Dnmt3a (DNA methyltransferase 3 alpha) - Rat Genome Database

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Gene: Dnmt3a (DNA methyltransferase 3 alpha) Rattus norvegicus
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Symbol: Dnmt3a
Name: DNA methyltransferase 3 alpha
RGD ID: 1303336
Description: Enables chromatin binding activity. Involved in several processes, including cellular response to ethanol; hepatocyte apoptotic process; and positive regulation of cellular response to hypoxia. Located in nucleus. Used to study lung carcinoma and middle cerebral artery infarction. Biomarker of congenital heart disease; hepatocellular carcinoma; and prostatitis. Human ortholog(s) of this gene implicated in Tatton-Brown-Rahman syndrome; hematologic cancer (multiple); and stomach cancer. Orthologous to human DNMT3A (DNA methyltransferase 3 alpha); PARTICIPATES IN DNA modification pathway; methionine cycle/metabolic pathway; cysteine and methionine metabolic pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cysteine methyltransferase DNMT3A; DNA (cytosine-5)-methyltransferase 3A; DNA (cytosine-5-)-methyltransferase 3 alpha; DNA methyltransferase 3A; MGC109195
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Dnmt3a-ps1   Dnmt3a-ps3  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8632,507,316 - 32,621,678 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl632,512,070 - 32,614,970 (+)EnsemblGRCr8
mRatBN7.2626,791,517 - 26,902,161 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,822,609 - 26,896,687 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx627,114,932 - 27,188,991 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0627,430,833 - 27,504,894 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0626,909,402 - 26,983,738 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0628,205,375 - 28,346,052 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl628,235,695 - 28,340,577 (+)Ensemblrn6Rnor6.0
Rnor_5.0638,132,683 - 38,149,613 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0638,044,960 - 38,082,583 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4626,802,612 - 26,878,878 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera626,297,300 - 26,371,904 (+)NCBICelera
RGSC_v3.1626,805,564 - 26,881,831 (+)NCBI
Cytogenetic Map6q14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISO)
acute monocytic leukemia  (ISO)
acute myeloid leukemia  (ISO)
acute promyelocytic leukemia  (ISO)
amyotrophic lateral sclerosis  (ISO)
autism spectrum disorder  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
bone marrow disease  (ISO)
Brain Hypoxia-Ischemia  (IEP)
Breast Neoplasms  (ISO)
Carcinogenesis  (IDA)
chronic myeloid leukemia  (ISO)
clear cell renal cell carcinoma  (ISO)
congenital heart disease  (IEP)
Craniofacial Abnormalities  (ISO)
Crohn's disease  (ISO)
depressive disorder  (ISO)
Desbuquois dysplasia  (ISO)
diffuse large B-cell lymphoma  (ISO)
Dwarfism  (ISO)
endometriosis  (ISO)
endometriosis of uterus  (ISO)
Facies  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
Growth Disorders  (ISO)
hepatocellular carcinoma  (IEP,ISO)
Heyn-Sproul-Jackson Syndrome  (ISO)
Immunoblastic Lymphadenopathy  (ISO)
intellectual disability  (ISO)
juvenile myelomonocytic leukemia  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (IDA)
Lung Neoplasms  (ISO)
melanoma  (ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (IMP)
multiple myeloma  (ISO)
Muscle Hypotonia  (ISO)
myelodysplastic syndrome  (ISO)
myeloid neoplasm  (ISO)
Neoplasm Recurrence, Local  (ISO)
Nervous System Malformations  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
peripheral T-cell lymphoma  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
prostate adenocarcinoma  (ISO)
prostatitis  (IEP)
sciatic neuropathy  (ISO)
Sezary's disease  (ISO)
stomach cancer  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
Tatton-Brown-Rahman syndrome  (ISO,ISS)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-(hydroxymethyl)cytosine  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amitrole  (EXP)
amphetamine  (EXP)
androgen antagonist  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
