Ppp1r1b (protein phosphatase 1, regulatory (inhibitor) subunit 1B) - Rat Genome Database

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Gene: Ppp1r1b (protein phosphatase 1, regulatory (inhibitor) subunit 1B) Rattus norvegicus
Analyze
Symbol: Ppp1r1b
Name: protein phosphatase 1, regulatory (inhibitor) subunit 1B
RGD ID: 621859
Description: Enables dopamine receptor binding activity. Involved in several processes, including memory; response to cocaine; and response to nicotine. Located in dendritic spine head and dendritic spine neck. Is active in glutamatergic synapse and postsynapse. Used to study depressive disorder; schizophrenia; status epilepticus; and withdrawal disorder. Biomarker of Huntington's disease and brain infarction. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human PPP1R1B (protein phosphatase 1 regulatory inhibitor subunit 1B); PARTICIPATES IN dopamine signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Darpp-32; Darpp32; dopamine- and cAMP-regulated neuronal phosphoprotein; dopamine- and cAMP-regulated phosphoprotein DARPP-32; neuronal phosphoprotein DARPP-32; protein phosphatase 1 regulatory subunit 1B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81083,843,948 - 83,853,063 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1083,844,036 - 83,853,063 (+)EnsemblGRCr8
mRatBN7.21083,347,731 - 83,356,775 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,347,731 - 83,356,775 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1088,292,064 - 88,301,109 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01087,790,149 - 87,799,194 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,182,801 - 83,191,846 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,303,727 - 86,312,770 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,303,727 - 86,312,762 (+)Ensemblrn6Rnor6.0
Rnor_5.01086,100,811 - 86,109,854 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41087,121,889 - 87,131,587 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1082,095,371 - 82,102,275 (+)NCBICelera
RGSC_v3.11087,143,530 - 87,145,100 (+)NCBI
Cytogenetic Map10q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
5-methoxytryptamine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clorgyline  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
corticosterone  (ISO)
corticotropin  (ISO)
Cuprizon  (EXP)
curcumin  (EXP)
cyhalothrin  (EXP)
DDE  (EXP)
deguelin  (ISO)
dextran sulfate  (ISO)
dichloroacetic acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzacamene  (EXP)
erianin  (ISO)
ethanol  (ISO)
eticlopride(1+)  (ISO)
Evodiamine  (ISO)
fluoxetine  (ISO)
furan  (EXP,ISO)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
graphite  (EXP)
haloperidol  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
ketamine  (EXP)
ketanserin  (ISO)
linuron  (EXP)
LY294002  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
microcystin-LR  (EXP)
morphine  (EXP,ISO)
nickel atom  (ISO)
oxidopamine  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
Pargyline  (ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
quinpirole  (ISO)
resveratrol  (ISO)
roflumilast  (EXP)
rotenone  (EXP,ISO)
SB 431542  (ISO)
serotonin  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
U-73122  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincristine  (ISO)
wortmannin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Neuronal replacement from endogenous precursors in the adult brain after stroke. Arvidsson A, etal., Nat Med. 2002 Sep;8(9):963-70. doi: 10.1038/nm747. Epub 2002 Aug 5.
2. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
3. DARPP-32 binds to tra2-beta1 and influences alternative splicing. Benderska N, etal., Biochim Biophys Acta. 2010 May-Jun;1799(5-6):448-53. doi: 10.1016/j.bbagrm.2010.01.003. Epub 2010 Jan 13.
4. Spatial distribution of DARPP-32 in dendritic spines. Blom H, etal., PLoS One. 2013 Sep 10;8(9):e75155. doi: 10.1371/journal.pone.0075155. eCollection 2013.
5. Sex differences in a transgenic rat model of Huntington's disease: decreased 17beta-estradiol levels correlate with reduced numbers of DARPP32+ neurons in males. Bode FJ, etal., Hum Mol Genet. 2008 Sep 1;17(17):2595-609. doi: 10.1093/hmg/ddn159. Epub 2008 May 23.
6. Chronic hyperdopaminergic activity of schizophrenia is associated with increased ¿FosB levels and cdk-5 signaling in the nucleus accumbens. Cantrup R, etal., Neuroscience. 2012 Oct 11;222:124-35. doi: 10.1016/j.neuroscience.2012.07.027. Epub 2012 Jul 20.
