Casp4 (caspase 4) - Rat Genome Database

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Gene: Casp4 (caspase 4) Rattus norvegicus
Analyze
Symbol: Casp4
Name: caspase 4
RGD ID: 621757
Description: Enables scaffold protein binding activity. Predicted to be involved in several processes, including cellular response to amyloid-beta; positive regulation of signal transduction; and response to bacterium. Predicted to act upstream of or within several processes, including ectopic germ cell programmed cell death; positive regulation of cytokine production; and positive regulation of defense response. Located in neuronal cell body. Part of protein-containing complex. Orthologous to several human genes including CASP4 (caspase 4); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2,4-trimethylbenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Casp11; caspase 11; caspase 4, apoptosis-related cysteine peptidase; MGC124949
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8810,883,817 - 10,919,978 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl810,883,769 - 10,920,727 (+)EnsemblGRCr8
mRatBN7.282,599,017 - 2,635,097 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl82,598,876 - 2,635,092 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx86,570,604 - 6,598,288 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.084,868,372 - 4,896,060 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.082,851,833 - 2,886,754 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.082,616,391 - 2,651,682 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl82,635,851 - 2,651,652 (+)Ensemblrn6Rnor6.0
Rnor_5.082,638,624 - 2,673,915 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.482,038,626 - 2,075,722 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera84,218,310 - 4,234,223 (+)NCBICelera
RGSC_v3.182,038,610 - 2,075,144 (+)NCBI
Cytogenetic Map8q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-tert-butylhydroquinone  (ISO)
3',4'-dimethoxyflavone  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methyladenine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (EXP)
5-fluorouracil  (ISO)
acetamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
ATP  (ISO)
bafilomycin A1  (ISO)
BAPTA  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
Bergenin  (EXP)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (EXP,ISO)
carbon nanotube  (ISO)
casticin  (ISO)
chalcones  (ISO)
cholesterol  (EXP)
choline  (ISO)
cisplatin  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
Cuprizon  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
DDE  (EXP)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
dihydrocapsaicin  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethyl methanesulfonate  (ISO)
fenofibrate  (EXP)
fisetin  (ISO)
flavonols  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furosemide  (EXP)
Fusarenone X  (ISO)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indole-3-methanol  (EXP)
irinotecan  (ISO)
isoflurane  (EXP)
kojic acid  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium chloride  (ISO)
lithium hydride  (EXP)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
menadione  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methylisothiazolinone  (ISO)
methylseleninic acid  (ISO)
metyrapone  (ISO)
Mitotane  (EXP)
Myrtucommulone A  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
naled  (ISO)
nickel atom  (ISO)
nickel subsulfide  (ISO)
nitrates  (EXP)
Nutlin-3  (ISO)
obeticholic acid  (ISO)
ouabain  (ISO)
oxybenzone  (EXP)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
pirinixic acid  (ISO)
platycodin D  (ISO)
potassium chromate  (ISO)
progesterone  (EXP)
propylparaben  (ISO)
pterostilbene  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
Riluzole  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sanguinarine  (ISO)
sarin  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
Sunset Yellow FCF  (EXP)
tauroursodeoxycholic acid  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (EXP)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
tunicamycin  (ISO)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vorinostat  (ISO)
wedelolactone  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury. de Rivero Vaccari JP, etal., J Cereb Blood Flow Metab. 2009 Jul;29(7):1251-61. Epub 2009 Apr 29.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway. Hur J, etal., FEBS Lett 2001 Oct 26;507(2):157-62.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. The pannexin 1 channel activates the inflammasome in neurons and astrocytes. Silverman WR, etal., J Biol Chem. 2009 Jul 3;284(27):18143-51. Epub 2009 May 5.
