Tbp (TATA box binding protein) - Rat Genome Database

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Gene: Tbp (TATA box binding protein) Rattus norvegicus
Analyze
Symbol: Tbp
Name: TATA box binding protein
RGD ID: 67398
Description: Enables DNA binding activity. Contributes to RNA polymerase II general transcription initiation factor activity. Involved in positive regulation of DNA-templated transcription and spermatogenesis. Part of transcription factor TFIID complex. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; schizophrenia; spinocerebellar ataxia type 17; and type 1 diabetes mellitus. Orthologous to human TBP (TATA-box binding protein); PARTICIPATES IN cisplatin drug pathway; RNA polymerase I transcription pathway; RNA polymerase II transcription initiation pathway; INTERACTS WITH 2,4-dinitrotoluene; fipronil; thioacetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC93994; TATA-box-binding protein; TFIID
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8165,136,420 - 65,153,515 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl165,136,448 - 65,190,899 (+)EnsemblGRCr8
mRatBN7.2156,463,330 - 56,480,430 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl156,463,618 - 56,510,016 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx161,312,927 - 61,329,705 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0169,976,468 - 69,993,260 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0163,222,896 - 63,239,688 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0157,491,381 - 57,509,335 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl157,491,643 - 57,508,449 (+)Ensemblrn6Rnor6.0
Rnor_5.0158,419,943 - 58,438,618 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4154,390,756 - 54,407,563 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera152,668,920 - 52,685,703 (+)NCBICelera
RGSC_v3.1154,393,700 - 54,410,507 (+)NCBI
Cytogenetic Map1q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. TIP120B: a novel TIP120-family protein that is expressed specifically in muscle tissues. Aoki T, etal., Biochem Biophys Res Commun 1999 Aug 11;261(3):911-6.
2. Expanded trinucleotide repeats in the TBP/SCA17 gene mapped to chromosome 6q27 are associated with schizophrenia. Chen CM, etal., Schizophr Res. 2005 Oct 15;78(2-3):131-6.
3. increased Expression of TBP/TFIID after spinal cord injury in adult rats. Ding T, etal., Cell Mol Neurobiol. 2014 Jul;34(5):669-77. doi: 10.1007/s10571-014-0048-7. Epub 2014 Apr 8.
4. Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. Dumay-Odelot H, etal., Cell Cycle. 2010 Sep 15;9(18):3687-99. Epub 2010 Sep 1.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Structural insights into transcription initiation by RNA polymerase II. Grunberg S and Hahn S, Trends Biochem Sci. 2013 Dec;38(12):603-11. doi: 10.1016/j.tibs.2013.09.002. Epub 2013 Oct 11.
8. Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor. Huang S, etal., Brain. 2011 Jul;134(Pt 7):1943-58.
9. Isolation of rat TATA factor as an active 75kDa protein complex. Igarashi A, etal., Biochem Biophys Res Commun. 1994 Nov 15;204(3):1125-30.
10. A novel transgenic rat model for spinocerebellar ataxia type 17 recapitulates neuropathological changes and supplies in vivo imaging biomarkers. Kelp A, etal., J Neurosci. 2013 May 22;33(21):9068-81. doi: 10.1523/JNEUROSCI.5622-12.2013.
11. TFIIB-related factors in RNA polymerase I transcription. Knutson BA and Hahn S, Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):265-73. doi: 10.1016/j.bbagrm.2012.08.003. Epub 2012 Aug 30.
12. Structural bioinformatics of the general transcription factor TFIID. Malkowska M, etal., Biochimie. 2013 Apr;95(4):680-91. doi: 10.1016/j.biochi.2012.10.024. Epub 2012 Nov 9.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein. Nakamura K, etal., Hum Mol Genet. 2001 Jul 1;10(14):1441-8.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Association of a CAG/CAA repeat sequence in the TBP gene with type I diabetes. Owerbach D, etal., Biochem Biophys Res Commun. 2004 Oct 22;323(3):865-9.
17. No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes. Payne F, etal., Biochem Biophys Res Commun. 2005 Jun 3;331(2):435-41.
