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Platinum (Pt)-containing drugs, or platinating agents such as cisplatin, carboplatin and oxaliplatin are chemotherapy agents used in the treatment of several cancer types such as head and neck, testicular, ovarian, cervical, colorectal and non-small cell lung tumors. It is agreed that the main target of these compounds is DNA with the drugs forming DNA adducts. Pt-induced DNA lesions activate the DNA damage response machinery halting DNA replication and promoting cell cycle arrest, nucleotide ex

Pathway Diagram:

Elsevier Inc. uptaken_cisplatin --+> cisplatin response pathway Atp7b --+> decreased sensitivity/increased resistance Atp7b Atox1 ---- uptaken_cisplatin nucleotide excision repair pathway --+> decreased sensitivity/increased resistance Slc31a1 Atox1 uptaken_cisplatin ---> effluxed_cisplatin cisplatin DNA damage response pathway --+> nucleotide excision repair pathway DNA damage response pathway ---| DNA replication pathway aquated_cisplatin ---> cisplatin_DNA_adducts cisplatin_DNA_adducts --+> DNA damage response pathway nucleotide excision repair pathway ---| cisplatin_DNA_adducts Atox1 ---> Atp7b Atox1 ---> Atp7a Atp7a cisplatin_DNA_adducts ---| RNA polymerase II transcription pathway cisplatin_DNA_adducts ---- Pt-DNA adducts interactors cisplatin ---> uptaken_cisplatin Pt-DNA adducts interactors uptaken_cisplatin effluxed_cisplatin nucleotide excision repair pathway DNA replication pathway RNA polymerase II transcription pathway aquated_cisplatin DNA damage response pathway --+> intrinsic apoptotic pathway cisplatin_DNA_adducts ---| cancer cells cisplatin_DNA_adducts ---| non-small cell lung cancer pathway cisplatin_DNA_adducts cisplatin_DNA_adducts ---| colorectal cancer pathway colorectal cancer pathway cancer cells non-small cell lung cancer pathway cisplatin response pathway intrinsic apoptotic pathway DNA damage response pathway Atox1 --+> decreased sensitivity/increased resistance uptaken_cisplatin ---> aquated_cisplatin decreased sensitivity/increased resistance

Genes in Pathway:

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cisplatin drug pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atox1 antioxidant 1 copper chaperone JBrowse link 10 40,790,850 40,805,886 RGD:8548474
G Atp7a ATPase copper transporting alpha JBrowse link X 77,076,085 77,193,644 RGD:8548473
G Atp7b ATPase copper transporting beta JBrowse link 16 74,865,516 74,944,935 RGD:8548473
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:8548475
G Slc31a1 solute carrier family 31 member 1 JBrowse link 5 78,222,504 78,249,358 RGD:8548473
G Ssrp1 structure specific recognition protein 1 JBrowse link 3 72,447,516 72,457,621 RGD:8548475
G Tbp TATA box binding protein JBrowse link 1 57,491,381 57,509,335 RGD:8548475
G Ubtf upstream binding transcription factor, RNA polymerase I JBrowse link 10 90,250,275 90,265,772 RGD:8548475
G Ybx1 Y box binding protein 1 JBrowse link 5 138,319,754 138,336,721 RGD:8548475

