Pfkm (phosphofructokinase, muscle) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Pfkm (phosphofructokinase, muscle) Rattus norvegicus
Analyze
Symbol: Pfkm
Name: phosphofructokinase, muscle
RGD ID: 68419
Description: Enables several functions, including 6-phosphofructokinase activity; anion binding activity; and identical protein binding activity. Involved in fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; and glycolytic process. Predicted to be located in apical plasma membrane; nucleus; and sperm principal piece. Predicted to be part of 6-phosphofructokinase complex. Predicted to be active in cytosol and membrane. Human ortholog(s) of this gene implicated in glycogen storage disease VII. Orthologous to human PFKM (phosphofructokinase, muscle); PARTICIPATES IN Fanconi syndrome pathway; glycogen storage disease type VII pathway; glycolysis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-D.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6-phosphofructokinase type A; 6-phosphofructokinase, muscle type; ATP-dependent 6-phosphofructokinase, muscle type; ATP-PFK; PFK-A; Pfk-M; phosphofructo-1-kinase isozyme A; phosphofructokinase 1; phosphofructokinase-A; phosphofructokinase-M; phosphohexokinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87131,100,684 - 131,138,250 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7131,100,753 - 131,138,248 (+)EnsemblGRCr8
mRatBN7.27129,221,679 - 129,259,192 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7129,221,653 - 129,259,192 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7131,031,658 - 131,055,839 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07133,257,199 - 133,281,380 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07133,169,669 - 133,193,851 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07139,702,066 - 139,722,132 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7139,685,573 - 139,722,132 (+)Ensemblrn6Rnor6.0
Rnor_5.07138,837,772 - 138,857,276 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47136,826,122 - 136,846,040 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7125,730,934 - 125,751,002 (+)NCBICelera
RGSC_v3.17136,898,639 - 136,922,477 (+)NCBI
RH 3.4 Map71088.6RGD
Cytogenetic Map7q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2,4-D  (EXP)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-tert-Octylphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
ADP  (ISO)
aflatoxin B1  (ISO)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
angiotensin II  (EXP)
aristolochic acids  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
beta-D-fructofuranose 2,6-bisphosphate  (ISO)
bicalutamide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
citric acid  (ISO)
clofibrate  (ISO)
clotrimazole  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
coumarin 460  (ISO)
cyclosporin A  (ISO)
daunorubicin  (EXP)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dinophysistoxin 1  (ISO)
doxorubicin  (EXP,ISO)
epoxiconazole  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gallic acid  (ISO)
glutathione  (ISO)
Ile(5)-angiotensin II  (EXP)
indole-3-methanol  (EXP)
indometacin  (EXP)
inulin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
methamphetamine  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
niclosamide  (ISO)
ochratoxin A  (EXP)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (ISO)
progesterone  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
6-phosphofructokinase complex  (IBA,IEA,ISO)
apical plasma membrane  (IEA,ISO)
cytoplasm  (IEA)
cytosol  (IEA,ISO)
membrane  (IBA)
nucleus  (IEA,ISO)
sperm principal piece  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Fatal familial infantile glycogen storage disease: multisystem phosphofructokinase deficiency. Amit R, etal., Muscle Nerve. 1992 Apr;15(4):455-8.
2. Rapid changes in carbohydrate metabolism in muscle induced by triiodothyronine; the role of glucose 1,6-bisphosphate. Chen-Zion M, etal., Biochem Mol Med. 1995 Oct;56(1):19-25.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Crystallization and preliminary crystallographic analysis of human muscle phosphofructokinase, the main regulator of glycolysis. Kloos M, etal., Acta Crystallogr F Struct Biol Commun. 2014 May;70(Pt 5):578-82. doi: 10.1107/S2053230X14008723. Epub 2014 Apr 25.
7. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
8. Characterization of expression of phosphofructokinase isoforms in isolated rat pancreatic islets and purified beta cells and cloning and expression of the rat phosphofructokinase-A isoform. Ma Z, etal., Biochim Biophys Acta 1996 Aug 14;1308(2):151-63.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Expression of mouse phosphofructokinase-M gene alternative transcripts: evidence for the conserved two-promoter system. Nakajima H, etal., Biochem J 1994 Oct 15;303 ( Pt 2):449-53.
11. Cloning of human muscle phosphofructokinase cDNA. Nakajima H, etal., FEBS Lett 1987 Oct 19;223(1):113-6.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Impairment of glucose metabolism in hearts from rats treated with endotoxin. Tessier JP, etal., Cardiovasc Res. 2003 Oct 15;60(1):119-30.
20. Control of phosphofructokinase from rat skeletal muscle. Effects of fructose diphosphate, AMP, ATP, and citrate. Tornheim K and Lowenstein JM, J Biol Chem. 1976 Dec 10;251(23):7322-8.
21. Activation of muscle phosphofructokinase by fructose 2,6-bisphosphate and fructose 1,6-bisphosphate is differently affected by other regulatory metabolites. Tornheim K J Biol Chem. 1985 Jul 5;260(13):7985-9.
22. Isoenzymes of phosphofructokinase in the rat. Demonstration of the three non-identical subunits by biochemical, immunochemical and kinetic studies. Vora S, etal., Biochem J. 1985 Jul 15;229(2):333-41.
23. Structure of the entire human muscle phosphofructokinase-encoding gene: a two-promoter system. Yamasaki T, etal., Gene 1991 Aug 15;104(2):277-82.
Additional References at PubMed
PMID:2521854   PMID:2960695   PMID:6444532   PMID:6444721   PMID:6451249   PMID:7825568   PMID:8780720   PMID:11785984   PMID:12477932   PMID:12649290   PMID:14760703   PMID:17492776  
PMID:17595219   PMID:17720578   PMID:19292454   PMID:19696889   PMID:19889946   PMID:23376485   PMID:24625528   PMID:25416956   PMID:25796446   PMID:26316108   PMID:28545955   PMID:29476059  
PMID:32357304  


Genomics

Comparative Map Data
Pfkm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87131,100,684 - 131,138,250 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7131,100,753 - 131,138,248 (+)EnsemblGRCr8
mRatBN7.27129,221,679 - 129,259,192 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7129,221,653 - 129,259,192 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7131,031,658 - 131,055,839 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07133,257,199 - 133,281,380 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07133,169,669 - 133,193,851 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07139,702,066 - 139,722,132 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7139,685,573 - 139,722,132 (+)Ensemblrn6Rnor6.0
Rnor_5.07138,837,772 - 138,857,276 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47136,826,122 - 136,846,040 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7125,730,934 - 125,751,002 (+)NCBICelera
RGSC_v3.17136,898,639 - 136,922,477 (+)NCBI
RH 3.4 Map71088.6RGD
Cytogenetic Map7q36NCBI
PFKM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381248,105,353 - 48,146,404 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1248,105,139 - 48,150,704 (+)Ensemblhg38GRCh38
GRCh371248,499,136 - 48,540,187 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361246,802,817 - 46,826,154 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341246,802,814 - 46,826,154NCBI
Celera1247,297,160 - 47,337,691 (+)NCBICelera
Cytogenetic Map12q13.11NCBI
HuRef1245,531,136 - 45,571,668 (+)NCBIHuRef
CHM1_11248,465,088 - 48,505,624 (+)NCBICHM1_1
T2T-CHM13v2.01248,066,690 - 48,107,749 (+)NCBIT2T-CHM13v2.0
Pfkm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391597,990,470 - 98,030,328 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1597,990,470 - 98,030,332 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381598,092,589 - 98,132,447 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1598,092,589 - 98,132,451 (+)Ensemblmm10GRCm38
MGSCv371597,923,020 - 97,962,878 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361597,940,155 - 97,960,485 (+)NCBIMGSCv36mm8
Celera15100,219,444 - 100,262,084 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1554.09NCBI