18. Transcription of the TATA binding protein gene is highly up-regulated during spermatogenesis. Persengiev SP, etal., Mol Endocrinol. 1996 Jun;10(6):742-7.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. Hepatitis C virus NS5A protein binds TBP and p53, inhibiting their DNA binding and p53 interactions with TBP and ERCC3. Qadri I, etal., Biochim Biophys Acta. 2002 Oct 21;1592(2):193-204.
21. TBP, a polyglutamine tract containing protein, accumulates in Alzheimer's disease. Reid SJ, etal., Brain Res Mol Brain Res. 2004 Jun 18;125(1-2):120-8.
22. An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps. Remmers EF, etal., Transplant Proc 1999 May;31(3):1549-54.
23. GOA pipeline RGD automated data pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. The presence of TATA-binding protein in the brainstem, correlated with sleep apnea in SIDS victims. Sawaguchi T, etal., Early Hum Dev. 2003 Dec;75 Suppl:S109-18.
26. Fundamental cellular processes do not require vertebrate-specific sequences within the TATA-binding protein. Schmidt EE, etal., J Biol Chem 2003 Feb 21;278(8):6168-74. Epub 2002 Dec 5.
27. RNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation. Schneider DA Gene. 2012 Feb 10;493(2):176-84. doi: 10.1016/j.gene.2011.08.006. Epub 2011 Aug 26.
28. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
29. Inhibition of transcription by platinum antitumor compounds. Todd RC and Lippard SJ, Metallomics. 2009;1(4):280-91. doi: 10.1039/b907567d.
30. Insoluble TATA-binding protein accumulation in Huntington's disease cortex. van Roon-Mom WM, etal., Brain Res Mol Brain Res. 2002 Dec 30;109(1-2):1-10.
31. A structural perspective on RNA polymerase I and RNA polymerase III transcription machineries. Vannini A Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):258-64. doi: 10.1016/j.bbagrm.2012.09.009. Epub 2012 Sep 29.
32. Selective alterations of transcription factors in MPP+-induced neurotoxicity in PC12 cells. Xu Z, etal., Neurotoxicology. 2005 Aug;26(4):729-37.
33. Molecular cloning of a novel 120-kDa TBP-interacting protein. Yogosawa S, etal., Biochem Biophys Res Commun 1996 Dec 13;229(2):612-7.
34. Association of the rat heterogeneous nuclear RNA-ribonucleoprotein F with TATA-binding protein. Yoshida T, etal., FEBS Lett 1999 Aug 27;457(2):251-4.
Additional References at PubMed
PMID:7724559   PMID:7729427   PMID:7933101   PMID:8626665   PMID:9027316   PMID:9722567   PMID:9841876   PMID:10526239   PMID:11005381   PMID:11861477   PMID:12411709   PMID:12665565  
PMID:12676957   PMID:14580349   PMID:15601870   PMID:15641800   PMID:15927180   PMID:16263792   PMID:16522640   PMID:16540471   PMID:16822332   PMID:17242199   PMID:17641088   PMID:18218637  
PMID:18722179   PMID:18838386   PMID:19235719   PMID:19861239   PMID:21245044   PMID:22194471   PMID:22323595   PMID:24289924   PMID:25336585   PMID:26638071   PMID:27007846   PMID:27193682  
PMID:27923787   PMID:28134789  


Genomics

Comparative Map Data
Tbp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8165,136,420 - 65,153,515 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl165,136,448 - 65,190,899 (+)EnsemblGRCr8
mRatBN7.2156,463,330 - 56,480,430 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl156,463,618 - 56,510,016 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx161,312,927 - 61,329,705 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0169,976,468 - 69,993,260 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0163,222,896 - 63,239,688 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0157,491,381 - 57,509,335 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl157,491,643 - 57,508,449 (+)Ensemblrn6Rnor6.0
Rnor_5.0158,419,943 - 58,438,618 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4154,390,756 - 54,407,563 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera152,668,920 - 52,685,703 (+)NCBICelera
RGSC_v3.1154,393,700 - 54,410,507 (+)NCBI
Cytogenetic Map1q12NCBI
TBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386170,554,369 - 170,572,859 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6170,554,302 - 170,572,870 (+)Ensemblhg38GRCh38
GRCh376170,863,457 - 170,881,947 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366170,705,396 - 170,723,872 (+)NCBIBuild 36Build 36hg18NCBI36
Build 346170,781,102 - 170,799,578NCBI
Celera6171,658,683 - 171,677,210 (+)NCBICelera
