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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69274
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp2
Name: caspase 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp2increases activityEXP 6480464CTDBenzo(a)pyrene results in increased activity of CASP2 proteinPMID:22051199
Casp2multiple interactionsEXP 6480464CTDGlycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP2 protein]PMID:22051199
Casp2increases expressionISOCASP2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of CASP2 mRNAPMID:32234424
Casp2increases expressionISOCasp2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CASP2 proteinPMID:22342234
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