Opa1 (OPA1, mitochondrial dynamin like GTPase) - Rat Genome Database

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Gene: Opa1 (OPA1, mitochondrial dynamin like GTPase) Rattus norvegicus
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Symbol: Opa1
Name: OPA1, mitochondrial dynamin like GTPase
RGD ID: 708423
Description: Enables kinase binding activity. Involved in several processes, including cellular response to L-glutamate; intracellular distribution of mitochondria; and positive regulation of cellular component organization. Located in mitochondrial inner membrane. Used to study transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); chronic kidney disease; ocular hypertension; rhinitis; and steatotic liver disease. Human ortholog(s) of this gene implicated in Behr syndrome; dominant optic atrophy plus syndrome; mitochondrial DNA depletion syndrome 14; optic atrophy; and optic atrophy 1. Orthologous to human OPA1 (OPA1 mitochondrial dynamin like GTPase); PARTICIPATES IN mitochondria fusion pathway; INTERACTS WITH 2,6-dinitrotoluene; 4-DAMP(1+); acrolein.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dynamin-like 120 kDa protein, mitochondrial; dynamin-like GTPase OPA1, mitochondrial; LOC171116; MGC124921; mitochondrial OPA1; optic atrophy 1; optic atrophy 1 (autosomal dominant); optic atrophy 1 homolog; optic atrophy 1 homolog (human); optic atrophy 1-like protein; optic atrophy protein 1 homolog; RN protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81184,612,943 - 84,690,025 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1184,615,340 - 84,689,955 (-)EnsemblGRCr8
mRatBN7.21171,108,100 - 71,185,170 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1171,109,873 - 71,185,109 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1179,954,641 - 80,028,866 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01172,589,604 - 72,663,829 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01171,643,710 - 71,718,085 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01174,717,600 - 74,793,902 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1174,720,254 - 74,793,803 (-)Ensemblrn6Rnor6.0
Rnor_5.01177,761,813 - 77,840,630 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41173,005,470 - 73,058,136 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1170,077,956 - 70,151,932 (-)NCBICelera
RGSC_v3.11173,063,058 - 73,115,780 (-)NCBI
Cytogenetic Map11q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dicyclohexylcarbodiimide  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (EXP)
2-methoxy-17beta-estradiol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-DAMP(1+)  (EXP)
4-phenylbutyric acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
A-967079  (ISO)
acetaldehyde  (ISO)
aconitine  (ISO)
acrolein  (EXP,ISO)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (EXP,ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
Bardoxolone methyl  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (EXP)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carnosic acid  (ISO)
CCCP  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP,ISO)
curcumin  (EXP)
cycloheximide  (EXP)
D-glucose  (EXP,ISO)
DDE  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diafenthiuron  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (EXP)
dioxygen  (EXP)
diquat  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
efavirenz  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
fenbendazole  (ISO)
fenofibrate  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
glucose  (EXP,ISO)
hexadecanoic acid  (ISO)
Honokiol  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
lamivudine  (ISO)
lenvatinib  (EXP)
Licarin A  (ISO)
lipoic acid  (ISO)
lycopene  (ISO)
manganese(II) chloride  (ISO)
melatonin  (EXP,ISO)
metformin  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
monocrotaline  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (EXP)
nitrogen dioxide  (ISO)
ochratoxin A  (ISO)
okadaic acid  (EXP)
oxidopamine  (EXP,ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (EXP)
piroxicam  (ISO)
Pseudolaric acid B  (ISO)
psoralen  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
regorafenib  (EXP)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
Salvianolic acid A  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sevoflurane  (EXP)
silibinin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sulfur dioxide  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