Cytogenetic Map6q27NCBI
HuRef6168,368,477 - 168,387,004 (+)NCBIHuRef
CHM1_16171,124,696 - 171,144,174 (+)NCBICHM1_1
T2T-CHM13v2.06171,927,920 - 171,946,405 (+)NCBIT2T-CHM13v2.0
Tbp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391715,720,150 - 15,737,689 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1715,720,150 - 15,748,641 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381715,499,888 - 15,517,427 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1715,499,888 - 15,528,379 (+)Ensemblmm10GRCm38
MGSCv371715,636,852 - 15,654,391 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361715,208,038 - 15,221,746 (+)NCBIMGSCv36mm8
Celera1716,285,165 - 16,302,716 (+)NCBICelera
Cytogenetic Map17A2NCBI
cM Map178.95NCBI
Tbp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554113,268,147 - 3,285,077 (-)Ensembl
ChiLan1.0NW_0049554113,268,147 - 3,285,567 (-)NCBIChiLan1.0ChiLan1.0
TBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25190,831,188 - 190,849,739 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16188,732,844 - 188,751,386 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06168,714,214 - 168,732,744 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16173,800,204 - 173,818,744 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6173,800,240 - 173,826,909 (+)EnsemblpanPan2panpan1.1
TBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11272,458,959 - 72,479,271 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1272,459,041 - 72,479,124 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1272,221,201 - 72,241,583 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01273,444,412 - 73,464,611 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1273,441,852 - 73,464,514 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11272,717,146 - 72,737,106 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01272,539,334 - 72,559,523 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01272,930,358 - 72,950,554 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tbp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946151,203,571 - 151,222,342 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493709846,248 - 65,441 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493709846,572 - 65,304 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.115,669 - 23,675 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TBP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11397,661,905 - 97,678,640 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1397,660,864 - 97,681,497 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604069,659,919 - 69,679,427 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tbp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248506,359,418 - 6,375,391 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248506,359,382 - 6,375,391 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tbp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v114478,386 - 495,276 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tbp
78 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:64
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000002038
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat

Markers in Region
Tbp  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2156,467,687 - 56,467,977 (+)MAPPERmRatBN7.2
Rnor_6.0157,495,713 - 57,496,002NCBIRnor6.0
Rnor_5.0158,424,271 - 58,424,560UniSTSRnor5.0
RGSC_v3.4154,394,826 - 54,395,115UniSTSRGSC3.4
Celera152,672,990 - 52,673,279UniSTS
Cytogenetic Map1q12UniSTS
Tbp  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2156,480,048 - 56,480,246 (+)MAPPERmRatBN7.2
Rnor_6.0157,508,071 - 57,508,268NCBIRnor6.0
Rnor_5.0158,438,183 - 58,438,380UniSTSRnor5.0
Celera152,685,324 - 52,685,521UniSTS
Cytogenetic Map1q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002038   ⟹   ENSRNOP00000002038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl165,136,448 - 65,154,429 (+)Ensembl
mRatBN7.2 Ensembl156,463,618 - 56,480,427 (+)Ensembl
Rnor_6.0 Ensembl157,491,643 - 57,508,449 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105252   ⟹   ENSRNOP00000088616
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl165,136,454 - 65,164,907 (+)Ensembl
mRatBN7.2 Ensembl156,463,618 - 56,491,438 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106038   ⟹   ENSRNOP00000091348
