GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp2 | multiple interactions | EXP | | 6480464 | CTD | [oxaliplatin co-treated with Topotecan] results in decreased expression of CASP2 mRNA | PMID:25729387 | Casp2 | increases cleavage | ISO | CASP2 (Homo sapiens) | 6480464 | CTD | Topotecan results in increased cleavage of CASP2 protein | PMID:19812371 | Casp2 | increases cleavage | ISO | Casp2 (Mus musculus) | 6480464 | CTD | Topotecan results in increased cleavage of CASP2 protein | PMID:19812371 | Casp2 | multiple interactions | ISO | CASP2 (Homo sapiens) | 6480464 | CTD | benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Topotecan results in increased cleavage of CASP2 protein]; pifithrin promotes the reaction [Topotecan results in increased cleavage of CASP2 protein]; TP53 inhibits the reaction [Topotecan results in increased cleavage of CASP2 protein] | PMID:19812371 | Casp2 | multiple interactions | ISO | Casp2 (Mus musculus) | 6480464 | CTD | APAF1 promotes the reaction [Topotecan results in increased cleavage of CASP2 protein]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Topotecan results in increased cleavage of CASP2 protein]; TRP53 inhibits the reaction [Topotecan results in increased cleavage of CASP2 protein] | PMID:19812371 | |
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