trans-cinnamic acid  (EXP)
triphenyl phosphate  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
verteporfin  (EXP)
vinclozolin  (EXP)
XAV939  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
calcium import into the mitochondrion  (IMP)
cellular response to glucose stimulus  (IEP)
cellular response to hypoxia  (IEP)
cellular response to L-glutamate  (IEP)
cellular senescence  (IEA,ISO,ISS)
cochlea development  (IEP)
cristae formation  (IEA,ISO)
GTP metabolic process  (IEA,ISO,ISS)
inner mitochondrial membrane organization  (IEA,ISO,ISS)
intracellular distribution of mitochondria  (IMP)
membrane fusion  (IEA)
membrane tubulation  (IEA,ISO,ISS)
mitochondrial fusion  (IBA,IEA,ISO,ISS)
mitochondrial inner membrane fusion  (IEA,ISO,ISS)
mitochondrion organization  (IDA,IEA,IMP,ISO,ISS)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IEA,ISO,ISS)
negative regulation of intrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of release of cytochrome c from mitochondria  (IEA,ISO,ISS)
neural tube closure  (ISO)
peroxisome fission  (IBA)
positive regulation of cellular response to insulin stimulus  (IMP)
positive regulation of dendrite development  (IMP)
positive regulation of dendritic spine morphogenesis  (IMP)
positive regulation of insulin receptor signaling pathway  (IMP)
positive regulation of interleukin-17 production  (IEA,ISO,ISS)
positive regulation of mitochondrial fusion  (IMP)
positive regulation of neuron maturation  (IMP)
positive regulation of T-helper 17 cell lineage commitment  (IEA,ISO,ISS)
protein complex oligomerization  (IEA,ISO)
regulation of mitochondrion organization  (IEA)
response to curcumin  (IEP)
response to electrical stimulus  (IEP)
response to muscle activity  (IEP)
response to nutrient levels  (IEP)
retina development in camera-type eye  (IEP)
visual perception  (IEA,ISO,ISS)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy. Alavi MV, etal., Brain. 2007 Apr;130(Pt 4):1029-42. Epub 2007 Feb 21.
2. Curcumin prevents mitochondrial dynamics disturbances in early 5/6 nephrectomy: Relation to oxidative stress and mitochondrial bioenergetics. Aparicio-Trejo OE, etal., Biofactors. 2016 Nov 1. doi: 10.1002/biof.1338.
3. A major marker for normal tension glaucoma: association with polymorphisms in the OPA1 gene. Aung T, etal., Hum Genet. 2002 Jan;110(1):52-6. Epub 2001 Nov 23.
4. Investigating the association between OPA1 polymorphisms and glaucoma: comparison between normal tension and high tension primary open angle glaucoma. Aung T, etal., Hum Genet. 2002 May;110(5):513-4. Epub 2002 Apr 10.
5. OPA1 loss of function affects in vitro neuronal maturation. Bertholet AM, etal., Brain. 2013 May;136(Pt 5):1518-33. doi: 10.1093/brain/awt060. Epub 2013 Mar 29.
6. OPA1, the disease gene for optic atrophy type Kjer, is expressed in the inner ear. Bette S, etal., Histochem Cell Biol. 2007 Nov;128(5):421-30. Epub 2007 Sep 8.
7. In utero exposure to prepregnancy maternal obesity and postweaning high-fat diet impair regulators of mitochondrial dynamics in rat placenta and offspring. Borengasser SJ, etal., Physiol Genomics. 2014 Dec 1;46(23):841-50. doi: 10.1152/physiolgenomics.00059.2014. Epub 2014 Oct 21.
8. Down-regulation of OPA1 in patients with primary open angle glaucoma. Bosley TM, etal., Mol Vis. 2011 Apr 27;17:1074-9.
9. Mitochondrial OPA1, apoptosis, and heart failure. Chen L, etal., Cardiovasc Res. 2009 Oct 1;84(1):91-9. doi: 10.1093/cvr/cvp181. Epub 2009 Jun 3.
10. OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability. Chen L, etal., J Am Heart Assoc. 2012 Oct;1(5):e003012. doi: 10.1161/JAHA.112.003012. Epub 2012 Oct 25.
11. Mutation survey of the optic atrophy 1 gene in 193 Chinese families with suspected hereditary optic neuropathy. Chen Y, etal., Mol Vis. 2013;19:292-302. Epub 2013 Feb 6.
12. Autosomal dominant optic atrophy: penetrance and expressivity in patients with OPA1 mutations. Cohn AC, etal., Am J Ophthalmol. 2007 Apr;143(4):656-62. Epub 2007 Feb 15.
13. Mitochondria dynamism: of shape, transport and cell migration. da Silva AF, etal., Cell Mol Life Sci. 2014 Jun;71(12):2313-24. doi: 10.1007/s00018-014-1557-8. Epub 2014 Jan 18.
14. Inducible nitric oxide synthase-mediated alteration of mitochondrial OPA1 expression in ocular hypertensive rats. Dai Y, etal., Invest Ophthalmol Vis Sci. 2011 Apr 16;52(5):2468-76. doi: 10.1167/iovs.10-5873.
15. Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function. Davies VJ, etal., Hum Mol Genet. 2007 Jun 1;16(11):1307-18. Epub 2007 Apr 11.
16. Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through mitochondrial Ca2+ uptake. del Campo A, etal., Am J Physiol Endocrinol Metab. 2014 Jan 1;306(1):E1-E13. doi: 10.1152/ajpendo.00146.2013. Epub 2013 Oct 1.
17. Solving a 50 year mystery of a missing OPA1 mutation: more insights from the first family diagnosed with autosomal dominant optic atrophy. Fuhrmann N, etal., Mol Neurodegener. 2010 Jun 14;5:25. doi: 10.1186/1750-1326-5-25.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
20. PM2.5-Induced Oxidative Stress and Mitochondrial Damage in the Nasal Mucosa of Rats. Guo Z, etal., Int J Environ Res Public Health. 2017 Jan 29;14(2). pii: E134. doi: 10.3390/ijerph14020134.
21. OPA1 mutations and mitochondrial DNA haplotypes in autosomal dominant optic atrophy. Han J, etal., Genet Med. 2006 Apr;8(4):217-25.
22. Parkin overexpression protects retinal ganglion cells against glutamate excitotoxicity. Hu X, etal., Mol Vis. 2017 Jul 19;23:447-456. eCollection 2017.
23. Regulation of mitochondrial morphology through proteolytic cleavage of OPA1. Ishihara N, etal., EMBO J. 2006 Jul 12;25(13):2966-77. Epub 2006 Jun 15.
24. Expression of mitochondrial fusion-fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition. Javadov S, etal., Basic Res Cardiol. 2011 Jan;106(1):99-109. doi: 10.1007/s00395-010-0122-3. Epub 2010 Oct 1.
25. Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina. Ju WK, etal., Invest Ophthalmol Vis Sci. 2009 Feb;50(2):707-16. doi: 10.1167/iovs.08-2499. Epub 2008 Oct 20.
26. Glutamate receptor activation triggers OPA1 release and induces apoptotic cell death in ischemic rat retina. Ju WK, etal., Mol Vis. 2008;14:2629-38. Epub 2008 Dec 31.
27. Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells. Ju WK, etal., Mol Vis. 2009;15:120-34. Epub 2009 Jan 19.
28. Increased optic atrophy type 1 expression protects retinal ganglion cells in a mouse model of glaucoma. Ju WK, etal., Mol Vis. 2010 Jul 15;16:1331-42.
29. Expression of the Opa1 mitochondrial protein in retinal ganglion cells: its downregulation causes aggregation of the mitochondrial network. Kamei S, etal., Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4288-94.
30. Mitochondrial remodeling following fission inhibition by 15d-PGJ2 involves molecular changes in mitochondrial fusion protein OPA1. Kar R, etal., Biochem Biophys Res Commun. 2010 Sep 3;399(4):548-54. doi: 10.1016/j.bbrc.2010.07.108. Epub 2010 Aug 1.
31. Effect of electrical stimulation-induced resistance exercise on mitochondrial fission and fusion proteins in rat skeletal muscle. Kitaoka Y, etal., Appl Physiol Nutr Metab. 2015 Nov;40(11):1137-42. doi: 10.1139/apnm-2015-0184. Epub 2015 Jul 14.
32. Effect of ambient PM(2.5) on lung mitochondrial damage and fusion/fission gene expression in rats. Li R, etal., Chem Res Toxicol. 2015 Mar 16;28(3):408-18. doi: 10.1021/tx5003723. Epub 2015 Jan 16.
33. Mitochondrial damage: an important mechanism of ambient PM2.5 exposure-induced acute heart injury in rats. Li R, etal., J Hazard Mater. 2015 Apr 28;287:392-401. doi: 10.1016/j.jhazmat.2015.02.006. Epub 2015 Feb 4.
34. Identification of two novel OPA1 mutations in Chinese families with autosomal dominant optic atrophy. Li Y, etal., Mol Vis. 2008;14:2451-7. Epub 2008 Dec 29.
35. High-lard and high-fish-oil diets differ in their effects on function and dynamic behaviour of rat hepatic mitochondria. Lionetti L, etal., PLoS One. 2014 Mar 24;9(3):e92753. doi: 10.1371/journal.pone.0092753. eCollection 2014.
