KIF3C (kinesin family member 3C) - Rat Genome Database

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Gene: KIF3C (kinesin family member 3C) Homo sapiens
Analyze
Symbol: KIF3C
Name: kinesin family member 3C
RGD ID: 731540
HGNC Page HGNC:6321
Description: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be located in microtubule cytoskeleton; neuronal cell body; and neuronal ribonucleoprotein granule. Predicted to be part of kinesin complex. Predicted to be active in microtubule.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: KIF3C variant protein; kinesin-like protein KIF3C
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38225,926,598 - 25,982,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl225,926,598 - 25,982,749 (-)EnsemblGRCh38hg38GRCh38
GRCh37226,149,467 - 26,205,366 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36226,002,959 - 26,058,947 (-)NCBINCBI36Build 36hg18NCBI36
Build 34226,061,118 - 26,117,054NCBI
Celera225,989,739 - 26,045,730 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef225,886,207 - 25,942,013 (-)NCBIHuRef
CHM1_1226,079,044 - 26,135,487 (-)NCBICHM1_1
T2T-CHM13v2.0225,961,945 - 26,017,861 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9446808   PMID:9450952   PMID:9480755   PMID:9487132   PMID:12477932   PMID:15489334   PMID:16344560   PMID:17043677   PMID:17881655   PMID:18187620   PMID:21873635   PMID:26272184  
PMID:26496610   PMID:27173435   PMID:28514442   PMID:28581483   PMID:29507755   PMID:30021884   PMID:30948266   PMID:31413325   PMID:31615875   PMID:32020481   PMID:32129710   PMID:32296183  
PMID:33150178   PMID:33961781   PMID:34193018   PMID:34315543   PMID:35271311   PMID:37752101  


Genomics

Comparative Map Data
KIF3C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38225,926,598 - 25,982,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl225,926,598 - 25,982,749 (-)EnsemblGRCh38hg38GRCh38
GRCh37226,149,467 - 26,205,366 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36226,002,959 - 26,058,947 (-)NCBINCBI36Build 36hg18NCBI36
Build 34226,061,118 - 26,117,054NCBI
Celera225,989,739 - 26,045,730 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef225,886,207 - 25,942,013 (-)NCBIHuRef
CHM1_1226,079,044 - 26,135,487 (-)NCBICHM1_1
T2T-CHM13v2.0225,961,945 - 26,017,861 (-)NCBIT2T-CHM13v2.0
Kif3c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39123,415,132 - 3,456,494 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl123,415,132 - 3,456,494 (+)EnsemblGRCm39 Ensembl
GRCm38123,365,132 - 3,406,494 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl123,365,132 - 3,406,494 (+)EnsemblGRCm38mm10GRCm38
MGSCv37123,365,132 - 3,406,494 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36123,365,132 - 3,406,494 (+)NCBIMGSCv36mm8
Celera123,292,187 - 3,333,551 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map121.77NCBI
Kif3c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8632,086,879 - 32,125,812 (+)NCBIGRCr8
mRatBN7.2626,367,092 - 26,406,033 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,366,531 - 26,406,130 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx626,659,683 - 26,698,621 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0626,975,571 - 27,014,501 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0626,453,926 - 26,492,858 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0627,768,943 - 27,815,611 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl627,768,943 - 27,815,611 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0637,579,445 - 37,625,883 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4626,342,388 - 26,381,233 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1626,345,340 - 26,384,186 (+)NCBI
Celera625,843,783 - 25,882,712 (+)NCBICelera
Cytogenetic Map6q14NCBI
Kif3c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554697,958,481 - 8,001,738 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554697,960,224 - 8,001,161 (-)NCBIChiLan1.0ChiLan1.0
