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Gene: Kif3c (kinesin family member 3C) Rattus norvegicus

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Symbol:

Kif3c

Name:

kinesin family member 3C

RGD ID:

621538

Description:

Enables kinesin binding activity and microtubule binding activity. Involved in positive regulation of neuron projection development. Located in several cellular components, including microtubule plus-end; neuronal ribonucleoprotein granule; and synaptic vesicle. Orthologous to human KIF3C (kinesin family member 3C); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

kinesin-like protein KIF3C

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KIF3C (kinesin family member 3C)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Kif3c (kinesin family member 3C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Kif3c (kinesin family member 3C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KIF3C (kinesin family member 3C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KIF3C (kinesin family member 3C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Kif3c (kinesin family member 3C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KIF3C (kinesin family member 3C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	KIF3C (kinesin family member 3C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Kif3c (kinesin family member 3C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Kif3c (kinesin family member 3C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	KIF3C (kinesin family member 3C)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Kif3c (kinesin family member 3C)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Klp68D	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Klp68D	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	klp-11	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	klp-11	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	kif3c	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	kif3c	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	32,086,879 - 32,125,812 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	32,086,124 - 32,126,066 (+)	Ensembl				GRCr8
mRatBN7.2	6	26,367,092 - 26,406,033 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	26,366,531 - 26,406,130 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	26,659,683 - 26,698,621 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	26,975,571 - 27,014,501 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	26,453,926 - 26,492,858 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	27,768,943 - 27,815,611 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	27,768,943 - 27,815,611 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	37,579,445 - 37,625,883 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	26,342,388 - 26,381,233 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	25,843,783 - 25,882,712 (+)	NCBI		Celera
RGSC_v3.1	6	26,345,340 - 26,384,186 (+)	NCBI
Cytogenetic Map	6	q14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amyotrophic lateral sclerosis type 1 (ISO)

atrial fibrillation (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

cadmium dichloride (EXP)

calcitriol (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

D-gluconic acid (EXP)

DDE (ISO)

dibutyl phthalate (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

ethanol (ISO)

gentamycin (EXP)

hypochlorous acid (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (ISO)

pirinixic acid (EXP,ISO)

propanal (ISO)

raloxifene (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

succimer (ISO)

tamoxifen (ISO)

testosterone (ISO)

thioacetamide (EXP)

thiram (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

tungsten (ISO)

tunicamycin (ISO)

uranium atom (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

microtubule-based movement (IBA,IEA)

positive regulation of neuron projection development (IMP)

Cellular Component

axon (IDA)

cytoplasm (IBA,IEA)

cytoskeleton (IEA)

dendrite (IDA)

growth cone (IDA)

kinesin complex (IBA)

microtubule (IBA,IEA)

microtubule cytoskeleton (IDA)

microtubule plus-end (IDA)

neuronal cell body (IDA)

neuronal ribonucleoprotein granule (IDA)

synaptic vesicle (IDA)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IBA)

cytoskeletal motor activity (IEA)

kinesin binding (IPI)

microtubule binding (IBA,IDA,IEA)

microtubule motor activity (IBA,IEA)

nucleotide binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules.	Davidovic L, etal., Hum Mol Genet. 2007 Dec 15;16(24):3047-58. Epub 2007 Sep 19.
2.	Identification of kinesin-like molecules in myogenic cells.	Faire K, etal., Eur J Cell Biol 1998 Sep;77(1):27-34.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	The kinesin-2 family member KIF3C regulates microtubule dynamics and is required for axon growth and regeneration.	Gumy LF, etal., J Neurosci. 2013 Jul 10;33(28):11329-45. doi: 10.1523/JNEUROSCI.5221-12.2013.
6.	KIF3C and KIF3A form a novel neuronal heteromeric kinesin that associates with membrane vesicles.	Muresan V, etal., Mol Biol Cell 1998 Mar;9(3):637-52.
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Kif3c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	32,086,879 - 32,125,812 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	32,086,124 - 32,126,066 (+)	Ensembl				GRCr8
mRatBN7.2	6	26,367,092 - 26,406,033 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	26,366,531 - 26,406,130 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	26,659,683 - 26,698,621 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	26,975,571 - 27,014,501 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	26,453,926 - 26,492,858 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	27,768,943 - 27,815,611 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	27,768,943 - 27,815,611 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	37,579,445 - 37,625,883 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	26,342,388 - 26,381,233 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	25,843,783 - 25,882,712 (+)	NCBI		Celera
RGSC_v3.1	6	26,345,340 - 26,384,186 (+)	NCBI
Cytogenetic Map	6	q14	NCBI

