Casp2 (caspase 2) - Rat Genome Database

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Gene: Casp2 (caspase 2) Rattus norvegicus
Analyze
Symbol: Casp2
Name: caspase 2
RGD ID: 69274
Description: Predicted to enable cysteine-type endopeptidase activity; identical protein binding activity; and protein domain specific binding activity. Involved in luteolysis; neural retina development; and positive regulation of neuron apoptotic process. Predicted to be located in nucleus. Predicted to be part of endopeptidase complex. Predicted to be active in cytoplasm. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human CASP2 (caspase 2); INTERACTS WITH (R)-noradrenaline; (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CASP-2; caspase-2; ICH-1 protease; protease ICH-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8472,116,265 - 72,134,023 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl472,116,246 - 72,134,022 (+)EnsemblGRCr8
mRatBN7.2471,149,632 - 71,167,388 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl471,149,669 - 71,167,379 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx476,069,535 - 76,087,171 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0471,982,792 - 72,000,428 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0470,402,261 - 70,419,895 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0471,652,358 - 71,670,228 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl471,652,354 - 71,670,239 (+)Ensemblrn6Rnor6.0
Rnor_5.04136,454,723 - 136,474,625 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4470,029,728 - 70,047,164 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera466,080,364 - 66,098,003 (+)NCBICelera
RGSC_v3.1470,305,857 - 70,323,294 (+)NCBI
Cytogenetic Map4q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-dexrazoxane  (ISO)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(R)-noradrenaline  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2'-Hydroxy-2,3,5'-trimethoxychalcone  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
3,3',5,5'-tetraiodothyroacetic acid  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-nitropropanoic acid  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amsacrine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
betaxolol  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
brefeldin A  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium acetate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
casticin  (ISO)
CGP 52608  (ISO)
chelerythrine  (ISO)
chitosan  (EXP)
chromium(6+)  (ISO)
Cinobufotalin  (ISO)
cisplatin  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (EXP)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diepoxybutane  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
Dimethyl phthalate  (EXP)
dimethylarsinic acid  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
epichlorohydrin  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenpropathrin  (EXP)
flavanones  (ISO)
folic acid  (ISO)
furan  (EXP)
furosemide  (EXP)
gardenin B  (ISO)
gentamycin  (EXP)
glycyrrhizinic acid  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
isobutanol  (ISO)
isoflurane  (EXP)
isoprenaline  (EXP)
L-ascorbic acid  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lovastatin  (ISO)
LY294002  (EXP)
manganese(II) chloride  (EXP)
mechlorethamine  (ISO)
menadione  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
Mitotane  (EXP)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Myrtucommulone A  (ISO)
N-[2-amino-6-[(4-fluorophenyl)methylamino]-3-pyridinyl]carbamic acid ethyl ester  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetyl-L-tryptophan  (ISO)
nickel dichloride  (EXP)
nicotine  (EXP)
norfloxacin  (ISO)
NS-398  (ISO)
ochratoxin A  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
oxybenzone  (EXP)
oxybuprocaine  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
phenylephrine  (ISO)
picoxystrobin  (ISO)
picrotoxin  (EXP)
pifithrin-alpha hydrobromide  (EXP,ISO)
podophyllotoxin  (ISO)
Pranoprofen  (ISO)
propylparaben  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium cyanate  (ISO)
sodium dichromate  (ISO)
staurosporine  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (ISO)
Terfenadine  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
topotecan  (EXP,ISO)
triadimefon  (EXP)
Tributyltin oxide  (EXP)
tunicamycin  (ISO)
undecane  (EXP)
urethane  (EXP)
usnic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
violacein  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
mitochondrion  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Caspases from apoptotic myocytes degrade extracellular matrix: a novel remodeling paradigm. Cowan KN, etal., FASEB J. 2005 Nov;19(13):1848-50. Epub 2005 Aug 25.
2. Interleukin-1 beta-converting enzyme-related proteases (IRPs) and mammalian cell death: dissociation of IRP-induced oligonucleosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle. Flaws JA, etal., Endocrinology 1995 Nov;136(11):5042-53.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Two caspase-2 transcripts are expressed in rat hippocampus after global cerebral ischemia. Jin K, etal., J Neurochem. 2002 Apr;81(1):25-35.
