Nr2f2 (nuclear receptor subfamily 2, group F, member 2) - Rat Genome Database

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Gene: Nr2f2 (nuclear receptor subfamily 2, group F, member 2) Rattus norvegicus
Analyze
Symbol: Nr2f2
Name: nuclear receptor subfamily 2, group F, member 2
RGD ID: 69305
Description: Enables sequence-specific DNA binding activity. Involved in positive regulation of systemic arterial blood pressure; regulation of DNA-templated transcription; and response to estradiol. Predicted to be located in nucleus. Used to study hypertension. Human ortholog(s) of this gene implicated in 46,XX sex reversal 5. Orthologous to human NR2F2 (nuclear receptor subfamily 2 group F member 2); PARTICIPATES IN forkhead class A signaling pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: apolipoprotein A-I regulatory protein 1; apolipoprotein AI regulatory protein 1; ARP-1; COUP transcription factor 2; COUP transcription factor II; COUP-TF II; COUP-TF2; COUPb; nuclear receptor subfamily 2 group F member 2; ovalbumin upstream promoter beta nuclear receptor; Tfcoup2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Nr2f2em1Mcwi
Genetic Models: SS-Nr2f2em1Mcwi
Candidate Gene For: Bp313
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81133,419,161 - 133,434,290 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1133,420,227 - 133,431,975 (-)EnsemblGRCr8
mRatBN7.21124,008,282 - 124,022,521 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1124,009,181 - 124,022,031 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1132,007,025 - 132,012,975 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01139,177,092 - 139,183,046 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01131,989,976 - 131,995,932 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01131,447,671 - 131,465,749 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1131,448,447 - 131,460,473 (-)Ensemblrn6Rnor6.0
Rnor_5.01132,486,697 - 132,499,845 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41125,280,974 - 125,286,929 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1116,179,533 - 116,185,445 (-)NCBICelera
RGSC_v3.11125,359,316 - 125,365,272 (-)NCBI
Cytogenetic Map1q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
brequinar  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CHIR 99021  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (EXP)
dinophysistoxin 1  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
genistein  (EXP,ISO)
glyphosate  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
maneb  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
prostaglandin E2  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
topiramate  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. ARP-1/COUP-TF II determines hepatoma phenotype by acting as both a transcriptional repressor of microsomal triglyceride transfer protein and an inducer of CYP7A1. Kang S, etal., J Biol Chem 2003 Aug 15;278(33):30478-86. Epub 2003 May 30.
4. The expression of Hedgehog genes (Ihh, Dhh) and Hedgehog target genes (Ptc1, Gli1, Coup-TfII) is affected by estrogenic stimuli in the uterus of immature female rats. Katayama S, etal., Toxicol Appl Pharmacol. 2006 Dec 15;217(3):375-83. Epub 2006 Oct 6.
5. Mutation within the hinge region of the transcription factor Nr2f2 attenuates salt-sensitive hypertension. Kumarasamy S, etal., Nat Commun. 2015 Feb 17;6:6252. doi: 10.1038/ncomms7252.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7823919   PMID:8910285   PMID:9343308   PMID:12972613   PMID:15546392   PMID:15548577   PMID:15572686   PMID:15829524   PMID:15875024   PMID:16251273   PMID:16721029   PMID:16912278  
PMID:17404209   PMID:18765640   PMID:18798693   PMID:18815287   PMID:19210544   PMID:19231526   PMID:19796622   PMID:20130170   PMID:21879463   PMID:23378030   PMID:24234421   PMID:24466353  
PMID:25372459   PMID:36648143  


