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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71028
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adh4
Name: alcohol dehydrogenase 4 (class II), pi polypeptide
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adh4affects oxidationISOADH4 (Homo sapiens)6480464CTDADH4 promoter polymorphism affects the oxidation of EthanolPMID:19182438
Adh4decreases expressionISOAdh4 (Mus musculus)6480464CTDEthanol results in decreased expression of ADH4 mRNAPMID:19637192
Adh4increases metabolic processingISOADH4 (Homo sapiens)6480464CTDADH4 protein results in increased metabolism of EthanolPMID:19822198
Adh4increases oxidationISOADH4 (Homo sapiens)6480464CTDADH4 protein results in increased oxidation of EthanolPMID:19182438 PMID:21167143 PMID:23220590
Adh4multiple interactionsISOADH4 (Homo sapiens)6480464CTD2,6-dichloro-4-nitrophenol inhibits the reaction [ADH4 protein results in increased metabolism of Ethanol]; Cimetidine inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol]; fomepizole inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol]; Pentachlorophenol inhibits the reaction [ADH4 protein results in increased metabolism of Ethanol]PMID:19822198 PMID:21167143 PMID:23220590
Adh4multiple interactionsISOAdh4 (Mus musculus)6480464CTDZinc inhibits the reaction [Ethanol results in decreased expression of ADH4 mRNA]PMID:19637192
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