RGD Reference Report - DNMT3A mutation analysis in adult patients with acute lymphoblastic leukemia. - Rat Genome Database

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DNMT3A mutation analysis in adult patients with acute lymphoblastic leukemia.

Authors: Liu, YN  Zhang, N  Wu, Y  Yang, L  Ding, XY  Zhou, JF  Xiao, M 
Citation: Liu YN, etal., J Huazhong Univ Sci Technolog Med Sci. 2015 Jun;35(3):337-42. doi: 10.1007/s11596-015-1434-1. Epub 2015 Jun 14.
RGD ID: 11041131
Pubmed: PMID:26072070   (View Abstract at PubMed)
DOI: DOI:10.1007/s11596-015-1434-1   (Journal Full-text)

DNA methyl-transferase 3A (DNMT3A) mutation has recently been identified as an independent risk factor for patients with acute myeloid leukemia (AML). However, reports are scanty on its rate and subsequent impact on patients with acute lymphoblastic leukemia (ALL), especially in Chinese population. In this study, we investigated the incidence and prognostic implication of DNMT3A mutation in 57 Chinese adult ALL patients. A total of 3 (5.3%) T-ALL cases were found to have the DNMT3A R882H mutation, which was significantly greater than that found in B-ALL subtype (P=0.048). The patients aged between 40 and 60 years old had higher mutation rate than other age groups (P=0.042). Patients with DNMT3A mutation had shorter overall survival (OS) than their wild-type counterparts. Our study demonstrated that Chinese ALL patients might develop DNMT3A mutation, which exerts a negative impact on their prognosis. These findings might help in risk stratification and treatment choice for Chinese ALL patients.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
T-cell acute lymphoblastic leukemia susceptibilityIAGP 11041131associated with Precursor Cell Lymphoblastic Leukemia-Lymphoma and DNA:missense mutation:exon:p.R882H(human)RGD 
T-cell acute lymphoblastic leukemia susceptibilityISODNMT3A (Homo sapiens)11041131; 11041131associated with Precursor Cell Lymphoblastic Leukemia-Lymphoma and DNA:missense mutation:exon:p.R882H(human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Abnormal leukocyte count  IAGP 11041131associated with Precursor Cell Lymphoblastic Leukemia-Lymphoma and DNA:missense mutation:p.R882H(human) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Dnmt3a  (DNA methyltransferase 3 alpha)

Genes (Mus musculus)
Dnmt3a  (DNA methyltransferase 3A)

Genes (Homo sapiens)
DNMT3A  (DNA methyltransferase 3 alpha)


Additional Information