Serpinb2 (serpin family B member 2) - Rat Genome Database

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Gene: Serpinb2 (serpin family B member 2) Rattus norvegicus
Analyze
Symbol: Serpinb2
Name: serpin family B member 2
RGD ID: 621823
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of apoptotic process. Predicted to be located in cytoplasm and extracellular region. Predicted to be active in cornified envelope and extracellular space. Orthologous to human SERPINB2 (serpin family B member 2); PARTICIPATES IN fibrinolysis pathway; Entamoebiasis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-glucopyranose; 3,4-dichloroaniline.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: PAI-2; Pai2a; plasminogen activator inhibitor 2 type A; serine (or cysteine) peptidase inhibitor, clade B, member 2; serine (or cysteine) proteinase inhibitor, clade B, member 2; serpin B2; serpin peptidase inhibitor, clade B (ovalbumin), member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81324,051,933 - 24,065,032 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1324,056,021 - 24,065,031 (+)EnsemblGRCr8
mRatBN7.21323,537,312 - 23,551,823 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1323,541,400 - 23,550,408 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1323,911,693 - 23,920,701 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01325,196,153 - 25,205,159 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01323,881,884 - 23,890,888 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01327,449,907 - 27,463,015 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1327,449,934 - 27,463,010 (+)Ensemblrn6Rnor6.0
Rnor_5.01332,599,834 - 32,612,855 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41313,632,596 - 13,641,605 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1323,386,792 - 23,395,714 (+)NCBICelera
RGSC_v3.11313,607,205 - 13,616,214 (+)NCBI
Cytogenetic Map13p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dichloroaniline  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arachidonic acid  (ISO)
aripiprazole  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beryllium sulfate  (ISO)
beta-D-glucosamine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bleomycin A2  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
citric acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dichloromethane  (ISO)
Didecyldimethylammonium  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
drometrizole  (ISO)
EGTA acetoxymethyl ester  (ISO)
enalapril  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
fulvestrant  (ISO)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
graphite  (EXP)
hexane  (ISO)
isobutanol  (ISO)
isotretinoin  (ISO)
L-ascorbic acid  (ISO)
lasalocid  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
lucanthone  (ISO)
malathion  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
melphalan  (ISO)
methimazole  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mirex  (EXP)
mitomycin C  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nifedipine  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
perfluorobutyric acid  (ISO)
perfluorooctanoic acid  (ISO)
Pf-06840003  (ISO)
phenethyl caffeate  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
Soman  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Immunochemically detected placental proteins and their biological functions. Bohn H, etal., Arch Gynecol Obstet 1991;249(3):107-18.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Basic mechanisms and regulation of fibrinolysis. Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. The expression of plasminogen activator system in a rat model of periodontal wound healing. Xiao Y, etal., J Periodontol 2001 Jul;72(7):849-57.

Genomics

Comparative Map Data
Serpinb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81324,051,933 - 24,065,032 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1324,056,021 - 24,065,031 (+)EnsemblGRCr8
mRatBN7.21323,537,312 - 23,551,823 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1323,541,400 - 23,550,408 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1323,911,693 - 23,920,701 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01325,196,153 - 25,205,159 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01323,881,884 - 23,890,888 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01327,449,907 - 27,463,015 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1327,449,934 - 27,463,010 (+)Ensemblrn6Rnor6.0
Rnor_5.01332,599,834 - 32,612,855 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41313,632,596 - 13,641,605 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1323,386,792 - 23,395,714 (+)NCBICelera
RGSC_v3.11313,607,205 - 13,616,214 (+)NCBI
Cytogenetic Map13p11NCBI
SERPINB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381863,887,705 - 63,903,888 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1863,871,692 - 63,903,888 (+)Ensemblhg38GRCh38
GRCh371861,554,939 - 61,571,122 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361859,705,922 - 59,722,100 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341859,705,921 - 59,722,100NCBI
Celera1858,275,397 - 58,291,583 (+)NCBICelera
Cytogenetic Map18q21.33-q22.1NCBI
HuRef1858,256,074 - 58,272,260 (+)NCBIHuRef
CHM1_11861,551,138 - 61,567,323 (+)NCBICHM1_1
T2T-CHM13v2.01864,092,785 - 64,108,961 (+)NCBIT2T-CHM13v2.0
Serpinb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391107,439,153 - 107,453,330 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1107,439,153 - 107,463,208 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381107,500,892 - 107,525,600 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1107,511,423 - 107,535,478 (+)Ensemblmm10GRCm38
MGSCv371109,408,000 - 109,422,177 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361109,343,020 - 109,353,145 (+)NCBIMGSCv36mm8
Celera1110,350,054 - 110,364,218 (+)NCBICelera
Cytogenetic Map1E2.1NCBI
cM Map150.34NCBI
Serpinb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540247,711,215 - 47,720,755 (+)Ensembl
ChiLan1.0NW_00495540247,707,182 - 47,720,688 (+)NCBIChiLan1.0ChiLan1.0
SERPINB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21781,394,008 - 81,410,303 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11867,086,750 - 67,102,914 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01857,242,498 - 57,258,676 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11860,553,350 - 60,569,509 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1860,553,323 - 60,569,594 (+)EnsemblpanPan2panpan1.1
SERPINB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1113,260,288 - 13,276,727 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl113,260,387 - 13,272,980 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha114,221,011 - 14,237,472 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0113,115,363 - 13,131,846 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl113,115,383 - 13,128,076 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1113,153,943 - 13,170,407 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0113,083,198 - 13,099,654 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0113,332,245 - 13,348,711 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Serpinb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494426,566,424 - 26,579,970 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364971,805,957 - 1,814,911 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364971,805,957 - 1,814,911 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1157,872,212 - 157,886,602 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11157,871,919 - 157,886,525 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21175,502,720 - 175,517,267 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SERPINB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11815,906,461 - 15,922,636 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1815,906,469 - 15,922,594 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660609,770,527 - 9,786,645 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpinb2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11086,180,939 - 86,189,893 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Serpinb2
85 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:282
Count of miRNA genes:176
Interacting mature miRNAs:192
Transcripts:ENSRNOT00000003409
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317027Aia22Adjuvant induced arthritis QTL 222.29joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)13134785618Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131244842148744906Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131186625456866254Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
2317034Aia9Adjuvant induced arthritis QTL 94.62joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131228551734884386Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)13308875548088755Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131244842147969993Rat
631672Iddm12Insulin dependent diabetes mellitus QTL 122.20.0032blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)13600200837088115Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131746828262468282Rat
2303030Bp327Blood pressure QTL 327arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)13143736554Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
2317044Aia23Adjuvant induced arthritis QTL 232.3joint integrity trait (VT:0010548)ankle joint diameter (CMO:0002148)131228551734884386Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13600200847359539Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131771133662711336Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13134785618Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131186625456866254Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
13 3 30 35 64 69 40 67 40 6 188 119 11 14 14 46 29

