TBP (TATA box binding protein) - Rat Genome Database

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Keyword

Gene: TBP (TATA box binding protein) Homo sapiens

Symbol:

TBP

Name:

TATA box binding protein

Description:

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

GTF2D; GTF2D1; HDL4; MGC117320; MGC126054; MGC126055; OTTHUMP00000017703; SCA17; TATA sequence-binding protein; TATA-box binding protein N-terminal domain; TATA-box factor; TATA-box-binding protein; TFIID; transcription initiation factor TFIID TBP subunit

Orthologs:

Mus musculus : Tbp (TATA box binding protein) MGI
Rattus norvegicus : Tbp (TATA box binding protein)

Is Marker For:

QTLs: BW323_H BMD3_H

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	6	170,889,964 - 170,908,485	+	NCBI
Human Genome Assembly HuRef	6	168,368,477 - 168,387,004	+	NCBI
Human Genome Assembly GRCh37	6	170,863,421 - 170,881,958	+	NCBI
Human Genome Assembly Build 36	6	170,705,396 - 170,723,872	+	NCBI
Human Cytogenetic Map	6	q27		NCBI
Human Genome Assembly	6	170,781,102 - 170,799,578		NCBI