KIF3C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212100,536,872 - 100,591,788 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A100,540,100 - 100,595,754 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A25,927,039 - 25,982,715 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A26,020,025 - 26,074,961 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A26,020,025 - 26,074,961 (-)Ensemblpanpan1.1panPan2
KIF3C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11720,090,374 - 20,128,703 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1720,091,759 - 20,128,562 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1719,986,149 - 20,024,501 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01720,411,768 - 20,450,554 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1720,411,774 - 20,451,095 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11720,098,664 - 20,136,938 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01720,109,348 - 20,147,627 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01720,155,378 - 20,193,906 (-)NCBIUU_Cfam_GSD_1.0
Kif3c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629264,402,587 - 64,442,970 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364936,396,276 - 6,435,266 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364936,396,606 - 6,435,266 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KIF3C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3112,966,804 - 113,014,624 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13112,963,424 - 113,014,632 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23119,943,241 - 119,968,158 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KIF3C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11481,666,884 - 81,717,489 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1481,666,793 - 81,717,508 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604530,438,707 - 30,491,806 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kif3c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247388,127,797 - 8,171,697 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247388,128,594 - 8,171,638 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KIF3C
22 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2p25.3-23.1(chr2:30141-31766749)x3 copy number gain See cases [RCV000052929] Chr2:30141..31766749 [GRCh38]
Chr2:30141..31991818 [GRCh37]
Chr2:20141..31845322 [NCBI36]
Chr2:2p25.3-23.1		 pathogenic
GRCh38/hg38 2p25.3-16.1(chr2:66097-55570637)x3 copy number gain See cases [RCV000052933] Chr2:66097..55570637 [GRCh38]
Chr2:66097..55797773 [GRCh37]
Chr2:56097..55651277 [NCBI36]
Chr2:2p25.3-16.1		 pathogenic
GRCh38/hg38 2p23.3(chr2:25759602-27297636)x3 copy number gain See cases [RCV000052629] Chr2:25759602..27297636 [GRCh38]
Chr2:25982471..27520504 [GRCh37]
Chr2:25835975..27374008 [NCBI36]
Chr2:2p23.3		 uncertain significance
NM_002254.6(KIF3C):c.1872C>T (p.Thr624=) single nucleotide variant Malignant melanoma [RCV000060535] Chr2:25954284 [GRCh38]
Chr2:26177153 [GRCh37]
Chr2:26030657 [NCBI36]
Chr2:2p23.3		 not provided
GRCh38/hg38 2p25.3-23.2(chr2:30341-28419664)x3 copy number gain See cases [RCV000135398] Chr2:30341..28419664 [GRCh38]
Chr2:30341..28642531 [GRCh37]
Chr2:20341..28496035 [NCBI36]
Chr2:2p25.3-23.2		 pathogenic
GRCh38/hg38 2p23.3(chr2:25064306-27154398)x1 copy number loss See cases [RCV000137065] Chr2:25064306..27154398 [GRCh38]
Chr2:25287175..27377266 [GRCh37]
Chr2:25140679..27230770 [NCBI36]
Chr2:2p23.3		 uncertain significance
GRCh38/hg38 2p25.3-23.3(chr2:17019-26318846)x3 copy number gain See cases [RCV000137344] Chr2:17019..26318846 [GRCh38]
Chr2:17019..26541714 [GRCh37]
Chr2:7019..26395218 [NCBI36]
Chr2:2p25.3-23.3		 pathogenic
GRCh38/hg38 2p23.3(chr2:25819153-26272376)x1 copy number loss See cases [RCV000141873] Chr2:25819153..26272376 [GRCh38]
Chr2:26042022..26495244 [GRCh37]
Chr2:25895526..26348748 [NCBI36]
Chr2:2p23.3		 uncertain significance
GRCh38/hg38 2p25.3-22.3(chr2:12770-33711509)x3 copy number gain See cases [RCV000141829] Chr2:12770..33711509 [GRCh38]
Chr2:12770..33936576 [GRCh37]
Chr2:2770..33790080 [NCBI36]
