Sh2b3 (SH2B adaptor protein 3) - Rat Genome Database

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Gene: Sh2b3 (SH2B adaptor protein 3) Rattus norvegicus
Analyze
Symbol: Sh2b3
Name: SH2B adaptor protein 3
RGD ID: 68411
Description: Enables phosphate ion binding activity. Involved in negative regulation of sprouting angiogenesis and regulation of regulatory T cell differentiation. Used to study hypertension. Human ortholog(s) of this gene implicated in colorectal cancer; essential thrombocythemia; familial erythrocytosis 1; myelofibrosis; and type 1 diabetes mellitus. Orthologous to human SH2B3 (SH2B adaptor protein 3); PARTICIPATES IN erythropoietin signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: linker of T-cell receptor pathways; Lnk; lymphocyte adapter protein; lymphocyte-specific adapter protein Lnk; SH2B adapter protein 3; signal transduction protein Lnk
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Sh2b3em1Mcwi ; Sh2b3em2Mcwi
Genetic Models: SS-Sh2b3em1Mcwi ; SS-Sh2b3em2Mcwi ; SS-Sh2b3em2Mcwi-/- ; SS-Sh2b3em1Mcwi-/+ ; SS-Sh2b3em1Mcwi-/-
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,391,755 - 40,414,336 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1240,392,633 - 40,414,335 (+)EnsemblGRCr8
mRatBN7.21234,731,934 - 34,753,617 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,731,911 - 34,753,616 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1235,904,822 - 35,926,500 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,516,036 - 36,537,714 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,568,505 - 35,590,183 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01240,261,990 - 40,265,757 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,244,081 - 40,265,757 (+)Ensemblrn6Rnor6.0
Rnor_5.01242,132,947 - 42,136,714 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41235,954,679 - 35,958,446 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1236,414,671 - 36,418,438 (+)NCBICelera
RGSC_v3.11235,818,066 - 35,821,834 (+)NCBI
Cytogenetic Map12q16NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
hexachlorobenzene  (EXP)
indometacin  (ISO)
inulin  (ISO)
isobutanol  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nitrates  (ISO)
okadaic acid  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prothioconazole  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis. Flister MJ, etal., Circ Cardiovasc Genet. 2015 Apr;8(2):294-304. doi: 10.1161/CIRCGENETICS.114.000527. Epub 2015 Jan 27.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Genetic analysis of adult-onset autoimmune diabetes. Howson JM, etal., Diabetes. 2011 Oct;60(10):2645-53. Epub 2011 Aug 26.
4. Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinase. Huang X, etal., Proc Natl Acad Sci U S A 1995 Dec 5;92(25):11618-22.
5. Rat messenger RNA for the retinal pigment epithelium-specific protein RPE65 gradually accumulates in two weeks from late embryonic days. Manes G, etal., FEBS Lett 1998 Feb 20;423(2):133-7.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. LNK protein: Low expression in human colorectal carcinoma and relationship with tumor invasion. Pan J, etal., Biomed Pharmacother. 2020 Jan;121:109467. doi: 10.1016/j.biopha.2019.109467. Epub 2019 Nov 6.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. Plagnol V, etal., PLoS Genet. 2011 Aug;7(8):e1002216. doi: 10.1371/journal.pgen.1002216. Epub 2011 Aug 4.
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation. Rudemiller NP, etal., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer. Timofeeva MN, etal., Sci Rep. 2015 Nov 10;5:16286. doi: 10.1038/srep16286.
19. Creation and preliminary characterization of a leptin knockout rat. Vaira S, etal., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4.
Additional References at PubMed
PMID:11805142   PMID:14612394   PMID:15337790   PMID:20404132   PMID:22028877   PMID:26101343   PMID:27430239   PMID:31799683  


Genomics

Comparative Map Data
Sh2b3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,391,755 - 40,414,336 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1240,392,633 - 40,414,335 (+)EnsemblGRCr8
mRatBN7.21234,731,934 - 34,753,617 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,731,911 - 34,753,616 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1235,904,822 - 35,926,500 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,516,036 - 36,537,714 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,568,505 - 35,590,183 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01240,261,990 - 40,265,757 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,244,081 - 40,265,757 (+)Ensemblrn6Rnor6.0
Rnor_5.01242,132,947 - 42,136,714 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41235,954,679 - 35,958,446 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1236,414,671 - 36,418,438 (+)NCBICelera
RGSC_v3.11235,818,066 - 35,821,834 (+)NCBI
Cytogenetic Map12q16NCBI
SH2B3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812111,404,730 - 111,451,623 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12111,405,000 - 111,451,623 (+)Ensemblhg38GRCh38
GRCh3712111,843,727 - 111,889,427 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612110,328,135 - 110,373,810 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3412110,306,471 - 110,352,146NCBI
Celera12111,470,186 - 111,515,861 (+)NCBICelera
Cytogenetic Map12q24.12NCBI
HuRef12108,858,506 - 108,903,968 (+)NCBIHuRef
CHM1_112111,811,712 - 111,857,391 (+)NCBICHM1_1
T2T-CHM13v2.012111,385,588 - 111,432,181 (+)NCBIT2T-CHM13v2.0
Sh2b3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395121,953,544 - 121,975,706 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5121,953,551 - 121,975,709 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385121,815,481 - 121,837,645 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5121,815,488 - 121,837,646 (-)Ensemblmm10GRCm38
MGSCv375122,267,224 - 122,286,810 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365122,077,832 - 122,097,418 (-)NCBIMGSCv36mm8
Celera5118,907,377 - 118,942,299 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map561.99NCBI
Sh2b3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554828,096,160 - 8,097,765 (+)Ensembl
ChiLan1.0NW_0049554828,079,905 - 8,100,791 (+)NCBIChiLan1.0ChiLan1.0
SH2B3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210119,471,325 - 119,518,001 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112119,467,715 - 119,514,391 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012108,977,344 - 109,024,029 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112112,371,797 - 112,418,746 (+)NCBIPanPan1.1PanPan1.1panPan2
SH2B3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1269,033,851 - 9,073,095 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl269,005,281 - 9,070,204 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha269,206,973 - 9,235,670 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0269,303,831 - 9,332,542 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,292,891 - 9,329,651 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,259,823 - 9,288,511 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0269,322,052 - 9,350,491 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0269,275,536 - 9,304,251 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sh2b3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118155,352,543 - 155,375,181 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365584,104,534 - 4,123,869 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365584,103,898 - 4,126,883 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SH2B3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1432,623,286 - 32,664,606 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11432,623,286 - 32,664,606 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21434,618,865 - 34,660,151 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SH2B3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111106,657,601 - 106,703,940 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11106,670,685 - 106,700,619 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037138,394,084 - 138,440,116 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sh2b3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474720,730,751 - 20,759,625 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474720,729,142 - 20,759,631 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Sh2b3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11632,007,303 - 32,028,364 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sh2b3
153 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1318
Count of miRNA genes:274
Interacting mature miRNAs:359
Transcripts:ENSRNOT00000030583, ENSRNOT00000073611, ENSRNOT00000075776
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123776414551558799Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122977552242298555Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)123424347543352593Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat


Genetic Models
This gene Sh2b3 is modified in the following models/strains:
SS-Sh2b3em1Mcwi     SS-Sh2b3em2Mcwi     SS-Sh2b3em2Mcwi-/-     SS-Sh2b3em1Mcwi-/+     SS-Sh2b3em1Mcwi-/-    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000030583   ⟹   ENSRNOP00000038125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1240,392,633 - 40,414,335 (+)Ensembl
mRatBN7.2 Ensembl1234,731,911 - 34,753,616 (+)Ensembl
Rnor_6.0 Ensembl1240,244,081 - 40,265,757 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000143806   ⟹   ENSRNOP00000110469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1240,392,654 - 40,414,334 (+)Ensembl
RefSeq Acc Id: NM_001402348   ⟹   NP_001389277
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,392,656 - 40,414,336 (+)NCBI
mRatBN7.21234,731,934 - 34,753,617 (+)NCBI
RefSeq Acc Id: XM_063271603   ⟹   XP_063127673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,392,935 - 40,414,336 (+)NCBI
RefSeq Acc Id: XM_063271604   ⟹   XP_063127674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,391,755 - 40,414,336 (+)NCBI
RefSeq Acc Id: XM_063271605   ⟹   XP_063127675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,410,221 - 40,414,336 (+)NCBI
Ensembl Acc Id: ENSRNOP00000038125   ⟸   ENSRNOT00000030583
RefSeq Acc Id: NP_001389277   ⟸   NM_001402348
- UniProtKB: D4ABY6 (UniProtKB/TrEMBL),   A6J1C7 (UniProtKB/TrEMBL),   A6J1C6 (UniProtKB/TrEMBL),   A6J1C5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127674   ⟸   XM_063271604
- Peptide Label: isoform X1
- UniProtKB: A6J1C6 (UniProtKB/TrEMBL),   A6J1C7 (UniProtKB/TrEMBL),   D4ABY6 (UniProtKB/TrEMBL),   A6J1C5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127673   ⟸   XM_063271603
- Peptide Label: isoform X1
- UniProtKB: A6J1C6 (UniProtKB/TrEMBL),   A6J1C7 (UniProtKB/TrEMBL),   D4ABY6 (UniProtKB/TrEMBL),   A6J1C5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127675   ⟸   XM_063271605
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000110469   ⟸   ENSRNOT00000143806
Protein Domains
SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50745-F1-model_v2 AlphaFold P50745 1-368 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68411 AgrOrtholog
BioCyc Gene G2FUF-19221 BioCyc
Ensembl Genes ENSRNOG00000028198 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000030583 ENTREZGENE
  ENSRNOT00000143806 ENTREZGENE
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot
InterPro SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SH2B UniProtKB/Swiss-Prot
  SH2B3_SH2 UniProtKB/Swiss-Prot
NCBI Gene 58838 ENTREZGENE
PANTHER PTHR10872 UniProtKB/Swiss-Prot
  PTHR10872:SF1 UniProtKB/Swiss-Prot
Pfam SH2 UniProtKB/Swiss-Prot
PhenoGen Sh2b3 PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
PROSITE SH2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000028198 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55550 UniProtKB/Swiss-Prot
TIGR TC229436
UniProt A6J1C5 ENTREZGENE, UniProtKB/TrEMBL
  A6J1C6 ENTREZGENE, UniProtKB/TrEMBL
  A6J1C7 ENTREZGENE, UniProtKB/TrEMBL
  D4ABY6 ENTREZGENE
  P50745 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-18 Sh2b3  SH2B adaptor protein 3  Lnk  linker of T-cell receptor pathways  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Lnk  linker of T-cell receptor pathways      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a Src homology 2 (SH2) domain and a tyrosine phosphorylation site 68272
gene_function interacts with phospholipase C gamma 1, phosphatidylinositol 3-kinase, and Grb-2 in activated T-cells 68272