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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68419
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pfkm
Name: phosphofructokinase, muscle
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pfkmaffects expressionISOPfkm (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of PFKM mRNAPMID:21570461
Pfkmdecreases expressionISOPFKM (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of PFKM mRNAPMID:23152189
Pfkmmultiple interactionsISOPFKM (Homo sapiens)6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PFKM mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PFKM mRNA]PMID:23152189
Pfkmmultiple interactionsISOPfkm (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PFKM mRNAPMID:17942748
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