Folr1 (folate receptor alpha) - Rat Genome Database

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Gene: Folr1 (folate receptor alpha) Rattus norvegicus
Analyze
Symbol: Folr1
Name: folate receptor alpha
RGD ID: 71032
Description: Predicted to enable folic acid binding activity; folic acid receptor activity; and signaling receptor activity. Predicted to be involved in several processes, including circulatory system development; nervous system development; and regulation of signal transduction. Predicted to act upstream of or within folic acid metabolic process. Located in brush border membrane. Human ortholog(s) of this gene implicated in cerebral folate receptor alpha deficiency. Orthologous to human FOLR1 (folate receptor alpha); PARTICIPATES IN altered folate cycle metabolic pathway; folate cycle metabolic pathway; endocytosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fbp1; folate binding protein 1; folate receptor 1; folate receptor 1 (adult)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,631,462 - 165,650,430 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1165,631,462 - 165,642,669 (-)EnsemblGRCr8
mRatBN7.21156,219,460 - 156,238,436 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,219,460 - 156,230,667 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1164,209,769 - 164,220,975 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01171,389,863 - 171,401,069 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,267,520 - 164,278,567 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01166,934,457 - 166,945,864 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1166,934,460 - 166,943,592 (-)Ensemblrn6Rnor6.0
Rnor_5.01173,124,242 - 173,135,651 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41159,315,191 - 159,324,141 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1154,298,870 - 154,310,077 (-)NCBICelera
RGSC_v3.11159,394,208 - 159,403,158 (-)NCBI
Cytogenetic Map1q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
5-methyltetrahydrofolic acid  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
chloroethene  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
diallyl trisulfide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (ISO)
diiodine  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
eugenol  (EXP)
flavonoids  (EXP)
flurbiprofen  (ISO)
folic acid  (EXP,ISO)
gallic acid  (ISO)
genistein  (ISO)
glucose  (ISO)
glycidol  (EXP)
glycidyl methacrylate  (ISO)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
ICI D1694  (ISO)
lead diacetate  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
progesterone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
theophylline  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Internalization and intracellular transport of folate-binding protein in rat kidney proximal tubule. Birn H, etal., Am J Physiol. 1993 Feb;264(2 Pt 1):C302-10.
2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
3. Folate deficiency reduces the GPI-anchored folate-binding protein in rat renal tubules. da Costa M, etal., Am J Physiol Cell Physiol 2000 Apr;278(4):C812-21.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Gene Data Set MGD Curation, June 12, 2002
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Coding sequence, genomic organization and expression of a folate binding protein gene in the rat. Sadasivan E, etal., Gene 2000 Aug 22;254(1-2):219-28.
13. Folate-regulated changes in gene expression in the anterior neural tube of folate binding protein-1 (Folbp1)-deficient murine embryos. Spiegelstein O, etal., Neurochem Res 2004 Jun;29(6):1105-12.
14. Update and new concepts in vitamin responsive disorders of folate transport and metabolism. Watkins D and Rosenblatt DS, J Inherit Metab Dis. 2012 Jul;35(4):665-70. doi: 10.1007/s10545-011-9418-1. Epub 2011 Nov 23.
Additional References at PubMed
PMID:2527252   PMID:8033114   PMID:10787414   PMID:12477932   PMID:12854656   PMID:14722620   PMID:17286298   PMID:19116913   PMID:19199708   PMID:19581412   PMID:20424322   PMID:21649587  
PMID:23243496   PMID:23376485   PMID:23533145   PMID:23851396   PMID:26667416   PMID:27011008   PMID:30113208   PMID:36675153  


Genomics

Comparative Map Data
Folr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,631,462 - 165,650,430 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1165,631,462 - 165,642,669 (-)EnsemblGRCr8
mRatBN7.21156,219,460 - 156,238,436 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,219,460 - 156,230,667 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1164,209,769 - 164,220,975 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01171,389,863 - 171,401,069 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,267,520 - 164,278,567 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01166,934,457 - 166,945,864 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1166,934,460 - 166,943,592 (-)Ensemblrn6Rnor6.0
Rnor_5.01173,124,242 - 173,135,651 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41159,315,191 - 159,324,141 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1154,298,870 - 154,310,077 (-)NCBICelera
RGSC_v3.11159,394,208 - 159,403,158 (-)NCBI
Cytogenetic Map1q32NCBI
FOLR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381172,189,709 - 72,196,323 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1172,189,558 - 72,196,323 (+)Ensemblhg38GRCh38
GRCh371171,900,753 - 71,907,367 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361171,578,250 - 71,585,014 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341171,580,855 - 71,585,014NCBI
Celera1169,202,176 - 69,208,941 (+)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1168,193,609 - 68,200,378 (+)NCBIHuRef
CHM1_11171,784,063 - 71,790,828 (+)NCBICHM1_1
T2T-CHM13v2.01172,116,250 - 72,122,864 (+)NCBIT2T-CHM13v2.0
Folr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397101,507,551 - 101,519,974 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7101,507,538 - 101,519,995 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387101,858,331 - 101,870,788 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7101,858,331 - 101,870,788 (-)Ensemblmm10GRCm38
MGSCv377109,006,845 - 109,019,197 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367101,732,152 - 101,744,504 (-)NCBIMGSCv36mm8
Celera7102,230,147 - 102,242,481 (-)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.67NCBI
Folr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541419,187,388 - 19,197,728 (-)Ensembl
ChiLan1.0NW_00495541419,188,830 - 19,197,728 (-)NCBIChiLan1.0ChiLan1.0
LOC100994139
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2973,138,207 - 73,144,766 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11174,180,529 - 74,188,172 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01167,268,721 - 67,275,498 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11170,492,039 - 70,498,665 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1170,492,039 - 70,498,665 (+)EnsemblpanPan2panpan1.1
LOC609612
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12125,944,350 - 25,951,010 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2125,714,017 - 25,720,656 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02126,153,187 - 26,159,847 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2126,153,297 - 26,159,800 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12125,944,449 - 25,951,109 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02126,160,593 - 26,167,256 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02126,062,191 - 26,068,851 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Folr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494759,892,012 - 59,897,666 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364981,491,547 - 1,497,226 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364981,489,916 - 1,497,200 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOLR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl96,757,040 - 6,760,402 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.196,753,513 - 6,760,433 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.297,515,002 - 7,521,923 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FOLR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1163,405,513 - 63,413,372 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl163,406,597 - 63,413,352 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604362,470,494 - 62,476,997 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Folr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248174,820,163 - 4,851,339 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248174,830,164 - 4,850,565 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Folr1
110 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:83
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000026962
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889419Cstrr2Cold stress response QTL 20.05urine catecholamine amount (VT:0010502)absolute change in urine norepinephrine level (CMO:0001634)1165278545168003898Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1153680016182383862Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1159863716177663210Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
D1Bda29  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81165,632,013 - 165,632,361 (+)Marker Load Pipeline
mRatBN7.21156,220,011 - 156,220,359 (+)MAPPERmRatBN7.2
Rnor_6.01166,935,009 - 166,935,356NCBIRnor6.0
Rnor_5.01173,124,794 - 173,125,141UniSTSRnor5.0
RGSC_v3.41159,315,739 - 159,316,086UniSTSRGSC3.4
Celera1154,299,422 - 154,299,769UniSTS
Cytogenetic Map1q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 60 160 86 85 54 88 54 6 340 181 11 131 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_133527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF219904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF219905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF219906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC157811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM059473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM060472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU095827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000026962   ⟹   ENSRNOP00000026962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1165,631,462 - 165,642,669 (-)Ensembl
mRatBN7.2 Ensembl1156,219,460 - 156,230,667 (-)Ensembl
Rnor_6.0 Ensembl1166,934,462 - 166,943,592 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079675   ⟹   ENSRNOP00000071311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1166,934,460 - 166,939,541 (-)Ensembl
RefSeq Acc Id: NM_133527   ⟹   NP_598211
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,631,462 - 165,642,669 (-)NCBI
mRatBN7.21156,219,460 - 156,230,667 (-)NCBI
Rnor_6.01166,934,457 - 166,945,845 (-)NCBI
Rnor_5.01173,124,242 - 173,135,651 (-)NCBI
RGSC_v3.41159,315,191 - 159,324,141 (-)RGD
Celera1154,298,870 - 154,310,077 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229842   ⟹   XP_006229904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,631,466 - 165,639,634 (-)NCBI
mRatBN7.21156,219,574 - 156,227,508 (-)NCBI
Rnor_6.01166,934,457 - 166,942,684 (-)NCBI
Rnor_5.01173,124,242 - 173,135,651 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588710   ⟹   XP_017444199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,631,466 - 165,641,291 (-)NCBI
mRatBN7.21156,219,464 - 156,229,294 (-)NCBI
Rnor_6.01166,934,457 - 166,944,455 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588711   ⟹   XP_017444200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,631,466 - 165,641,288 (-)NCBI
mRatBN7.21156,219,464 - 156,229,293 (-)NCBI
Rnor_6.01166,934,457 - 166,945,864 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085665   ⟹   XP_038941593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,631,466 - 165,650,430 (-)NCBI
mRatBN7.21156,219,460 - 156,238,435 (-)NCBI
RefSeq Acc Id: XM_039085707   ⟹   XP_038941635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,631,466 - 165,650,430 (-)NCBI
mRatBN7.21156,219,574 - 156,238,436 (-)NCBI
RefSeq Acc Id: XM_039085757   ⟹   XP_038941685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,631,466 - 165,650,428 (-)NCBI
mRatBN7.21156,219,464 - 156,238,434 (-)NCBI
RefSeq Acc Id: XM_063273293   ⟹   XP_063129363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,631,466 - 165,639,566 (-)NCBI
RefSeq Acc Id: XM_063273361   ⟹   XP_063129431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,631,466 - 165,650,428 (-)NCBI
RefSeq Acc Id: XM_063273405   ⟹   XP_063129475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,631,466 - 165,642,650 (-)NCBI
RefSeq Acc Id: NP_598211   ⟸   NM_133527
- Peptide Label: precursor
- UniProtKB: G3V8M6 (UniProtKB/TrEMBL),   A6I6X2 (UniProtKB/TrEMBL),   Q9JL02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229904   ⟸   XM_006229842
- Peptide Label: isoform X1
- UniProtKB: G3V8M6 (UniProtKB/TrEMBL),   A6I6X2 (UniProtKB/TrEMBL),   Q9JL02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444200   ⟸   XM_017588711
- Peptide Label: isoform X1
- UniProtKB: G3V8M6 (UniProtKB/TrEMBL),   A6I6X2 (UniProtKB/TrEMBL),   Q9JL02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444199   ⟸   XM_017588710
- Peptide Label: isoform X1
- UniProtKB: G3V8M6 (UniProtKB/TrEMBL),   A6I6X2 (UniProtKB/TrEMBL),   Q9JL02 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071311   ⟸   ENSRNOT00000079675
Ensembl Acc Id: ENSRNOP00000026962   ⟸   ENSRNOT00000026962
RefSeq Acc Id: XP_038941593   ⟸   XM_039085665
- Peptide Label: isoform X1
- UniProtKB: G3V8M6 (UniProtKB/TrEMBL),   A6I6X2 (UniProtKB/TrEMBL),   Q9JL02 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941685   ⟸   XM_039085757
- Peptide Label: isoform X1
- UniProtKB: G3V8M6 (UniProtKB/TrEMBL),   A6I6X2 (UniProtKB/TrEMBL),   Q9JL02 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941635   ⟸   XM_039085707
- Peptide Label: isoform X1
- UniProtKB: G3V8M6 (UniProtKB/TrEMBL),   A6I6X2 (UniProtKB/TrEMBL),   Q9JL02 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129431   ⟸   XM_063273361
- Peptide Label: isoform X1
- UniProtKB: Q9JL02 (UniProtKB/TrEMBL),   A6I6X2 (UniProtKB/TrEMBL),   G3V8M6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129475   ⟸   XM_063273405
- Peptide Label: isoform X1
- UniProtKB: Q9JL02 (UniProtKB/TrEMBL),   A6I6X2 (UniProtKB/TrEMBL),   G3V8M6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129363   ⟸   XM_063273293
- Peptide Label: isoform X2
- UniProtKB: Q9JL02 (UniProtKB/TrEMBL)
Protein Domains
Folate receptor-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V8M6-F1-model_v2 AlphaFold G3V8M6 1-255 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690263
Promoter ID:EPDNEW_R786
Type:multiple initiation site
Name:Folr1_1
Description:folate receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01166,943,650 - 166,943,710EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71032 AgrOrtholog
BioCyc Gene G2FUF-58272 BioCyc
Ensembl Genes ENSRNOG00000019902 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026962 ENTREZGENE
  ENSRNOT00000026962.6 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9088301 IMAGE-MGC_LOAD
InterPro Folate_rcpt UniProtKB/TrEMBL
  Folate_rcpt-like UniProtKB/TrEMBL
KEGG Report rno:171049 UniProtKB/TrEMBL
MGC_CLONE MGC:187337 IMAGE-MGC_LOAD
NCBI Gene 171049 ENTREZGENE
PANTHER Folt_rcpt UniProtKB/TrEMBL
  PTHR10517:SF15 UniProtKB/TrEMBL
Pfam Folate_rec UniProtKB/TrEMBL
PhenoGen Folr1 PhenoGen
RatGTEx ENSRNOG00000019902 RatGTEx
UniProt A6I6X2 ENTREZGENE, UniProtKB/TrEMBL
  A6I6X6_RAT UniProtKB/TrEMBL
  A9UMV5_RAT UniProtKB/TrEMBL
  G3V8M6 ENTREZGENE, UniProtKB/TrEMBL
  Q9JL02 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-05-23 Folr1  folate receptor alpha  Folr1  folate receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-29 Folr1  folate receptor 1  Folr1  folate receptor 1 (adult)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Folr1  folate receptor 1 (adult)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization protein found on the brush borders of kidney tubules 1358236
gene_function reabsorbs folate from the renal tubular fluid 1358236
gene_homology 72-92% homology with Folr1 cDNAs from mouse, human and pig; high amino acid sequence homology among known members of the folate receptor family 70742
gene_regulation the shorter of the two mRNA species in the kidney may be transcribed from a second promoter immediately upstream of exon 3, possibly located within the second intron 70742
gene_regulation protein levels increase in tissue culture cells under conditions of low folate concentration 1358236
gene_regulation in vivo under conditions of low folate concentration, levels of Folr1 protein but not mRNA are decreased in kidney, apparently due to the proteolysis of unsaturated receptor resulting from decreased levels of folate in the glomerular filtrate; levels of protein in liver and brain are essentially unaffected under the same conditions 1358236
gene_transcript kidney expresses two transcripts which differ in the length of their 5' untranslated regions by 311 nucleotides; the mRNA expressed in brain is intermediate in length between the two kidney transcripts 70742
gene_transcript approximately 10 kb in size and has 7 exons and 6 introns 70742