36. Dynamic changes of mitochondrial fusion and fission proteins after transient cerebral ischemia in mice. Liu W, etal., J Neurosci Res. 2012 Jun;90(6):1183-9. doi: 10.1002/jnr.23016. Epub 2012 Feb 16.
37. No association between OPA1 polymorphisms and primary open-angle glaucoma in three different populations. Liu Y, etal., Mol Vis. 2007 Nov 26;13:2137-41.
38. Mitochondrial dysfunction is associated with a pro-apoptotic cellular environment in senescent cardiac muscle. Ljubicic V, etal., Mech Ageing Dev. 2010 Feb;131(2):79-88. doi: 10.1016/j.mad.2009.12.004. Epub 2009 Dec 29.
39. The OPA1 gene polymorphism is associated with normal tension and high tension glaucoma. Mabuchi F, etal., Am J Ophthalmol. 2007 Jan;143(1):125-130. Epub 2006 Oct 23.
40. Exercise and Doxorubicin Treatment Modulate Cardiac Mitochondrial Quality Control Signaling. Marques-Aleixo I, etal., Cardiovasc Toxicol. 2017 May 23. doi: 10.1007/s12012-017-9412-4.
41. Hydrogen sulfide pretreatment improves mitochondrial function in myocardial hypertrophy via a SIRT3 dependent manner. Meng G, etal., Br J Pharmacol. 2017 May 15. doi: 10.1111/bph.13861.
42. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
43. Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration. Misko AL, etal., J Neurosci. 2012 Mar 21;32(12):4145-55. doi: 10.1523/JNEUROSCI.6338-11.2012.
44. Novel mutations in the OPA1 gene and associated clinical features in Japanese patients with optic atrophy. Nakamura M, etal., Ophthalmology. 2006 Mar;113(3):483-488.e1.
45. Adaptive plasticity of autophagic proteins to denervation in aging skeletal muscle. O'Leary MF, etal., Am J Physiol Cell Physiol. 2013 Mar 1;304(5):C422-30. doi: 10.1152/ajpcell.00240.2012. Epub 2012 Dec 5.
46. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
47. The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery. Palmer CS, etal., Cell Signal. 2011 Oct;23(10):1534-45. doi: 10.1016/j.cellsig.2011.05.021. Epub 2011 Jun 13.
48. OPA1, the disease gene for autosomal dominant optic atrophy, is specifically expressed in ganglion cells and intrinsic neurons of the retina. Pesch UE, etal., Invest Ophthalmol Vis Sci 2004 Nov;45(11):4217-25.
49. Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload. Piquereau J, etal., Cardiovasc Res. 2012 Jun 1;94(3):408-17. doi: 10.1093/cvr/cvs117. Epub 2012 Mar 8.
50. Novel OPA1 mutations identified in Japanese pedigrees with optic atrophy. Qin M, etal., Mol Vis. 2006 May 12;12:485-91.
51. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
52. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
53. Comprehensive gene review and curation RGD comprehensive gene curation
54. Perturbation in mitochondrial network dynamics and in complex I dependent cellular respiration in schizophrenia. Rosenfeld M, etal., Biol Psychiatry. 2011 May 15;69(10):980-8. doi: 10.1016/j.biopsych.2011.01.010. Epub 2011 Mar 11.
55. Dual function of mitochondrial Nm23-H4 protein in phosphotransfer and intermembrane lipid transfer: a cardiolipin-dependent switch. Schlattner U, etal., J Biol Chem. 2013 Jan 4;288(1):111-21. doi: 10.1074/jbc.M112.408633. Epub 2012 Nov 13.
56. Compromised mitochondrial remodeling in compensatory hypertrophied myocardium of spontaneously hypertensive rat. Tang Y, etal., Cardiovasc Pathol. 2013 Nov 14. pii: S1054-8807(13)00200-7. doi: 10.1016/j.carpath.2013.11.002.
57. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. Wang X, etal., J Neurosci. 2009 Jul 15;29(28):9090-103. doi: 10.1523/JNEUROSCI.1357-09.2009.
58. Vagal nerve stimulation improves mitochondrial dynamics via an M3 receptor/CaMKKß/AMPK pathway in isoproterenol-induced myocardial ischaemia. Xue RQ, etal., J Cell Mol Med. 2017 Jan;21(1):58-71. doi: 10.1111/jcmm.12938. Epub 2016 Aug 5.