Additional References at PubMed
PMID:11536012   PMID:12477932   PMID:15123740   PMID:16920334   PMID:19890920   PMID:22002608   PMID:32617860   PMID:35988500   PMID:35990672   PMID:38864370  


Genomics

Comparative Map Data
Casp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8810,883,817 - 10,919,978 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl810,883,769 - 10,920,727 (+)EnsemblGRCr8
mRatBN7.282,599,017 - 2,635,097 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl82,598,876 - 2,635,092 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx86,570,604 - 6,598,288 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.084,868,372 - 4,896,060 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.082,851,833 - 2,886,754 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.082,616,391 - 2,651,682 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl82,635,851 - 2,651,652 (+)Ensemblrn6Rnor6.0
Rnor_5.082,638,624 - 2,673,915 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.482,038,626 - 2,075,722 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera84,218,310 - 4,234,223 (+)NCBICelera
RGSC_v3.182,038,610 - 2,075,144 (+)NCBI
Cytogenetic Map8q11NCBI
CASP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811104,942,866 - 104,968,574 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11104,942,866 - 104,969,366 (-)Ensemblhg38GRCh38
GRCh3711104,813,593 - 104,839,301 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611104,318,804 - 104,344,535 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3411104,318,804 - 104,344,503NCBI
Celera11101,977,781 - 102,003,518 (-)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11100,744,534 - 100,770,269 (-)NCBIHuRef
CHM1_111104,696,522 - 104,722,254 (-)NCBICHM1_1
T2T-CHM13v2.011104,946,956 - 104,972,673 (-)NCBIT2T-CHM13v2.0
Casp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3995,308,816 - 5,336,791 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl95,308,828 - 5,336,783 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3895,308,849 - 5,336,791 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl95,308,828 - 5,336,783 (+)Ensemblmm10GRCm38
MGSCv3795,308,860 - 5,336,791 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3695,308,874 - 5,336,717 (+)NCBIMGSCv36mm8
Celera3117,367,159 - 117,395,096 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
CASP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29105,734,010 - 105,759,789 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111106,822,318 - 106,848,104 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01199,883,353 - 99,909,185 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111103,366,138 - 103,391,849 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11103,366,138 - 103,391,824 (-)EnsemblpanPan2panpan1.1
CASP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1527,133,778 - 27,147,954 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl527,132,565 - 27,149,736 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha527,064,601 - 27,078,777 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0527,170,519 - 27,184,696 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl527,169,891 - 27,186,517 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1527,212,077 - 27,226,245 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0527,098,364 - 27,112,532 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0527,257,464 - 27,271,644 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC100522887
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1935,167,567 - 35,185,791 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2939,189,534 - 39,208,073 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103248367
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1196,315,781 - 96,342,057 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl196,315,569 - 96,342,016 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604329,555,456 - 29,581,392 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Casp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624918145,661 - 187,006 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Casp4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v182,175,169 - 2,210,060 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Casp4
273 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:68
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000061973
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000061973   ⟹   ENSRNOP00000058685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl810,883,769 - 10,919,948 (+)Ensembl
mRatBN7.2 Ensembl82,598,876 - 2,635,092 (+)Ensembl
Rnor_6.0 Ensembl82,635,851 - 2,651,652 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000127348   ⟹   ENSRNOP00000104886