aripiprazole  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asiatic acid  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Brodifacoum  (ISO)
buta-1,3-diene  (ISO)
Butylparaben  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
cannabidiol  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
citalopram  (EXP)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumarin  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cycloheximide  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-penicillamine  (ISO)
daidzein  (EXP)
daidzein 7-O-beta-D-glucoside  (EXP)
DDE  (EXP)
DDT  (EXP)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
Diallyltetrasulfane  (EXP)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dieldrin  (ISO)
diethylstilbestrol  (EXP,ISO)
Difenacoum  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP,ISO)
enzacamene  (EXP)
ethanol  (ISO)
fenvalerate  (EXP)
Flocoumafen  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (EXP)
gentamycin  (EXP)
gibberellin A3  (EXP)
glycitein  (EXP)
glycitin  (EXP)
glyphosate  (EXP,ISO)
guggulsterone  (ISO)
hexane  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
isoprenaline  (EXP,ISO)
isorhapontigenin  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
malathion  (EXP)
mancozeb  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP)
mitomycin C  (ISO)
Monobutylphthalate  (ISO)
morphine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP)
ozone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
patulin  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
potassium dichromate  (EXP)
procyanidin B2  (ISO)
pterostilbene  (ISO)
pyrethrins  (EXP)
quartz  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
sinefungin  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tangeretin  (ISO)
tartrazine  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tyrphostin AG 1478  (ISO)
uranium atom  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vinyl carbamate  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
withaferin A  (ISO)
wortmannin  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)
chromosome, centromeric region  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO,ISS)
euchromatin  (IEA,ISO,ISS)
heterochromatin  (IEA,ISO)
nuclear matrix  (IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO,ISS)
XY body  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Exposure to caregiver maltreatment alters expression levels of epigenetic regulators in the medial prefrontal cortex. Blaze J and Roth TL, Int J Dev Neurosci. 2013 Dec;31(8):804-10. doi: 10.1016/j.ijdevneu.2013.10.001. Epub 2013 Oct 10.
2. A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension. Cavuoto P and Fenech MF, Cancer Treat Rev. 2012 Oct;38(6):726-36. doi: 10.1016/j.ctrv.2012.01.004. Epub 2012 Feb 17.
3. A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. Chen T, etal., J Biol Chem. 2002 Oct 11;277(41):38746-54. Epub 2002 Jul 22.
4. Vinclozolin exposure in utero induces postpubertal prostatitis and reduces sperm production via a reversible hormone-regulated mechanism. Cowin PA, etal., Endocrinology. 2010 Feb;151(2):783-92. doi: 10.1210/en.2009-0982. Epub 2010 Jan 7.
5. Cancer epigenetics: from mechanism to therapy. Dawson MA and Kouzarides T, Cell. 2012 Jul 6;150(1):12-27. doi: 10.1016/j.cell.2012.06.013.
6. Playing TETris with DNA modifications. Delatte B, etal., EMBO J. 2014 Jun 2;33(11):1198-211. doi: 10.15252/embj.201488290. Epub 2014 May 13.
7. DNMT3A R882 mutations in patients with cytogenetically normal acute myeloid leukemia and myelodysplastic syndrome. El Ghannam D, etal., Blood Cells Mol Dis. 2014 Jun-Aug;53(1-2):61-6. doi: 10.1016/j.bcmd.2014.01.004. Epub 2014 Feb 8.
8. A functional polymorphism in the DNA methyltransferase-3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma. Fan H, etal., BMC Med. 2010 Feb 3;8:12. doi: 10.1186/1741-7015-8-12.
9. Alteration in methylation pattern of GATA-4 promoter region in vitamin A-deficient offspring's heart. Feng Y, etal., J Nutr Biochem. 2013 Jul;24(7):1373-80. doi: 10.1016/j.jnutbio.2012.11.005. Epub 2013 Jan 17.
10. [Expression and significance of DNA methyltransferase in sera of patients with lung cancer]. Feng YJ, etal., Zhonghua Yi Xue Za Zhi. 2013 Dec 24;93(48):3822-5.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats. Ghoshal K, etal., J Nutr. 2006 Jun;136(6):1522-7.
13. The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL. Grossmann V, etal., Genes Chromosomes Cancer. 2013 Apr;52(4):410-22. doi: 10.1002/gcc.22039. Epub 2013 Jan 23.
14. Change in microRNAs associated with neuronal adaptive responses in the nucleus accumbens under neuropathic pain. Imai S, etal., J Neurosci. 2011 Oct 26;31(43):15294-9. doi: 10.1523/JNEUROSCI.0921-11.2011.
15. Phenotypic switching induced by damaged matrix is associated with DNA methyltransferase 3A (DNMT3A) activity and nuclear localization in smooth muscle cells (SMC). Jiang JX, etal., PLoS One. 2013 Aug 7;8(8):e69089. doi: 10.1371/journal.pone.0069089. eCollection 2013.
16. Effect of DNA Demethylation in Experimental Encapsulating Peritoneal Sclerosis. Kim KH, etal., Ther Apher Dial. 2014 Sep 26. doi: 10.1111/1744-9987.12186.
17. Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. LaPlant Q, etal., Nat Neurosci. 2010 Sep;13(9):1137-43. doi: 10.1038/nn.2619. Epub 2010 Aug 22.
18. Identification of 11 pseudogenes in the DNA methyltransferase gene family in rodents and humans and implications for the functional loci. Lees-Murdock DJ, etal., Genomics 2004 Jul;84(1):193-204.
19. DNMT3A mutations and prognostic significance in childhood acute lymphoblastic leukemia. Li W, etal., Leuk Lymphoma. 2015 Apr;56(4):1066-71. doi: 10.3109/10428194.2014.947607. Epub 2014 Nov 10.
20. Recurrent DNMT3A R882 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome. Lin J, etal., PLoS One. 2011;6(10):e26906. doi: 10.1371/journal.pone.0026906. Epub 2011 Oct 31.
21. Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a. Liu WB, etal., Toxicol Appl Pharmacol. 2011 Feb 15;251(1):70-8. doi: 10.1016/j.taap.2010.12.002. Epub 2010 Dec 14.
22. Aberrant immunoreactivity of deoxyribonucleic acid methyltransferases in adenomyosis. Liu X and Guo SW, Gynecol Obstet Invest. 2012;74(2):100-8. Epub 2012 May 4.
23. DNMT3A mutation analysis in adult patients with acute lymphoblastic leukemia. Liu YN, etal., J Huazhong Univ Sci Technolog Med Sci. 2015 Jun;35(3):337-42. doi: 10.1007/s11596-015-1434-1. Epub 2015 Jun 14.
24. Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis. Loree J, etal., Int J Radiat Biol. 2006 Nov;82(11):805-15.
25. Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma. Majumder S, etal., J Biol Chem. 2002 May 3;277(18):16048-58. Epub 2002 Feb 13.
26. Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia. Marcucci G, etal., J Clin Oncol. 2012 Mar 1;30(7):742-50. doi: 10.1200/JCO.2011.39.2092. Epub 2012 Jan 30.
27. Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation. Mayle A, etal., Blood. 2015 Jan 22;125(4):629-38.
28. Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression. Melas PA, etal., Int J Neuropsychopharmacol. 2012 Jun;15(5):669-79. doi: 10.1017/S1461145711000940. Epub 2011 Jun 20.
29. Perinatal programming of adult rat germ cell death after exposure to xenoestrogens: role of microRNA miR-29 family in the down-regulation of DNA methyltransferases and Mcl-1. Meunier L, etal., Endocrinology. 2012 Apr;153(4):1936-47. doi: 10.1210/en.2011-1109. Epub 2012 Feb 14.
30. Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Mizuno S, etal., Blood. 2001 Mar 1;97(5):1172-9.
31. DNA methylation pathway alterations in an autochthonous murine model of prostate cancer. Morey SR, etal., Cancer Res. 2006 Dec 15;66(24):11659-67.
32. MicroRNA miR-29c down-regulation leading to de-repression of its target DNA methyltransferase 3a promotes ischemic brain damage. Pandi G, etal., PLoS One. 2013;8(3):e58039. doi: 10.1371/journal.pone.0058039. Epub 2013 Mar 13.
33. DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma. Park HJ, etal., Cancer Lett. 2006 Feb 28;233(2):271-8.
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. Cocaine represses protein phosphatase-1Cbeta through DNA methylation and Methyl-CpG Binding Protein-2 recruitment in adult rat brain. Pol Bodetto S, etal., Neuropharmacology. 2013 Oct;73:31-40. doi: 10.1016/j.neuropharm.2013.05.005. Epub 2013 May 18.
36. GOA pipeline RGD automated data pipeline
37. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. Effects of acute ethanol exposure on anxiety measures and epigenetic modifiers in the extended amygdala of adolescent rats. Sakharkar AJ, etal., Int J Neuropsychopharmacol. 2014 Dec;17(12):2057-67. doi: 10.1017/S1461145714001047. Epub 2014 Jun 26.
40. Influence of developmental lead exposure on expression of DNA methyltransferases and methyl cytosine-binding proteins in hippocampus. Schneider JS, etal., Toxicol Lett. 2013 Feb 13;217(1):75-81. doi: 10.1016/j.toxlet.2012.12.004. Epub 2012 Dec 15.
41. DNMT3A Mutational Status Affects the Results of Dose-Escalated Induction Therapy in Acute Myelogenous Leukemia. Sehgal AR, etal., Clin Cancer Res. 2015 Apr 1;21(7):1614-20. doi: 10.1158/1078-0432.CCR-14-0327. Epub 2015 Jan 21.
42. Dexamethasone induces a putative repressor complex and chromatin modifications in the CRH promoter. Sharma D, etal., Mol Endocrinol. 2013 Jul;27(7):1142-52. doi: 10.1210/me.2013-1079. Epub 2013 May 13.
43. Cellular epigenetic modifications of neural stem cell differentiation. Singh RP, etal., Cell Transplant. 2009;18(10):1197-211. doi: 10.3727/096368909X12483162197204. Epub 2009 Aug 5.
44. Decreased DNA methyltransferase 3A and 3B mRNA expression in peripheral blood mononuclear cells and increased plasma SAH concentration in adult patients with idiopathic thrombocytopenic purpura. Tao J, etal., J Clin Immunol. 2008 Sep;28(5):432-9. doi: 10.1007/s10875-008-9223-2. Epub 2008 Aug 6.
45. Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis. Tryndyak VP, etal., Carcinogenesis. 2006 Aug;27(8):1713-20. Epub 2006 Apr 22.
46. DNA methyltransferase 3a expression decreases during apoptosis in primary cultures of hepatocytes. Vinken M, etal., Toxicol In Vitro. 2010 Mar;24(2):445-51. doi: 10.1016/j.tiv.2009.10.003. Epub 2009 Oct 13.
47. Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Walter MJ, etal., Leukemia. 2011 Jul;25(7):1153-8. doi: 10.1038/leu.2011.44. Epub 2011 Mar 18.
48. Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS. Wong M, etal., Front Cell Neurosci. 2013 Dec 25;7:279. doi: 10.3389/fncel.2013.00279. eCollection 2013.
49. Chronic cerebrovascular hypoperfusion affects global DNA methylation and histone acetylation in rat brain. Wu X, etal., Neurosci Bull. 2013 Dec;29(6):685-92. doi: 10.1007/s12264-013-1345-8. Epub 2013 May 28.
50. Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1, DNMT3A, and DNMT3B in women with endometriosis. Wu Y, etal., Fertil Steril. 2007 Jan;87(1):24-32. Epub 2006 Nov 1.
51. [Effects of bromopropane exposure on expression of DNA methyltransferases and level of histone acetylation in testis of male rats]. Zhang Q, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2013 Feb;31(2):92-5.
52. Regulation of DNA methylation by ethanol induces tissue plasminogen activator expression in astrocytes. Zhang X, etal., J Neurochem. 2014 Feb;128(3):344-9. doi: 10.1111/jnc.12465. Epub 2013 Oct 28.
53. DNMT3A intragenic hypomethylation is associated with adverse prognosis in acute myeloid leukemia. Zhang YY, etal., Leuk Res. 2015 Oct;39(10):1041-7. doi: 10.1016/j.leukres.2015.06.015. Epub 2015 Jul 6.
54. Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels. Zimmermann N, etal., Biochem J. 2012 Nov 15;448(1):93-102. doi: 10.1042/BJ20120674.
Additional References at PubMed
PMID:9662389   PMID:10555141   PMID:11399089   PMID:11934864   PMID:12477932   PMID:14752048   PMID:15215868   PMID:15456878   PMID:15616584   PMID:15739230   PMID:17938196   PMID:18042343  
PMID:19786833   PMID:20385583   PMID:20548288   PMID:20577743   PMID:21047779   PMID:21518035   PMID:23042785   PMID:24527678   PMID:24656771   PMID:24945829   PMID:25190601   PMID:25416223  
PMID:25476906   PMID:25743254   PMID:28267064   PMID:28270689   PMID:29056068   PMID:29786779   PMID:30114436   PMID:30478443   PMID:30950138   PMID:31576007   PMID:33230530   PMID:36430472  
PMID:37592110   PMID:37804593   PMID:37986543  


Genomics

Comparative Map Data
Dnmt3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8632,507,316 - 32,621,678 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl632,512,070 - 32,614,970 (+)EnsemblGRCr8
mRatBN7.2626,791,517 - 26,902,161 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,822,609 - 26,896,687 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx627,114,932 - 27,188,991 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0627,430,833 - 27,504,894 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0626,909,402 - 26,983,738 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0628,205,375 - 28,346,052 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl628,235,695 - 28,340,577 (+)Ensemblrn6Rnor6.0
Rnor_5.0638,132,683 - 38,149,613 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0638,044,960 - 38,082,583 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4626,802,612 - 26,878,878 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera626,297,300 - 26,371,904 (+)NCBICelera
RGSC_v3.1626,805,564 - 26,881,831 (+)NCBI
Cytogenetic Map6q14NCBI
DNMT3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38225,227,874 - 25,342,590 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl225,227,855 - 25,342,590 (-)Ensemblhg38GRCh38
GRCh37225,450,743 - 25,565,459 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36225,309,349 - 25,418,963 (-)NCBIBuild 36Build 36hg18NCBI36
Celera225,296,144 - 25,405,816 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef225,193,733 - 25,302,862 (-)NCBIHuRef
CHM1_1225,385,740 - 25,495,369 (-)NCBICHM1_1
T2T-CHM13v2.0225,263,222 - 25,377,928 (-)NCBIT2T-CHM13v2.0
Dnmt3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39123,851,559 - 3,964,442 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl123,856,007 - 3,964,443 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38123,801,559 - 3,914,443 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl123,806,007 - 3,914,443 (+)Ensemblmm10GRCm38
MGSCv37123,806,980 - 3,914,443 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36123,835,027 - 3,914,455 (+)NCBIMGSCv36mm8
Celera123,763,156 - 3,842,112 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map121.99NCBI
Dnmt3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554697,269,952 - 7,367,059 (-)Ensembl
ChiLan1.0NW_0049554697,264,431 - 7,367,059 (-)NCBIChiLan1.0ChiLan1.0
DNMT3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212101,173,664 - 101,289,206 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A101,177,630 - 101,288,083 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A25,229,593 - 25,344,733 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A25,331,095 - 25,441,785 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A25,331,095 - 25,412,605 (-)EnsemblpanPan2panpan1.1
DNMT3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11719,489,524 - 19,563,074 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1719,492,193 - 19,563,902 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1719,382,990 - 19,486,679 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01719,761,597 - 19,865,311 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1719,767,351 - 19,865,307 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11719,495,608 - 19,599,241 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01719,505,342 - 19,609,205 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01719,551,811 - 19,655,519 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dnmt3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629263,826,309 - 63,930,744 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364936,935,386 - 7,007,610 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364936,963,406 - 7,013,256 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNMT3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3113,528,926 - 113,603,087 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13113,501,972 - 113,609,148 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23120,579,692 - 120,663,698 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNMT3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11482,313,414 - 82,427,170 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1482,402,826 - 82,420,819 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604529,732,050 - 29,846,532 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnmt3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247387,485,842 - 7,581,056 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247387,481,084 - 7,581,332 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dnmt3a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1724,482,595 - 24,583,861 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dnmt3a
809 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:252
Count of miRNA genes:163
Interacting mature miRNAs:183
Transcripts:ENSRNOT00000047210
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63118500276185002Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)63093763275937632Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)62228825732981219Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat

Markers in Region
RH130466  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6q14UniSTS
BE113641  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2626,870,598 - 26,870,759 (+)MAPPERmRatBN7.2
Rnor_6.0628,314,514 - 28,314,674NCBIRnor6.0
Rnor_5.0638,123,550 - 38,123,710UniSTSRnor5.0
RGSC_v3.4626,851,172 - 26,851,332UniSTSRGSC3.4
Celera626,345,870 - 26,346,030UniSTS
RH 3.4 Map6118.19UniSTS
Cytogenetic Map6q14UniSTS
BF398717  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2626,880,909 - 26,881,078 (+)MAPPERmRatBN7.2
Rnor_6.0628,325,476 - 28,325,644NCBIRnor6.0
Rnor_5.0638,134,512 - 38,134,680UniSTSRnor5.0
RGSC_v3.4626,861,704 - 26,861,872UniSTSRGSC3.4
Celera626,356,203 - 26,356,371UniSTS
RH 3.4 Map6116.5UniSTS
Cytogenetic Map6q14UniSTS
RH135183  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2815,316,303 - 15,316,508 (+)MAPPERmRatBN7.2
mRatBN7.2626,896,118 - 26,896,328 (+)MAPPERmRatBN7.2
Rnor_6.0628,340,009 - 28,340,218NCBIRnor6.0
Rnor_6.0817,367,986 - 17,368,190NCBIRnor6.0
Rnor_5.0817,441,518 - 17,441,722UniSTSRnor5.0
Rnor_5.0638,149,045 - 38,149,254UniSTSRnor5.0
RGSC_v3.4626,878,310 - 26,878,519UniSTSRGSC3.4
RGSC_v3.4815,674,220 - 15,674,424UniSTSRGSC3.4
Celera816,746,468 - 16,746,672UniSTS
Celera626,371,336 - 26,371,545UniSTS
Cytogenetic Map6q14UniSTS
RH139204  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6q14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001003957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001003958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC089916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000047210   ⟹   ENSRNOP00000046524
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl632,512,070 - 32,614,970 (+)Ensembl
mRatBN7.2 Ensembl626,822,609 - 26,896,687 (+)Ensembl
Rnor_6.0 Ensembl628,235,695 - 28,340,577 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089093   ⟹   ENSRNOP00000069441
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl628,323,647 - 28,340,577 (+)Ensembl
RefSeq Acc Id: NM_001003957   ⟹   NP_001003957
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,598,602 - 32,616,204 (+)NCBI
mRatBN7.2626,879,081 - 26,896,687 (+)NCBI
Rnor_6.0628,323,647 - 28,340,577 (+)NCBI
Rnor_5.0638,132,683 - 38,149,613 (+)NCBI
RGSC_v3.4626,802,612 - 26,878,878 (+)RGD
Celera626,354,374 - 26,371,904 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001003958   ⟹   NP_001003958
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,542,145 - 32,616,204 (+)NCBI
mRatBN7.2626,822,609 - 26,896,687 (+)NCBI
Rnor_6.0628,235,695 - 28,340,577 (+)NCBI
Rnor_5.0638,044,960 - 38,082,583 (+)NCBI
Rnor_5.0638,132,683 - 38,149,613 (+)NCBI
RGSC_v3.4626,802,612 - 26,878,878 (+)RGD
Celera626,297,300 - 26,371,904 (+)RGD
Sequence:
RefSeq Acc Id: XM_017594267   ⟹   XP_017449756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,511,329 - 32,621,678 (+)NCBI
mRatBN7.2626,791,871 - 26,902,161 (+)NCBI
Rnor_6.0628,205,766 - 28,346,052 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594268   ⟹   XP_017449757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,507,316 - 32,621,678 (+)NCBI
mRatBN7.2626,791,556 - 26,902,161 (+)NCBI
Rnor_6.0628,205,375 - 28,346,052 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112661   ⟹   XP_038968589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,512,003 - 32,621,678 (+)NCBI
mRatBN7.2626,792,467 - 26,902,161 (+)NCBI
RefSeq Acc Id: XM_039112662   ⟹   XP_038968590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,513,266 - 32,621,678 (+)NCBI
mRatBN7.2626,796,662 - 26,902,161 (+)NCBI
RefSeq Acc Id: XM_039112663   ⟹   XP_038968591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,513,266 - 32,621,678 (+)NCBI
mRatBN7.2626,800,586 - 26,902,161 (+)NCBI
RefSeq Acc Id: XM_039112664   ⟹   XP_038968592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,512,001 - 32,621,678 (+)NCBI
mRatBN7.2626,792,460 - 26,902,161 (+)NCBI
RefSeq Acc Id: XM_039112666   ⟹   XP_038968594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,512,003 - 32,613,989 (+)NCBI
mRatBN7.2626,792,467 - 26,894,469 (+)NCBI
RefSeq Acc Id: XM_039112667   ⟹   XP_038968595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,578,980 - 32,621,678 (+)NCBI
mRatBN7.2626,822,831 - 26,902,161 (+)NCBI
RefSeq Acc Id: XM_039112668   ⟹   XP_038968596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,598,792 - 32,621,678 (+)NCBI
mRatBN7.2626,879,284 - 26,902,161 (+)NCBI
RefSeq Acc Id: XM_063262261   ⟹   XP_063118331
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,568,574 - 32,621,678 (+)NCBI
RefSeq Acc Id: NP_001003958   ⟸   NM_001003958
- Peptide Label: isoform 1
