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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621757 Species: Rattus norvegicus RGD Object: Gene Symbol: Casp4 Name: caspase 4, apoptosis-related cysteine peptidase

Acc ID: CHEBI:16113 Term: cholesterol Definition: A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group. CasRN: 57-88-5 Chemical ID: MESH:D002784

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of CASP4 mRNA] Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of CASP4 mRNA]	PMID:19477266
increases expression	EXP		6480464	CTD	Cholesterol analog results in increased expression of CASP4 mRNA	PMID:19477266