Dnm1 (dynamin 1) - Rat Genome Database

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Gene: Dnm1 (dynamin 1) Rattus norvegicus
Analyze
Symbol: Dnm1
Name: dynamin 1
RGD ID: 71096
Description: Enables several functions, including D2 dopamine receptor binding activity; SH3 domain binding activity; and enzyme binding activity. Involved in G protein-coupled receptor internalization; positive regulation of synaptic vesicle endocytosis; and response to amyloid-beta. Located in Golgi apparatus; cytoplasmic vesicle; and varicosity. Part of protein-containing complex. Is active in presynaptic endocytic zone membrane. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 31A and developmental and epileptic encephalopathy 31B. Orthologous to human DNM1 (dynamin 1); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B-dynamin; D100; Dnm; dynamin I; dynamin, brain; dynamin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,002,535 - 36,055,220 (-)NCBIGRCr8
mRatBN7.2315,604,782 - 15,648,654 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,604,784 - 15,648,538 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,673,501 - 18,717,036 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,258,494 - 27,302,030 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,509,288 - 25,553,054 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,338,081 - 11,382,043 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,338,083 - 11,382,043 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0316,686,951 - 16,730,913 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,434,778 - 11,478,452 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1311,331,147 - 11,374,785 (-)NCBI
Celera310,349,401 - 10,391,382 (-)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Butylparaben  (EXP)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (EXP)
cyclosporin A  (ISO)
DDE  (EXP)
deguelin  (ISO)
dextran sulfate  (ISO)
doxorubicin  (ISO)
enilconazole  (ISO)
enniatin  (EXP)
entinostat  (ISO)
enzacamene  (EXP)
ethanol  (ISO)
ethylparaben  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gallic acid  (ISO)
gallocatechin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
linuron  (EXP)
lipopolysaccharide  (ISO)
methamphetamine  (ISO)
methoxychlor  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
perfluorohexanesulfonic acid  (ISO)
phenol red  (ISO)
pirinixic acid  (ISO)
rotenone  (ISO)
sodium arsenite  (EXP,ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP)
thifluzamide  (ISO)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. Ahn S, etal., J Biol Chem 2002 Jul 19;277(29):26642-51.
2. Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis. Anggono V and Robinson PJ, J Neurochem. 2007 Aug;102(3):931-43. Epub 2007 Apr 16.
3. Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis. Anggono V, etal., Nat Neurosci. 2006 Jun;9(6):752-60. doi: 10.1038/nn1695. Epub 2006 Apr 30.
4. Dynamin 1 isoform roles in a mouse model of severe childhood epileptic encephalopathy. Asinof S, etal., Neurobiol Dis. 2016 Nov;95:1-11. doi: 10.1016/j.nbd.2016.06.014. Epub 2016 Jun 28.
5. Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I. Baillat G, etal., J Biol Chem 2002 May 24;277(21):18961-6.
6. Differential distribution of dynamin isoforms in mammalian cells. Cao H, etal., Mol Biol Cell. 1998 Sep;9(9):2595-609.
7. Changed clathrin regulatory proteins in the brains of Alzheimer's disease patients and animal models. Cao Y, etal., J Alzheimers Dis. 2010;22(1):329-42. doi: 10.3233/JAD-2010-100162.
8. Tuba, a GEF for CDC42, links dynamin to actin regulatory proteins. Cestra G, etal., Methods Enzymol. 2005;404:537-45.
9. The Abl/Arg substrate ArgBP2/nArgBP2 coordinates the function of multiple regulatory mechanisms converging on the actin cytoskeleton. Cestra G, etal., Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1731-6. Epub 2005 Jan 19.
10. Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate. Chen-Hwang MC, etal., J Biol Chem 2002 May 17;277(20):17597-604.
11. Phospholipase C-gamma1 is a guanine nucleotide exchange factor for dynamin-1 and enhances dynamin-1-dependent epidermal growth factor receptor endocytosis. Choi JH, etal., J Cell Sci. 2004 Aug 1;117(Pt 17):3785-95. doi: 10.1242/jcs.01220. Epub 2004 Jul 13.
12. Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation. Evers DM, etal., Nat Neurosci. 2010 Oct;13(10):1199-207. doi: 10.1038/nn.2624. Epub 2010 Aug 29.
13. The crystal structure of dynamin. Ford MG, etal., Nature. 2011 Sep 18;477(7366):561-6. doi: 10.1038/nature10441.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Proteomic analysis of TRPC5- and TRPC6-binding partners reveals interaction with the plasmalemmal Na(+)/K(+)-ATPase. Goel M, etal., Pflugers Arch. 2005 Oct;451(1):87-98. Epub 2005 Jul 16.
17. Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer. Gray NW, etal., Curr Biol. 2003 Mar 18;13(6):510-5.
18. Dynamin activates NO production in rat renal inner medullary collecting ducts via protein-protein interaction with NOS1. Hyndman KA, etal., Am J Physiol Renal Physiol. 2011 Apr 13.
19. The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling link that orchestrates ciliary morphogenesis in postmitotic neurons. Ikeuchi Y, etal., Cell Rep. 2013 Sep 12;4(5):879-89. doi: 10.1016/j.celrep.2013.07.042. Epub 2013 Aug 29.
20. Receptor-type PTP-NP inhibition of Dynamin-1 GTPase activity is associated with neuronal depolarization. Jiang S, etal., Cell Signal. 2006 Sep;18(9):1439-46. Epub 2006 Jan 18.
21. Dynamin-2 associates with the dopamine receptor signalplex and regulates internalization of activated D2 receptors. Kabbani N, etal., Cell Signal. 2004 Apr;16(4):497-503.
22. Interaction of SPIN90 with dynamin I and its participation in synaptic vesicle endocytosis. Kim Y, etal., J Neurosci. 2005 Oct 12;25(41):9515-23.
23. Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis. Krendel M, etal., FEBS Lett. 2007 Feb 20;581(4):644-50. Epub 2007 Jan 18.
24. The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis. Lai MM, etal., J Biol Chem. 2000 Nov 3;275(44):34017-20.
25. SPIN90/WISH interacts with PSD-95 and regulates dendritic spinogenesis via an N-WASP-independent mechanism. Lee S, etal., EMBO J. 2006 Oct 18;25(20):4983-95. Epub 2006 Sep 21.
26. Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization. Lin JW, etal., Nat Neurosci. 2000 Dec;3(12):1282-90.
27. Postsynaptic positioning of endocytic zones and AMPA receptor cycling by physical coupling of dynamin-3 to Homer. Lu J, etal., Neuron. 2007 Sep 20;55(6):874-89.
28. The juxtamembrane region of synaptotagmin 1 interacts with dynamin 1 and regulates vesicle fission during compensatory endocytosis in endocrine cells. McAdam RL, etal., J Cell Sci. 2015 Jun 15;128(12):2229-35. doi: 10.1242/jcs.161505. Epub 2015 May 11.
29. Gene Data Set MGD Curation, June 12, 2002
30. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
31. Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin. Micheva KD, etal., J Biol Chem. 1997 Oct 24;272(43):27239-45. doi: 10.1074/jbc.272.43.27239.
32. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins. Obar RA, etal., Nature 1990 Sep 20;347(6290):256-61.
34. EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis? Okamoto M, etal., J Biol Chem 1999 Jun 25;274(26):18446-54.
35. Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton. Okamoto PM, etal., J Biol Chem 2001 Dec 21;276(51):48458-65.
36. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
37. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
38. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
39. Syndapin isoforms participate in receptor-mediated endocytosis and actin organization. Qualmann B and Kelly RB, J Cell Biol 2000 Mar 6;148(5):1047-62.
40. Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein. Qualmann B, etal., Mol Biol Cell 1999 Feb;10(2):501-13.
41. Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase. Ramjaun AR, etal., J Biol Chem 2001 Aug 3;276(31):28913-9.