Chr2:2p25.3-22.3		 pathogenic
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2		 benign
GRCh38/hg38 2p24.1-23.2(chr2:22579652-28525186)x1 copy number loss See cases [RCV000142071] Chr2:22579652..28525186 [GRCh38]
Chr2:22802524..28748053 [GRCh37]
Chr2:22656029..28601557 [NCBI36]
Chr2:2p24.1-23.2		 pathogenic
GRCh38/hg38 2p25.3-21(chr2:236816-45983232)x3 copy number gain See cases [RCV000143682] Chr2:236816..45983232 [GRCh38]
Chr2:236816..46210371 [GRCh37]
Chr2:226816..46063875 [NCBI36]
Chr2:2p25.3-21		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
NM_002254.8(KIF3C):c.1973A>G (p.Gln658Arg) single nucleotide variant Inborn genetic diseases [RCV003271082] Chr2:25951822 [GRCh38]
Chr2:26174691 [GRCh37]
Chr2:2p23.3		 uncertain significance
GRCh37/hg19 2p23.3(chr2:24315204-26384655)x3 copy number gain not provided [RCV000682143] Chr2:24315204..26384655 [GRCh37]
Chr2:2p23.3		 uncertain significance
GRCh37/hg19 2p24.1-16.3(chr2:22665048-52850368)x3 copy number gain not provided [RCV000752875] Chr2:22665048..52850368 [GRCh37]
Chr2:2p24.1-16.3		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
NM_002254.8(KIF3C):c.164C>T (p.Pro55Leu) single nucleotide variant Inborn genetic diseases [RCV003266538] Chr2:25981754 [GRCh38]
Chr2:26204623 [GRCh37]
Chr2:2p23.3		 uncertain significance
GRCh37/hg19 2p23.3-21(chr2:24881528-43460021)x3 copy number gain not provided [RCV001532444] Chr2:24881528..43460021 [GRCh37]
Chr2:2p23.3-21		 likely pathogenic
GRCh37/hg19 2p23.3(chr2:25938039-26385614)x3 copy number gain not provided [RCV001259153] Chr2:25938039..26385614 [GRCh37]
Chr2:2p23.3		 uncertain significance
GRCh37/hg19 2p23.3-21(chr2:24601818-43466284)x3 copy number gain See cases [RCV001581099] Chr2:24601818..43466284 [GRCh37]
Chr2:2p23.3-21		 pathogenic
NC_000002.11:g.(?_24443763)_(27746306_?)dup duplication Short-rib thoracic dysplasia 10 with or without polydactyly [RCV001911738] Chr2:24443763..27746306 [GRCh37]
Chr2:2p23.3		 uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373) copy number gain Mosaic trisomy 2 [RCV002280628] Chr2:1..243199373 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
NC_000002.11:g.(?_24443763)_(29022169_?)dup duplication Tatton-Brown-Rahman overgrowth syndrome [RCV003113871]|not provided [RCV003113870] Chr2:24443763..29022169 [GRCh37]
Chr2:2p23.3-23.2		 uncertain significance|no classifications from unflagged records
NC_000002.11:g.(?_24443763)_(30143525_?)dup duplication not provided [RCV003113441] Chr2:24443763..30143525 [GRCh37]
Chr2:2p23.3-23.1		 uncertain significance
GRCh37/hg19 2p23.3(chr2:24641638-26473160)x1 copy number loss Tatton-Brown-Rahman overgrowth syndrome [RCV002276513] Chr2:24641638..26473160 [GRCh37]
Chr2:2p23.3		 not provided
GRCh37/hg19 2p25.1-q13(chr2:11504318-111365996)x1 copy number loss See cases [RCV002287563] Chr2:11504318..111365996 [GRCh37]
Chr2:2p25.1-q13		 pathogenic
GRCh37/hg19 2p25.3-22.3(chr2:706460-35523639)x3 copy number gain not provided [RCV002473946] Chr2:706460..35523639 [GRCh37]
Chr2:2p25.3-22.3		 pathogenic
NM_002254.8(KIF3C):c.1486A>C (p.Met496Leu) single nucleotide variant Inborn genetic diseases [RCV002997842] Chr2:25980432 [GRCh38]
Chr2:26203301 [GRCh37]
Chr2:2p23.3		 uncertain significance
NM_002254.8(KIF3C):c.2354G>A (p.Arg785His) single nucleotide variant Inborn genetic diseases [RCV002968316] Chr2:25929006 [GRCh38]
Chr2:26151875 [GRCh37]
Chr2:2p23.3		 likely benign
NM_002254.8(KIF3C):c.425G>A (p.Arg142Gln) single nucleotide variant Inborn genetic diseases [RCV002693914] Chr2:25981493 [GRCh38]
Chr2:26204362 [GRCh37]
Chr2:2p23.3		 uncertain significance
NM_002254.8(KIF3C):c.1586T>C (p.Met529Thr) single nucleotide variant Inborn genetic diseases [RCV002781823] Chr2:25956404 [GRCh38]
Chr2:26179273 [GRCh37]
Chr2:2p23.3		 uncertain significance
NM_002254.8(KIF3C):c.1151A>G (p.Gln384Arg) single nucleotide variant Inborn genetic diseases [RCV003001153] Chr2:25980767 [GRCh38]
Chr2:26203636 [GRCh37]
Chr2:2p23.3		 uncertain significance
NM_002254.8(KIF3C):c.613G>A (p.Gly205Ser) single nucleotide variant Inborn genetic diseases [RCV002891473] Chr2:25981305 [GRCh38]
