Per1 (period circadian regulator 1) - Rat Genome Database

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Gene: Per1 (period circadian regulator 1) Rattus norvegicus
Analyze
Symbol: Per1
Name: period circadian regulator 1
RGD ID: 727863
Description: Predicted to enable several functions, including DNA binding activity; enzyme binding activity; and transcription corepressor binding activity. Involved in several processes, including neural retina development; regulation of cytokine production involved in inflammatory response; and regulation of intracellular signal transduction. Located in nucleus. Biomarker of alcohol use disorder. Orthologous to human PER1 (period circadian regulator 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: circadian clock protein PERIOD 1; MGC112772; period 1; period circadian clock 1; period circadian protein homolog 1; period homolog 1; period homolog 1 (Drosophila); rper1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Per1em3Mcwi ; Per1em1Smoc
Genetic Models: SS-Per1em3Mcwi ; SD-Per1em1Smoc
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,299,002 - 54,313,804 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1054,302,641 - 54,314,211 (+)EnsemblGRCr8
mRatBN7.21053,800,126 - 53,814,963 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1053,805,535 - 53,814,431 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1058,467,299 - 58,476,195 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01057,955,897 - 57,964,793 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,464,077 - 53,472,969 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01055,681,761 - 55,696,557 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1055,687,050 - 55,695,994 (+)Ensemblrn6Rnor6.0
Rnor_5.01055,424,863 - 55,439,853 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41055,859,851 - 55,868,747 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1052,971,073 - 52,979,969 (+)NCBICelera
RGSC_v3.11055,873,530 - 55,882,148 (+)NCBI
Cytogenetic Map10q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-(tert-butylamino)-1-(2-chlorophenyl)ethanol  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
9-cis-retinoic acid  (ISO)
acrolein  (EXP)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cocaine  (EXP,ISO)
cocaine hydrochloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cortisol  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dapsone  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
Didecyldimethylammonium  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
ethanol  (ISO)
finasteride  (EXP)
fluoranthene  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (EXP)
gallic acid  (ISO)
gallocatechin  (ISO)
gentamycin  (EXP)
glyphosate  (EXP,ISO)
GSK-J4  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
ketamine  (EXP)
lead diacetate  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
melatonin  (EXP)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
mifepristone  (EXP,ISO)
morphine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
Pf-06840003  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
prednisolone  (ISO)
progesterone  (EXP,ISO)
rac-lactic acid  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
SCH-351591  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
sotorasib  (ISO)
sulindac  (EXP)
tamoxifen  (ISO)
testosterone  (EXP)
tetraphene  (ISO)
thapsigargin  (EXP,ISO)
thiabendazole  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. Brown SA, etal., Science. 2005 Apr 29;308(5722):693-6.
2. Chronic ethanol consumption impairs the circadian rhythm of pro-opiomelanocortin and period genes mRNA expression in the hypothalamus of the male rat. Chen CP, etal., J Neurochem. 2004 Mar;88(6):1547-54. doi: 10.1046/j.1471-4159.2003.02300.x.
3. Prenatal ethanol exposure alters the expression of period genes governing the circadian function of beta-endorphin neurons in the hypothalamus. Chen CP, etal., J Neurochem. 2006 May;97(4):1026-33. doi: 10.1111/j.1471-4159.2006.03839.x.
4. Per and neuropeptide expression in the rat suprachiasmatic nuclei: compartmentalization and differential cellular induction by light. Dardente H, etal., Brain Res 2002 Dec 27;958(2):261-71.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Reduced expression of circadian clock genes in male alcoholic patients. Huang MC, etal., Alcohol Clin Exp Res. 2010 Nov;34(11):1899-904. doi: 10.1111/j.1530-0277.2010.01278.x. Epub 2010 Aug 24.
7. Clock genes outside the suprachiasmatic nucleus involved in manifestation of locomotor activity rhythm in rats. Masubuchi S, etal., Eur J Neurosci 2000 Dec;12(12):4206-14.
