19	26,681,015 - 26,681,255	UniSTS
Cytogenetic Map	19	q11	UniSTS

AA555564

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	27,157,106 - 27,157,155 (+)	MAPPER	mRatBN7.2
mRatBN7.2	16	18,919,438 - 18,919,486 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	20,669,759 - 20,669,806	NCBI	Rnor6.0
Rnor_6.0	19	30,820,088 - 30,820,136	NCBI	Rnor6.0
Rnor_5.0	19	41,725,371 - 41,725,419	UniSTS	Rnor5.0
Rnor_5.0	16	20,525,238 - 20,525,285	UniSTS	Rnor5.0
RGSC_v3.4	16	19,426,189 - 19,426,236	UniSTS	RGSC3.4
RGSC_v3.4	19	29,006,376 - 29,006,424	UniSTS	RGSC3.4
Celera	19	26,674,176 - 26,674,224	UniSTS
Celera	16	19,110,815 - 19,110,862	UniSTS
Cytogenetic Map	16	p14	UniSTS
Cytogenetic Map	19	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	89	59	6	353	189	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108444	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097821	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097823	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097824	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063278117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063278118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GQ140625	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000024390 ⟹ ENSRNOP00000024390

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	44,035,070 - 44,143,567 (+)	Ensembl
mRatBN7.2 Ensembl	19	27,131,262 - 27,239,236 (+)	Ensembl
Rnor_6.0 Ensembl	19	30,794,571 - 30,902,005 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000083219 ⟹ ENSRNOP00000071006

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	44,052,629 - 44,143,617 (+)	Ensembl
mRatBN7.2 Ensembl	19	27,131,262 - 27,239,236 (+)	Ensembl
Rnor_6.0 Ensembl	19	30,794,571 - 30,902,008 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000140164 ⟹ ENSRNOP00000109555

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	44,035,070 - 44,143,567 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000169434 ⟹ ENSRNOP00000102564

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	44,035,063 - 44,143,567 (+)	Ensembl

RefSeq Acc Id:

NM_001108444 ⟹ NP_001101914

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	44,035,693 - 44,143,617 (+)	NCBI
mRatBN7.2	19	27,131,262 - 27,239,236 (+)	NCBI
Rnor_6.0	19	30,794,290 - 30,903,819 (+)	NCBI
Rnor_5.0	19	41,699,636 - 41,808,268 (+)	NCBI
RGSC_v3.4	19	28,980,284 - 29,088,877 (+)	RGD
Celera	19	26,648,689 - 26,756,049 (+)	RGD

Sequence:

