Kif5b (kinesin family member 5B) - Rat Genome Database

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Gene: Kif5b (kinesin family member 5B) Rattus norvegicus
Analyze
Symbol: Kif5b
Name: kinesin family member 5B
RGD ID: 621559
Description: Enables JUN kinase binding activity; microtubule lateral binding activity; and microtubule motor activity. Involved in axonal transport; hippocampus development; and positive regulation of transport. Located in axonal growth cone; microtubule cytoskeleton; and perinuclear region of cytoplasm. Is active in postsynaptic cytosol. Orthologous to human KIF5B (kinesin family member 5B); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; mitochondria transport pathway; N-cadherin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: conventional kinesin heavy chain; Khc; kinesin-1 heavy chain; ubiquitous kinesin heavy chain; UKHC
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81756,185,386 - 56,222,990 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1756,185,380 - 56,223,008 (+)EnsemblGRCr8
mRatBN7.21751,489,904 - 51,527,508 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1751,489,944 - 51,527,508 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1754,663,892 - 54,694,120 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01758,666,828 - 58,697,056 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01752,804,979 - 52,835,181 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01754,181,416 - 54,219,048 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1754,181,419 - 54,212,096 (+)Ensemblrn6Rnor6.0
Rnor_5.01751,875,803 - 51,913,435 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41759,697,082 - 59,727,314 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1747,501,097 - 47,531,289 (+)NCBICelera
RGSC_v3.11759,728,937 - 59,735,497 (+)NCBI
Cytogenetic Map17q12.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
doxorubicin  (EXP)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
glucose  (EXP)
hypochlorous acid  (ISO)
ivermectin  (ISO)
methimazole  (EXP)
methoxychlor  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenol red  (ISO)
phenylephrine  (EXP)
poly(I:C)  (EXP)
propiconazole  (ISO)
pyrogallol  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Diabetes alters KIF1A and KIF5B motor proteins in the hippocampus. Baptista FI, etal., PLoS One. 2013 Jun 12;8(6):e65515. doi: 10.1371/journal.pone.0065515. Print 2013.
2. Activation of conventional kinesin motors in clusters by Shaw voltage-gated K+ channels. Barry J, etal., J Cell Sci. 2013 May 1;126(Pt 9):2027-41. doi: 10.1242/jcs.122234. Epub 2013 Mar 13.
3. Association of dystrobrevin and regulatory subunit of protein kinase A: a new role for dystrobrevin as a scaffold for signaling proteins. Ceccarini M, etal., J Mol Biol. 2007 Aug 31;371(5):1174-87. doi: 10.1016/j.jmb.2007.06.019. Epub 2007 Jun 14.
4. Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells. Fujita T, etal., Biochem Biophys Res Commun. 2007 Sep 28;361(3):605-10. Epub 2007 Jul 23.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons. Gumy LF, etal., Neuron. 2017 Apr 19;94(2):347-362.e7. doi: 10.1016/j.neuron.2017.03.046.
8. Daxx functions as a scaffold of a protein assembly constituted by GLUT4, JNK1 and KIF5B. Lalioti VS, etal., J Cell Physiol. 2009 Feb;218(2):416-26. doi: 10.1002/jcp.21614.
9. A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity. Ligon LA, etal., J Biol Chem. 2004 Apr 30;279(18):19201-8. Epub 2004 Feb 24.
10. Regulation of mitochondrial transport in neurons. Lin MY and Sheng ZH, Exp Cell Res. 2015 May 15;334(1):35-44. doi: 10.1016/j.yexcr.2015.01.004. Epub 2015 Jan 19.
11. Membrane damage-induced vesicle-vesicle fusion of dysferlin-containing vesicles in muscle cells requires microtubules and kinesin. McDade JR and Michele DE, Hum Mol Genet. 2014 Apr 1;23(7):1677-86. doi: 10.1093/hmg/ddt557. Epub 2013 Nov 7.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase. Pekkurnaz G, etal., Cell. 2014 Jul 3;158(1):54-68. doi: 10.1016/j.cell.2014.06.007.
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. The role of Kif5B in axonal localization of Kv1 K(+) channels. Rivera J, etal., Eur J Neurosci. 2007 Jan;25(1):136-46.
19. Surface-decoration of microtubules by human tau. Santarella RA, etal., J Mol Biol. 2004 Jun 4;339(3):539-53.
20. Rho GTPases in insulin-stimulated glucose uptake. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
21. KIF5B promotes the forward transport and axonal function of the voltage-gated sodium channel Nav1.8. Su YY, etal., J Neurosci. 2013 Nov 6;33(45):17884-96. doi: 10.1523/JNEUROSCI.0539-13.2013.