5. Role of caspase 2 in apoptotic signaling in primate and murine germ cells. Johnson C, etal., Biol Reprod. 2008 Nov;79(5):806-14. Epub 2008 Jul 9.
6. Identification of gene family of caspases in rat kidney and altered expression in ischemia-reperfusion injury. Kaushal GP, etal., Am J Physiol 1998 Mar;274(3 Pt 2):F587-95.
7. Expression of Nedd2/ICH-1 (caspase-2) in the developing rat retina. Kojima M, etal., Neurosci Res. 1998 Jul;31(3):211-7.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Increased expression of caspase 2 in experimental and human temporal lobe epilepsy. Narkilahti S, etal., Neuromolecular Med. 2007;9(2):129-44.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Expression of caspase-2, -3, -8 and -9 proteins and enzyme activity in the corpus luteum of the rat at different stages during the natural estrous cycle. Peluffo MC, etal., Reproduction. 2006 Sep;132(3):465-75.
12. Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease. Pompl PN, etal., Arch Neurol. 2003 Mar;60(3):369-76.
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Cloning and expression of the cDNA encoding rat caspase-2. Sato N, etal., Gene 1997 Nov 20;202(1-2):127-32.
16. Differential expression of rat brain caspase family proteins during development and aging. Shimohama S, etal., Biochem Biophys Res Commun. 2001 Dec 21;289(5):1063-6.
17. Differential subcellular localization of caspase family proteins in the adult rat brain. Shimohama S, etal., Neurosci Lett. 2001 Nov 27;315(3):125-8.
18. Age-associated increases in the activity of multiple caspases in Fisher 344 rat organs. Zhang Y, etal., Exp Gerontol. 2002 Jun;37(6):777-89.
19. ARC protects rat cardiomyocytes against oxidative stress through inhibition of caspase-2 mediated mitochondrial pathway. Zhang YQ and Herman B, J Cell Biochem. 2006 Oct 1;99(2):575-88.
Additional References at PubMed
PMID:9044836   PMID:10931486   PMID:10980123   PMID:11536012   PMID:12477715   PMID:16183742   PMID:18181021   PMID:19593445   PMID:21677688   PMID:21726810   PMID:21903589   PMID:22531785  
PMID:23451279   PMID:23815625   PMID:25416956   PMID:26871637   PMID:30193318   PMID:31515488   PMID:31533600   PMID:32605511  


Genomics

Comparative Map Data
Casp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8472,116,265 - 72,134,023 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl472,116,246 - 72,134,022 (+)EnsemblGRCr8
mRatBN7.2471,149,632 - 71,167,388 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl471,149,669 - 71,167,379 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx476,069,535 - 76,087,171 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0471,982,792 - 72,000,428 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0470,402,261 - 70,419,895 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0471,652,358 - 71,670,228 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl471,652,354 - 71,670,239 (+)Ensemblrn6Rnor6.0
Rnor_5.04136,454,723 - 136,474,625 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4470,029,728 - 70,047,164 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera466,080,364 - 66,098,003 (+)NCBICelera
RGSC_v3.1470,305,857 - 70,323,294 (+)NCBI
Cytogenetic Map4q24NCBI
CASP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387143,288,351 - 143,307,696 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7143,288,215 - 143,307,696 (+)Ensemblhg38GRCh38
GRCh377142,985,444 - 143,004,789 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367142,695,524 - 142,714,907 (+)NCBIBuild 36Build 36hg18NCBI36
Celera7137,822,267 - 137,841,650 (+)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7137,322,670 - 137,342,153 (+)NCBIHuRef
CHM1_17142,922,195 - 142,941,676 (+)NCBICHM1_1
T2T-CHM13v2.07144,643,759 - 144,663,112 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27142,387,424 - 142,406,906 (+)NCBI
Casp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39642,241,942 - 42,259,442 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl642,241,919 - 42,259,442 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38642,264,902 - 42,282,508 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl642,264,985 - 42,282,508 (+)Ensemblmm10GRCm38
MGSCv37642,215,038 - 42,232,495 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36642,194,646 - 42,212,103 (+)NCBIMGSCv36mm8
Celera642,209,337 - 42,226,794 (+)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map620.54NCBI
