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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | increases expression | ISO | RGD:68622 | 6480464 | Ethinyl Estradiol results in increased expression of PFKM mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of PFKM mRNA | CTD | PMID:17351261 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:68622 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PFKM mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:68622 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PFKM mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:68621 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PFKM mRNA | CTD | PMID:23152189 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:68621 | 6480464 | 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PFKM mRNA]; more ... | CTD | PMID:23152189 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:68622 | 6480464 | Tetrachlorodibenzodioxin affects the expression of PFKM mRNA | CTD | PMID:21570461 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of PFKM mRNA | CTD | PMID:21346803 | 2-butoxyethanol | increases expression | ISO | RGD:68622 | 6480464 | n-butoxyethanol results in increased expression of PFKM mRNA | CTD | PMID:19812364 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:68622 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PFKM mRNA | CTD | PMID:20188158 | 7,12-dimethyltetraphene | increases expression | ISO | RGD:68621 | 6480464 | 9,10-Dimethyl-1,2-benzanthracene results in increased expression of PFKM mRNA | CTD | PMID:19502547 | aflatoxin B1 | decreases expression | ISO | RGD:68621 | 6480464 | Aflatoxin B1 results in decreased expression of PFKM mRNA | CTD | PMID:22100608 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of PFKM mRNA | CTD | PMID:16483693 | benzo[a]pyrene | decreases expression | ISO | RGD:68622 | 6480464 | Benzo(a)pyrene results in decreased expression of PFKM mRNA | CTD | PMID:22228805 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PFKM mRNA | CTD | PMID:18180321 | carmustine | decreases expression | ISO | RGD:68621 | 6480464 | Carmustine results in decreased expression of PFKM mRNA | CTD | PMID:15980968 | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of PFKM mRNA | CTD | PMID:22982409 | copper atom | decreases expression | EXP | | 6480464 | Copper results in decreased expression of PFKM mRNA | CTD | PMID:22465980 | copper(0) | decreases expression | EXP | | 6480464 | Copper results in decreased expression of PFKM mRNA | CTD | PMID:22465980 | coumarin 460 | increases expression | ISO | RGD:68621 | 6480464 | 4-methyl-7-diethylaminocoumarin results in increased expression of PFKM mRNA | CTD | PMID:19502547 | daunorubicin | decreases expression | EXP | | 6480464 | Daunorubicin results in decreased expression of PFKM mRNA | CTD | PMID:9038198 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of PFKM mRNA | CTD | PMID:21266533 | dibutyl phthalate | decreases expression | ISO | RGD:68622 | 6480464 | Dibutyl Phthalate results in decreased expression of PFKM mRNA | CTD | PMID:21266533 | diethylstilbestrol | decreases expression | EXP | | 6480464 | Diethylstilbestrol results in decreased expression of PFKM mRNA | CTD | PMID:17011747 | diethylstilbestrol | increases expression | EXP | | 6480464 | Diethylstilbestrol results in increased expression of PFKM mRNA | CTD | PMID:17011747 | doxorubicin | decreases expression | EXP | | 6480464 | Doxorubicin results in decreased expression of PFKM mRNA | CTD | PMID:9038198 | indole-3-methanol | affects expression | EXP | | 6480464 | indole-3-carbinol affects the expression of PFKM mRNA | CTD | PMID:21396975 | lead(0) | decreases expression | ISO | RGD:68621 | 6480464 | Lead results in decreased expression of PFKM mRNA | CTD | PMID:19921347 | ochratoxin A | increases expression | EXP | | 6480464 | ochratoxin A results in increased expression of PFKM mRNA | CTD | PMID:19717638 | paracetamol | affects expression | ISO | RGD:68622 | 6480464 | Acetaminophen affects the expression of PFKM mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | RGD:68621 | 6480464 | Acetaminophen results in decreased expression of PFKM mRNA | CTD | PMID:22230336 | pirinixic acid | multiple interactions | ISO | RGD:68621 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PFKM mRNA | CTD | PMID:19710929 | rosiglitazone | decreases expression | EXP | | 6480464 | rosiglitazone results in decreased expression of PFKM mRNA | CTD | PMID:19211718 | rosiglitazone | affects expression | ISO | RGD:68622 | 6480464 | rosiglitazone affects the expression of PFKM protein | CTD | PMID:21347706 | vancomycin | increases expression | ISO | RGD:68622 | 6480464 | Vancomycin results in increased expression of PFKM mRNA | CTD | PMID:18930951 | zinc sulfate | decreases expression | ISO | RGD:68621 | 6480464 | Zinc Sulfate results in decreased expression of PFKM mRNA | CTD | PMID:12756304 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Fructose and mannose metabolism |