42. GOA pipeline RGD automated data pipeline
43. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
44. The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain. Ringstad N, etal., Proc Natl Acad Sci U S A 1997 Aug 5;94(16):8569-74.
45. Isoform-selective interaction of the adaptor protein Tks5/FISH with Sos1 and dynamins. Rufer AC, etal., J Mol Biol. 2009 Jul 31;390(5):939-50. doi: 10.1016/j.jmb.2009.05.025. Epub 2009 May 21.
46. Synaptic vesicle endocytosis. Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
47. Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton. Salazar MA, etal., J Biol Chem. 2003 Dec 5;278(49):49031-43. doi: 10.1074/jbc.M308104200. Epub 2003 Sep 22.
48. Chloride intracellular channel protein CLIC4 (p64H1) binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms. Suginta W, etal., Biochem J. 2001 Oct 1;359(Pt 1):55-64.
49. Tubular membrane invaginations coated by dynamin rings are induced by GTP-gamma S in nerve terminals. Takei K, etal., Nature. 1995 Mar 9;374(6518):186-90. doi: 10.1038/374186a0.
50. Endophilin isoforms have distinct characteristics in interactions with N-type Ca2+ channels and dynamin I. Tian Q, etal., Neurosci Bull. 2012 Oct;28(5):483-92. doi: 10.1007/s12264-012-1257-z. Epub 2012 Jul 13.
51. CAP (Cbl associated protein) regulates receptor-mediated endocytosis. Tosoni D and Cestra G, FEBS Lett. 2009 Jan 22;583(2):293-300. doi: 10.1016/j.febslet.2008.12.047. Epub 2008 Dec 29.
52. Nitric oxide regulates endocytosis by S-nitrosylation of dynamin. Wang G, etal., Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1295-300. Epub 2006 Jan 23.
53. Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis. Wigge P, etal., Mol Biol Cell 1997 Oct;8(10):2003-15.
54. Expression of the endocytic proteins dynamin and amphiphysin in rat gastric enterochromaffin-like cells. Zanner R, etal., J Cell Sci. 2004 May 1;117(Pt 11):2369-76.
55. Evidence that dystroglycan is associated with dynamin and regulates endocytosis. Zhan Y, etal., J Biol Chem. 2005 May 6;280(18):18015-24. Epub 2005 Feb 22.
Additional References at PubMed
PMID:8402898   PMID:9182529   PMID:9195986   PMID:9694653   PMID:9736607   PMID:9742220   PMID:9813051   PMID:10206341   PMID:10430869   PMID:10521508   PMID:10908605   PMID:11856729  
PMID:11879655   PMID:12606338   PMID:14704270   PMID:14985338   PMID:15123615   PMID:15287745   PMID:15581494   PMID:15834155   PMID:15953416   PMID:16141317   PMID:16864575   PMID:16903783  
PMID:17463283   PMID:17499934   PMID:17525220   PMID:17634366   PMID:17681954   PMID:19222995   PMID:19706678   PMID:20107062   PMID:20127811   PMID:20160074   PMID:20428113   PMID:20448150  
PMID:20526333   PMID:20700106   PMID:20700442   PMID:21112282   PMID:21307259   PMID:21689597   PMID:21730063   PMID:21927000   PMID:21957258   PMID:21962517   PMID:22120110   PMID:22681889  
PMID:22871113   PMID:23103755   PMID:23260429   PMID:23533145   PMID:23687302   PMID:23716698   PMID:23746204   PMID:23785143   PMID:23999152   PMID:24643165   PMID:26302298   PMID:29476059  
PMID:29604406   PMID:30069048   PMID:32357304  


Genomics

Comparative Map Data
Dnm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,002,535 - 36,055,220 (-)NCBIGRCr8
mRatBN7.2315,604,782 - 15,648,654 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,604,784 - 15,648,538 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,673,501 - 18,717,036 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,258,494 - 27,302,030 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,509,288 - 25,553,054 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,338,081 - 11,382,043 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,338,083 - 11,382,043 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0316,686,951 - 16,730,913 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,434,778 - 11,478,452 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1311,331,147 - 11,374,785 (-)NCBI
Celera310,349,401 - 10,391,382 (-)NCBICelera
Cytogenetic Map3p12NCBI
DNM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389128,203,379 - 128,255,244 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9128,191,655 - 128,255,248 (+)EnsemblGRCh38hg38GRCh38