7. Dopamine enhancement of NMDA currents in dissociated medium-sized striatal neurons: role of D1 receptors and DARPP-32. Flores-Hernandez J, etal., J Neurophysiol 2002 Dec;88(6):3010-20.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Environmental enrichment alters nicotine-mediated locomotor sensitization and phosphorylation of DARPP-32 and CREB in rat prefrontal cortex. Gomez AM, etal., PLoS One. 2012;7(8):e44149. doi: 10.1371/journal.pone.0044149. Epub 2012 Aug 31.
10. Intrastriatal injection of ionomycin profoundly changes motor response to l-DOPA and its underlying molecular mechanisms. Han C, etal., Neuroscience. 2017 Jan 6;340:23-33. doi: 10.1016/j.neuroscience.2016.10.033. Epub 2016 Oct 19.
11. D1 receptor modulation of memory retrieval performance is associated with changes in pCREB and pDARPP-32 in rat prefrontal cortex. Hotte M, etal., Behav Brain Res. 2006 Jul 15;171(1):127-33. Epub 2006 May 9.
12. Nanotherapeutic approach for opiate addiction using DARPP-32 gene silencing in an animal model of opiate addiction. Ignatowski TA, etal., J Neuroimmune Pharmacol. 2015 Mar;10(1):136-52. doi: 10.1007/s11481-015-9585-1. Epub 2015 Jan 22.
13. DARPP-32 to quantify intracerebral hemorrhage-induced neuronal death in basal ganglia. Jin H, etal., Transl Stroke Res. 2013 Feb;4(1):130-4. doi: 10.1007/s12975-012-0232-3. Epub 2012 Dec 12.
14. Activation of Protein Kinases and Phosphatases Coupled to Glutamate Receptors Regulates the Phosphorylation State of DARPP32 at Threonine 75 After Repeated Exposure to Cocaine in the Rat Dorsal Striatum in a Ca2+-Dependent Manner. Kim J, etal., Int J Neuropsychopharmacol. 2015 Jul 4;18(12). pii: pyv075. doi: 10.1093/ijnp/pyv075.
15. Revisiting DARPP-32 in postmortem human brain: changes in schizophrenia and bipolar disorder and genetic associations with t-DARPP-32 expression. Kunii Y, etal., Mol Psychiatry. 2014 Feb;19(2):192-9. doi: 10.1038/mp.2012.174. Epub 2013 Jan 8.
16. Decreased calcineurin and increased phosphothreonine-DARPP-32 in the striatum of rats behaviorally sensitized to methamphetamine. Lin XH, etal., Synapse 2002 Jun 1;44(3):181-7.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Colocalization of dopamine receptor subtypes with dopamine and cAMP-regulated phosphoprotein (DARPP-32) in rat brain. Rajput PS, etal., Neurosci Res. 2009 Sep;65(1):53-63. Epub 2009 May 22.
20. GOA pipeline RGD automated data pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Proteomic analysis of alterations induced by perinatal hypoxic-ischemic brain injury. Rosenkranz K, etal., J Proteome Res. 2012 Dec 7;11(12):5794-803. doi: 10.1021/pr3005869. Epub 2012 Nov 27.
23. PPARa modulation of mesolimbic dopamine transmission rescues depression-related behaviors. Scheggi S, etal., Neuropharmacology. 2016 Nov;110(Pt A):251-259. doi: 10.1016/j.neuropharm.2016.07.024. Epub 2016 Jul 22.
24. [Research on expression and function of phosphorylated DARPP-32 on pentylenetetrazol-induced epilepsy model of rat]. Wang W, etal., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2014 Jun;31(3):637-41.