22. c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) regulates neuronal axon elongation in a kinesin- and JNK-dependent manner. Sun T, etal., J Biol Chem. 2013 May 17;288(20):14531-43. doi: 10.1074/jbc.M113.464453. Epub 2013 Apr 10.
23. Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria. Tanaka Y, etal., Cell 1998 Jun 26;93(7):1147-58.
24. Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin. Twelvetrees AE, etal., Neuron. 2010 Jan 14;65(1):53-65. doi: 10.1016/j.neuron.2009.12.007.
25. Molecular motors implicated in the axonal transport of tau and alpha-synuclein. Utton MA, etal., J Cell Sci. 2005 Oct 15;118(Pt 20):4645-54. Epub 2005 Sep 21.
26. Expression of neuronal kinesin heavy chain is developmentally regulated in the central nervous system of the rat. Vignali G, etal., J Neurochem. 1997 Nov;69(5):1840-9.
27. Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity. Yang S, etal., Redox Biol. 2014;3:63-71. doi: 10.1016/j.redox.2014.04.001. Epub 2014 Apr 12.
Additional References at PubMed
PMID:7514426   PMID:10573845   PMID:12805290   PMID:15644324   PMID:16018997   PMID:16260607   PMID:16301330   PMID:17013387   PMID:17200414   PMID:17200416   PMID:17360972   PMID:17611281  
PMID:17887960   PMID:18004302   PMID:19144319   PMID:19675065   PMID:19825938   PMID:19828815   PMID:19946888   PMID:20386726   PMID:20682791   PMID:20863816   PMID:21048148   PMID:25002582  
PMID:25468996   PMID:25644797   PMID:26316108   PMID:26656703   PMID:27094714   PMID:27219061   PMID:29476059   PMID:30053369   PMID:30978476   PMID:33953268   PMID:34154701   PMID:36773735  


Genomics

Comparative Map Data
Kif5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81756,185,386 - 56,222,990 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1756,185,380 - 56,223,008 (+)EnsemblGRCr8
mRatBN7.21751,489,904 - 51,527,508 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1751,489,944 - 51,527,508 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1754,663,892 - 54,694,120 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01758,666,828 - 58,697,056 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01752,804,979 - 52,835,181 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01754,181,416 - 54,219,048 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1754,181,419 - 54,212,096 (+)Ensemblrn6Rnor6.0
Rnor_5.01751,875,803 - 51,913,435 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41759,697,082 - 59,727,314 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1747,501,097 - 47,531,289 (+)NCBICelera
RGSC_v3.11759,728,937 - 59,735,497 (+)NCBI
Cytogenetic Map17q12.1NCBI
KIF5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381032,009,015 - 32,056,425 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1032,009,014 - 32,056,454 (-)Ensemblhg38GRCh38
GRCh371032,297,943 - 32,345,353 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361032,340,077 - 32,385,221 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341032,340,076 - 32,385,221NCBI
Celera1032,062,826 - 32,110,627 (-)NCBICelera
Cytogenetic Map10p11.22NCBI
HuRef1032,018,111 - 32,065,919 (-)NCBIHuRef
CHM1_11032,299,660 - 32,347,071 (-)NCBICHM1_1
T2T-CHM13v2.01032,037,647 - 32,085,426 (-)NCBIT2T-CHM13v2.0
Kif5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39186,201,005 - 6,241,524 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl186,201,002 - 6,242,174 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38186,201,005 - 6,241,524 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl186,201,002 - 6,242,174 (-)Ensemblmm10GRCm38
MGSCv37186,201,003 - 6,241,522 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36186,202,209 - 6,241,498 (-)NCBIMGSCv36mm8
Celera186,247,889 - 6,288,660 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map184.46NCBI
Kif5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542923,631,282 - 23,678,562 (-)Ensembl
ChiLan1.0NW_00495542923,632,246 - 23,678,797 (-)NCBIChiLan1.0ChiLan1.0
KIF5B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2844,659,162 - 44,706,677 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11044,664,488 - 44,712,585 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01032,138,964 - 32,186,448 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11032,731,150 - 32,778,242 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1032,731,150 - 32,778,242 (-)EnsemblpanPan2panpan1.1