KIF3C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	25,926,598 - 25,982,497 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	25,926,589 - 25,982,761 (-)	Ensembl			hg38	GRCh38
GRCh37	2	26,149,467 - 26,205,366 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	26,002,959 - 26,058,947 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	26,061,118 - 26,117,054	NCBI
Celera	2	25,989,739 - 26,045,730 (-)	NCBI		Celera
Cytogenetic Map	2	p23.3	NCBI
HuRef	2	25,886,207 - 25,942,013 (-)	NCBI		HuRef
CHM1_1	2	26,079,044 - 26,135,487 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	25,961,945 - 26,017,861 (-)	NCBI		T2T-CHM13v2.0

Kif3c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	3,415,132 - 3,456,494 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	3,415,132 - 3,456,494 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	3,365,132 - 3,406,494 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	3,365,132 - 3,406,494 (+)	Ensembl			mm10	GRCm38
MGSCv37	12	3,365,132 - 3,406,494 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	3,365,132 - 3,406,494 (+)	NCBI		MGSCv36	mm8
Celera	12	3,292,187 - 3,333,551 (+)	NCBI		Celera
Cytogenetic Map	12	A1.1	NCBI
cM Map	12	1.77	NCBI

Kif3c
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955469	7,958,481 - 8,001,738 (-)	Ensembl
ChiLan1.0	NW_004955469	7,960,224 - 8,001,161 (-)	NCBI	ChiLan1.0	ChiLan1.0

KIF3C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	100,536,872 - 100,591,788 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	100,540,100 - 100,595,754 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	25,927,039 - 25,982,715 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	26,020,025 - 26,074,961 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	26,020,025 - 26,074,961 (-)	Ensembl			panPan2	panpan1.1

KIF3C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	20,090,374 - 20,128,703 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	20,091,759 - 20,128,562 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	19,986,149 - 20,024,501 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	20,411,768 - 20,450,554 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	20,411,774 - 20,451,095 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	20,098,664 - 20,136,938 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	20,109,348 - 20,147,627 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	20,155,378 - 20,193,906 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Kif3c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	64,402,587 - 64,442,970 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	6,396,276 - 6,435,266 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936493	6,396,606 - 6,435,266 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KIF3C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	112,966,804 - 113,014,624 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	112,963,424 - 113,014,632 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	119,943,241 - 119,968,158 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KIF3C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	81,666,884 - 81,717,489 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	81,666,793 - 81,717,508 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666045	30,438,707 - 30,491,806 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kif3c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	8,127,797 - 8,171,697 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624738	8,128,594 - 8,171,638 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Kif3c
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	24,057,072 - 24,097,169 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Kif3c
112 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	98
Count of miRNA genes:	84
Interacting mature miRNAs:	89
Transcripts:	ENSRNOT00000015820
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1975879	46975879	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
8552910	Pigfal5	Plasma insulin-like growth factor 1 level QTL 5	4.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	22653889	67653889	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	3239989	48239989	Rat
1331779	Rf38	Renal function QTL 38	2.876		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	31185002	76185002	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1975879	46975879	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1975879	46975879	Rat
1598843	Cm63	Cardiac mass QTL 63	2.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	1	44788383	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1975879	46975879	Rat
2292616	Ept15	Estrogen-induced pituitary tumorigenesis QTL 15	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	1	44788383	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1975879	46975879	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	26618314	86868070	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	20859430	113082285	Rat
2301964	Bp323	Blood pressure QTL 323	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	86868070	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	3239989	48239989	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	3239989	48239989	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	26618314	86868070	Rat
1300128	Rf16	Renal function QTL 16	3.89		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	1	40163351	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	30937632	75937632	Rat
70199	Coreg1	Compensatory renal growth QTL 1	11.8		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	6	14599473	63457687	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	16089372	61967788	Rat
1358190	Ept1	Estrogen-induced pituitary tumorigenesis QTL 1	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	1	44788383	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	3239989	48239989	Rat
1359023	Bp272	Blood pressure QTL 272	2.5		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	22288257	32981219	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	22288257	67288257	Rat

Markers in Region

D6Wox30

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	26,405,092 - 26,405,315 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	27,814,671 - 27,814,893	NCBI	Rnor6.0
Rnor_5.0	6	37,624,943 - 37,625,165	UniSTS	Rnor5.0
RGSC_v3.4	6	26,380,293 - 26,380,515	UniSTS	RGSC3.4
Celera	6	25,881,772 - 25,881,994	UniSTS
Cytogenetic Map	6	q14	UniSTS