Pfkm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555006,978,893 - 7,022,309 (+)Ensembl
ChiLan1.0NW_0049555006,979,169 - 7,020,375 (+)NCBIChiLan1.0ChiLan1.0
PFKM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21046,018,686 - 46,059,557 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11246,015,444 - 46,056,280 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01240,584,321 - 40,625,245 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11241,459,346 - 41,500,101 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1241,459,346 - 41,499,476 (-)EnsemblpanPan2panpan1.1
PFKM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1276,620,300 - 6,640,649 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl276,620,300 - 6,663,670 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2739,641,501 - 39,686,323 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0276,687,848 - 6,732,671 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl276,687,848 - 6,732,740 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1276,625,373 - 6,670,151 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0276,660,147 - 6,704,882 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02739,930,101 - 39,974,930 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pfkm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494567,132,891 - 67,175,202 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365126,006,046 - 6,032,899 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365126,006,247 - 6,031,939 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PFKM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl578,476,123 - 78,526,997 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1578,475,473 - 78,525,052 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2581,673,123 - 81,695,166 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5q25NCBI
PFKM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11144,332,857 - 44,378,273 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1144,334,605 - 44,377,877 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037202,000,136 - 202,046,219 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pfkm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248164,131,752 - 4,156,749 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248164,132,511 - 4,156,809 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pfkm
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11270,920,090 - 270,943,768 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pfkm
233 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:44
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000013374
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7116269196132020414Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
Pfkm  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87131,137,986 - 131,138,214 (+)Marker Load Pipeline
mRatBN7.27129,258,928 - 129,259,156 (+)MAPPERmRatBN7.2
Rnor_6.07139,721,869 - 139,722,096NCBIRnor6.0
Rnor_5.07138,857,013 - 138,857,240UniSTSRnor5.0
RGSC_v3.47136,845,777 - 136,846,004UniSTSRGSC3.4
Celera7125,750,739 - 125,750,966UniSTS
RH 3.4 Map71088.6UniSTS
Cytogenetic Map7q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000078579   ⟹   ENSRNOP00000070507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7131,118,072 - 131,138,248 (+)Ensembl
mRatBN7.2 Ensembl7129,235,040 - 129,259,192 (+)Ensembl
Rnor_6.0 Ensembl7139,698,148 - 139,722,132 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088376   ⟹   ENSRNOP00000075742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7131,100,753 - 131,138,248 (+)Ensembl
mRatBN7.2 Ensembl7129,221,653 - 129,259,192 (+)Ensembl
Rnor_6.0 Ensembl7139,685,573 - 139,721,950 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115728   ⟹   ENSRNOP00000090398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7131,100,753 - 131,138,248 (+)Ensembl
mRatBN7.2 Ensembl7129,221,653 - 129,259,192 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000169921   ⟹   ENSRNOP00000110440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7131,118,069 - 131,138,248 (+)Ensembl
RefSeq Acc Id: NM_031715   ⟹   NP_113903