| Galactose metabolism | |
| Glycolysis / Gluconeogenesis | |
| Metabolic pathways | |
| Pentose phosphate pathway | |
| Pathway Interaction Database | Validated targets of C-MYC transcriptional activation (PID:200056) |
Disease Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Fructose and mannose metabolism |
| Galactose metabolism | |
| Glycolysis / Gluconeogenesis | |
| Metabolic pathways | |
| Pentose phosphate pathway | |
| Pathway Interaction Database | Validated targets of C-MYC transcriptional activation (PID:200056) |
References - curated| 1. |
Amit R, etal., Muscle Nerve. 1992 Apr;15(4):455-8. |
| 2. |
Chen-Zion M, etal., Biochem Mol Med. 1995 Oct;56(1):19-25. |
| 3. |
GOA data from the GO Consortium |
| 4. |
KEGG |
| 5. |
Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 |
| 6. |
Ma Z, etal., Biochim Biophys Acta 1996 Aug 14;1308(2):151-63. |
| 7. |
MGD data from the GO Consortium |
| 8. |
Nakajima H, etal., Biochem J 1994 Oct 15;303 ( Pt 2):449-53. |
| 9. |
Nakajima H, etal., FEBS Lett 1987 Oct 19;223(1):113-6. |
| 10. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 11. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 12. |
RGD automated data pipeline |
| 13. |
RGD automated import pipeline for gene-chemical interactions |
| 14. |
RGD Automated Pipelines |
| 15. |
Tessier JP, etal., Cardiovasc Res. 2003 Oct 15;60(1):119-30. |
| 16. |
Tornheim K and Lowenstein JM, J Biol Chem. 1976 Dec 10;251(23):7322-8. |
| 17. |
Tornheim K J Biol Chem. 1985 Jul 5;260(13):7985-9. |
| 18. |
Vora S, etal., Biochem J. 1985 Jul 15;229(2):333-41. |
| 19. |
Yamasaki T, etal., Gene 1991 Aug 15;104(2):277-82. |
References - uncurated
RGD Disease Portals| Pfkm has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Pfkm (Rattus norvegicus) |
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| PFKM (Homo sapiens) |
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| Pfkm (Mus musculus) |
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Position Markers| Pfkm |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_031715 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06052684 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01052574 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC094212 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474035 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D21869 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D21870 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FN433010 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ211719 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U25651 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_031715 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_113903 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_113903 | (Get FASTA) |
| GenBank Protein | AAC52786 | (Get FASTA) |
| AAH94212 | (Get FASTA) | |
| BAA21013 | (Get FASTA) | |
| BAA21894 | (Get FASTA) | |
| CBA11529 | (Get FASTA) | |
| EDL87083 | (Get FASTA) | |
| EDL87084 | (Get FASTA) | |
| EDL87085 | (Get FASTA) | |
| EDL87086 | (Get FASTA) | |
| P47858 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000009628 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000013374 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000013374 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 65152 | ENTREZGENE |
| Germonline | ENSRNOG00000009628 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 20101 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7314667 | IMAGE-MGC_LOAD |
| InterPro | 6-phosphofructokinase_euk | UniProtKB/Swiss-Prot |
| Phosphofructokinase | UniProtKB/Swiss-Prot | |
| Phosphofructokinase | UniProtKB/Swiss-Prot | |
| Phosphofructokinase_CS | UniProtKB/Swiss-Prot | |
| IPI | IPI00231293 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:65152 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:105392 | IMAGE-MGC_LOAD |
| Pfam | PFK | UniProtKB/Swiss-Prot |
| PIRSF | ATP_PFK_euk | UniProtKB/Swiss-Prot |
| PRINTS | PHFRCTKINASE | UniProtKB/Swiss-Prot |
| PROSITE | PHOSPHOFRUCTOKINASE | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Ppfruckinase | UniProtKB/Swiss-Prot |
| TIGRFAMs | 6PF1K_euk | UniProtKB/Swiss-Prot |
| UniGene | Rn.11004 | ENTREZGENE |
| UniProt | K6PF_RAT | UniProtKB/Swiss-Prot |
| Q52KS1_RAT | UniProtKB/TrEMBL | |
| Q9Z1I3_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2002-06-10 | Pfkm | phosphofructokinase, muscle | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | expressed at high levels in muscle and in in pancreatic beta cells | 68288 |
| More on Pfkm | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 68419 |
| Created: | 2001-07-11 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