Chr2:26204174 [GRCh37]
Chr2:2p23.3		 uncertain significance
NM_002254.8(KIF3C):c.782C>A (p.Ala261Glu) single nucleotide variant Inborn genetic diseases [RCV002873265] Chr2:25981136 [GRCh38]
Chr2:26204005 [GRCh37]
Chr2:2p23.3		 uncertain significance
NM_002254.8(KIF3C):c.1666A>T (p.Met556Leu) single nucleotide variant Inborn genetic diseases [RCV002940883] Chr2:25955645 [GRCh38]
Chr2:26178514 [GRCh37]
Chr2:2p23.3		 uncertain significance
NM_002254.8(KIF3C):c.1214G>A (p.Arg405Gln) single nucleotide variant Inborn genetic diseases [RCV003172975] Chr2:25980704 [GRCh38]
Chr2:26203573 [GRCh37]
Chr2:2p23.3		 uncertain significance
NM_002254.8(KIF3C):c.1655G>A (p.Arg552His) single nucleotide variant Inborn genetic diseases [RCV003220865] Chr2:25955656 [GRCh38]
Chr2:26178525 [GRCh37]
Chr2:2p23.3		 uncertain significance
NM_002254.8(KIF3C):c.1888A>C (p.Lys630Gln) single nucleotide variant Inborn genetic diseases [RCV003199047] Chr2:25954268 [GRCh38]
Chr2:26177137 [GRCh37]
Chr2:2p23.3		 uncertain significance
NM_002254.8(KIF3C):c.2333C>G (p.Ser778Cys) single nucleotide variant Inborn genetic diseases [RCV003172837] Chr2:25929027 [GRCh38]
Chr2:26151896 [GRCh37]
Chr2:2p23.3		 uncertain significance
NM_002254.8(KIF3C):c.2022G>A (p.Met674Ile) single nucleotide variant Inborn genetic diseases [RCV003205460] Chr2:25930048 [GRCh38]
Chr2:26152917 [GRCh37]
Chr2:2p23.3		 uncertain significance
NM_002254.8(KIF3C):c.1921G>C (p.Glu641Gln) single nucleotide variant Inborn genetic diseases [RCV003304265] Chr2:25951874 [GRCh38]
Chr2:26174743 [GRCh37]
Chr2:2p23.3		 uncertain significance
GRCh37/hg19 2p23.3(chr2:24962301-26257604)x1 copy number loss not provided [RCV003223075] Chr2:24962301..26257604 [GRCh37]
Chr2:2p23.3		 uncertain significance
NM_002254.8(KIF3C):c.2129T>C (p.Met710Thr) single nucleotide variant Inborn genetic diseases [RCV003350417] Chr2:25929464 [GRCh38]
Chr2:26152333 [GRCh37]
Chr2:2p23.3		 uncertain significance
GRCh37/hg19 2p23.3(chr2:25878353-26157646)x3 copy number gain not provided [RCV003484063] Chr2:25878353..26157646 [GRCh37]
Chr2:2p23.3		 uncertain significance
NM_002254.8(KIF3C):c.712C>T (p.Arg238Ter) single nucleotide variant KIF3C-related neurodevelopmental disorder [RCV003412559] Chr2:25981206 [GRCh38]
Chr2:26204075 [GRCh37]
Chr2:2p23.3		 uncertain significance
GRCh37/hg19 2p23.3(chr2:25929370-26572068)x1 copy number loss not specified [RCV003986372] Chr2:25929370..26572068 [GRCh37]
Chr2:2p23.3		 uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR186hsa-miR-186-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Target Of
Summary Value
Count of predictions:5223
Count of miRNA genes:1025
Interacting mature miRNAs:1250
Transcripts:ENST00000264712, ENST00000405914, ENST00000417737, ENST00000455394, ENST00000475453, ENST00000488341, ENST00000496378
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D2S1253  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37226,171,367 - 26,171,680UniSTSGRCh37
Build 36226,024,871 - 26,025,184RGDNCBI36
Celera226,011,648 - 26,011,961RGD
Cytogenetic Map2p23UniSTS
HuRef225,908,104 - 25,908,417UniSTS
KIF3C_8426  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37226,150,632 - 26,151,488UniSTSGRCh37
Build 36226,004,136 - 26,004,992RGDNCBI36
Celera225,990,916 - 25,991,772RGD
HuRef225,887,384 - 25,888,240UniSTS
RH12717  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37226,150,685 - 26,150,825UniSTSGRCh37
Build 36226,004,189 - 26,004,329RGDNCBI36
Celera225,990,969 - 25,991,109RGD
Cytogenetic Map2p23UniSTS
HuRef225,887,437 - 25,887,577UniSTS
GeneMap99-GB4 RH Map289.92UniSTS
RH66315  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37226,149,551 - 26,149,694UniSTSGRCh37
Build 36226,003,055 - 26,003,198RGDNCBI36
Celera225,989,835 - 25,989,978RGD
Cytogenetic Map2p23UniSTS
HuRef225,886,303 - 25,886,446UniSTS
GeneMap99-GB4 RH Map297.79UniSTS
HSC2CB052  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37226,150,712 - 26,150,928UniSTSGRCh37
Build 36226,004,216 - 26,004,432RGDNCBI36
Celera225,990,996 - 25,991,212RGD