59. Evaluation of the association between OPA1 polymorphisms and primary open-angle glaucoma in Barbados families. Yao W, etal., Mol Vis. 2006 Jun 12;12:649-54.
60. Novel mutations of the OPA1 gene in Chinese dominant optic atrophy. Yen MY, etal., Ophthalmology. 2010 Feb;117(2):392-6.e1. doi: 10.1016/j.ophtha.2009.07.019. Epub 2009 Dec 6.
61. High glucose concentration abrogates sevoflurane post-conditioning cardioprotection by advancing mitochondrial fission but dynamin-related protein 1 inhibitor restores these effects. Yu J, etal., Acta Physiol (Oxf). 2016 Sep 29. doi: 10.1111/apha.12812.
62. Sevoflurane postconditioning attenuates cardiomyocyte hypoxia/reoxygenation injury via restoring mitochondrial morphology. Yu J, etal., PeerJ. 2016 Nov 3;4:e2659. eCollection 2016.
63. The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons. Yu W, etal., Hum Mol Genet. 2011 Aug 15;20(16):3227-40. doi: 10.1093/hmg/ddr235. Epub 2011 May 25.
64. Exercise pretreatment promotes mitochondrial dynamic protein OPA1 expression after cerebral ischemia in rats. Zhang L, etal., Int J Mol Sci. 2014 Mar 13;15(3):4453-63. doi: 10.3390/ijms15034453.
Additional References at PubMed
PMID:11017080   PMID:11847212   PMID:12477932   PMID:12504110   PMID:12509422   PMID:12865426   PMID:14651853   PMID:15489334   PMID:15755804   PMID:15899901   PMID:15912498   PMID:16839884  
PMID:17008324   PMID:17035996   PMID:17545159   PMID:18158317   PMID:18614015   PMID:19046944   PMID:19946888   PMID:20038678   PMID:20185555   PMID:20436456   PMID:21149567   PMID:23220553  
PMID:23453807   PMID:23494933   PMID:24632637   PMID:26316108   PMID:26530815   PMID:27667664   PMID:27890624   PMID:28746876   PMID:29476059   PMID:30988455   PMID:31505169   PMID:31519870  
PMID:32901846   PMID:33119220   PMID:33383158   PMID:37814860   PMID:38986925  


Genomics

Comparative Map Data
Opa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81184,612,943 - 84,690,025 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1184,615,340 - 84,689,955 (-)EnsemblGRCr8
mRatBN7.21171,108,100 - 71,185,170 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1171,109,873 - 71,185,109 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1179,954,641 - 80,028,866 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01172,589,604 - 72,663,829 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01171,643,710 - 71,718,085 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01174,717,600 - 74,793,902 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1174,720,254 - 74,793,803 (-)Ensemblrn6Rnor6.0
Rnor_5.01177,761,813 - 77,840,630 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41173,005,470 - 73,058,136 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1170,077,956 - 70,151,932 (-)NCBICelera
RGSC_v3.11173,063,058 - 73,115,780 (-)NCBI
Cytogenetic Map11q22NCBI
OPA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383193,593,208 - 193,697,811 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3193,593,144 - 193,697,811 (+)Ensemblhg38GRCh38
GRCh373193,310,997 - 193,415,600 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363194,793,806 - 194,898,009 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343194,793,813 - 194,898,017NCBI
Celera3191,726,124 - 191,830,778 (+)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3190,698,074 - 190,803,338 (+)NCBIHuRef
CHM1_13193,273,732 - 193,378,486 (+)NCBICHM1_1
T2T-CHM13v2.03196,288,807 - 196,394,453 (+)NCBIT2T-CHM13v2.0
Opa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391629,398,099 - 29,481,924 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1629,398,152 - 29,473,702 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381629,579,281 - 29,663,127 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1629,579,334 - 29,654,884 (+)Ensemblmm10GRCm38
MGSCv371629,579,428 - 29,652,576 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361629,499,089 - 29,572,237 (+)NCBIMGSCv36mm8
Celera1630,084,446 - 30,156,121 (+)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1620.65NCBI
Opa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542014,923,575 - 15,007,081 (-)Ensembl
ChiLan1.0NW_00495542014,927,490 - 15,007,082 (-)NCBIChiLan1.0ChiLan1.0
OPA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22191,515,499 - 191,620,475 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13191,520,223 - 191,625,197 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03190,890,242 - 190,995,133 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13201,207,609 - 201,312,358 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3201,207,607 - 201,312,358 (+)EnsemblpanPan2panpan1.1
OPA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12352,068,123 - 52,154,410 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2352,068,118 - 52,151,593 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2351,880,860 - 51,967,154 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02352,711,633 - 52,798,264 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2352,711,607 - 52,797,401 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12352,292,969 - 52,379,474 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02352,346,071 - 52,432,352 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02352,630,584 - 52,717,188 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Opa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602123,136,008 - 123,222,290 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367111,032,935 - 1,106,847 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367111,027,531 - 1,113,796 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13130,624,796 - 130,719,083 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113130,624,771 - 130,718,345 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213140,148,025 - 140,230,316 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OPA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11587,679,656 - 87,778,767 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1587,679,077 - 87,779,102 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604161,348,078 - 61,447,152 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Opa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473063,911,066 - 63,995,596 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473063,911,066 - 63,994,886 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Opa1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1414,478,312 - 14,556,210 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Opa1
508 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:653
Count of miRNA genes:181
Interacting mature miRNAs:210
Transcripts:ENSRNOT00000002338, ENSRNOT00000002343, ENSRNOT00000063999
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)118295102896351019Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat

Markers in Region
D11Rat105  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81184,639,732 - 84,639,939 (+)Marker Load Pipeline
mRatBN7.21171,134,896 - 71,135,104 (+)MAPPERmRatBN7.2
Rnor_6.01174,743,188 - 74,743,395NCBIRnor6.0
Rnor_5.01177,789,916 - 77,790,123UniSTSRnor5.0
RGSC_v3.41173,007,964 - 73,008,171RGDRGSC3.4
RGSC_v3.41173,007,964 - 73,008,171UniSTSRGSC3.4
Celera1170,101,928 - 70,102,133UniSTS
RGSC_v3.11173,065,553 - 73,065,760RGD
RH 3.4 Map11572.6UniSTS
RH 3.4 Map11572.6RGD
RH 2.0 Map11123.0RGD
SHRSP x BN Map1134.4799RGD
Cytogenetic Map11q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001433907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_133585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY333988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY510274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY660011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY660012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY683458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC111071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U93197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000002338   ⟹   ENSRNOP00000002338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1184,637,170 - 84,685,185 (-)Ensembl
mRatBN7.2 Ensembl1171,132,335 - 71,180,355 (-)Ensembl
Rnor_6.0 Ensembl1174,722,819 - 74,793,673 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000002343   ⟹   ENSRNOP00000002343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1184,615,340 - 84,689,955 (-)Ensembl
mRatBN7.2 Ensembl1171,109,873 - 71,185,109 (-)Ensembl
Rnor_6.0 Ensembl1174,720,254 - 74,793,803 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104752   ⟹   ENSRNOP00000086026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1184,615,340 - 84,689,955 (-)Ensembl
mRatBN7.2 Ensembl1171,109,873 - 71,185,109 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111984   ⟹   ENSRNOP00000079139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1184,615,340 - 84,689,955 (-)Ensembl
mRatBN7.2 Ensembl1171,109,873 - 71,185,109 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117359   ⟹   ENSRNOP00000084440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1184,615,340 - 84,689,955 (-)Ensembl
mRatBN7.2 Ensembl1171,109,873 - 71,185,109 (-)Ensembl
RefSeq Acc Id: NM_133585   ⟹   NP_598269
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81184,615,589 - 84,689,900 (-)NCBI