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl810,883,776 - 10,920,727 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000148101   ⟹   ENSRNOP00000108989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl810,884,001 - 10,918,808 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000165692   ⟹   ENSRNOP00000105500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl810,903,468 - 10,920,727 (+)Ensembl
RefSeq Acc Id: NM_053736   ⟹   NP_446188
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8810,884,045 - 10,919,978 (+)NCBI
mRatBN7.282,599,153 - 2,635,086 (+)NCBI
Rnor_6.082,616,391 - 2,651,682 (+)NCBI
Rnor_5.082,638,624 - 2,673,915 (+)NCBI
RGSC_v3.482,038,626 - 2,075,722 (+)RGD
Celera84,218,310 - 4,234,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063264773   ⟹   XP_063120843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8810,883,960 - 10,919,978 (+)NCBI
RefSeq Acc Id: XM_063264774   ⟹   XP_063120844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8810,883,960 - 10,919,404 (+)NCBI
RefSeq Acc Id: XM_063264775   ⟹   XP_063120845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8810,902,842 - 10,919,978 (+)NCBI
RefSeq Acc Id: XR_005487740
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8810,883,817 - 10,919,978 (+)NCBI
mRatBN7.282,599,017 - 2,635,097 (+)NCBI
RefSeq Acc Id: XR_010053917
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8810,883,960 - 10,919,978 (+)NCBI
RefSeq Acc Id: NP_446188   ⟸   NM_053736
- UniProtKB: Q3MHS1 (UniProtKB/TrEMBL),   A6JN17 (UniProtKB/TrEMBL),   Q91XW7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000058685   ⟸   ENSRNOT00000061973
RefSeq Acc Id: XP_063120843   ⟸   XM_063264773
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063120844   ⟸   XM_063264774
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063120845   ⟸   XM_063264775
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000104886   ⟸   ENSRNOT00000127348
Ensembl Acc Id: ENSRNOP00000108989   ⟸   ENSRNOT00000148101
Ensembl Acc Id: ENSRNOP00000105500   ⟸   ENSRNOT00000165692
Protein Domains
CARD   Caspase family p10   Caspase family p20

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PSM0-F1-model_v2 AlphaFold E9PSM0 1-356 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621757 AgrOrtholog
BioCyc Gene G2FUF-31820 BioCyc
Ensembl Genes ENSRNOG00000033697 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061973 ENTREZGENE
  ENSRNOT00000061973.6 UniProtKB/TrEMBL
  ENSRNOT00000127348 ENTREZGENE
  ENSRNOT00000127348.1 UniProtKB/TrEMBL
  ENSRNOT00000148101.1 UniProtKB/TrEMBL
  ENSRNOT00000165692 ENTREZGENE
  ENSRNOT00000165692.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  3.40.50.1460 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7382967 IMAGE-MGC_LOAD
InterPro CARD UniProtKB/TrEMBL
  Caspase-like_dom UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  Pept_C14 UniProtKB/TrEMBL
  Pept_C14_caspase UniProtKB/TrEMBL
  Pept_C14_ICE_p20 UniProtKB/TrEMBL
  Pept_C14_ICE_p20_AS UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/TrEMBL
  Pept_C14_p45_core UniProtKB/TrEMBL
KEGG Report rno:114555 UniProtKB/TrEMBL
MGC_CLONE MGC:124949 IMAGE-MGC_LOAD
NCBI Gene 114555 ENTREZGENE
PANTHER CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18 UniProtKB/TrEMBL
  CASPASE-1 UniProtKB/TrEMBL
Pfam CARD UniProtKB/TrEMBL
  Peptidase_C14 UniProtKB/TrEMBL
PhenoGen Casp4 PhenoGen
PIRSF Caspase_ICE UniProtKB/TrEMBL
PRINTS IL1BCENZYME UniProtKB/TrEMBL
PROSITE CARD UniProtKB/TrEMBL
  CASPASE_CYS UniProtKB/TrEMBL
  CASPASE_HIS UniProtKB/TrEMBL
  CASPASE_P10 UniProtKB/TrEMBL
  CASPASE_P20 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033697 RatGTEx
SMART CARD UniProtKB/TrEMBL
  CASc UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
  SSF52129 UniProtKB/TrEMBL
UniProt A0ABK0LKQ1_RAT UniProtKB/TrEMBL
  A0ABK0LSU6_RAT UniProtKB/TrEMBL
  A0ABK0M2X1_RAT UniProtKB/TrEMBL
  A6JN17 ENTREZGENE, UniProtKB/TrEMBL
  E9PSM0_RAT UniProtKB/TrEMBL
  Q3MHS1 ENTREZGENE, UniProtKB/TrEMBL
  Q91XW7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Casp4  caspase 4  Casp4  caspase 4, apoptosis-related cysteine peptidase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Casp4  caspase 4, apoptosis-related cysteine peptidase  Casp11  caspase 11  Symbol and Name updated 1299863 APPROVED
2005-01-28 Casp11    Casp4  caspase 11  Symbol updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2004-09-10 Casp4  caspase 11  Casp11    Symbol and Name updated 1299863 APPROVED
2002-08-07 Casp11  caspase 11      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology aa sequence shares 88.7% similarity to mouse Casp11 632459
gene_pathway inflammatory induction of Casp11 may be mediated through the p38 MAPK pathway 632459
gene_protein protein masses 43 kDa 632459