Gene: TBP (TATA-box binding protein) Homo sapiens
Symbol: TBP
Name: TATA-box binding protein
Description: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GTF2D; GTF2D1; HDL4; MGC117320; MGC126054; MGC126055; OTTHUMP00000017703; SCA17; TATA sequence-binding protein; TATA-box binding protein N-terminal domain; TATA-box factor; TATA-box-binding protein; TFIID; transcription initiation factor TFIID TBP subunit
Orthologs:
Is Marker For: QTLs:   BW323_H   BMD3_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386170,554,333 - 170,572,870 (+)NCBIGRCh38hg38GRCh38
GRCh376170,863,384 - 170,881,958 (+)NCBIGRCh37hg19GRCh37
Build 366170,705,396 - 170,723,872 (+)NCBINCBI36hg18NCBI36
Build 346170,781,102 - 170,799,578NCBI
Celera6171,658,683 - 171,677,210 (+)NCBI
Cytogenetic Map6q27NCBImapview
HuRef6168,368,477 - 168,387,004 (+)NCBI
CHM1_16171,124,696 - 171,144,174 (+)NCBI
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TBP
Entrez Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 68980
Created: 2001-11-06
Species: Homo sapiens
Last Modified: 2016-05-10
Status: ACTIVE