GRCh379130,965,658 - 131,017,523 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369130,005,484 - 130,057,348 (+)NCBINCBI36Build 36hg18NCBI36
Build 349128,045,216 - 128,097,081NCBI
Celera9101,616,559 - 101,668,431 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,579,095 - 100,630,981 (+)NCBIHuRef
CHM1_19131,116,687 - 131,168,550 (+)NCBICHM1_1
T2T-CHM13v2.09140,410,459 - 140,462,358 (+)NCBIT2T-CHM13v2.0
Dnm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,198,483 - 32,243,361 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,198,483 - 32,243,350 (-)EnsemblGRCm39 Ensembl
GRCm38232,308,471 - 32,353,349 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,308,471 - 32,353,338 (-)EnsemblGRCm38mm10GRCm38
MGSCv37232,163,991 - 32,208,824 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36232,130,480 - 32,175,282 (-)NCBIMGSCv36mm8
Celera232,012,962 - 32,058,530 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Dnm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955570752,335 - 781,770 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955570752,335 - 781,770 (+)NCBIChiLan1.0ChiLan1.0
DNM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,097,345 - 11,149,229 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,099,693 - 11,151,525 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0999,324,385 - 99,376,262 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19128,008,224 - 128,045,224 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9128,004,508 - 128,044,690 (+)Ensemblpanpan1.1panPan2
DNM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,252,802 - 55,298,244 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,252,347 - 55,298,244 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,447,720 - 54,493,024 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0956,174,435 - 56,220,232 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,174,449 - 56,220,234 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1954,934,788 - 54,980,303 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,249,424 - 55,295,001 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,340,932 - 55,386,497 (-)NCBIUU_Cfam_GSD_1.0
Dnm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947196,001,590 - 196,029,515 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,767,897 - 15,801,211 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648715,767,897 - 15,797,722 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,653,070 - 268,702,222 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,653,045 - 268,702,233 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,643,339 - 302,692,544 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,874,098 - 9,927,737 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl129,878,966 - 9,927,744 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660796,308,667 - 6,359,204 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247606,604,787 - 6,646,622 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247606,605,902 - 6,646,575 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dnm1
180 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir140rno-miR-140-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18845019

Predicted Target Of
Summary Value
Count of predictions:590
Count of miRNA genes:209
Interacting mature miRNAs:240
Transcripts:ENSRNOT00000042762, ENSRNOT00000047921, ENSRNOT00000064039, ENSRNOT00000068349
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1558657Cm43Cardiac mass QTL 436.60.0000000293heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat

Markers in Region
BF386076  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2315,608,065 - 15,608,245 (+)MAPPERmRatBN7.2
Rnor_6.0311,341,356 - 11,341,535NCBIRnor6.0
Rnor_5.0316,690,226 - 16,690,405UniSTSRnor5.0
RGSC_v3.4311,438,051 - 11,438,230UniSTSRGSC3.4
Celera310,352,676 - 10,352,855UniSTS
RH 3.4 Map385.71UniSTS
Cytogenetic Map3p11UniSTS
AW533536  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2315,623,503 - 15,623,700 (+)MAPPERmRatBN7.2
Rnor_6.0311,357,004 - 11,357,200NCBIRnor6.0
Rnor_5.0316,705,874 - 16,706,070UniSTSRnor5.0
RGSC_v3.4311,453,415 - 11,453,611UniSTSRGSC3.4
RH 3.4 Map372.6UniSTS
Cytogenetic Map3p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 5 2 2 70 26 32 3