Cytogenetic Map2p23UniSTS
HuRef225,887,464 - 25,887,680UniSTS
GeneMap99-GB4 RH Map289.92UniSTS
Whitehead-RH Map2157.6UniSTS
UniSTS:67245  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37226,149,484 - 26,149,762UniSTSGRCh37
Build 36226,002,988 - 26,003,266RGDNCBI36
Celera225,989,768 - 25,990,046RGD
HuRef225,886,236 - 25,886,514UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 437 426 386 27 155 30 972 166 3469 86 380 300 12 40 675
Low 1978 2472 1126 384 1751 222 3288 1869 265 329 1076 1310 163 1 1164 2017 5 2
Below cutoff 22 93 212 211 35 211 96 162 4 4 3 96 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_002254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005264299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054341956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC013449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC064847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF018164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF035621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ002223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ002224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ002225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ002226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ002227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ002228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ002229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC092406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC130423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC132783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC144223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ432434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX571741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB303776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF456639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000264712   ⟹   ENSP00000264712
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl225,926,598 - 25,982,497 (-)Ensembl
RefSeq Acc Id: ENST00000405914   ⟹   ENSP00000385030
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl225,928,753 - 25,982,749 (-)Ensembl
RefSeq Acc Id: ENST00000417737   ⟹   ENSP00000393676
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl225,926,602 - 25,982,497 (-)Ensembl
RefSeq Acc Id: ENST00000455394   ⟹   ENSP00000410407
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl225,926,602 - 25,982,497 (-)Ensembl
RefSeq Acc Id: ENST00000475453
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl225,954,131 - 25,980,622 (-)Ensembl
RefSeq Acc Id: ENST00000488341
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl225,951,370 - 25,956,439 (-)Ensembl
RefSeq Acc Id: ENST00000496378
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl225,929,419 - 25,951,919 (-)Ensembl
RefSeq Acc Id: NM_002254   ⟹   NP_002245
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38225,926,598 - 25,982,497 (-)NCBI
GRCh37226,149,455 - 26,205,443 (-)RGD
Build 36226,002,959 - 26,058,947 (-)NCBI Archive
Celera225,989,739 - 26,045,730 (-)RGD
HuRef225,886,207 - 25,942,013 (-)RGD
CHM1_1226,079,044 - 26,135,487 (-)NCBI
T2T-CHM13v2.0225,961,945 - 26,017,861 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005264299   ⟹   XP_005264356
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38225,926,598 - 25,982,497 (-)NCBI
GRCh37226,149,455 - 26,205,443 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054341956   ⟹   XP_054197931
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0225,961,945 - 26,017,861 (-)NCBI
Protein Sequences
Protein RefSeqs NP_002245 (Get FASTA)   NCBI Sequence Viewer  
  XP_005264356 (Get FASTA)   NCBI Sequence Viewer  
  XP_054197931 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC05302 (Get FASTA)   NCBI Sequence Viewer  
  AAC39562 (Get FASTA)   NCBI Sequence Viewer  
  AAH42486 (Get FASTA)   NCBI Sequence Viewer  
  AAH92406 (Get FASTA)   NCBI Sequence Viewer  
  AAI30424 (Get FASTA)   NCBI Sequence Viewer  