Genomics

Comparative Map Data
Nr2f2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81133,419,161 - 133,434,290 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1133,420,227 - 133,431,975 (-)EnsemblGRCr8
mRatBN7.21124,008,282 - 124,022,521 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1124,009,181 - 124,022,031 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1132,007,025 - 132,012,975 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01139,177,092 - 139,183,046 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01131,989,976 - 131,995,932 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01131,447,671 - 131,465,749 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1131,448,447 - 131,460,473 (-)Ensemblrn6Rnor6.0
Rnor_5.01132,486,697 - 132,499,845 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41125,280,974 - 125,286,929 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1116,179,533 - 116,185,445 (-)NCBICelera
RGSC_v3.11125,359,316 - 125,365,272 (-)NCBI
Cytogenetic Map1q31NCBI
NR2F2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381596,326,046 - 96,340,263 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1596,325,797 - 96,340,263 (+)Ensemblhg38GRCh38
GRCh371596,869,275 - 96,883,492 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361594,674,950 - 94,683,048 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341594,674,949 - 94,683,045NCBI
Celera1573,285,358 - 73,299,693 (+)NCBICelera
Cytogenetic Map15q26.2NCBI
HuRef1572,999,792 - 73,013,983 (+)NCBIHuRef
CHM1_11596,711,246 - 96,725,580 (+)NCBICHM1_1
T2T-CHM13v2.01594,090,629 - 94,104,848 (+)NCBIT2T-CHM13v2.0
Nr2f2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39770,001,694 - 70,016,494 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl770,001,692 - 70,016,483 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38770,351,946 - 70,366,746 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl770,351,944 - 70,366,735 (-)Ensemblmm10GRCm38
MGSCv37777,496,836 - 77,511,632 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36770,226,952 - 70,240,235 (-)NCBIMGSCv36mm8
Celera767,807,423 - 67,836,911 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map738.66NCBI
Nr2f2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541624,141,888 - 24,168,585 (+)Ensembl
ChiLan1.0NW_00495541624,148,052 - 24,154,406 (+)NCBIChiLan1.0ChiLan1.0
NR2F2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21685,870,526 - 85,903,632 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11589,569,489 - 89,582,674 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01575,008,879 - 75,021,981 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11594,196,494 - 94,210,599 (+)NCBIPanPan1.1PanPan1.1panPan2
NR2F2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1344,135,143 - 44,148,836 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl344,136,463 - 44,148,524 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha346,838,728 - 46,852,294 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0344,548,234 - 44,561,807 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl344,475,116 - 44,561,446 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1344,070,866 - 44,084,429 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0344,300,713 - 44,314,268 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0344,625,819 - 44,639,411 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nr2f2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640139,433,402 - 139,446,616 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364836,886,153 - 6,900,997 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364836,886,447 - 6,900,986 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR2F2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl783,076,124 - 83,090,535 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1783,076,119 - 83,090,250 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2788,960,806 - 88,972,751 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NR2F2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12914,889,526 - 14,901,848 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2914,891,737 - 14,903,813 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605931,706,856 - 31,720,520 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr2f2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247687,701,674 - 7,728,408 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247687,713,771 - 7,728,102 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Nr2f2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12130,020,767 - 130,034,500 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nr2f2
110 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:65
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000014152
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132889797152403053Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760602142582180Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1124975316152612788Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1111404407142582336Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429152404087Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
2325726Eae30Experimental allergic encephalomyelitis QTL 30nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1132463342138003629Rat

Markers in Region
RH133250  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,014,364 - 124,014,551 (+)MAPPERmRatBN7.2
Rnor_6.01131,452,853 - 131,453,039NCBIRnor6.0
Rnor_5.01132,491,879 - 132,492,065UniSTSRnor5.0
RGSC_v3.41125,285,093 - 125,285,279UniSTSRGSC3.4
Celera1116,183,609 - 116,183,795UniSTS
RH 3.4 Map11451.09UniSTS
Cytogenetic Map1q31UniSTS
D1Bda25  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,010,253 - 124,010,462 (+)MAPPERmRatBN7.2
Rnor_6.01131,448,744 - 131,448,952NCBIRnor6.0
Rnor_5.01132,487,770 - 132,487,978UniSTSRnor5.0
RGSC_v3.41125,280,981 - 125,281,189UniSTSRGSC3.4
Celera1116,179,540 - 116,179,748UniSTS
Cytogenetic Map1q31UniSTS
RH141740  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,010,196 - 124,010,411 (+)MAPPERmRatBN7.2
Rnor_6.01131,448,687 - 131,448,901NCBIRnor6.0
Rnor_5.01132,487,713 - 132,487,927UniSTSRnor5.0
RGSC_v3.41125,280,924 - 125,281,138UniSTSRGSC3.4
Celera1116,179,483 - 116,179,697UniSTS
RH 3.4 Map11451.2UniSTS
Cytogenetic Map1q31UniSTS
PMC316637P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,013,509 - 124,013,975 (+)MAPPERmRatBN7.2
Rnor_6.01131,451,998 - 131,452,463NCBIRnor6.0
Rnor_5.01132,491,024 - 132,491,489UniSTSRnor5.0
RGSC_v3.41125,284,238 - 125,284,703UniSTSRGSC3.4
Celera1116,182,754 - 116,183,219UniSTS
Cytogenetic Map1q31UniSTS