8. Thyroid transcription factor 1, a homeodomain containing transcription factor, contributes to regulating periodic oscillations in GnRH gene expression. Matagne V, etal., J Neuroendocrinol. 2012 Jun;24(6):916-29. doi: 10.1111/j.1365-2826.2012.02302.x.
9. Expression and light sensitivity of clock genes Per1 and Per2 and immediate-early gene c-fos within the retina of early postnatal Wistar rats. Matejů K, etal., J Comp Neurol. 2010 Sep 1;518(17):3630-44. doi: 10.1002/cne.22421.
10. A novel protein interacts with a clock-related protein, rPer1. Matsuki T, etal., Brain Res 2001 Oct 19;916(1-2):1-10.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Indication of circadian oscillations in the rat pancreas. Muhlbauer E, etal., FEBS Lett. 2004 Apr 23;564(1-2):91-6.
13. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Clock gene Per1 regulates the production of CCL2 and interleukin-6 through p38, JNK1 and NF-kappaB activation in spinal astrocytes. Sugimoto T, etal., Mol Cell Neurosci. 2014 Mar;59:37-46. doi: 10.1016/j.mcn.2014.01.003. Epub 2014 Jan 19.
18. The circadian rhythm of Per1 gene product in the rat suprachiasmatic nucleus and its modulation by seasonal changes in daylength. Sumova A, etal., Brain Res 2002 Aug 30;947(2):260-70.
19. Ca2+/cAMP response element-binding protein (CREB)-dependent activation of Per1 is required for light-induced signaling in the suprachiasmatic nucleus circadian clock. Tischkau SA, etal., J Biol Chem 2003 Jan 10;278(2):718-23.
20. Effect of fluoxetine and cocaine on the expression of clock genes in the mouse hippocampus and striatum. Uz T, etal., Neuroscience. 2005;134(4):1309-16. doi: 10.1016/j.neuroscience.2005.05.003.
Additional References at PubMed
PMID:9635423   PMID:9856465   PMID:9989497   PMID:11122368   PMID:11395012   PMID:11591712   PMID:12213820   PMID:12397359   PMID:12477932   PMID:12670312   PMID:12710990   PMID:12810087  
PMID:14564007   PMID:14625086   PMID:14645221   PMID:14701732   PMID:15038852   PMID:15147242   PMID:15388282   PMID:15864751   PMID:15888647   PMID:15917222   PMID:16177029   PMID:16537451  
PMID:16675517   PMID:17045749   PMID:18208549   PMID:18316400   PMID:18400210   PMID:18411297   PMID:18810660   PMID:19036829   PMID:19222559   PMID:19490091   PMID:19559014   PMID:19710508  
PMID:19740747   PMID:19887760   PMID:20106950   PMID:20159955   PMID:20424134   PMID:20647694   PMID:20649850   PMID:20738730   PMID:21061153   PMID:21076970   PMID:21135158   PMID:21163331  
PMID:21420468   PMID:21680841   PMID:21767615   PMID:21775066   PMID:21952132   PMID:22940729   PMID:23133559   PMID:23136757   PMID:23417420   PMID:23443664   PMID:23513468   PMID:23785138  
PMID:24005054   PMID:24154698   PMID:24378737   PMID:24413057   PMID:24549704   PMID:24610784   PMID:24619734   PMID:25338089   PMID:25573753   PMID:25760074   PMID:26271538   PMID:26656624  
PMID:26892296   PMID:26901093   PMID:27362940   PMID:27365111   PMID:27655894   PMID:29165002   PMID:30627637   PMID:35870088   PMID:36093781   PMID:36450128   PMID:37338051   PMID:37907921  
PMID:39010104  


Genomics

Comparative Map Data
Per1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,299,002 - 54,313,804 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1054,302,641 - 54,314,211 (+)EnsemblGRCr8
mRatBN7.21053,800,126 - 53,814,963 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1053,805,535 - 53,814,431 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1058,467,299 - 58,476,195 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01057,955,897 - 57,964,793 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,464,077 - 53,472,969 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01055,681,761 - 55,696,557 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1055,687,050 - 55,695,994 (+)Ensemblrn6Rnor6.0
Rnor_5.01055,424,863 - 55,439,853 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41055,859,851 - 55,868,747 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1052,971,073 - 52,979,969 (+)NCBICelera
RGSC_v3.11055,873,530 - 55,882,148 (+)NCBI
Cytogenetic Map10q24NCBI
PER1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38178,140,472 - 8,152,404 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl178,140,467 - 8,156,506 (-)Ensemblhg38GRCh38