25. DARPP-32, Jack of All Trades... Master of Which? Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.
Additional References at PubMed
PMID:10669419   PMID:10807923   PMID:10854268   PMID:12409216   PMID:12477932   PMID:15287884   PMID:15515184   PMID:15536496   PMID:16020482   PMID:16428298   PMID:17008016   PMID:17010100  
PMID:17552992   PMID:17680995   PMID:17693396   PMID:17884291   PMID:17919461   PMID:17953657   PMID:18415674   PMID:18496528   PMID:18923023   PMID:18954090   PMID:18985320   PMID:19041388  
PMID:19474310   PMID:19782104   PMID:22116741   PMID:22301787   PMID:22462413   PMID:23250204   PMID:24978930   PMID:26119931   PMID:26463938   PMID:26639316   PMID:27998980   PMID:28257887  
PMID:30181585   PMID:33096475  


Genomics

Comparative Map Data
Ppp1r1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81083,843,948 - 83,853,063 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1083,844,036 - 83,853,063 (+)EnsemblGRCr8
mRatBN7.21083,347,731 - 83,356,775 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,347,731 - 83,356,775 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1088,292,064 - 88,301,109 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01087,790,149 - 87,799,194 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,182,801 - 83,191,846 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,303,727 - 86,312,770 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,303,727 - 86,312,762 (+)Ensemblrn6Rnor6.0
Rnor_5.01086,100,811 - 86,109,854 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41087,121,889 - 87,131,587 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1082,095,371 - 82,102,275 (+)NCBICelera
RGSC_v3.11087,143,530 - 87,145,100 (+)NCBI
Cytogenetic Map10q31NCBI
PPP1R1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381739,626,707 - 39,636,624 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1739,626,740 - 39,636,626 (+)Ensemblhg38GRCh38
GRCh371737,783,205 - 37,792,877 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,036,705 - 35,046,404 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341735,038,278 - 35,046,405NCBI
Celera1734,442,912 - 34,452,611 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1733,576,900 - 33,586,601 (+)NCBIHuRef
CHM1_11738,019,003 - 38,028,704 (+)NCBICHM1_1
T2T-CHM13v2.01740,489,777 - 40,500,194 (+)NCBIT2T-CHM13v2.0
Ppp1r1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,239,232 - 98,248,622 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,239,230 - 98,248,622 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381198,348,406 - 98,357,796 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,348,404 - 98,357,796 (+)Ensemblmm10GRCm38
MGSCv371198,210,052 - 98,219,109 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361198,164,828 - 98,173,885 (+)NCBIMGSCv36mm8
Celera11108,003,018 - 108,012,075 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1161.75NCBI
Ppp1r1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,389,533 - 14,394,169 (+)Ensembl
ChiLan1.0NW_00495545114,378,186 - 14,394,910 (+)NCBIChiLan1.0ChiLan1.0
PPP1R1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21925,318,752 - 25,328,622 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11727,213,568 - 27,223,301 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01717,652,216 - 17,662,085 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,868,965 - 17,878,116 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,868,965 - 17,878,120 (-)EnsemblpanPan2panpan1.1
PPP1R1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,838,198 - 22,847,924 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,838,576 - 22,848,142 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha922,310,605 - 22,319,844 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0923,631,857 - 23,641,339 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,631,868 - 23,641,337 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,404,434 - 22,413,913 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,665,479 - 22,674,943 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,790,595 - 22,800,065 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppp1r1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560222,243,802 - 22,252,420 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649014,822,213 - 14,831,349 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649014,822,246 - 14,831,337 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,680,980 - 22,690,952 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11222,681,244 - 22,690,978 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,071,451 - 23,079,039 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,530,640 - 66,541,025 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,530,488 - 66,541,242 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607737,442,205 - 37,453,029 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,431,689 - 3,439,545 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247953,432,179 - 3,439,490 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ppp1r1b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1956,035,765 - 56,044,881 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ppp1r1b
