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Platinum (Pt)-containing drugs, or platinating agents such as cisplatin, carboplatin and oxaliplatin are chemotherapy agents used in the treatment of several cancer types such as head and neck, testicular, ovarian, cervical, colorectal and non-small cell lung tumors. It is agreed that the main target of these compounds is DNA with the drugs forming DNA adducts. Pt-induced DNA lesions activate the DNA damage response machinery halting DNA replication and promoting cell cycle arrest, nucleotide ex

Pathway Diagram:

Elsevier Inc. uptaken_cisplatin --+> cisplatin response pathway Atp7b --+> decreased sensitivity/increased resistance Atp7b Atox1 ---- uptaken_cisplatin nucleotide excision repair pathway --+> decreased sensitivity/increased resistance Slc31a1 Atox1 uptaken_cisplatin ---> effluxed_cisplatin cisplatin DNA damage response pathway --+> nucleotide excision repair pathway DNA damage response pathway ---| DNA replication pathway aquated_cisplatin ---> cisplatin_DNA_adducts cisplatin_DNA_adducts --+> DNA damage response pathway nucleotide excision repair pathway ---| cisplatin_DNA_adducts Atox1 ---> Atp7b Atox1 ---> Atp7a Atp7a cisplatin_DNA_adducts ---| RNA polymerase II transcription pathway cisplatin_DNA_adducts ---- Pt-DNA adducts interactors cisplatin ---> uptaken_cisplatin Pt-DNA adducts interactors uptaken_cisplatin effluxed_cisplatin nucleotide excision repair pathway DNA replication pathway RNA polymerase II transcription pathway aquated_cisplatin DNA damage response pathway --+> intrinsic apoptotic pathway cisplatin_DNA_adducts ---| cancer cells cisplatin_DNA_adducts ---| non-small cell lung cancer pathway cisplatin_DNA_adducts cisplatin_DNA_adducts ---| colorectal cancer pathway colorectal cancer pathway cancer cells non-small cell lung cancer pathway cisplatin response pathway intrinsic apoptotic pathway DNA damage response pathway Atox1 --+> decreased sensitivity/increased resistance uptaken_cisplatin ---> aquated_cisplatin decreased sensitivity/increased resistance

Genes in Pathway:

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cisplatin drug pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atox1 antioxidant 1 copper chaperone JBrowse link 10 40,790,850 40,805,886 RGD:8548474
G Atp7a ATPase copper transporting alpha JBrowse link X 77,076,085 77,193,644 RGD:8548473
G Atp7b ATPase copper transporting beta JBrowse link 16 74,865,516 74,944,935 RGD:8548473
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:8548475
G Slc31a1 solute carrier family 31 member 1 JBrowse link 5 78,222,504 78,249,358 RGD:8548473
G Ssrp1 structure specific recognition protein 1 JBrowse link 3 72,447,516 72,457,621 RGD:8548475
G Tbp TATA box binding protein JBrowse link 1 57,491,381 57,509,335 RGD:8548475
G Ubtf upstream binding transcription factor, RNA polymerase I JBrowse link 10 90,250,275 90,265,772 RGD:8548475
G Ybx1 Y box binding protein 1 JBrowse link 5 138,319,754 138,336,721 RGD:8548475

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the cisplatin drug pathway

References Associated with the cisplatin drug pathway:

Ontology Path Diagram:

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