• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621757 Species: Rattus norvegicus RGD Object: Gene Symbol: Casp4 Name: caspase 4, apoptosis-related cysteine peptidase

Acc ID: CHEBI:9516 Term: thapsigargin Definition: A hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations. CasRN: 67526-95-8 Chemical ID: MESH:D019284

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1343162	6480464	CTD	Thapsigargin results in increased cleavage of and results in increased activity of CASP4 protein	PMID:17559149