Sequence


Ensembl Acc Id: ENSRNOT00000003409   ⟹   ENSRNOP00000003409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1324,056,021 - 24,065,031 (+)Ensembl
mRatBN7.2 Ensembl1323,541,400 - 23,550,408 (+)Ensembl
Rnor_6.0 Ensembl1327,449,934 - 27,463,010 (+)Ensembl
RefSeq Acc Id: NM_021696   ⟹   NP_067728
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81324,056,021 - 24,065,032 (+)NCBI
mRatBN7.21323,541,400 - 23,550,409 (+)NCBI
Rnor_6.01327,454,006 - 27,463,015 (+)NCBI
Rnor_5.01332,599,834 - 32,612,855 (+)NCBI
RGSC_v3.41313,632,596 - 13,641,605 (+)RGD
Celera1323,386,792 - 23,395,714 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249639   ⟹   XP_006249701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81324,051,939 - 24,065,032 (+)NCBI
mRatBN7.21323,537,337 - 23,551,823 (+)NCBI
Rnor_6.01327,449,994 - 27,463,015 (+)NCBI
Rnor_5.01332,599,834 - 32,612,855 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769495   ⟹   XP_008767717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81324,051,933 - 24,065,032 (+)NCBI
mRatBN7.21323,537,312 - 23,551,823 (+)NCBI
Rnor_6.01327,449,907 - 27,463,015 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_067728 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249701 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767717 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA45864 (Get FASTA)   NCBI Sequence Viewer  
  EDL91757 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003409
  ENSRNOP00000003409.4
GenBank Protein P29524 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_067728   ⟸   NM_021696
- UniProtKB: P29524 (UniProtKB/Swiss-Prot),   A6JSV9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249701   ⟸   XM_006249639
- Peptide Label: isoform X1
- UniProtKB: P29524 (UniProtKB/Swiss-Prot),   A6JSV9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767717   ⟸   XM_008769495
- Peptide Label: isoform X1
- UniProtKB: P29524 (UniProtKB/Swiss-Prot),   A6JSV9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003409   ⟸   ENSRNOT00000003409
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29524-F1-model_v2 AlphaFold P29524 1-416 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698755
Promoter ID:EPDNEW_R9279
Type:single initiation site
Name:Serpinb2_1
Description:serpin family B member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01327,449,925 - 27,449,985EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621823 AgrOrtholog
BioCyc Gene G2FUF-18579 BioCyc
Ensembl Genes ENSRNOG00000002460 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003409 ENTREZGENE
  ENSRNOT00000003409.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot
  3.30.497.10 UniProtKB/Swiss-Prot
InterPro PAI-2 UniProtKB/Swiss-Prot
  Serpin_CS UniProtKB/Swiss-Prot
  Serpin_dom UniProtKB/Swiss-Prot
  Serpin_fam UniProtKB/Swiss-Prot
  Serpin_sf UniProtKB/Swiss-Prot
  Serpin_sf_1 UniProtKB/Swiss-Prot
  Serpin_sf_2 UniProtKB/Swiss-Prot
KEGG Report rno:60325 UniProtKB/Swiss-Prot
NCBI Gene 60325 ENTREZGENE
PANTHER PTHR11461 UniProtKB/Swiss-Prot
  PTHR11461:SF61 UniProtKB/Swiss-Prot
Pfam Serpin UniProtKB/Swiss-Prot
PhenoGen Serpinb2 PhenoGen
PROSITE SERPIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002460 RatGTEx
SMART SERPIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot
UniProt A6JSV9 ENTREZGENE, UniProtKB/TrEMBL
  P29524 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Serpinb2  serpin family B member 2  Serpinb2  serpin peptidase inhibitor, clade B (ovalbumin), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-01-19 Serpinb2  serpin peptidase inhibitor, clade B (ovalbumin), member 2  Serpinb2  serine (or cysteine) peptidase inhibitor, clade B, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Serpinb2  serine (or cysteine) peptidase inhibitor, clade B, member 2  Serpinb2  serine (or cysteine) proteinase inhibitor, clade B, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Serpinb2  serine (or cysteine) proteinase inhibitor, clade B, member 2  Pai2a  plasminogen activator inhibitor 2 type A  Symbol and Name updated 1299863 APPROVED
2002-08-07 Pai2a  plasminogen activator inhibitor 2 type A      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process mediates the formation of fibrin matrix on the root surface and its replacement by granulation tissue, and the subsequent formation of the attachment of soft tissue to the root surface during the later stages of wound repair 724606