AW523935

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	26,406,109 - 26,406,265 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	27,815,688 - 27,815,843	NCBI	Rnor6.0
Rnor_5.0	6	37,625,960 - 37,626,115	UniSTS	Rnor5.0
RGSC_v3.4	6	26,381,310 - 26,381,465	UniSTS	RGSC3.4
Celera	6	25,882,789 - 25,882,944	UniSTS
RH 3.4 Map	6	117.4	UniSTS
Cytogenetic Map	6	q14	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	161	91	90	59	90	59	6	352	190	10	140	79	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053486	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF083330	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ223599	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000015820 ⟹ ENSRNOP00000015820

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	32,086,124 - 32,126,066 (+)	Ensembl
mRatBN7.2 Ensembl	6	26,366,531 - 26,406,130 (+)	Ensembl
Rnor_6.0 Ensembl	6	27,768,943 - 27,815,611 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094149 ⟹ ENSRNOP00000091006

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	32,086,124 - 32,124,862 (+)	Ensembl
mRatBN7.2 Ensembl	6	26,366,531 - 26,405,083 (+)	Ensembl

RefSeq Acc Id:

NM_053486 ⟹ NP_445938

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	32,086,879 - 32,125,812 (+)	NCBI
mRatBN7.2	6	26,367,092 - 26,406,033 (+)	NCBI
Rnor_6.0	6	27,768,943 - 27,815,611 (+)	NCBI
Rnor_5.0	6	37,579,445 - 37,625,883 (+)	NCBI
RGSC_v3.4	6	26,342,388 - 26,381,233 (+)	RGD
Celera	6	25,843,783 - 25,882,712 (+)	RGD

Sequence:

show sequence

CTGATCCCGACTTAGGAGTAAGGGCAGGAGGACCGCCCAGGCTGCAGAGCGGCCCACCTGGAAG
GACAGAGCTGCAAGATGGCCAGTAAGACCAAGGCCAGCGAGGCCCTGAAGGTGGTGGCCCGGTG
CCGCCCCCTCAGTAGGAAGGAGGAGGCTGCTGGTCATGAGCAGATTCTGACCATGGACGTGAAA
CTGGGCCAGGTGACTCTGCGAAACCCCCGCGCGGCACCCGGGGAGCTGCCCAAGACCTTCACTT
TTGATGCTGTGTATGACGCTAGCTCCAAGCAGGCCGACCTGTATGATGAAACGGTGAGGCCCCT
GATAGACTCGGTGCTTCAGGGTTTCAATGGCACCGTATTTGCCTATGGCCAGACTGGCACTGGC
AAGACCTACACCATGCAGGGGACCTGGGTGGAGCCAGAGCTCCGCGGGGTTATCCCCAATGCCT
TTGAGCACATCTTCACCCACATTTCCCGCTCCCAGAACCAGCAGTACCTGGTTCGTGCCTCCTA
CTTGGAGATCTACCAGGAGGAGATTCGAGACCTGCTATCCAAGGAGCCAGGCAAAAGGCTAGAA
CTGAAGGAGAATCCTGAAACAGGGGTCTACATCAAGGACCTCTCTTCCTTTGTCACCAAGAATG
TCAAGGAGATTGAACACGTGATGAACCTGGGGAACCAAGCCCGGGCAGTAGGCAGCACCCACAT
GAATGAGGTCAGCTCCCGGTCCCATGCCATCTTTGTTATCACAGTGGAGTGCAGTGAGCGTGGC
TCCGATGGACAGGACCATATCCGAGTAGGCAAGCTCAACCTGGTAGACCTGGCCGGCAGTGAGA
GGCAGAACAAGGCAGGTCCCAACACACCTGGAGGGCCAGCCACACAGTCAACAGCTGGTGGTGG
CGGCGGAGGTGGCGGCACTAGTGGTTCTGGCAGTAGTGGAGAGAGGCCTAAGGAAGCTTCTAAA
ATCAATCTTTCACTGTCCGCCCTGGGCAATGTGATTGCTGCTTTGGCTGGCAACAGGAGCACCC
ACATCCCCTACCGGGACTCCAAGCTGACCCGGCTGCTCCAAGACTCATTGGGGGGCAATGCCAA
GACCATCATGGTGGCCACACTGGGTCCAGCTTCTCATAGCTACGACGAGAGCCTCTCCACCCTG
CGCTTTGCGAACCGAGCCAAGAACATCAAGAACAAACCGCGGGTGAACGAGGACCCCAAGGACA
CGCTGCTTAGGGAATTCCAGGAAGAGATCGCCCGCTTGAAGGCCCAGCTTGAGAAGAAGGGGAT
GCTGGGAAAGCGACCTCGGAGAAAGAGCAGTCGCAGAAAGAAGGCCGTGTCTGCTCCGGCCGGC
TATCCAGAGGGGGCCGTAATTGAGGCTTGGGTGGCTGAAGAGGAAGATGATAACAACAATAATC
ACCGCCCACCCCAGCCCACCCTGGAGGCCGCTTTGGAGAAAAACATGGAGAATTACCTGCAGGA
ACAGAAAGAGCGGCTGGAGGAGGAGAAGGCGGCCATCCAGGATGACCGCAGCCTCGTGAGTGAG
GAGAAGCAGAAGCTTCTAGAAGAGAAGGAGAAGATGCTGGAGGATCTGAAGCGGGAGCAGCAGG
CCACAGAGCTGCTTGCAGCCAAGTACAAGGCCATGGAAAGCAAGCTACTCATTGGGGGGCGGAA
CATCATGGATCACACCAACGAACAACAGAAGATGTTGGAACTGAAGCGACAGGAGATTGCAGAA
CAGAAACGGCGTGAACGGGAAATGCAGCAGGAGATGCTGCTCCGAGATGAAGAGACCATGGAGC
TACGTGGTACCTACTCGTCCCTGCAGCAGGAGGTGGAAGTTAAAACCAAGAAACTCAAGAAGCT
CTATGCCAAGCTACAGGCGGTGAAGGCAGAGATCCAGGACCAACATGAGGAGTACATCCGCGTG
CGGCAGGACCTGGAGGAGGCGCAGAATGAGCAGACCCGGGAACTCAAGCTCAAGTACCTCATCA
TTGAGAACTTCATCCCCCCTGAGGAGAAGAACAAGATCATGAACCGGCTTTTCCTGGACTGTGA
GGAGGAGCAGTGGAAGTTCCAGCCCCTGGTGCCAGCTGGAGTGAATAACAGCCAAATGAAGAAG
CGTCCAACTTCTGCAGTGGGCTACAAGAGACCTATCAGCCAGTATGCTCGGGTTGCCATGGCAA
TGGGGTCCCATCCCAGATACAGGGCTGAAAATATAATGTTTTTGGAACTGGATGTATCCCCGCC
GGCCATCTTTGAGATGGAATTTTCTCATGACCAAGAACAAGATCCACGAGTACTACACATGGAG
AGGCTCATGCGGTTGGACAGCTTTCTGGAGAGACCTTCCACGTCTAAAGTGCGAAAGTCGAGAT
CCTGGTGCCAGAGTCCTCAGCGGCCTCCACCACCCTCCACAGTTCATGCCTCCATGGCCTCTGC
TCCTCTGCACCCTGCAACAGTGGTAGACCATGACTGACACCCTTCAGTCAGGCTGCCCATCACA
AAGACTCCTAGGACAGGGCAGCCATCCCTGGTTCATCCCATCTGATGCTTGGTGCGCGCGTGTG
TGGGGTGTGTATGCATGTGTGTGTGTGTGAACTAGTGTGTGTACTAGTGTGTGTGAAGGGGCAA
GAAACCGGCAGGTGGTGCCTCTGCCTGTTCTCCGGGCCTCCTTTATTTAATTCTGTTATTTATT
CGTGGAGCTTGGTTAGTGAGGAGAGATTCCCCTCGCTTGAGCTGCCTGGGCCTGCCATGGTCAC
TGCATAGCTTCCTGTTCTGGCTGAGGAGAGACCTCAGTCAGGCCCCAAGCTCCTCACGTCAGCT
GCCCCTGAGGGAAGATGGCTAGTGCCTGAGAAGACAGTGCTTCCTTTACCCGTCCAAGTTCACA
GTTTCCATCTTCTTGTCTGATGGTGAGCAGCCCCTGATGCTTTCTGAGGCTGGGAAACTGCGGG
TGTCCACTGAGGGCAAGAGGTGTCCTAACAGTGTTGGGCTTGCACTCCTGGTGGACTGAGCCTT
GCTCACCTCTTCCTGGGCCCTAAACTCTTCGAGCCTCCAGGGCTCTTTCCCAAGGACTTTCAGT
AGCCTAATACTCATCCCAGGCTCTCCGGCCTTGGCAAGAACTCGTGGCTTCCCCAACTCCACTT
CATTGCCAGCCCTCTCTACCCTGGGATTGGGAATTGTGAACCAAACAGTTGTTGCTACCACGAG
ACCTACAGGAAGTGGAACAGTGTGGAAAACGCATGGAATGTCATCAGGGGCACTCTCTCCTCAG
TTCCTCTGGTTTCCTTCTCTCCTCCAAGAAGTTCCTTTGGAGAACAAACCATCAGACTCCCTCT
CCTCATGTGAGGTGTAGCTTTTCCTGCTCTGATCACTGTTCCCTGAAGCTGTCAGGTCTCAGTC
CACAGTGGAAAGAATCGGTGTCATTCC