- UniProtKB: Q1LZ52 (UniProtKB/Swiss-Prot),   Q1LZ53 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001003957   ⟸   NM_001003957
- Peptide Label: isoform 2
- UniProtKB: Q1LZ53 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017449757   ⟸   XM_017594268
- Peptide Label: isoform X1
- UniProtKB: Q1LZ52 (UniProtKB/Swiss-Prot),   Q1LZ53 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017449756   ⟸   XM_017594267
- Peptide Label: isoform X1
- UniProtKB: Q1LZ52 (UniProtKB/Swiss-Prot),   Q1LZ53 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069441   ⟸   ENSRNOT00000089093
Ensembl Acc Id: ENSRNOP00000046524   ⟸   ENSRNOT00000047210
RefSeq Acc Id: XP_038968592   ⟸   XM_039112664
- Peptide Label: isoform X1
- UniProtKB: Q1LZ53 (UniProtKB/Swiss-Prot),   Q1LZ52 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038968589   ⟸   XM_039112661
- Peptide Label: isoform X1
- UniProtKB: Q1LZ53 (UniProtKB/Swiss-Prot),   Q1LZ52 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038968594   ⟸   XM_039112666
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038968590   ⟸   XM_039112662
- Peptide Label: isoform X1
- UniProtKB: Q1LZ53 (UniProtKB/Swiss-Prot),   Q1LZ52 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038968591   ⟸   XM_039112663
- Peptide Label: isoform X1
- UniProtKB: Q1LZ53 (UniProtKB/Swiss-Prot),   Q1LZ52 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038968595   ⟸   XM_039112667
- Peptide Label: isoform X3
- UniProtKB: A6HAG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968596   ⟸   XM_039112668
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063118331   ⟸   XM_063262261
- Peptide Label: isoform X4
Protein Domains
ADD   PHD-type   PWWP   SAM-dependent MTase C5-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q1LZ53-F1-model_v2 AlphaFold Q1LZ53 1-908 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303336 AgrOrtholog
BioCyc Gene G2FUF-38289 BioCyc
Ensembl Genes ENSRNOG00000026649 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000047210 ENTREZGENE
  ENSRNOT00000047210.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.30.140 UniProtKB/Swiss-Prot
  3.40.50.150 UniProtKB/Swiss-Prot
  PWWP, helical domain UniProtKB/Swiss-Prot
InterPro ADD UniProtKB/Swiss-Prot
  ADD_DNMT3A UniProtKB/Swiss-Prot
  C5_DNA_meth_AS UniProtKB/Swiss-Prot
  C5_MeTfrase UniProtKB/Swiss-Prot
  DNM3A_N UniProtKB/Swiss-Prot
  DNMT3_ADD UniProtKB/Swiss-Prot
  DNMT3_ADD_PHD UniProtKB/Swiss-Prot
  PWWP_dom UniProtKB/Swiss-Prot
  SAM-dependent_MTases UniProtKB/Swiss-Prot
KEGG Report rno:444984 UniProtKB/Swiss-Prot
NCBI Gene 444984 ENTREZGENE
PANTHER DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED UniProtKB/Swiss-Prot
  PTHR23068:SF10 UniProtKB/Swiss-Prot
Pfam ADD_DNMT3 UniProtKB/Swiss-Prot
  ADDz_Dnmt3b UniProtKB/Swiss-Prot
  DNA_methylase UniProtKB/Swiss-Prot
  DNM3A_N UniProtKB/Swiss-Prot
  PWWP UniProtKB/Swiss-Prot
PhenoGen Dnmt3a PhenoGen
PROSITE ADD UniProtKB/Swiss-Prot
  C5_MTASE_1 UniProtKB/Swiss-Prot
  PWWP UniProtKB/Swiss-Prot
  SAM_MT_C5 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000026649 RatGTEx
SMART PWWP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot
  Tudor/PWWP/MBT UniProtKB/Swiss-Prot
UniProt A6HAG2 ENTREZGENE, UniProtKB/TrEMBL
  DNM3A_RAT UniProtKB/Swiss-Prot
  Q1LZ52 ENTREZGENE
  Q1LZ53 ENTREZGENE
  Q5FVL1_RAT UniProtKB/TrEMBL
UniProt Secondary Q1LZ52 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Dnmt3a  DNA methyltransferase 3 alpha  Dnmt3a  DNA (cytosine-5-)-methyltransferase 3 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-11 Dnmt3a  DNA (cytosine-5-)-methyltransferase 3 alpha  Dnmt3a  DNA methyltransferase 3A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-14 Dnmt3a  DNA methyltransferase 3A      Symbol and Name status set to provisional 70820 PROVISIONAL