Low 3 39 52 39 19 39 8 11 4 9 9 8 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000047921   ⟹   ENSRNOP00000041582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,608,553 - 15,648,538 (-)Ensembl
Rnor_6.0 Ensembl311,338,611 - 11,382,004 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000064039   ⟹   ENSRNOP00000060845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,604,793 - 15,648,538 (-)Ensembl
Rnor_6.0 Ensembl311,338,083 - 11,382,043 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097377   ⟹   ENSRNOP00000080068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,608,469 - 15,648,538 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102787   ⟹   ENSRNOP00000091634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,604,793 - 15,648,538 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110861   ⟹   ENSRNOP00000095659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,604,784 - 15,648,538 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115917   ⟹   ENSRNOP00000093707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,608,541 - 15,648,538 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118464   ⟹   ENSRNOP00000092707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,604,784 - 15,648,538 (-)Ensembl
RefSeq Acc Id: NM_080689   ⟹   NP_542420
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,002,535 - 36,046,289 (-)NCBI
mRatBN7.2315,604,791 - 15,648,538 (-)NCBI
Rnor_6.0311,338,081 - 11,382,043 (-)NCBI
Rnor_5.0316,686,951 - 16,730,913 (-)NCBI
RGSC_v3.4311,434,778 - 11,478,452 (-)RGD
Celera310,349,401 - 10,391,382 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104141   ⟹   XP_038960069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,002,535 - 36,046,421 (-)NCBI
mRatBN7.2315,604,782 - 15,648,652 (-)NCBI
RefSeq Acc Id: XM_039104142   ⟹   XP_038960070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,002,535 - 36,046,414 (-)NCBI
mRatBN7.2315,604,782 - 15,648,650 (-)NCBI
RefSeq Acc Id: XM_039104143   ⟹   XP_038960071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,002,535 - 36,046,421 (-)NCBI
mRatBN7.2315,604,782 - 15,648,652 (-)NCBI
RefSeq Acc Id: XM_039104144   ⟹   XP_038960072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,002,535 - 36,046,409 (-)NCBI
mRatBN7.2315,604,782 - 15,648,649 (-)NCBI
RefSeq Acc Id: XM_039104145   ⟹   XP_038960073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,002,535 - 36,046,417 (-)NCBI
mRatBN7.2315,604,782 - 15,648,651 (-)NCBI
RefSeq Acc Id: XM_039104147   ⟹   XP_038960075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,002,535 - 36,046,415 (-)NCBI
mRatBN7.2315,604,782 - 15,648,653 (-)NCBI
RefSeq Acc Id: XM_039104148   ⟹   XP_038960076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,002,535 - 36,046,422 (-)NCBI
mRatBN7.2315,604,782 - 15,648,654 (-)NCBI
RefSeq Acc Id: XM_039104151   ⟹   XP_038960079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,003,602 - 36,046,410 (-)NCBI
mRatBN7.2315,605,849 - 15,648,649 (-)NCBI
RefSeq Acc Id: XM_063283019   ⟹   XP_063139089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,002,535 - 36,055,220 (-)NCBI
RefSeq Acc Id: XM_063283020   ⟹   XP_063139090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,003,607 - 36,046,419 (-)NCBI
RefSeq Acc Id: XM_063283022   ⟹   XP_063139092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,006,301 - 36,046,410 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_542420   ⟸   NM_080689
- UniProtKB: A0A8L2QKR5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000041582   ⟸   ENSRNOT00000047921
RefSeq Acc Id: ENSRNOP00000060845   ⟸   ENSRNOT00000064039
RefSeq Acc Id: XP_038960076   ⟸   XM_039104148
- Peptide Label: isoform X7
- UniProtKB: A0A8I6ALW7 (UniProtKB/TrEMBL),   A0A8L2QKR5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960075   ⟸   XM_039104147
- Peptide Label: isoform X8
- UniProtKB: A0A8L2QKR5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960071   ⟸   XM_039104143
- Peptide Label: isoform X4
- UniProtKB: A0A8L2QKR5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960069   ⟸   XM_039104141
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AHJ0 (UniProtKB/TrEMBL),   A0A8L2QKR5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960073   ⟸   XM_039104145
- Peptide Label: isoform X6
