GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp2 | increases activity | EXP | | 6480464 | CTD | Doxorubicin results in increased activity of CASP2 protein | PMID:19801490 | Casp2 | multiple interactions | EXP | | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP2 protein]]; Doxorubicin results in increased cleavage of and results in increased activity of CASP2 protein; NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP2 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP2 protein] | PMID:16687611 PMID:19801490 | Casp2 | decreases expression | ISO | Casp2 (Mus musculus) | 6480464 | CTD | Doxorubicin results in decreased expression of CASP2 mRNA | PMID:16439991 | Casp2 | increases activity | ISO | CASP2 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased activity of CASP2 protein | PMID:15917298 PMID:22609468 PMID:30769864 | Casp2 | increases expression | ISO | CASP2 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased expression of CASP2 mRNA alternative form | PMID:14757846 | Casp2 | increases response to substance | ISO | CASP2 (Homo sapiens) | 6480464 | CTD | CASP2 protein results in increased susceptibility to Doxorubicin | PMID:15917298 | Casp2 | increases splicing | ISO | CASP2 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased splicing of CASP2 mRNA | PMID:14757846 | Casp2 | multiple interactions | ISO | CASP2 (Homo sapiens) | 6480464 | CTD | benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Doxorubicin promotes the reaction [CASP2 protein results in increased cleavage of PRKCD protein]]; benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Doxorubicin results in increased activity of CASP2 protein]; CCAR1 protein affects the reaction [Doxorubicin results in increased activity of CASP2 protein]; Doxorubicin promotes the reaction [CASP2 protein results in increased cleavage of PRKCD protein] | PMID:15917298 PMID:30769864 | |
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