  AAI32784 (Get FASTA)   NCBI Sequence Viewer  
  AAI44224 (Get FASTA)   NCBI Sequence Viewer  
  AAX88877 (Get FASTA)   NCBI Sequence Viewer  
  AAY24261 (Get FASTA)   NCBI Sequence Viewer  
  BAG57162 (Get FASTA)   NCBI Sequence Viewer  
  CAA05252 (Get FASTA)   NCBI Sequence Viewer  
  CAA05253 (Get FASTA)   NCBI Sequence Viewer  
  CAA05254 (Get FASTA)   NCBI Sequence Viewer  
  CAA05255 (Get FASTA)   NCBI Sequence Viewer  
  CAA05256 (Get FASTA)   NCBI Sequence Viewer  
  CAA05257 (Get FASTA)   NCBI Sequence Viewer  
  CAA05258 (Get FASTA)   NCBI Sequence Viewer  
  CAE11867 (Get FASTA)   NCBI Sequence Viewer  
  EAX00712 (Get FASTA)   NCBI Sequence Viewer  
  EAX00713 (Get FASTA)   NCBI Sequence Viewer  
  EAX00714 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000264712
  ENSP00000264712.3
  ENSP00000385030.1
  ENSP00000393676.1
  ENSP00000410407.1
GenBank Protein O14782 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_002245   ⟸   NM_002254
- UniProtKB: Q53SX5 (UniProtKB/Swiss-Prot),   Q4ZG18 (UniProtKB/Swiss-Prot),   O43544 (UniProtKB/Swiss-Prot),   Q562F7 (UniProtKB/Swiss-Prot),   O14782 (UniProtKB/Swiss-Prot),   A2RU78 (UniProtKB/TrEMBL),   B7ZM25 (UniProtKB/TrEMBL),   Q7Z2W5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005264356   ⟸   XM_005264299
- Peptide Label: isoform X1
- UniProtKB: B7ZM25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000410407   ⟸   ENST00000455394
RefSeq Acc Id: ENSP00000393676   ⟸   ENST00000417737
RefSeq Acc Id: ENSP00000385030   ⟸   ENST00000405914
RefSeq Acc Id: ENSP00000264712   ⟸   ENST00000264712
RefSeq Acc Id: XP_054197931   ⟸   XM_054341956
- Peptide Label: isoform X1
Protein Domains
Kinesin motor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O14782-F1-model_v2 AlphaFold O14782 1-793 view protein structure

Promoters
RGD ID:6859816
Promoter ID:EPDNEW_H3072
Type:initiation region
Name:KIF3C_1
Description:kinesin family member 3C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38225,982,484 - 25,982,544EPDNEW
RGD ID:6797177
Promoter ID:HG_KWN:31841
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000405914,   NM_002254,   OTTHUMT00000325597,   OTTHUMT00000325600,   UC010EYJ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36226,058,719 - 26,059,219 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6321 AgrOrtholog
COSMIC KIF3C COSMIC
Ensembl Genes ENSG00000084731 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000264712 ENTREZGENE
  ENST00000264712.8 UniProtKB/Swiss-Prot
  ENST00000405914.1 UniProtKB/Swiss-Prot
  ENST00000417737.5 UniProtKB/TrEMBL
  ENST00000455394.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.850.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000084731 GTEx
HGNC ID HGNC:6321 ENTREZGENE
Human Proteome Map KIF3C Human Proteome Map
InterPro Kinesin-like_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinesin_motor_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinesin_motor_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3797 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 3797 ENTREZGENE
OMIM 602845 OMIM
PANTHER CENTROMERE PROTEIN E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KINESIN-LIKE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Kinesin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30104 PharmGKB
PRINTS KINESINHEAVY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE KINESIN_MOTOR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KINESIN_MOTOR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART KISc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2RU78 ENTREZGENE, UniProtKB/TrEMBL
  B7ZM25 ENTREZGENE, UniProtKB/TrEMBL
  F8WAR6_HUMAN UniProtKB/TrEMBL
  F8WER6_HUMAN UniProtKB/TrEMBL
  I6L9B9_HUMAN UniProtKB/TrEMBL
  KIF3C_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  O43544 ENTREZGENE
  Q4ZG18 ENTREZGENE
  Q53SX5 ENTREZGENE
  Q562F7 ENTREZGENE
  Q7Z2W5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O43544 UniProtKB/Swiss-Prot
  Q4ZG18 UniProtKB/Swiss-Prot
  Q53SX5 UniProtKB/Swiss-Prot
  Q562F7 UniProtKB/Swiss-Prot