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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727863
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Per1
Name: period circadian regulator 1
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Per1affects expressionEXP 6480464CTDCocaine affects the expression of PER1 mRNAPMID:20187946
Per1increases expressionEXP 6480464CTDCocaine results in increased expression of PER1 mRNAPMID:27899881
Per1increases expressionISOPer1 (Mus musculus)6480464CTDCocaine results in increased expression of PER1 mRNA; Cocaine results in increased expression of PER1 proteinPMID:15994025 PMID:23776671
Per1multiple interactionsISOPer1 (Mus musculus)6480464CTD[Cocaine co-treated with FOS protein mutant form] results in decreased expression of PER1 mRNA; Cocaine promotes the reaction [NPAS2 protein binds to PER1 promoter]PMID:18355967 PMID:23776671
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