GRCh37178,043,790 - 8,055,722 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,984,515 - 7,996,427 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34177,984,514 - 7,996,427NCBI
Celera178,071,402 - 8,083,393 (-)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,938,702 - 7,950,693 (-)NCBIHuRef
CHM1_1178,052,563 - 8,064,533 (-)NCBICHM1_1
T2T-CHM13v2.0178,045,861 - 8,057,819 (-)NCBIT2T-CHM13v2.0
Per1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391168,985,934 - 69,000,791 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1168,986,043 - 69,000,786 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381169,095,108 - 69,109,965 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,095,217 - 69,109,960 (+)Ensemblmm10GRCm38
MGSCv371168,912,458 - 68,923,462 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361168,915,144 - 68,926,155 (+)NCBIMGSCv36mm8
Celera1176,042,503 - 76,053,510 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.37NCBI
Per1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554678,797,912 - 8,813,365 (+)Ensembl
ChiLan1.0NW_0049554678,798,436 - 8,813,369 (+)NCBIChiLan1.0ChiLan1.0
PER1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21965,596,869 - 65,612,884 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11770,406,264 - 70,422,283 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01743,502,080 - 43,518,098 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11748,234,360 - 48,250,391 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1748,234,360 - 48,250,391 (+)EnsemblpanPan2panpan1.1
PER1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,957,517 - 32,972,368 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,957,127 - 32,968,465 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha533,093,740 - 33,108,538 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0533,060,413 - 33,075,282 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl533,060,416 - 33,077,964 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1533,027,318 - 33,042,194 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,983,113 - 32,998,003 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0533,163,138 - 33,177,939 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Per1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,892,738 - 47,907,968 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365951,366,875 - 1,382,170 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365951,366,883 - 1,382,138 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PER1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1253,361,889 - 53,374,248 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11253,361,863 - 53,376,723 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,836,920 - 55,851,890 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PER1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,520,122 - 7,536,176 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl167,520,006 - 7,531,940 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605913,868,521 - 13,884,549 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Per1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478610,707,075 - 10,719,859 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478610,706,495 - 10,722,110 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Per1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1948,699,910 - 48,709,309 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Per1
57 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:62
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000057136
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105269900459876693Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105429622767476781Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105429622758944345Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat


Genetic Models
This gene Per1 is modified in the following models/strains:
SS-Per1em3Mcwi     SD-Per1em1Smoc    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000057136   ⟹   ENSRNOP00000053964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1054,302,641 - 54,313,781 (+)Ensembl