Genetic Models
This gene Nr2f2 is modified in the following models/strains:
SS-Nr2f2em1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 46 59 6 310 146 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000014152   ⟹   ENSRNOP00000014152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1133,420,227 - 133,426,179 (-)Ensembl
mRatBN7.2 Ensembl1124,010,247 - 124,016,202 (-)Ensembl
Rnor_6.0 Ensembl1131,448,737 - 131,454,689 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084336   ⟹   ENSRNOP00000072005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1133,420,227 - 133,431,975 (-)Ensembl
mRatBN7.2 Ensembl1124,009,181 - 124,022,031 (-)Ensembl
Rnor_6.0 Ensembl1131,448,447 - 131,460,473 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100190   ⟹   ENSRNOP00000078685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1124,009,181 - 124,014,705 (-)Ensembl
RefSeq Acc Id: NM_080778   ⟹   NP_542956
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81133,420,227 - 133,426,179 (-)NCBI
mRatBN7.21124,010,247 - 124,016,202 (-)NCBI
Rnor_6.01131,448,737 - 131,454,689 (-)NCBI
Rnor_5.01132,486,697 - 132,499,845 (-)NCBI
RGSC_v3.41125,280,974 - 125,286,929 (-)RGD
Celera1116,179,533 - 116,185,445 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229366   ⟹   XP_006229428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81133,419,161 - 133,434,290 (-)NCBI
mRatBN7.21124,008,282 - 124,022,521 (-)NCBI
Rnor_6.01131,447,671 - 131,465,749 (-)NCBI
Rnor_5.01132,486,697 - 132,499,845 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588643   ⟹   XP_017444132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81133,419,161 - 133,425,607 (-)NCBI
mRatBN7.21124,008,282 - 124,015,639 (-)NCBI
Rnor_6.01131,447,671 - 131,454,067 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105995   ⟹   XP_038961923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81133,419,161 - 133,425,451 (-)NCBI
mRatBN7.21124,008,286 - 124,014,951 (-)NCBI
RefSeq Acc Id: NP_542956   ⟸   NM_080778
- UniProtKB: O09018 (UniProtKB/Swiss-Prot),   A6JBW1 (UniProtKB/TrEMBL),   A0A8I6A7N1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229428   ⟸   XM_006229366
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K1W0 (UniProtKB/TrEMBL),   A6JBW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444132   ⟸   XM_017588643
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000014152   ⟸   ENSRNOT00000014152
Ensembl Acc Id: ENSRNOP00000072005   ⟸   ENSRNOT00000084336
RefSeq Acc Id: XP_038961923   ⟸   XM_039105995
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZLR6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078685   ⟸   ENSRNOT00000100190
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O09018-F1-model_v2 AlphaFold O09018 1-414 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690115
Promoter ID:EPDNEW_R637
Type:initiation region
Name:Nr2f2_1
Description:nuclear receptor subfamily 2, group F, member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01131,460,507 - 131,460,567EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69305 AgrOrtholog
BioCyc Gene G2FUF-58933 BioCyc
Ensembl Genes ENSRNOG00000010308 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014152 ENTREZGENE
  ENSRNOT00000014152.4 UniProtKB/Swiss-Prot
  ENSRNOT00000084336 ENTREZGENE
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot
  Nuclear_hormone_rcpt_NR2 UniProtKB/Swiss-Prot
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
KEGG Report rno:113984 UniProtKB/Swiss-Prot
NCBI Gene 113984 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/Swiss-Prot
Pfam Hormone_recep UniProtKB/Swiss-Prot
  zf-C4 UniProtKB/Swiss-Prot
PharmGKB NR2F2 RGD
PhenoGen Nr2f2 PhenoGen
PRINTS COUPTNFACTOR UniProtKB/Swiss-Prot
  STRDHORMONER UniProtKB/Swiss-Prot
  STROIDFINGER UniProtKB/Swiss-Prot
PROSITE NR_LBD UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010308 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot
  ZnF_C4 UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF48508 UniProtKB/Swiss-Prot
TIGR TC206011
UniProt A0A0G2K1W0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZLR6 ENTREZGENE
  A0A8I6A7N1 ENTREZGENE, UniProtKB/TrEMBL
  A6JBW0 ENTREZGENE, UniProtKB/TrEMBL
  A6JBW1 ENTREZGENE, UniProtKB/TrEMBL
  COT2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Nr2f2  nuclear receptor subfamily 2, group F, member 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process a transcriptional repressor for the microsomal triglyceride transfer protein gene but a transcriptional activator for the CYP7A1 gene 737636