show sequence

GCTGCCTAGGCGGCGGGACGGTGCGCCTGGCGGCCAGGAGGGTGCACTGAAAGAAGGCCGGAGA
GACCTGGTCCCCGCGGTTCCCGATCGGGTTCCTCTTCGGTCCGCGGATCTGCGGGAGAGAGGTT
CGATCGCCAGCACAGGGCGCGGGGAGCCGGGCCGCCCCGTCGGGGGAATCTGCGACGTCCTCTG
GGCTGCGTGTGCTCGCTGTGCCCGGAGCGCGTCCGCTGTGTCCACCAACCCCTCCGGTGCCTGG
TCCTCCAGCCCTCACGGCGTGCACCATGAGCGGCGGCGAAGTGGTTTGCTCGGGATGGCTCCGC
AAGTCCCCCCCGGAGAAGAAGTTGAAGCGTTATGCGTGGAAGAGAAGGTGGTTTGTGTTGCGCA
GTGGCCGTTTGACCGGAGACCCCGATGTCCTGGAGTATTACAAAAACGATCATGCCAAGAAGCC
TATCCGGATTATTGATTTAAATTTATGTCAGCAAGTTGATGCTGGGTTGACATTCAACAAAAAG
GAGTTTGAGAACAGCTACATCTTTGATATCAACACCATCGATCGGATTTTTTACTTGGTGGCGG
ACAGCGAAGAAGACATGAACAAGTGGGTCCGTTGTATCTGTGACATCTGTGGGTTCAATCCCAC
AGAAGAAGATCCCGTGAGGCCGCTGGCCAGCTCCTCACAAGCACCTGCTGATTCACCGTTCGCC
ATAAATACAGCACCAGCCTCCGCCCACATGGAACCATCTTCAGTCGCGCTACCTCCCTCTTACC
AACTCATCAGCCTCCCACCACACCCAGACACTCTCGGCCTCCGGGAGGACCCGCAAGACTACCT
CTTGCTGATCAACTGTCAGAGCAAGAAGCCTGAACCCACCAGAGCCCATTTTGACTCTGCCAAA
CCCACCTCTTCTGAGACAGACTGCAATGACAACGTCCCTTCCCACAAGCCTCCTGCTTCCTCCC
AGGGCAAACACGGAATGAACGGCTTTTTTCAGCAGCAAATGGTGTATGACTGCCCACCACCGCG
GGTTACATCGGTCTCTGGCGAGTCCGGCCTCTATAACCTGCCCAGGAGCTACTCCCATGACGTA
CTACCGAAGGAGTCCCCGTCAAGTACCGAGGCAGATGGAGAGCTTTACGTTTTTAATACACCGT
CTGGGACTTCAAGTGTAGAAGCTCAGATGAGACATGTGTCTATTAGTTACGACATTCCGCCAAC
ACCTGGCAACACTTACCAGGTCCCACGGACATTTCCAGAAGGCACACTGGGACAGTCATCGAAG
CTGGACACTATTCCTGACGTCCCCCCACCTCGGCCACCAAAGCCACATTCAACTCATGACCGGT
CTCCTGTGGAGACGTGCGGAGTGCCACGCACGGCATCAGACACTGACAGCAGTTACTGTATCCC
TCCGGCAGGCATGCCGCCCTCCCGGAGTAACACCATTTCCACCGTGGATCTGAACAAGTTACGG
AAAGATGCTGGTTCTCAAGATTGCTATGATATTCCACGGACCTTCCCGAGCGATAGATCCAGTT
CCTTGGAAGGCTTCCATAACCAGTTGAAAATCAAGAATGTGCTGGCTGCGGGCAATGTCTCGGG
AGAAGAGCTGGACGAGAACTACGTTCCCATGAACCCCAACTCGCCACCACGCCACCATCCCAGC
AGCTTCGCCGAACCGATTCAGGAACCAAACTACGTGCCAATGACCCCTGGGACCTTTGATTTTT
CTGCGTTTGGGATGCAAGTCCCTCCTCCTGCTCATCTGGGCTTCAGGTCCAGCCCAAAGACCCC
TCCCAGGAGGCCAGTTCCCGTTGCTGACTGTGAACCACCCCCGGTGGATAGGAACCTCAAGCCA
GACAGAAAAGTTAAGCCGGCACCTTTAGAAATCAAGCCTCTGTCAGAGTGGGAGGAGCTGCAGG
CCCCAGTCAGATCCCCCATCACCAGGAGCTTCGCTCGGGACTCCTCTAGGTTTCCCATGTCCCC
TCGGCCTGATTCTGTGCACAGCACGACATCGAGCAGTGACTCCCATGACAGTGAAGAGAACTAT
GTCCCCATGAACCCAAATCTGTCCAACGAAGATCAGAATCTCTTTTGCAACAACAGCCTCGAGG
GGGCGAGCAGCCCTATGACCAAACCCAAAGGAGATAAACAAGTCGAATACCTGGATTTAGACCT
AGAATCTGGGAAGTCCACACCACCACGGAAGCAAAAGAACAGTGGTTCGGGCAGCAGCATGTCT
GACGAGCGGGTGGATTACGTCGTGGTGGACCAACAGAAGACTCTGGCCCTGAAGAGTACCAGGG
AAGCTTGGACGGACGGCAGGCAGTCCACAGAGTCCGAGACACCCACCAAGAATGTGAAGTGAAG
CCGCACGGTCGCCGCTGCTGACAGAAGGAGCTGGGGGAGGAGAGGTGCCAGCGAAGAAGCTTCC
ACTCTGTAGCAGGGGCAGAGGAAAGGACCTCACACATGTTCACGTGAATTAGGTTGTGAATGGT
GCTGCGTGGTATTGAGTCTGTAACCTGTAAATAACCTGGGGAAGTAGTGTTTTAGCTCACCCAG
AAGCATCTGTCCCTAGTTAACCTGTAGTATAGGACACTGACGCACTTTCCATGTAAAACCTGGG
TTTGGGTCTTCCCAAGGGACCTTGGAAGAATCTCCTCAGGAGGTCTCCCTCCTCACACGACTCC
ATGTAACAGTTCCAAGTAAACTGAGCGGCTTTAGTTCTGGAAATTCCAGTTGAAGCTACAGGGC
TAACACCATTAACACAAGAAGTGGGTTCACAAATTTGCTTTTCCTTTAAAGGTAGTACCCATGA
GCCTAAGCTATAGAATATAGTTGGACTTGCCCTTCATTGTTTTCAAAAATTCCGGGGATAATGT
ATATATTGGTGTCAAGACCTAGTTCCCTGACTCATGTACACGTAGGTTTTAATAATAGGACTTT
GTTATGTTATTTTTTGTTGTTGTTGTTAATTACAGTGTCTTGGGTTCATCGTGTGAAGGTTCTG
CTGGGTAGGATCTCGCACCTTTAAAAAACTGCCTCTTAGTTACTCTAGTAAGCCCACAAATGTC
CACAGCATGGATCGGTGAGCTCTTCTTATTCCTGTTCACGTGCATTAAACATTGTTTGCAAAAG
GCAGATTGTCTGACTGACTAATCAGGTACGTCCAGGGCGCTGATGTGCTAATAACAGTGACCAG
GTTAAACCAAGCGCTTCAGTTAGGTGTTCGTTAATCCTCATCTTGGCTTAGAGTTAAGGAAACA
GTTGGCACTCTCTGTCAGTTGCAGCAACATACTGTGATTTTGAATGAGTTAGACAGTAATTCAA
GATTACCACTCTTAGGAATGAGACTCTCCCGACACCATAGAGCCCTTCCTATGGTTTTCTTTCT
TTTACTTAATATTCTTCTTGGCCTTATATTTAAATTCCTATGCAATTAATGTTTTATATCTGCA
TTTTTAGAAAAAGAAATGTCATTTTAAGTGATTCTTGTATGTAGCAAACACCTATTGCCTTTGT
GAGCAAATTAAGAATTTTGTACTGTGATTTGTACTCACTGCCCCAATTCTCCAACTGTTGGAGC
TTTGCTGTGCTGTGAAAGGCTGTAGTTGTGACCACCACCCAGCCAGATCTCCTGAGACCACAAA
GCAATGGTGCGAGTCTCTCACCTATAACGTGACATCGTCAGGTGTGGTCGTTGACTCTGAGTTA
GTGTCACTGTGTTACACCTGTCTGTCTAGGTTTGTGAGAAGCAGCTAGCGTTTTCCATTTTCAC
CCAAGTAAGTACAATGTCTCTGCACTGATCTGAGACTCACTGGTGGCTTGGGGAGGGGACACAG
AGAACAGAATGTCTATAGCAGAGGCTGGTCTCTCTCCGTTCAGACCTCTTAACTGTTGCCTGAG
TACACAATGTGCCCTGCTTTCTGGCCCACTGGCCACCGTGCTGTGCCTAATCTGTGTTCTCTGC
TTGCTTTTCCAGTCAGTCCACAAGCTGTGTTCATAACTAGATGGAATGTAGAATAGTTAACATT
AGATGCTTTTAAATGTTTGCTTCTTTTTAAACAAAAACTAAAACCCAGAACTGAATTTTGAGGT
GGATTTTTAAATAATAAAAAAAGGTTGTTTGAGTTTGGTGTGTGAGCTGTTTTGCTTTTGTTTT
TGTTTTTTTCCTTTTAA

