RGD Reference Report - Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer. - Rat Genome Database

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Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer.

Authors: Gray, NW  Fourgeaud, L  Huang, B  Chen, J  Cao, H  Oswald, BJ  Hemar, A  McNiven, MA 
Citation: Gray NW, etal., Curr Biol. 2003 Mar 18;13(6):510-5.
RGD ID: 8554278
Pubmed: PMID:12646135   (View Abstract at PubMed)

The dynamins comprise a large family of mechanoenzymes known to participate in membrane modeling events. All three conventional dynamin genes (Dyn1, Dyn2, Dyn3) are expressed in mammalian brain and produce more than 27 different dynamin proteins as a result of alternative splicing. Past studies have suggested that Dyn1 participates in specialized neuronal functions such as rapid synaptic vesicle recycling, while Dyn2 may mediate the conventional clathrin-mediated uptake of surface receptors. Currently, the distribution, expression, and function of Dyn3 in neurons, or in any other cell type, are completely undefined. Here, we demonstrate that Dyn1 and Dyn3 localize differentially in the synapse. Dyn1 concentrates within the presynaptic compartment, while Dyn3 localizes to dendritic spine tips. Within the postsynaptic density (PSD), we found Dyn3, but not Dyn1, to be part of a biochemically isolated complex comprised of Homer and metabotropic glutamate receptors. Finally, although dominant-negative Dyn3 did not seem to inhibit receptor endocytosis, overexpression of a specific Dyn3 spliced variant in mature neurons caused a marked remodeling of dendritic spines. These data suggest that Dyn3 is a postsynaptic dynamin and, like its binding partner Homer, plays a significant role in dendritic spine morphogenesis and remodeling.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
filopodium assembly involved_inIDA 8554278PMID:12646135UniProt 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
postsynaptic density located_inIDA 8554278PMID:12646135UniProt 
synaptic vesicle  IDA 8554278 RGD 
varicosity  IDA 8554278 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Dnm1  (dynamin 1)
Dnm3  (dynamin 3)


Additional Information