Pathway Gene Annotations

Disease Annotations Associated with Genes in the cisplatin drug pathway
Disease TermsGene Symbols
Acute Lung InjuryHmgb1
Acute-On-Chronic Liver FailureHmgb1
Adenocarcinoma, ColonHmgb1
Aging, PrematureHmgb1
Alzheimer DiseaseAtp7a , Hmgb1 , Tbp
Amyotrophic Lateral SclerosisHmgb1
Anemia, Iron-DeficiencyAtp7a
Anemia, RefractoryYbx1
Aortic RuptureAtp7a
Arthritis, ExperimentalHmgb1
Brain InjuriesHmgb1
Breast NeoplasmsAtp7b
Carcinoma, EndometrioidAtp7b
Carcinoma, Squamous Cell of Head and NeckAtp7b
CardiomegalyHmgb1 , Ubtf
Cerebral InfarctionHmgb1
Chemical and Drug Induced Liver InjuryHmgb1
Chronic Allograft DysfunctionHmgb1
Colonic NeoplasmsAtp7a
Colorectal NeoplasmsAtp7b
Congenital AbnormalitiesSlc31a1
Congenital Disorders of GlycosylationAtp7b
Cutis LaxaAtp7a
Diabetes Mellitus, ExperimentalHmgb1
Diabetes Mellitus, Type 1Tbp
Diabetic CardiomyopathiesAtp7a
Disease Models, AnimalAtp7a , Atp7b
Disease ProgressionAtp7b
Drug-Related Side Effects and Adverse ReactionsHmgb1
Embryo LossSlc31a1
Epilepsy, GeneralizedAtp7b
Esophageal Squamous Cell CarcinomaHmgb1
Fatty LiverAtp7b
Growth DisordersAtp7a
Heart FailureHmgb1
Heat StrokeHmgb1
Hepatitis, ChronicAtox1 , Atp7a
Hepatolenticular DegenerationAtp7a , Atp7b
Hernias, Diaphragmatic, CongenitalAtp7a
Huntington DiseaseTbp
Hypertension, PulmonaryAtp7a , Hmgb1 , Slc31a1
Infarction, Middle Cerebral ArteryHmgb1
InflammationAtp7b , Hmgb1
Intellectual DisabilitySlc31a1
Intestinal Reperfusion InjuryHmgb1
Ischemic Attack, TransientHmgb1
Kidney NeoplasmsAtp7b
Liver CirrhosisAtp7b
Liver DiseasesAtp7b
Liver Failure, AcuteAtp7b
Liver NeoplasmsAtp7b
Liver Neoplasms, ExperimentalAtp7a , Atp7b , Slc31a1
Liver Reperfusion InjuryHmgb1
Lung NeoplasmsAtox1
Lung Reperfusion InjuryHmgb1
Lymphatic MetastasisHmgb1
Manganese PoisoningSlc31a1
Menkes Kinky Hair SyndromeAtp7a
Mouth NeoplasmsAtp7b
Mucocutaneous Lymph Node SyndromeHmgb1
Multiple Organ FailureHmgb1
Myocardial InfarctionHmgb1 , Ybx1
Myocardial IschemiaHmgb1
Myocardial Reperfusion InjuryHmgb1
Myocarditis, Autoimmune, ExperimentalHmgb1
NecrosisHmgb1 , Slc31a1
Neurologic ManifestationsAtp7a
Neuropathy, PainfulHmgb1
Occipital Horn SyndromeAtp7a
Osteoarthritis, KneeHmgb1
Ovarian NeoplasmsAtp7b
Oxygen-Induced RetinopathyHmgb1
Pancreatitis, Experimental, Acute Hmgb1
Parkinson Disease, Late-OnsetTbp
Prenatal InjuriesAtp7a
Prostatic NeoplasmsAtp7b , Slc31a1
Pulmonary FibrosisHmgb1
Reperfusion InjuryHmgb1
Retina Reperfusion InjuryHmgb1
Sciatic NeuropathyHmgb1
Scleroderma, SystemicHmgb1
Sleep Apnea SyndromesTbp
Smith-Magenis SyndromeUbtf
Spinal Cord InjuriesHmgb1 , Tbp
Spinal Muscular Atrophy, Distal, X-Linked 3Atp7a
Spinocerebellar Ataxia 17Tbp
Spinocerebellar Ataxia, X-Linked 1Atp7a
Spinocerebellar AtaxiasTbp
Systemic VasculitisHmgb1
Tremor Hereditary Essential, 1Atp7b
Vascular System InjuriesAtp7a
Ventilator-Induced Lung InjuryHmgb1
Pathway Annotations Associated with Genes in the cisplatin drug pathway

References Associated with the cisplatin drug pathway:

Ontology Path Diagram:

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