hide sequence

RefSeq Acc Id:

XM_039097821 ⟹ XP_038953749

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	44,035,839 - 44,143,568 (+)	NCBI
mRatBN7.2	19	27,131,490 - 27,239,187 (+)	NCBI

RefSeq Acc Id:

XM_039097823 ⟹ XP_038953751

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	44,054,656 - 44,143,568 (+)	NCBI
mRatBN7.2	19	27,150,129 - 27,239,187 (+)	NCBI

RefSeq Acc Id:

XM_039097824 ⟹ XP_038953752

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	44,035,839 - 44,143,568 (+)	NCBI
mRatBN7.2	19	27,138,701 - 27,239,187 (+)	NCBI

RefSeq Acc Id:

XM_063278117 ⟹ XP_063134187

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	44,035,839 - 44,132,971 (+)	NCBI

RefSeq Acc Id:

XM_063278118 ⟹ XP_063134188

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	44,054,745 - 44,143,568 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101914	(Get FASTA)	NCBI Sequence Viewer
	XP_038953749	(Get FASTA)	NCBI Sequence Viewer
	XP_038953751	(Get FASTA)	NCBI Sequence Viewer
	XP_038953752	(Get FASTA)	NCBI Sequence Viewer
	XP_063134187	(Get FASTA)	NCBI Sequence Viewer
	XP_063134188	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ACS34829	(Get FASTA)	NCBI Sequence Viewer
	EDL92297	(Get FASTA)	NCBI Sequence Viewer
	EDL92298	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000024390
	ENSRNOP00000024390.4
	ENSRNOP00000071006
	ENSRNOP00000071006.3
	ENSRNOP00000102564
	ENSRNOP00000102564.1
	ENSRNOP00000109555.1

RefSeq Acc Id:

NP_001101914 ⟸ NM_001108444

- UniProtKB:

A6IYG9 (UniProtKB/TrEMBL), A0A0G2JZD5 (UniProtKB/TrEMBL), C6JUQ2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNL
CQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEDMNKWVRCICDICGFNPTEEDPVRPL
ASSSQAPADSPFAINTAPASAHMEPSSVALPPSYQLISLPPHPDTLGLREDPQDYLLLINCQSK
KPEPTRAHFDSAKPTSSETDCNDNVPSHKPPASSQGKHGMNGFFQQQMVYDCPPPRVTSVSGES
GLYNLPRSYSHDVLPKESPSSTEADGELYVFNTPSGTSSVEAQMRHVSISYDIPPTPGNTYQVP
RTFPEGTLGQSSKLDTIPDVPPPRPPKPHSTHDRSPVETCGVPRTASDTDSSYCIPPAGMPPSR
SNTISTVDLNKLRKDAGSQDCYDIPRTFPSDRSSSLEGFHNQLKIKNVLAAGNVSGEELDENYV
PMNPNSPPRHHPSSFAEPIQEPNYVPMTPGTFDFSAFGMQVPPPAHLGFRSSPKTPPRRPVPVA
DCEPPPVDRNLKPDRKVKPAPLEIKPLSEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHST
TSSSDSHDSEENYVPMNPNLSNEDQNLFCNNSLEGASSPMTKPKGDKQVEYLDLDLESGKSTPP
RKQKNSGSGSSMSDERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPTKNVK

hide sequence

Ensembl Acc Id:

ENSRNOP00000024390 ⟸ ENSRNOT00000024390

Ensembl Acc Id:

ENSRNOP00000071006 ⟸ ENSRNOT00000083219

RefSeq Acc Id:	XP_038953749 ⟸ XM_039097821
- Peptide Label:	isoform X1
- UniProtKB:	D3ZAL7 (UniProtKB/TrEMBL), A0A0G2JZD5 (UniProtKB/TrEMBL), C6JUQ2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038953752 ⟸ XM_039097824
- Peptide Label:	isoform X2
- UniProtKB:	A0A0G2JZD5 (UniProtKB/TrEMBL), C6JUQ2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038953751 ⟸ XM_039097823
- Peptide Label:	isoform X2
- UniProtKB:	A0A0G2JZD5 (UniProtKB/TrEMBL), C6JUQ2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063134187 ⟸ XM_063278117
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063134188 ⟸ XM_063278118
- Peptide Label:	isoform X4
- UniProtKB:	A0A0G2JZD5 (UniProtKB/TrEMBL), C6JUQ2 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000109555 ⟸ ENSRNOT00000140164

Ensembl Acc Id:

ENSRNOP00000102564 ⟸ ENSRNOT00000169434

Protein Domains

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2JZD5-F1-model_v2	AlphaFold	A0A0G2JZD5	1-720	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311085	AgrOrtholog
BioCyc Gene	G2FUF-5978	BioCyc
Ensembl Genes	ENSRNOG00000017879	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000024390	ENTREZGENE
	ENSRNOT00000024390.7	UniProtKB/TrEMBL
	ENSRNOT00000083219	ENTREZGENE
	ENSRNOT00000083219.3	UniProtKB/TrEMBL
	ENSRNOT00000140164.1	UniProtKB/TrEMBL
	ENSRNOT00000169434	ENTREZGENE
	ENSRNOT00000169434.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.29.30	UniProtKB/TrEMBL
InterPro	Gab1-4-like	UniProtKB/TrEMBL
	PH_type	UniProtKB/TrEMBL
	Pleckstrin_homology	UniProtKB/TrEMBL
KEGG Report	rno:361388	UniProtKB/TrEMBL
NCBI Gene	361388	ENTREZGENE
PANTHER	GRB2-ASSOCIATED-BINDING PROTEIN 1	UniProtKB/TrEMBL
	PTHR45960	UniProtKB/TrEMBL
Pfam	PF00169	UniProtKB/TrEMBL
PharmGKB	GAB1	RGD
PhenoGen	Gab1	PhenoGen
PROSITE	PH_DOMAIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000017879	RatGTEx
SMART	SM00233	UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/TrEMBL
UniProt	A0A0G2JZD5	ENTREZGENE
	A0ABK0M2Z7_RAT	UniProtKB/TrEMBL
	A0ABZ3NNQ1_RAT	UniProtKB/TrEMBL
	A6IYG9	ENTREZGENE, UniProtKB/TrEMBL
	C6JUQ2	ENTREZGENE, UniProtKB/TrEMBL
	D3ZAL7	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	A0A0G2JZD5	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-19	Gab1	GRB2-associated binding protein 1	Gab1	growth factor receptor bound protein 2-associated protein 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Gab1	growth factor receptor bound protein 2-associated protein 1	Gab1_predicted	growth factor receptor bound protein 2-associated protein 1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Gab1_predicted	growth factor receptor bound protein 2-associated protein 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)