40 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:113
Count of miRNA genes:82
Interacting mature miRNAs:103
Transcripts:ENSRNOT00000037752
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107870758585720738Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313384503487Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107395020983959619Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH130479  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,356,520 - 83,356,705 (+)MAPPERmRatBN7.2
Rnor_6.01086,312,516 - 86,312,700NCBIRnor6.0
Rnor_5.01086,109,600 - 86,109,784UniSTSRnor5.0
RGSC_v3.41087,131,335 - 87,131,519UniSTSRGSC3.4
RH 3.4 Map10809.6UniSTS
Cytogenetic Map10q31UniSTS
AU040756  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,356,375 - 83,356,612 (+)MAPPERmRatBN7.2
Rnor_6.01086,312,371 - 86,312,607NCBIRnor6.0
Rnor_5.01086,109,455 - 86,109,691UniSTSRnor5.0
RGSC_v3.41087,131,190 - 87,131,426UniSTSRGSC3.4
Cytogenetic Map10q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 155 79 82 51 32 51 6 282 126 9 138 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000037752   ⟹   ENSRNOP00000034614
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1083,845,545 - 83,853,063 (+)Ensembl
mRatBN7.2 Ensembl1083,347,731 - 83,356,767 (+)Ensembl
Rnor_6.0 Ensembl1086,303,727 - 86,312,762 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107401   ⟹   ENSRNOP00000077715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1083,844,036 - 83,853,055 (+)Ensembl
mRatBN7.2 Ensembl1083,347,731 - 83,356,767 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109859   ⟹   ENSRNOP00000094600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1083,849,604 - 83,853,055 (+)Ensembl
mRatBN7.2 Ensembl1083,353,422 - 83,356,775 (+)Ensembl
RefSeq Acc Id: NM_138521   ⟹   NP_612530
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81083,844,018 - 83,853,061 (+)NCBI
mRatBN7.21083,347,731 - 83,356,773 (+)NCBI
Rnor_6.01086,303,727 - 86,312,768 (+)NCBI
Rnor_5.01086,100,811 - 86,109,854 (+)NCBI
RGSC_v3.41087,121,889 - 87,131,587 (+)RGD
Celera1082,095,371 - 82,102,275 (+)RGD
Sequence:
RefSeq Acc Id: XM_006247344   ⟹   XP_006247406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81083,849,328 - 83,853,063 (+)NCBI
mRatBN7.21083,353,017 - 83,356,775 (+)NCBI
Rnor_6.01086,308,710 - 86,312,770 (+)NCBI
Rnor_5.01086,100,811 - 86,109,854 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063269421   ⟹   XP_063125491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81083,843,948 - 83,853,063 (+)NCBI
RefSeq Acc Id: NP_612530   ⟸   NM_138521
- UniProtKB: Q6J4I0 (UniProtKB/Swiss-Prot),   A0A8I5YCG8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247406   ⟸   XM_006247344
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GL91 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034614   ⟸   ENSRNOT00000037752
Ensembl Acc Id: ENSRNOP00000094600   ⟸   ENSRNOT00000109859
Ensembl Acc Id: ENSRNOP00000077715   ⟸   ENSRNOT00000107401
RefSeq Acc Id: XP_063125491   ⟸   XM_063269421
- Peptide Label: isoform X2
- UniProtKB: A0A8I5YCG8 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6J4I0-F1-model_v2 AlphaFold Q6J4I0 1-205 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697657
Promoter ID:EPDNEW_R8181
Type:initiation region
Name:Ppp1r1b_1
Description:protein phosphatase 1, regulatory subunit 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01086,303,773 - 86,303,833EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621859 AgrOrtholog
BioCyc Gene G2FUF-23373 BioCyc
Ensembl Genes ENSRNOG00000028404 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000037752.4 UniProtKB/Swiss-Prot
  ENSRNOT00000107401 ENTREZGENE
  ENSRNOT00000109859 ENTREZGENE
IMAGE_CLONE IMAGE:7110316 IMAGE-MGC_LOAD
InterPro PPP1R1A/B/C UniProtKB/Swiss-Prot
KEGG Report rno:360616 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93809 IMAGE-MGC_LOAD
NCBI Gene Ppp1r1b ENTREZGENE
PANTHER PTHR15417 UniProtKB/Swiss-Prot
  PTHR15417:SF2 UniProtKB/Swiss-Prot
Pfam DARPP-32 UniProtKB/Swiss-Prot
PhenoGen Ppp1r1b PhenoGen
RatGTEx ENSRNOG00000028404 RatGTEx
UniProt A0A8I5YCG8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GL91 ENTREZGENE, UniProtKB/TrEMBL
  A6HIR3_RAT UniProtKB/TrEMBL
  A6HIR5_RAT UniProtKB/TrEMBL
  A6HIR7_RAT UniProtKB/TrEMBL
  PPR1B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Ppp1r1b  protein phosphatase 1, regulatory (inhibitor) subunit 1B      Symbol and Name updated 629477 APPROVED
2003-03-19 Ppp1r1b  protein phosphatase 1, regulatory (inhibitor) subunit 1B  Darpp32  neuronal phosphoprotein DARPP-32  Symbol and Name updated to reflect Human and Mouse nomenclature 61478 PROVISIONAL
2002-08-07 Darpp32  neuronal phosphoprotein DARPP-32      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 32 kDa 724660
gene_regulation phosphorylated by cAMP-dependent PKA 724660