Casp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955494353,310 - 368,873 (-)Ensembl
ChiLan1.0NW_004955494353,572 - 369,207 (-)NCBIChiLan1.0ChiLan1.0
CASP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26180,141,294 - 180,166,578 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1732,151,551 - 32,176,835 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07135,283,072 - 135,307,855 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17147,773,749 - 147,792,958 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7147,773,749 - 147,792,958 (+)EnsemblpanPan2panpan1.1
CASP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1166,378,447 - 6,396,251 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl166,379,913 - 6,396,646 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha167,368,808 - 7,385,123 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0166,232,171 - 6,251,272 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl166,232,210 - 6,250,056 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1166,181,045 - 6,197,357 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0166,032,942 - 6,049,262 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0166,108,280 - 6,124,667 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Casp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511812,149,166 - 12,164,126 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936527739,281 - 754,331 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936527739,325 - 754,259 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,941,937 - 6,966,061 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1186,946,432 - 6,966,088 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2187,183,208 - 7,206,964 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CASP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121112,172,614 - 112,189,574 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21112,172,733 - 112,188,744 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660728,895,441 - 8,914,545 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Casp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480011,451,038 - 11,468,205 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462480011,451,784 - 11,468,791 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Casp2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1697,937,054 - 97,954,856 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Casp2
86 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:394
Count of miRNA genes:218
Interacting mature miRNAs:288
Transcripts:ENSRNOT00000022543, ENSRNOT00000022672
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45808014680212111Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)44047145375939996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
2317577Eae24Experimental allergic encephalomyelitis QTL 24nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)46796011273752811Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)44049044275726188Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46390045888813920Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45960331980216952Rat

Markers in Region
RH127476  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2471,167,193 - 71,167,375 (+)MAPPERmRatBN7.2
Rnor_6.0471,670,034 - 71,670,215NCBIRnor6.0
Rnor_5.04136,474,431 - 136,474,612UniSTSRnor5.0
Celera466,097,809 - 66,097,990UniSTS
RH 3.4 Map4434.8UniSTS
Cytogenetic Map4q23UniSTS
RH140969  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2471,148,728 - 71,148,932 (+)MAPPERmRatBN7.2
Rnor_6.0471,651,439 - 71,651,642NCBIRnor6.0
Rnor_5.04136,453,800 - 136,454,003UniSTSRnor5.0
RGSC_v3.4470,028,735 - 70,028,938UniSTSRGSC3.4
Celera466,079,371 - 66,079,574UniSTS
RH 3.4 Map4433.61UniSTS
Cytogenetic Map4q23UniSTS
MARC_16655-16656:1017778016:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2471,152,168 - 71,152,636 (+)MAPPERmRatBN7.2
Rnor_6.0471,655,009 - 71,655,476NCBIRnor6.0
Rnor_5.04136,459,406 - 136,459,873UniSTSRnor5.0
Rnor_5.04136,457,492 - 136,457,959UniSTSRnor5.0
RGSC_v3.4470,031,877 - 70,032,344UniSTSRGSC3.4
Celera466,082,786 - 66,083,253UniSTS
Cytogenetic Map4q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000022543   ⟹   ENSRNOP00000022543
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl471,149,724 - 71,165,417 (+)Ensembl
Rnor_6.0 Ensembl471,652,434 - 71,668,257 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000022672   ⟹   ENSRNOP00000022672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl472,116,259 - 72,134,022 (+)Ensembl
