Adh4 (alcohol dehydrogenase 4 (class II), pi polypeptide) - Rat Genome Database

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Gene: Adh4 (alcohol dehydrogenase 4 (class II), pi polypeptide) Rattus norvegicus
Analyze
Symbol: Adh4
Name: alcohol dehydrogenase 4 (class II), pi polypeptide
RGD ID: 71028
Description: Predicted to enable several functions, including alcohol dehydrogenase [NAD(P)+] activity; benzaldehyde dehydrogenase (NAD+) activity; and retinoid binding activity. Involved in ovulation cycle and response to ethanol. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide); PARTICIPATES IN fatty acid metabolic pathway; gluconeogenesis pathway; glycolysis pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 1H-pyrazole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ac1002; ADH-1; ADH2; alcohol dehydrogenase 2; alcohol dehydrogenase 4; alcohol dehydrogenase 4-like; alcohol dehydrogenase class II; alcohol dehydrogenase II; all-trans-retinol dehydrogenase [NAD(+)] ADH4; class II alcohol dehydrogenase, pi subunit
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82229,622,092 - 229,640,120 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2229,622,095 - 229,641,879 (+)EnsemblGRCr8
mRatBN7.22226,948,717 - 226,966,747 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2226,947,466 - 226,987,591 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2234,697,253 - 234,715,474 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02232,596,984 - 232,615,201 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02227,461,666 - 227,479,885 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02243,702,035 - 243,720,063 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2243,700,784 - 243,740,899 (+)Ensemblrn6Rnor6.0
Rnor_5.02262,237,059 - 262,254,499 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42235,952,313 - 235,970,671 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2219,105,553 - 219,122,791 (+)NCBICelera
RGSC_v3.12235,939,028 - 235,957,343 (+)NCBI
Cytogenetic Map2q44NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinal  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
atazanavir sulfate  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chloroethene  (ISO)
cimetidine  (ISO)
clofibrate  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
dibenzofurans  (ISO)
dicrotophos  (ISO)
endosulfan  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylene glycol  (ISO)
fenofibrate  (ISO)
fipronil  (EXP)
flutamide  (EXP)
fomepizole  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GW 7647  (ISO)
indometacin  (EXP,ISO)
isoniazide  (ISO)
L-ethionine  (EXP)
Lasiocarpine  (ISO)
lead(0)  (ISO)
metformin  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP,ISO)
niclosamide  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
orphenadrine  (EXP)
ozone  (EXP)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
propan-2-ol  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Sunset Yellow FCF  (ISO)
tartrazine  (ISO)
tebuconazole  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
triadimefon  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Role of extrahepatic alcohol dehydrogenase in rat ethanol metabolism. Boleda MD, etal., Arch Biochem Biophys 1989 Oct;274(1):74-81.
2. Severity of alcohol withdrawal symptoms depends on developmental stage of Long-Evans rats. Chung CS, etal., Pharmacol Biochem Behav. 2008 Apr;89(2):137-44. Epub 2007 Dec 8.
3. Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain. Galter D, etal., Eur J Biochem 2003 Mar;270(6):1316-26.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Cloning and characterization of a novel rat alcohol dehydrogenase of class II type. Hoog JO FEBS Lett 1995 Jul 24;368(3):445-8.
7. Characterization of three isoenzymes of rat alcohol dehydrogenase. Tissue distribution and physical and enzymatic properties. Julia P, etal., Eur J Biochem 1987 Jan 2;162(1):179-89.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Gender differences in the genetic risk for alcohol dependence--the results of a pharmacogenetic study in Korean alcoholics. Kim SG, Nihon Arukoru Yakubutsu Igakkai Zasshi. 2009 Dec;44(6):680-5.
10. Gene Data Set MGD Curation, June 12, 2002
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Changes in the activity of alcohol dehydrogenase isoenzymes during the estrus cycle in the vagina of the rat. Nowak C, etal., Histochem J. 2000 Aug;32(8):515-20.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. A rodent model of low- to moderate-dose ethanol consumption during pregnancy: patterns of ethanol consumption and effects on fetal and offspring growth. Probyn ME, etal., Reprod Fertil Dev. 2012;24(6):859-70. doi: 10.1071/RD11200.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Ethanol concentration-dependent alterations in gene expression during acute binge drinking in the HIV-1 transgenic rat. Sarkar S and Chang SL, Alcohol Clin Exp Res. 2013 Jul;37(7):1082-90. doi: 10.1111/acer.12077. Epub 2013 Feb 15.