KIF5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1214,835,906 - 14,880,896 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl214,835,901 - 14,878,251 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha212,323,571 - 12,368,548 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0213,072,118 - 13,117,087 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl213,072,118 - 13,116,722 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1212,512,247 - 12,557,211 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0212,403,006 - 12,447,970 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0212,676,797 - 12,721,749 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kif5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934411,280,577 - 11,324,435 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936574779,777 - 823,970 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936574780,074 - 823,858 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KIF5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1042,637,109 - 42,693,491 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11042,637,105 - 42,693,551 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21047,233,047 - 47,293,409 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KIF5B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1931,321,615 - 31,369,549 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl931,320,549 - 31,369,519 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605640,295,395 - 40,343,097 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kif5b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248054,465,235 - 4,514,870 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248054,464,538 - 4,514,784 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Kif5b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11432,557,058 - 32,594,376 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kif5b
424 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:28
Interacting mature miRNAs:30
Transcripts:ENSRNOT00000023861
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174949693265155015Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175560459793006569Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat

Markers in Region
RH128765  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81756,216,109 - 56,216,307 (+)Marker Load Pipeline
mRatBN7.21751,520,627 - 51,520,825 (+)MAPPERmRatBN7.2
Rnor_6.01754,212,168 - 54,212,365NCBIRnor6.0
Rnor_5.01751,906,555 - 51,906,752UniSTSRnor5.0
RGSC_v3.41759,727,403 - 59,727,600UniSTSRGSC3.4
Celera1747,531,378 - 47,531,575UniSTS
Cytogenetic Map17q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000023861   ⟹   ENSRNOP00000023860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1756,185,380 - 56,223,008 (+)Ensembl
mRatBN7.2 Ensembl1751,489,944 - 51,527,508 (+)Ensembl
Rnor_6.0 Ensembl1754,181,419 - 54,212,096 (+)Ensembl
RefSeq Acc Id: NM_057202   ⟹   NP_476550
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81756,185,386 - 56,222,990 (+)NCBI
mRatBN7.21751,489,904 - 51,527,508 (+)NCBI
Rnor_6.01754,181,847 - 54,212,079 (+)NCBI
Rnor_5.01751,875,803 - 51,913,435 (+)NCBI
RGSC_v3.41759,697,082 - 59,727,314 (+)RGD
Celera1747,501,097 - 47,531,289 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_476550 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD39239 (Get FASTA)   NCBI Sequence Viewer  
  ABC25059 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023860
GenBank Protein Q2PQA9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_476550   ⟸   NM_057202
- UniProtKB: Q9WV65 (UniProtKB/Swiss-Prot),   Q2PQA9 (UniProtKB/Swiss-Prot),   A0A8L2QCP8 (UniProtKB/TrEMBL),   A6K9E2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023860   ⟸   ENSRNOT00000023861
Protein Domains
Kinesin motor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2PQA9-F1-model_v2 AlphaFold Q2PQA9 1-963 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700522
Promoter ID:EPDNEW_R11043
Type:initiation region
Name:Kif5b_1
Description:kinesin family member 5B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01754,181,444 - 54,181,504EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621559 AgrOrtholog
BioCyc Gene G2FUF-9060 BioCyc
Ensembl Genes ENSRNOG00000017466 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000023861 ENTREZGENE
Gene3D-CATH 3.40.850.10 UniProtKB/Swiss-Prot
  6.10.250.1590 UniProtKB/Swiss-Prot
InterPro Kinesin-like_fam UniProtKB/Swiss-Prot
  Kinesin_motor_CS UniProtKB/Swiss-Prot
  Kinesin_motor_dom UniProtKB/Swiss-Prot
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:117550 UniProtKB/Swiss-Prot
NCBI Gene 117550 ENTREZGENE
PANTHER CENTROMERE PROTEIN E UniProtKB/Swiss-Prot
  KINESIN-LIKE PROTEIN UniProtKB/Swiss-Prot
Pfam Kinesin UniProtKB/Swiss-Prot
PhenoGen Kif5b PhenoGen
PRINTS KINESINHEAVY UniProtKB/Swiss-Prot
PROSITE KINESIN_MOTOR_1 UniProtKB/Swiss-Prot
  KINESIN_MOTOR_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017466 RatGTEx
SMART KISc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8L2QCP8 ENTREZGENE, UniProtKB/TrEMBL
  A6K9E2 ENTREZGENE, UniProtKB/TrEMBL
  KINH_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9WV65 ENTREZGENE
UniProt Secondary Q9WV65 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Kif5b  kinesin family member 5B      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Kif5b  kinesin family member 5B      Symbol and Name status set to provisional 70820 PROVISIONAL