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,114,099 - 131,138,250 (+)NCBI
mRatBN7.27129,235,040 - 129,259,192 (+)NCBI
Rnor_6.07139,702,066 - 139,722,132 (+)NCBI
Rnor_5.07138,837,772 - 138,857,276 (+)NCBI
RGSC_v3.47136,826,122 - 136,846,040 (+)RGD
Celera7125,730,934 - 125,751,002 (+)RGD
Sequence:
RefSeq Acc Id: XM_039079863   ⟹   XP_038935791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,100,723 - 131,138,250 (+)NCBI
mRatBN7.27129,221,679 - 129,259,192 (+)NCBI
RefSeq Acc Id: XM_063264218   ⟹   XP_063120288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,100,760 - 131,138,250 (+)NCBI
RefSeq Acc Id: XM_063264219   ⟹   XP_063120289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,100,684 - 131,138,250 (+)NCBI
RefSeq Acc Id: XM_063264220   ⟹   XP_063120290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,100,751 - 131,138,250 (+)NCBI
RefSeq Acc Id: NP_113903   ⟸   NM_031715
- UniProtKB: Q63736 (UniProtKB/Swiss-Prot),   P47858 (UniProtKB/Swiss-Prot),   Q52KS1 (UniProtKB/TrEMBL),   A6KC58 (UniProtKB/TrEMBL),   A0A0G2JY38 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070507   ⟸   ENSRNOT00000078579
Ensembl Acc Id: ENSRNOP00000075742   ⟸   ENSRNOT00000088376
RefSeq Acc Id: XP_038935791   ⟸   XM_039079863
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KBC7 (UniProtKB/TrEMBL),   A0A8I6ADR0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090398   ⟸   ENSRNOT00000115728
RefSeq Acc Id: XP_063120289   ⟸   XM_063264219
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KBC7 (UniProtKB/TrEMBL),   A0A8I6ADR0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120290   ⟸   XM_063264220
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KBC7 (UniProtKB/TrEMBL),   A0A8I6ADR0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120288   ⟸   XM_063264218
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KBC7 (UniProtKB/TrEMBL),   A0A8I6ADR0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000110440   ⟸   ENSRNOT00000169921
Protein Domains
Phosphofructokinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47858-F1-model_v2 AlphaFold P47858 1-780 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695621
Promoter ID:EPDNEW_R6146
Type:multiple initiation site
Name:Pfkm_1
Description:phosphofructokinase, muscle
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07139,698,109 - 139,698,169EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68419 AgrOrtholog
BioCyc Gene G2FUF-32160 BioCyc
BioCyc Pathway ANAGLYCOLYSIS-PWY [glycolysis III (from glucose)] BioCyc
BioCyc Pathway Image ANAGLYCOLYSIS-PWY BioCyc
Ensembl Genes ENSRNOG00000057988 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000078579 ENTREZGENE
  ENSRNOT00000088376 ENTREZGENE
Gene3D-CATH 3.40.50.450 UniProtKB/Swiss-Prot
  3.40.50.460 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7314667 IMAGE-MGC_LOAD
InterPro 6-Pfructokinase_euk UniProtKB/Swiss-Prot
  ATP_PFK UniProtKB/Swiss-Prot
  PFK_vert-type UniProtKB/Swiss-Prot
  Phosphofructokinase_CS UniProtKB/Swiss-Prot
  Phosphofructokinase_dom UniProtKB/Swiss-Prot
  PKF_sf UniProtKB/Swiss-Prot
KEGG Report rno:65152 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105392 IMAGE-MGC_LOAD
NCBI Gene 65152 ENTREZGENE
PANTHER ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, MUSCLE TYPE UniProtKB/Swiss-Prot
  PHOSPHOFRUCTOKINASE UniProtKB/Swiss-Prot
Pfam PFK UniProtKB/Swiss-Prot
PhenoGen Pfkm PhenoGen
PIRSF ATP_PFK_euk UniProtKB/Swiss-Prot
PRINTS PHFRCTKINASE UniProtKB/Swiss-Prot
PROSITE PHOSPHOFRUCTOKINASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000057988 RatGTEx
Superfamily-SCOP SSF53784 UniProtKB/Swiss-Prot
UniProt A0A0G2JY38 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2KBC7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ADR0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M529_RAT UniProtKB/TrEMBL
  A0ABZ3NNC7_RAT UniProtKB/TrEMBL
  A6KC58 ENTREZGENE
  A6KC59_RAT UniProtKB/TrEMBL
  P47858 ENTREZGENE, UniProtKB/Swiss-Prot
  Q52KS1 ENTREZGENE, UniProtKB/TrEMBL
  Q63736 ENTREZGENE
UniProt Secondary Q63736 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Pfkm  phosphofructokinase, muscle      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed at high levels in muscle and in in pancreatic beta cells 68288