Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (1->4)-beta-D-glucan | multiple interactions | ISO | Nme4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of NME4 mRNA | CTD | PMID:36331819 | 1,2-dimethylhydrazine | increases expression | ISO | Nme4 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of NME4 mRNA | CTD | PMID:22206623 | 1-naphthyl isothiocyanate | decreases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in decreased expression of NME4 mRNA | CTD | PMID:30723492 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of NME4 mRNA | CTD | PMID:17557909 | 17beta-estradiol | increases expression | ISO | Nme4 (Mus musculus) | 6480464 | Estradiol results in increased expression of NME4 mRNA | CTD | PMID:19484750 | 17beta-estradiol | multiple interactions | ISO | NME4 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of NME4 mRNA | CTD | PMID:30165855 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | Nme4 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | Nme4 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Nme4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NME4 mRNA | CTD | PMID:21167638 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NME4 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Nme4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of NME4 mRNA | CTD | PMID:22666406 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Nme4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of NME4 mRNA | CTD | PMID:21570461 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Nme4 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of NME4 mRNA | CTD | PMID:28973697 | 5-fluorouracil | affects response to substance | ISO | NME4 (Homo sapiens) | 6480464 | NME4 protein affects the susceptibility to Fluorouracil | CTD | PMID:16217747 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of NME4 mRNA | CTD | PMID:22504374 and PMID:24780913 | acrylamide | decreases expression | ISO | NME4 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of NME4 mRNA | CTD | PMID:32763439 | afimoxifene | decreases response to substance | ISO | NME4 (Homo sapiens) | 6480464 | NME4 results in decreased susceptibility to afimoxifene | CTD | PMID:21233418 | all-trans-retinoic acid | decreases expression | ISO | NME4 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of NME4 mRNA | CTD | PMID:33167477 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of NME4 mRNA | CTD | PMID:16483693 | antirheumatic drug | increases expression | ISO | NME4 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of NME4 mRNA | CTD | PMID:24449571 | atrazine | decreases expression | ISO | NME4 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of NME4 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | increases expression | ISO | Nme4 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of NME4 mRNA | CTD | PMID:32417428 | benzo[a]pyrene | increases methylation | ISO | NME4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of NME4 promoter | CTD | PMID:27901495 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of NME4 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | ISO | NME4 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of NME4 protein | CTD | PMID:37567409 | bisphenol A | increases expression | ISO | Nme4 (Mus musculus) | 6480464 | bisphenol A results in increased expression of NME4 mRNA | CTD | PMID:32156529 | bisphenol A | decreases methylation | ISO | NME4 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of NME4 gene | CTD | PMID:31601247 | bisphenol A | affects expression | ISO | NME4 (Homo sapiens) | 6480464 | bisphenol A affects the expression of NME4 mRNA | CTD | PMID:30903817 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of NME4 mRNA | CTD | PMID:30816183 and PMID:34947998 | cadmium atom | increases expression | ISO | NME4 (Homo sapiens) | 6480464 | Cadmium results in increased expression of NME4 mRNA | CTD | PMID:24376830 | carbon nanotube | decreases expression | ISO | Nme4 (Mus musculus) | 6480464 | Nanotubes and Carbon results in decreased expression of NME4 mRNA | CTD | PMID:25620056 | cefaloridine | decreases expression | EXP | | 6480464 | Cephaloridine results in decreased expression of NME4 mRNA | CTD | PMID:18500788 | chloropicrin | decreases expression | ISO | NME4 (Homo sapiens) | 6480464 | chloropicrin results in decreased expression of NME4 mRNA | CTD | PMID:26352163 | chromium(6+) | affects expression | ISO | Nme4 (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of NME4 mRNA | CTD | PMID:28472532 | clobetasol | increases expression | ISO | Nme4 (Mus musculus) | 6480464 | Clobetasol results in increased expression of NME4 mRNA | CTD | PMID:27462272 | cobalt dichloride | decreases expression | ISO | NME4 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of NME4 mRNA | CTD | PMID:19320972 more ... | copper atom | multiple interactions | ISO | NME4 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of NME4 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | NME4 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of NME4 mRNA | CTD | PMID:20971185 | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of NME4 mRNA | CTD | PMID:26577399 | cyclosporin A | decreases expression | ISO | NME4 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of NME4 mRNA | CTD | PMID:20106945 more ... | dibutyl phthalate | decreases expression | ISO | Nme4 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of NME4 mRNA | CTD | PMID:17361019 and PMID:21266533 | dichloroacetic acid | increases expression | ISO | Nme4 (Mus musculus) | 6480464 | Dichloroacetic Acid results in increased expression