CASP4 (caspase 4, apoptosis-related cysteine peptidase)

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Keyword

Gene: CASP4 (caspase 4, apoptosis-related cysteine peptidase) Homo sapiens

Symbol:

CASP4

Name:

caspase 4, apoptosis-related cysteine peptidase

Description:

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

apoptotic cysteine protease Mih1/TX; CASP-4; caspase 4, apoptosis-related cysteine protease; caspase-4; ICE(rel)-II; ICE(rel)II; ICEREL-II; ICH-2; Mih1/TX; OTTHUMP00000231863; OTTHUMP00000231864; protease ICH-2; protease TX; TX

Orthologs:

Mus musculus : Casp4 (caspase 4, apoptosis-related cysteine peptidase) MGI
Rattus norvegicus : Casp4 (caspase 4, apoptosis-related cysteine peptidase)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	11	104,677,468 - 104,703,194	-	NCBI
Human Genome Assembly HuRef	11	100,744,534 - 100,770,269	-	NCBI
Human Genome Assembly GRCh37	11	104,813,594 - 104,839,325	-	NCBI
Human Genome Assembly Build 36	11	104,318,804 - 104,344,535	-	NCBI
Human Cytogenetic Map	11	q22.2-q22.3		NCBI
Human Genome Assembly	11	104,318,804 - 104,344,503		NCBI