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl165,136,448 - 65,154,429 (+)Ensembl
mRatBN7.2 Ensembl156,463,618 - 56,480,427 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114159   ⟹   ENSRNOP00000080115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl165,136,685 - 65,172,971 (+)Ensembl
mRatBN7.2 Ensembl156,463,618 - 56,489,745 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118785   ⟹   ENSRNOP00000077324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl165,136,685 - 65,162,624 (+)Ensembl
mRatBN7.2 Ensembl156,463,618 - 56,510,016 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000133009   ⟹   ENSRNOP00000106791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl165,136,685 - 65,190,899 (+)Ensembl
RefSeq Acc Id: NM_001004198   ⟹   NP_001004198
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8165,136,708 - 65,153,515 (+)NCBI
mRatBN7.2156,463,618 - 56,480,428 (+)NCBI
Rnor_6.0157,491,643 - 57,508,450 (+)NCBI
Rnor_5.0158,419,943 - 58,438,618 (+)NCBI
RGSC_v3.4154,390,756 - 54,407,563 (+)RGD
Celera152,668,920 - 52,685,703 (+)RGD
Sequence:
RefSeq Acc Id: XM_006227980   ⟹   XP_006228042
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8165,136,420 - 65,153,503 (+)NCBI
mRatBN7.2156,463,330 - 56,480,430 (+)NCBI
Rnor_6.0157,491,381 - 57,509,335 (+)NCBI
Rnor_5.0158,419,943 - 58,438,618 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063268389   ⟹   XP_063124459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8165,136,420 - 65,152,781 (+)NCBI
RefSeq Acc Id: NP_001004198   ⟸   NM_001004198
- UniProtKB: Q66HB1 (UniProtKB/TrEMBL),   F7FBK7 (UniProtKB/TrEMBL),   A0A8I5Y1F6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228042   ⟸   XM_006227980
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000002038   ⟸   ENSRNOT00000002038
Ensembl Acc Id: ENSRNOP00000080115   ⟸   ENSRNOT00000114159
Ensembl Acc Id: ENSRNOP00000088616   ⟸   ENSRNOT00000105252
Ensembl Acc Id: ENSRNOP00000077324   ⟸   ENSRNOT00000118785
Ensembl Acc Id: ENSRNOP00000091348   ⟸   ENSRNOT00000106038
RefSeq Acc Id: XP_063124459   ⟸   XM_063268389
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000106791   ⟸   ENSRNOT00000133009

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66HB1-F1-model_v2 AlphaFold Q66HB1 1-318 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689646
Promoter ID:EPDNEW_R170
Type:single initiation site
Name:Tbp_1
Description:TATA box binding protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0157,491,634 - 57,491,694EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:67398 AgrOrtholog
BioCyc Gene G2FUF-61309 BioCyc
Ensembl Genes ENSRNOG00000001489 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002038 ENTREZGENE
  ENSRNOT00000002038.6 UniProtKB/TrEMBL
  ENSRNOT00000105252.2 UniProtKB/TrEMBL
  ENSRNOT00000106038.2 UniProtKB/TrEMBL
  ENSRNOT00000114159 ENTREZGENE
  ENSRNOT00000114159.2 UniProtKB/TrEMBL
  ENSRNOT00000118785.2 UniProtKB/TrEMBL
  ENSRNOT00000133009.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.310.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7115389 IMAGE-MGC_LOAD
InterPro TBP UniProtKB/TrEMBL
  TBP_CS UniProtKB/TrEMBL
  TBP_dom_sf UniProtKB/TrEMBL
  TBP_eukaryotic UniProtKB/TrEMBL
KEGG Report rno:117526 UniProtKB/TrEMBL
MGC_CLONE MGC:93994 IMAGE-MGC_LOAD
NCBI Gene 117526 ENTREZGENE
PANTHER TBP UniProtKB/TrEMBL
Pfam TBP UniProtKB/TrEMBL
PhenoGen Tbp PhenoGen
PRINTS TIFACTORIID UniProtKB/TrEMBL
PROSITE TFIID UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001489 RatGTEx
Superfamily-SCOP TATA-box binding protein-like UniProtKB/TrEMBL
UniProt A0A8I5Y1F6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZNX4_RAT UniProtKB/TrEMBL
  A0A8I6A9T0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AFF5_RAT UniProtKB/TrEMBL
  A0ABK0LPC9_RAT UniProtKB/TrEMBL
  A6KB49_RAT UniProtKB/TrEMBL
  F7FBK7 ENTREZGENE, UniProtKB/TrEMBL
  Q66HB1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Tbp  TATA box binding protein      Symbol and Name status set to approved 70586 APPROVED
2001-10-25 Tbp  TATA box binding protein      Name updated 68916 RESERVED

RGD Curation Notes
Note Type Note Reference
gene_function binds specifically to the TATA box promoter element which lies close to the position of transcription initiation 1299882
gene_process plays a role in the activation of eukaryotic genes transcribed by DNA polymerase II 1299882