20. Molecular analysis of cluster headache. Zarrilli F, etal., Clin J Pain. 2015 Jan;31(1):52-7. doi: 10.1097/AJP.0000000000000075.
Additional References at PubMed
PMID:9982   PMID:518534   PMID:3466164   PMID:10407146   PMID:10514444   PMID:12477932   PMID:12787032   PMID:15369820   PMID:16081420   PMID:16787387   PMID:17257171   PMID:17279314  


Genomics

Comparative Map Data
Adh4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82229,622,092 - 229,640,120 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2229,622,095 - 229,641,879 (+)EnsemblGRCr8
mRatBN7.22226,948,717 - 226,966,747 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2226,947,466 - 226,987,591 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2234,697,253 - 234,715,474 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02232,596,984 - 232,615,201 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02227,461,666 - 227,479,885 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02243,702,035 - 243,720,063 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2243,700,784 - 243,740,899 (+)Ensemblrn6Rnor6.0
Rnor_5.02262,237,059 - 262,254,499 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42235,952,313 - 235,970,671 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2219,105,553 - 219,122,791 (+)NCBICelera
RGSC_v3.12235,939,028 - 235,957,343 (+)NCBI
Cytogenetic Map2q44NCBI
ADH4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38499,123,658 - 99,144,297 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl499,123,657 - 99,157,792 (-)Ensemblhg38GRCh38
GRCh374100,044,809 - 100,065,448 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364100,263,855 - 100,284,472 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344100,401,812 - 100,423,028NCBI
Celera497,342,359 - 97,362,981 (-)NCBICelera
Cytogenetic Map4q23NCBI
HuRef495,782,906 - 95,803,527 (-)NCBIHuRef
CHM1_14100,021,522 - 100,042,141 (-)NCBICHM1_1
T2T-CHM13v2.04102,438,693 - 102,459,340 (-)NCBIT2T-CHM13v2.0
Adh4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393138,121,217 - 138,138,444 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3138,121,227 - 138,136,653 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm383138,415,456 - 138,432,683 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3138,415,466 - 138,430,892 (+)Ensemblmm10GRCm38
MGSCv373138,078,461 - 138,093,856 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363138,352,896 - 138,368,279 (+)NCBIMGSCv36mm8
Celera3144,836,181 - 144,853,583 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map364.24NCBI
ADH4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2397,188,649 - 97,209,293 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1497,464,601 - 97,485,231 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0491,522,444 - 91,543,086 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14102,186,670 - 102,206,923 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4102,183,956 - 102,206,923 (-)EnsemblpanPan2panpan1.1
ADH4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13221,282,526 - 21,299,387 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3221,282,890 - 21,299,328 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3220,631,099 - 20,647,963 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03221,468,468 - 21,485,373 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3221,468,474 - 21,485,323 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13221,433,849 - 21,450,220 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03221,260,783 - 21,277,661 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03218,617,963 - 18,634,846 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
ADH4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8121,225,656 - 121,261,746 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18121,225,485 - 121,259,262 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X98,582,002 - 98,583,002 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28130,409,996 - 130,434,606 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADH4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1747,226,787 - 47,248,518 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl747,226,191 - 47,248,234 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603725,658,415 - 25,678,570 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Adh4
169 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:72
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000016891
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2212145502231732847Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2202029709236904960Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2210956252251712708Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2219814164239320906Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2214404877251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2214404877251712708Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2218051934251712708Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2214404877251712708Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2214404877251712708Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2221088977243501206Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2203664411248664411Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2214404877251712708Rat
