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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69274
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp2
Name: caspase 2
Acc ID: CHEBI:63632
Term: topotecan
Definition: A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.
Chemical ID: MESH:D019772
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp2multiple interactionsEXP 6480464CTD[oxaliplatin co-treated with Topotecan] results in decreased expression of CASP2 mRNAPMID:25729387
Casp2increases cleavageISOCASP2 (Homo sapiens)6480464CTDTopotecan results in increased cleavage of CASP2 proteinPMID:19812371
Casp2increases cleavageISOCasp2 (Mus musculus)6480464CTDTopotecan results in increased cleavage of CASP2 proteinPMID:19812371
Casp2multiple interactionsISOCASP2 (Homo sapiens)6480464CTDbenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Topotecan results in increased cleavage of CASP2 protein]; pifithrin promotes the reaction [Topotecan results in increased cleavage of CASP2 protein]; TP53 inhibits the reaction [Topotecan results in increased cleavage of CASP2 protein]PMID:19812371
Casp2multiple interactionsISOCasp2 (Mus musculus)6480464CTDAPAF1 promotes the reaction [Topotecan results in increased cleavage of CASP2 protein]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Topotecan results in increased cleavage of CASP2 protein]; TRP53 inhibits the reaction [Topotecan results in increased cleavage of CASP2 protein]PMID:19812371
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