Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69274
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp2
Name: caspase 2
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp2increases activityEXP 6480464CTDDoxorubicin results in increased activity of CASP2 proteinPMID:19801490
Casp2multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP2 protein]]; Doxorubicin results in increased cleavage of and results in increased activity of CASP2 protein; NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP2 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP2 protein]PMID:16687611 PMID:19801490
Casp2decreases expressionISOCasp2 (Mus musculus)6480464CTDDoxorubicin results in decreased expression of CASP2 mRNAPMID:16439991
Casp2increases activityISOCASP2 (Homo sapiens)6480464CTDDoxorubicin results in increased activity of CASP2 proteinPMID:15917298 PMID:22609468 PMID:30769864
Casp2increases expressionISOCASP2 (Homo sapiens)6480464CTDDoxorubicin results in increased expression of CASP2 mRNA alternative formPMID:14757846
Casp2increases response to substanceISOCASP2 (Homo sapiens)6480464CTDCASP2 protein results in increased susceptibility to DoxorubicinPMID:15917298
Casp2increases splicingISOCASP2 (Homo sapiens)6480464CTDDoxorubicin results in increased splicing of CASP2 mRNAPMID:14757846
Casp2multiple interactionsISOCASP2 (Homo sapiens)6480464CTDbenzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Doxorubicin promotes the reaction [CASP2 protein results in increased cleavage of PRKCD protein]]; benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Doxorubicin results in increased activity of CASP2 protein]; CCAR1 protein affects the reaction [Doxorubicin results in increased activity of CASP2 protein]; Doxorubicin promotes the reaction [CASP2 protein results in increased cleavage of PRKCD protein]PMID:15917298 PMID:30769864
Go Back to source page   Continue to Ontology report