- UniProtKB: A0A8L2QKR5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960070   ⟸   XM_039104142
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QKR5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960072   ⟸   XM_039104144
- Peptide Label: isoform X5
- UniProtKB: P21575 (UniProtKB/Swiss-Prot),   A0A8L2QKR5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960079   ⟸   XM_039104151
- Peptide Label: isoform X9
- UniProtKB: A0A8L2QKR5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000092707   ⟸   ENSRNOT00000118464
RefSeq Acc Id: ENSRNOP00000093707   ⟸   ENSRNOT00000115917
RefSeq Acc Id: ENSRNOP00000091634   ⟸   ENSRNOT00000102787
RefSeq Acc Id: ENSRNOP00000095659   ⟸   ENSRNOT00000110861
RefSeq Acc Id: ENSRNOP00000080068   ⟸   ENSRNOT00000097377
RefSeq Acc Id: XP_063139089   ⟸   XM_063283019
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063139090   ⟸   XM_063283020
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063139092   ⟸   XM_063283022
- Peptide Label: isoform X11
Protein Domains
Dynamin-type G   GED   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21575-F1-model_v2 AlphaFold P21575 1-864 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691982
Promoter ID:EPDNEW_R2507
Type:initiation region
Name:Dnm1_1
Description:dynamin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0311,382,098 - 11,382,158EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71096 AgrOrtholog
BIND 119589
  130460
  130589
  134462
  134465
BioCyc Gene G2FUF-50146 BioCyc
Ensembl Genes ENSRNOG00000033835 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047921.6 UniProtKB/TrEMBL
  ENSRNOT00000064039 ENTREZGENE
  ENSRNOT00000064039.5 UniProtKB/Swiss-Prot
  ENSRNOT00000097377.1 UniProtKB/TrEMBL
  ENSRNOT00000102787.1 UniProtKB/Swiss-Prot
  ENSRNOT00000110861.1 UniProtKB/TrEMBL
  ENSRNOT00000115917.1 UniProtKB/TrEMBL
  ENSRNOT00000118464.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin, middle domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dynamin UniProtKB/TrEMBL
  Dynamin_central UniProtKB/Swiss-Prot
  Dynamin_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_GTPase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_SF UniProtKB/Swiss-Prot
  Dynamin_stalk UniProtKB/TrEMBL
  G_DYNAMIN_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140694 UniProtKB/Swiss-Prot
NCBI Gene 140694 ENTREZGENE
PANTHER PTHR11566 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11566:SF32 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Dynamin_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dnm1 PhenoGen
PRINTS DYNAMIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_DYNAMIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_DYNAMIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033835 RatGTEx
SMART DYNc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZPV7_RAT UniProtKB/TrEMBL
  A0A8I6AHJ0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AKX2_RAT UniProtKB/TrEMBL
  A0A8I6ALW7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QKR5 ENTREZGENE, UniProtKB/TrEMBL
  A6JU54_RAT UniProtKB/TrEMBL
  A6JU55_RAT UniProtKB/TrEMBL
  DYN1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Dnm1  dynamin 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a highly conserved GTPase domain, a pleckstrin homology domain, a GTPase effector domain, and a proline-rich domain at the C terminus 625468
gene_function large GTPase 625468
gene_physical_interaction phosphorylation by Dyrk mediates the interaction with SH3 domain-containing proteins 625468
gene_physical_interaction interacts primarily through its pleckstrin homology domain and proline-rich domain with a large array of cellular components including proteins participating in endocytosis, maintenance of the cytoskeleton, and signal transduction 625468
gene_physical_interaction phosphorylation inhibits interaction with amphiphysin and endophilin 1 and the subsequent incorporation into the endocytic apparatus and enhances the interaction with Grb2 625468
gene_process plays an essential role in clathrin-mediated endocytosis and synaptic vesicle recycling 625468
gene_process major substrate for the Dual Specificity Yak1-related kinase (Dyrk) 625468
gene_product 100 kDa protein 625468