of NME4 mRNA | CTD | PMID:28962523 | dorsomorphin | multiple interactions | ISO | NME4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NME4 mRNA | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | NME4 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of NME4 mRNA | CTD | PMID:29803840 and PMID:30031762 | ethanol | increases expression | ISO | Nme4 (Mus musculus) | 6480464 | Ethanol results in increased expression of NME4 mRNA | CTD | PMID:19167417 | ethyl methanesulfonate | decreases expression | ISO | NME4 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in decreased expression of NME4 mRNA | CTD | PMID:23649840 | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of NME4 mRNA | CTD | PMID:30307764 | folic acid | affects expression | ISO | NME4 (Homo sapiens) | 6480464 | Folic Acid affects the expression of NME4 mRNA | CTD | PMID:16361273 | formaldehyde | decreases expression | ISO | NME4 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of NME4 mRNA | CTD | PMID:23649840 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of NME4 mRNA | CTD | PMID:25539665 more ... | furan | decreases methylation | EXP | | 6480464 | furan results in decreased methylation of NME4 gene | CTD | PMID:27387713 | indometacin | increases expression | EXP | | 6480464 | Indomethacin results in increased expression of NME4 mRNA | CTD | PMID:36868495 | lipopolysaccharide | increases expression | ISO | NME4 (Homo sapiens) | 6480464 | Lipopolysaccharides results in increased expression of NME4 mRNA | CTD | PMID:35953652 | mercury dichloride | decreases expression | EXP | | 6480464 | Mercuric Chloride results in decreased expression of NME4 mRNA | CTD | PMID:16507785 | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of NME4 mRNA | CTD | PMID:22504374 | methyl methanesulfonate | decreases expression | ISO | NME4 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of NME4 mRNA | CTD | PMID:23649840 | methylmercury chloride | decreases expression | ISO | NME4 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of NME4 mRNA | CTD | PMID:23179753 and PMID:27188386 | methylseleninic acid | decreases expression | ISO | NME4 (Homo sapiens) | 6480464 | methylselenic acid results in decreased expression of NME4 mRNA | CTD | PMID:18548127 | paclitaxel | decreases expression | ISO | NME4 (Homo sapiens) | 6480464 | Paclitaxel results in decreased expression of NME4 protein | CTD | PMID:15907983 | paracetamol | affects expression | ISO | Nme4 (Mus musculus) | 6480464 | Acetaminophen affects the expression of NME4 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of NME4 mRNA | CTD | PMID:33387578 | paracetamol | decreases expression | ISO | NME4 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of NME4 mRNA | CTD | PMID:22230336 | PCB138 | multiple interactions | ISO | Nme4 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Nme4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of NME4 mRNA | CTD | PMID:36331819 | phenylmercury acetate | decreases expression | ISO | NME4 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of NME4 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | NME4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NME4 mRNA | CTD | PMID:27188386 | pirinixic acid | increases expression | ISO | Nme4 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of NME4 mRNA | CTD | PMID:23811191 | quercetin | decreases expression | ISO | NME4 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of NME4 mRNA and Quercetin results in decreased expression of NME4 protein | CTD | PMID:15221776 and PMID:15309432 | resveratrol | increases expression | ISO | Nme4 (Mus musculus) | 6480464 | resveratrol results in increased expression of NME4 mRNA | CTD | PMID:22610192 | resveratrol | multiple interactions | ISO | NME4 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of NME4 mRNA | CTD | PMID:23557933 | SB 431542 | multiple interactions | ISO | NME4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NME4 mRNA | CTD | PMID:27188386 | silver atom | increases expression | ISO | Nme4 (Mus musculus) | 6480464 | Silver results in increased expression of NME4 mRNA | CTD | PMID:27131904 | silver(0) | increases expression | ISO | Nme4 (Mus musculus) | 6480464 | Silver results in increased expression of NME4 mRNA | CTD | PMID:27131904 | sunitinib | decreases expression | ISO | NME4 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of NME4 mRNA | CTD | PMID:31533062 | temozolomide | increases expression | ISO | NME4 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of NME4 mRNA | CTD | PMID:31758290 | thapsigargin | decreases expression | ISO | NME4 (Homo sapiens) | 6480464 | Thapsigargin results in decreased expression of NME4 mRNA | CTD | PMID:22378314 | thimerosal | decreases expression | ISO | NME4 (Homo sapiens) | 6480464 | Thimerosal results in decreased expression of NME4 mRNA | CTD | PMID:27188386 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of NME4 mRNA | CTD | PMID:23411599 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of NME4 mRNA | CTD | PMID:33387578 | tungsten | increases expression | ISO | Nme4 (Mus musculus) | 6480464 | Tungsten results in increased expression of NME4 mRNA | CTD | PMID:30912803 | tunicamycin | decreases expression | ISO | NME4 (Homo sapiens) | 6480464 | Tunicamycin results in decreased expression of NME4 mRNA | CTD | PMID:22378314 | valproic acid | affects expression | ISO | NME4 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of NME4 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | NME4 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of NME4 mRNA | CTD | PMID:23179753 more ... | |