hide sequence

Protein Sequences


Protein RefSeqs	NP_445938	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC33291	(Get FASTA)	NCBI Sequence Viewer
	CAA11465	(Get FASTA)	NCBI Sequence Viewer
	EDM03007	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000015820
GenBank Protein	O55165	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_445938 ⟸ NM_053486

- UniProtKB:

O88657 (UniProtKB/Swiss-Prot), O55165 (UniProtKB/Swiss-Prot), A6HAF2 (UniProtKB/TrEMBL), G3V7J8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASKTKASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVY
DASSKQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIF
THISRSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDLSSFVTKNVKEIE
HVMNLGNQARAVGSTHMNEVSSRSHAIFVITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKA
GPNTPGGPATQSTAGGGGGGGGTSGSGSSGERPKEASKINLSLSALGNVIAALAGNRSTHIPYR
DSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLRE
FQEEIARLKAQLEKKGMLGKRPRRKSSRRKKAVSAPAGYPEGAVIEAWVAEEEDDNNNNHRPPQ
PTLEAALEKNMENYLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLKREQQATELL
AAKYKAMESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMLLRDEETMELRGTY
SSLQQEVEVKTKKLKKLYAKLQAVKAEIQDQHEEYIRVRQDLEEAQNEQTRELKLKYLIIENFI
PPEEKNKIMNRLFLDCEEEQWKFQPLVPAGVNNSQMKKRPTSAVGYKRPISQYARVAMAMGSHP
RYRAENIMFLELDVSPPAIFEMEFSHDQEQDPRVLHMERLMRLDSFLERPSTSKVRKSRSWCQS
PQRPPPPSTVHASMASAPLHPATVVDHD

hide sequence

Ensembl Acc Id:

ENSRNOP00000015820 ⟸ ENSRNOT00000015820

Ensembl Acc Id:

ENSRNOP00000091006 ⟸ ENSRNOT00000094149

Protein Domains

Kinesin motor

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O55165-F1-model_v2	AlphaFold	O55165	1-796	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621538	AgrOrtholog
BioCyc Gene	G2FUF-38296	BioCyc
Ensembl Genes	ENSRNOG00000011394	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000015820	ENTREZGENE
Gene3D-CATH	3.40.850.10	UniProtKB/Swiss-Prot
InterPro	Kinesin-like_fam	UniProtKB/Swiss-Prot
	Kinesin_motor_CS	UniProtKB/Swiss-Prot
	Kinesin_motor_dom	UniProtKB/Swiss-Prot
	Kinesin_motor_dom_sf	UniProtKB/Swiss-Prot
	P-loop_NTPase	UniProtKB/Swiss-Prot
KEGG Report	rno:85248	UniProtKB/Swiss-Prot
NCBI Gene	85248	ENTREZGENE
PANTHER	CENTROMERE PROTEIN E	UniProtKB/Swiss-Prot
	KINESIN-LIKE PROTEIN	UniProtKB/Swiss-Prot
Pfam	Kinesin	UniProtKB/Swiss-Prot
PhenoGen	Kif3c	PhenoGen
PRINTS	KINESINHEAVY	UniProtKB/Swiss-Prot
PROSITE	KINESIN_MOTOR_1	UniProtKB/Swiss-Prot
	KINESIN_MOTOR_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000011394	RatGTEx
SMART	KISc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot
UniProt	A0A8I6AET8_RAT	UniProtKB/TrEMBL
	A6HAF2	ENTREZGENE, UniProtKB/TrEMBL
	G3V7J8	ENTREZGENE, UniProtKB/TrEMBL
	KIF3C_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	O88657	ENTREZGENE
UniProt Secondary	O88657	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Kif3c	kinesin family member 3C			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Kif3c	kinesin family member 3C			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in brain, retina, and lung	729208
gene_function	binds to microtubules in a nucleotide-dependent manner	729208

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD