Gene: TBP (TATA-box binding protein) Homo sapiens
Symbol: TBP
Name: TATA-box binding protein
Description: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GTF2D; GTF2D1; HDL4; MGC117320; MGC126054; MGC126055; OTTHUMP00000017703; SCA17; TATA sequence-binding protein; TATA-box binding protein N-terminal domain; TATA-box factor; TATA-box-binding protein; TFIID; transcription initiation factor TFIID TBP subunit
Is Marker For: QTLs:   BW323_H   BMD3_H  
Latest Assembly: Human Genome Assembly GRCh37
Human Genome Assembly GRCh386170,554,333 - 170,572,870+NCBI
Human Alternate Assembly CHM1_16171,124,696 - 171,144,174+NCBI
Human Genome Assembly HuRef6168,368,477 - 168,387,004+NCBI
Human Genome Assembly GRCh376170,863,384 - 170,881,958+NCBI
Human Celera Assembly6171,658,683 - 171,677,210+NCBI
Human Genome Assembly Build 366170,705,396 - 170,723,872+NCBI
Human Cytogenetic Map6q27 NCBI
Human Genome Assembly6170,781,102 - 170,799,578 NCBI

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Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TBP
Entrez Gene
Ensembl Gene
GBrowse: hg18 hg19
JBrowse: hg18 hg19
HGNC Report
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 68980
Created: 2001-11-06
Species: Homo sapiens
Last Modified: 2016-02-02
Status: ACTIVE