8693622Alc26Alcohol consumption QTL 262.40.667drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2223810546243965570Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
21 11 61 146 91 90 59 64 59 6 323 155 8 124 80 87 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000016891   ⟹   ENSRNOP00000016891
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2229,623,109 - 229,638,634 (+)Ensembl
mRatBN7.2 Ensembl2226,949,734 - 226,965,261 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000017252   ⟹   ENSRNOP00000017252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2226,975,098 - 226,987,591 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090253   ⟹   ENSRNOP00000069857
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2226,947,466 - 226,986,716 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104576   ⟹   ENSRNOP00000077866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2229,622,095 - 229,641,879 (+)Ensembl
mRatBN7.2 Ensembl2226,948,717 - 226,966,747 (+)Ensembl
RefSeq Acc Id: NM_017270   ⟹   NP_058966
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82229,622,092 - 229,640,120 (+)NCBI
mRatBN7.22226,948,717 - 226,966,747 (+)NCBI
Rnor_6.02243,702,035 - 243,720,063 (+)NCBI
Rnor_5.02262,237,059 - 262,254,499 (+)NCBI
RGSC_v3.42235,952,313 - 235,970,671 (+)RGD
Celera2219,105,553 - 219,122,791 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_058966 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI27505 (Get FASTA)   NCBI Sequence Viewer  
  CAA62241 (Get FASTA)   NCBI Sequence Viewer  
  EDL82319 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000077866
GenBank Protein Q64563 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058966   ⟸   NM_017270
- UniProtKB: Q64563 (UniProtKB/Swiss-Prot),   A1L128 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000077866   ⟸   ENSRNOT00000104576
Ensembl Acc Id: ENSRNOP00000069857   ⟸   ENSRNOT00000090253
Ensembl Acc Id: ENSRNOP00000017252   ⟸   ENSRNOT00000017252
Ensembl Acc Id: ENSRNOP00000016891   ⟸   ENSRNOT00000016891
Protein Domains
Alcohol dehydrogenase-like C-terminal   Enoyl reductase (ER)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64563-F1-model_v2 AlphaFold Q64563 1-377 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691787
Promoter ID:EPDNEW_R2312
Type:initiation region
Name:Adh4_2
Description:alcohol dehydrogenase 4 , pi polypeptide
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2313  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02243,702,010 - 243,702,070EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71028 AgrOrtholog
BioCyc Gene G2FUF-51067 BioCyc
Ensembl Genes ENSRNOG00000046357 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000104576 ENTREZGENE
Gene3D-CATH Medium-chain alcohol dehydrogenases, catalytic domain UniProtKB/Swiss-Prot
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7325543 IMAGE-MGC_LOAD
InterPro ADH_C UniProtKB/Swiss-Prot
  ADH_N UniProtKB/Swiss-Prot
  ADH_Zn_CS UniProtKB/Swiss-Prot
  GroES-like_sf UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  PKS_ER UniProtKB/Swiss-Prot
MGC_CLONE MGC:156669 IMAGE-MGC_LOAD
NCBI Gene 29646 ENTREZGENE
PANTHER ALCOHOL DEHYDROGENASE UniProtKB/Swiss-Prot
  PTHR43880:SF14 UniProtKB/Swiss-Prot
Pfam ADH_N UniProtKB/Swiss-Prot
  ADH_zinc_N UniProtKB/Swiss-Prot
PharmGKB ADH4 RGD
PhenoGen Adh4 PhenoGen
PROSITE ADH_ZINC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000046357 RatGTEx
SMART PKS_ER UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50129 UniProtKB/Swiss-Prot
  SSF51735 UniProtKB/Swiss-Prot
UniProt A1L128 ENTREZGENE, UniProtKB/TrEMBL
  A6HW33_RAT UniProtKB/TrEMBL
  ADH4_RAT UniProtKB/Swiss-Prot
  F7F9U1_RAT UniProtKB/TrEMBL
  Q64563 ENTREZGENE
  Q7TQ90_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Adh4  alcohol dehydrogenase 4 (class II), pi polypeptide      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs probably responsible for the residual ethanol oxidation activity seen in rats treated with the Adh inhibitor pyrazole 1358222
gene_expression mRNA expressed in liver, duodenum, kidney, stomach and testis 70799
gene_expression protein expressed most strongly in ocular tissues, stomach and lung 1358148
gene_homology 73% amino acid identity compared to human ADH class II, 55% identity vs rat class I, 57% vs rat class III and 52% vs rat class IV 70799
gene_protein rat protein has amino acid deletions around position 60 and positions 294-295 compared to the human ADH4 enzyme which may change the shape and binding properties of the active site pocket 70799
gene_protein protein consists of two 40 kDa subunits, contains four atoms of zinc, uses NAD+ as a cofactor, and demonstrates a broad substrate specificity with a Km for ethanol of 340 mM 1358148