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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727863
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Per1
Name: period circadian regulator 1
Acc ID: CHEBI:77013
Term: beta-naphthoflavone
Definition: An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone.
Chemical ID: MESH:D019324
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Per1decreases expressionISOPer1 (Mus musculus)6480464CTDbeta-Naphthoflavone results in decreased expression of PER1 mRNA; beta-Naphthoflavone results in decreased expression of PER1 proteinPMID:20106950
Per1multiple interactionsISOPer1 (Mus musculus)6480464CTDbeta-Naphthoflavone inhibits the reaction [CLOCK protein binds to PER1 promoter]; beta-Naphthoflavone inhibits the reaction [Colforsin results in increased expression of PER1 mRNA]; beta-Naphthoflavone promotes the reaction [AHR protein binds to PER1 promoter]PMID:20106950 PMID:23291558
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