mRatBN7.2 Ensembl1053,805,535 - 53,814,431 (+)Ensembl
Rnor_6.0 Ensembl1055,687,050 - 55,695,994 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100433   ⟹   ENSRNOP00000094096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1054,302,641 - 54,313,781 (+)Ensembl
mRatBN7.2 Ensembl1053,805,535 - 53,814,431 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000150049   ⟹   ENSRNOP00000103272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1054,302,641 - 54,314,211 (+)Ensembl
RefSeq Acc Id: NM_001034125   ⟹   NP_001029297
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,304,376 - 54,313,272 (+)NCBI
mRatBN7.21053,805,535 - 53,814,431 (+)NCBI
Rnor_6.01055,687,124 - 55,696,020 (+)NCBI
Rnor_5.01055,424,863 - 55,439,853 (+)NCBI
RGSC_v3.41055,859,851 - 55,868,747 (+)RGD
Celera1052,971,073 - 52,979,969 (+)RGD
Sequence:
RefSeq Acc Id: XM_006246613   ⟹   XP_006246675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,299,002 - 54,313,804 (+)NCBI
mRatBN7.21053,800,126 - 53,814,431 (+)NCBI
Rnor_6.01055,681,761 - 55,696,020 (+)NCBI
Rnor_5.01055,424,863 - 55,439,853 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006246614   ⟹   XP_006246676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,299,140 - 54,313,804 (+)NCBI
mRatBN7.21053,800,328 - 53,814,963 (+)NCBI
Rnor_6.01055,681,912 - 55,696,557 (+)NCBI
Rnor_5.01055,424,863 - 55,439,853 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001029297   ⟸   NM_001034125
- UniProtKB: Q2KMM8 (UniProtKB/Swiss-Prot),   Q8CHI5 (UniProtKB/Swiss-Prot),   A6HFN8 (UniProtKB/TrEMBL),   A0A8I6AM54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246675   ⟸   XM_006246613
- Peptide Label: isoform X1
- UniProtKB: Q2KMM8 (UniProtKB/Swiss-Prot),   Q8CHI5 (UniProtKB/Swiss-Prot),   A6HFN8 (UniProtKB/TrEMBL),   A0A8I6AM54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246676   ⟸   XM_006246614
- Peptide Label: isoform X1
- UniProtKB: Q2KMM8 (UniProtKB/Swiss-Prot),   Q8CHI5 (UniProtKB/Swiss-Prot),   A6HFN8 (UniProtKB/TrEMBL),   A0A8I6AM54 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000053964   ⟸   ENSRNOT00000057136
Ensembl Acc Id: ENSRNOP00000094096   ⟸   ENSRNOT00000100433
Ensembl Acc Id: ENSRNOP00000103272   ⟸   ENSRNOT00000150049
Protein Domains
PAC   PAS   Period circadian protein homolog 1-3 PAS-A   Period circadian protein homolog PER 1-3 bHLH-like   Period circadian-like C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CHI5-F1-model_v2 AlphaFold Q8CHI5 1-1293 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727863 AgrOrtholog
BioCyc Gene G2FUF-24586 BioCyc
Ensembl Genes ENSRNOG00000007387 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000057136.4 UniProtKB/Swiss-Prot
  ENSRNOT00000150049 ENTREZGENE
Gene3D-CATH PAS domain UniProtKB/Swiss-Prot
InterPro PAS UniProtKB/Swiss-Prot
  PAS-like_dom_sf UniProtKB/Swiss-Prot
  PAS_fold_3 UniProtKB/Swiss-Prot
  Per1-3_PAS-A UniProtKB/Swiss-Prot
  Period_circadian-like_C UniProtKB/Swiss-Prot
  Period_circadian_regulator UniProtKB/Swiss-Prot
KEGG Report rno:287422 UniProtKB/Swiss-Prot
NCBI Gene 287422 ENTREZGENE
PANTHER PERIOD CIRCADIAN PROTEIN UniProtKB/Swiss-Prot
  PERIOD CIRCADIAN PROTEIN HOMOLOG 1 UniProtKB/Swiss-Prot
Pfam bHLH_PER UniProtKB/Swiss-Prot
  PAS_3 UniProtKB/Swiss-Prot
  Per3-like_PAS-A UniProtKB/Swiss-Prot
  Period_C UniProtKB/Swiss-Prot
PhenoGen Per1 PhenoGen
PROSITE PAS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007387 RatGTEx
SMART PAS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55785 UniProtKB/Swiss-Prot
UniProt A0A0H2UHZ7_RAT UniProtKB/TrEMBL
  A0A8I6AM54 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LQ50_RAT UniProtKB/TrEMBL
  A6HFN8 ENTREZGENE, UniProtKB/TrEMBL
  PER1_RAT UniProtKB/Swiss-Prot
  Q2KMM8 ENTREZGENE
  Q498T1_RAT UniProtKB/TrEMBL
  Q8CHI5 ENTREZGENE
UniProt Secondary Q2KMM8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-09 Per1  period circadian regulator 1  Per1  period circadian clock 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-02 Per1  period circadian clock 1  Per1  period homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Per1  period homolog 1 (Drosophila)    period 1  Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the suprachiasmatic nucleus 1299576