mRatBN7.2 Ensembl471,149,669 - 71,167,379 (+)Ensembl
Rnor_6.0 Ensembl471,652,354 - 71,670,239 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112830   ⟹   ENSRNOP00000096921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl472,116,246 - 72,134,021 (+)Ensembl
RefSeq Acc Id: NM_022522   ⟹   NP_071967
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8472,116,357 - 72,134,023 (+)NCBI
mRatBN7.2471,149,722 - 71,167,388 (+)NCBI
Rnor_6.0471,652,432 - 71,670,228 (+)NCBI
Rnor_5.04136,454,723 - 136,474,625 (+)NCBI
RGSC_v3.4470,029,728 - 70,047,164 (+)RGD
Celera466,080,364 - 66,098,003 (+)RGD
Sequence:
RefSeq Acc Id: XM_039108318   ⟹   XP_038964246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8472,116,265 - 72,123,581 (+)NCBI
mRatBN7.2471,149,634 - 71,156,942 (+)NCBI
RefSeq Acc Id: XM_063286661   ⟹   XP_063142731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8472,116,265 - 72,131,459 (+)NCBI
RefSeq Acc Id: XM_063286662   ⟹   XP_063142732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8472,116,269 - 72,120,749 (+)NCBI
RefSeq Acc Id: XM_063286663   ⟹   XP_063142733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8472,116,270 - 72,120,124 (+)NCBI
RefSeq Acc Id: NP_071967   ⟸   NM_022522
- UniProtKB: O55194 (UniProtKB/Swiss-Prot),   O35398 (UniProtKB/Swiss-Prot),   Q9WUI6 (UniProtKB/Swiss-Prot),   P55215 (UniProtKB/Swiss-Prot),   A6IF65 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022543   ⟸   ENSRNOT00000022543
Ensembl Acc Id: ENSRNOP00000022672   ⟸   ENSRNOT00000022672
RefSeq Acc Id: XP_038964246   ⟸   XM_039108318
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063142731   ⟸   XM_063286661
- Peptide Label: isoform X1
- UniProtKB: A6IF66 (UniProtKB/TrEMBL),   D3ZLT0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142732   ⟸   XM_063286662
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063142733   ⟸   XM_063286663
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000096921   ⟸   ENSRNOT00000112830
Protein Domains
CARD   Caspase family p10   Caspase family p20

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55215-F1-model_v2 AlphaFold P55215 1-452 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693008
Promoter ID:EPDNEW_R3531
Type:initiation region
Name:Casp2_1
Description:caspase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0471,652,346 - 71,652,406EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69274 AgrOrtholog
BioCyc Gene G2FUF-45094 BioCyc
Ensembl Genes ENSRNOG00000016707 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022672 ENTREZGENE
  ENSRNOT00000022672.7 UniProtKB/Swiss-Prot
  ENSRNOT00000112830 ENTREZGENE
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot
  3.40.50.1460 UniProtKB/Swiss-Prot
  Caspase-like UniProtKB/Swiss-Prot
InterPro CARD UniProtKB/Swiss-Prot
  Caspase-like_dom_sf UniProtKB/Swiss-Prot
  Caspase_2 UniProtKB/Swiss-Prot
  Caspase_cys_AS UniProtKB/Swiss-Prot
  Caspase_his_AS UniProtKB/Swiss-Prot
  DEATH-like_dom_sf UniProtKB/Swiss-Prot
  Pept_C14 UniProtKB/Swiss-Prot
  Pept_C14_caspase UniProtKB/Swiss-Prot
  Pept_C14_p10 UniProtKB/Swiss-Prot
  Pept_C14_p20 UniProtKB/Swiss-Prot
  Pept_C14A UniProtKB/Swiss-Prot
KEGG Report rno:64314 UniProtKB/Swiss-Prot
NCBI Gene 64314 ENTREZGENE
PANTHER CASPASE 2 UniProtKB/Swiss-Prot
  CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18 UniProtKB/Swiss-Prot
Pfam CARD UniProtKB/Swiss-Prot
  Peptidase_C14 UniProtKB/Swiss-Prot
PhenoGen Casp2 PhenoGen
PIRSF Caspase_ICE UniProtKB/Swiss-Prot
PRINTS IL1BCENZYME UniProtKB/Swiss-Prot
PROSITE CARD UniProtKB/Swiss-Prot
  CASPASE_CYS UniProtKB/Swiss-Prot
  CASPASE_HIS UniProtKB/Swiss-Prot
  CASPASE_P10 UniProtKB/Swiss-Prot
  CASPASE_P20 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016707 RatGTEx
SMART CARD UniProtKB/Swiss-Prot
  CASc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot
  SSF52129 UniProtKB/Swiss-Prot
UniProt A6IF65 ENTREZGENE, UniProtKB/TrEMBL
  A6IF66 ENTREZGENE, UniProtKB/TrEMBL
  CASP2_RAT UniProtKB/Swiss-Prot
  D3ZLT0 ENTREZGENE
  O35398 ENTREZGENE
  O55194 ENTREZGENE
  P55215 ENTREZGENE
  Q9WUI6 ENTREZGENE
UniProt Secondary O35398 UniProtKB/Swiss-Prot
  O55194 UniProtKB/Swiss-Prot
  Q9WUI6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Casp2  caspase 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of the ICE/Ced-3 (caspase) family of proteases 68881