mRatBN7.21171,110,751 - 71,185,071 (-)NCBI
Rnor_6.01174,720,246 - 74,793,803 (-)NCBI
Rnor_5.01177,761,813 - 77,840,630 (-)NCBI
RGSC_v3.41173,005,470 - 73,058,136 (-)RGD
Celera1170,077,956 - 70,151,932 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248497   ⟹   XP_006248559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81184,612,943 - 84,690,005 (-)NCBI
mRatBN7.21171,108,100 - 71,185,170 (-)NCBI
Rnor_6.01174,717,600 - 74,793,902 (-)NCBI
Rnor_5.01177,761,813 - 77,840,630 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248498   ⟹   XP_006248560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81184,612,943 - 84,690,025 (-)NCBI
mRatBN7.21171,108,100 - 71,185,170 (-)NCBI
Rnor_6.01174,717,600 - 74,793,902 (-)NCBI
Rnor_5.01177,761,813 - 77,840,630 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248499   ⟹   XP_006248561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81184,612,943 - 84,689,999 (-)NCBI
mRatBN7.21171,108,100 - 71,185,170 (-)NCBI
Rnor_6.01174,717,600 - 74,793,902 (-)NCBI
Rnor_5.01177,761,813 - 77,840,630 (-)NCBI
Sequence:
RefSeq Acc Id: NP_598269   ⟸   NM_133585
- Peptide Label: precursor
- UniProtKB: Q6B435 (UniProtKB/Swiss-Prot),   Q5QJE9 (UniProtKB/Swiss-Prot),   Q5MPP2 (UniProtKB/Swiss-Prot),   Q5MPP1 (UniProtKB/Swiss-Prot),   O08681 (UniProtKB/Swiss-Prot),   Q6R611 (UniProtKB/Swiss-Prot),   Q2TA68 (UniProtKB/Swiss-Prot),   A0A8L2PZL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248560   ⟸   XM_006248498
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006248561   ⟸   XM_006248499
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006248559   ⟸   XM_006248497
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000002343   ⟸   ENSRNOT00000002343
Ensembl Acc Id: ENSRNOP00000002338   ⟸   ENSRNOT00000002338
Ensembl Acc Id: ENSRNOP00000079139   ⟸   ENSRNOT00000111984
Ensembl Acc Id: ENSRNOP00000084440   ⟸   ENSRNOT00000117359
Ensembl Acc Id: ENSRNOP00000086026   ⟸   ENSRNOT00000104752
Protein Domains
Dynamin-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2TA68-F1-model_v2 AlphaFold Q2TA68 1-960 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698231
Promoter ID:EPDNEW_R8755
Type:multiple initiation site
Name:Opa1_1
Description:OPA1, mitochondrial dynamin like GTPase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01174,793,820 - 74,793,880EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708423 AgrOrtholog
BioCyc Gene G2FUF-20984 BioCyc
Ensembl Genes ENSRNOG00000001717 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002343 ENTREZGENE
  ENSRNOT00000104752 ENTREZGENE
  ENSRNOT00000111984 ENTREZGENE
  ENSRNOT00000111984.1 UniProtKB/Swiss-Prot
  ENSRNOT00000117359 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7324017 IMAGE-MGC_LOAD
InterPro Dynamin_GTPase UniProtKB/Swiss-Prot
  Dynamin_N UniProtKB/Swiss-Prot
  Dynamin_SF UniProtKB/Swiss-Prot
  G_DYNAMIN_dom UniProtKB/Swiss-Prot
  OPA1_C UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:171116 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124921 IMAGE-MGC_LOAD
NCBI Gene 171116 ENTREZGENE
PANTHER PTHR11566 UniProtKB/Swiss-Prot
  PTHR11566:SF67 UniProtKB/Swiss-Prot
Pfam Dynamin_N UniProtKB/Swiss-Prot
  OPA1_C UniProtKB/Swiss-Prot
PhenoGen Opa1 PhenoGen
PRINTS DYNAMIN UniProtKB/Swiss-Prot
PROSITE G_DYNAMIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001717 RatGTEx
SMART DYNc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I5ZZK0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A517 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2PZL8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q0I8 ENTREZGENE, UniProtKB/TrEMBL
  A6JRV9_RAT UniProtKB/TrEMBL
  O08681 ENTREZGENE
  OPA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5MPP1 ENTREZGENE
  Q5MPP2 ENTREZGENE
  Q5QJE9 ENTREZGENE
  Q6B435 ENTREZGENE
  Q6R611 ENTREZGENE
UniProt Secondary O08681 UniProtKB/Swiss-Prot
  Q5MPP1 UniProtKB/Swiss-Prot
  Q5MPP2 UniProtKB/Swiss-Prot
  Q5QJE9 UniProtKB/Swiss-Prot
  Q6B435 UniProtKB/Swiss-Prot
  Q6R611 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 Opa1  OPA1, mitochondrial dynamin like GTPase  Opa1  optic atrophy 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-22 Opa1  optic atrophy 1  Opa1  optic atrophy 1 homolog (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Opa1  optic atrophy 1 homolog (human)  LOC171116  RN protein  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the human homolog causes autosomal dominant optic atrophy 1547836
gene_expression expressed in retinal ganglion cells, starburst amacrine cells and horizontal cells of the inner retina 1547836