Gene:	Cdk4 ( Rattus norvegicus ) cyclin-dependent kinase 4
Description:	positive regulator of the cell cycle; plays a role in cell cycle progression
Synonyms:	MGC:72728; MGC:91543; IMAGE:6921199; IMAGE:7104124;
ArrayIDs:	GE1100112; 6582381; 5901364; 6706012; L11007_at; 6169675; 1369950_at; 6741897; rc_AI177843_at; 6176869; 5853090; 6188435; 5970891; A_44_P125487; A_44_P388777; 6169615; 1372739_at; A_44_P388782; 5920341; 6707535; 6119075; 6094365;  (details...)
Gene Type:	protein-coding
Additional Data
Candidate gene for:	Ept7 - Estrogen-induced pituitary tumorigenesis QTL 7
Homologs
Homo sapiens: CDK4     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Cdk4     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Cdk4 genome assembly 3.1 7 67037674 - 67039905     Rat Celera Assembly 7 60029954 - 60032798     RGSC genome assembly v3.4 7 67016945 - 67019176     Cytogenetic 7 q22 Mus musculus Cdk4 Mouse genome assembly build 36.1 10 126500671 - 126504451     Cytogenetic 10 10 D3 Homo sapiens CDK4 human genome assembly 12 56428271 - 56432431     Human genome assembly build 36.2 12 56428270 - 56432431     Cytogenetic 12 q14   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology protein kinase activity,  nucleotide binding,  kinase activity ...  (details...)
Biological Process	Note Reference plays a key role in the G1/S transition in cell cycle 70761 Gene Ontology response to toxin,  response to hyperoxia,  positive regulation of cell proliferation ...  (details...)
Cellular Component	Gene Ontology transcription factor complex,  perinuclear region of cytoplasm,  nucleus ...  (details...)
Disease	Note Reference may mediate hypertrophic growth of cardiomyocytes in cardiac hypertrophy 704385 Ontology Ovarian Neoplasms,  Cardiomegaly,  Prostatic Neoplasms ...  (details...)
Phenotype	Ontology tumorigenesis,  cardiac hypertrophy,  Increased Cell Size (details...)
Pathway	Ontology S phase pathway,  G1 phase pathway (details...)
Physical interaction	Note Reference interacts with Ccnd3 70761
External Links
Databases	DATABASE ID SOURCE SMART: S_TKc IPI PROSITE: PROTEIN_KINASE_ATP IPI PROSITE: PROTEIN_KINASE_DOM IPI PROSITE: PROTEIN_KINASE_ST IPI UNIPARC: UPI000012742A IPI KEGG Report: rno:94201 ENTREZGENE HomoloGene Group ID: 55429 ENTREZGENE Germonline: 621120 Pfam: Pkinase IPI KEGG Pathway: 04115 ENTREZGENE KEGG Pathway: 05219 ENTREZGENE KEGG Pathway: 04110 ENTREZGENE KEGG Pathway: 05220 ENTREZGENE KEGG Pathway: 05214 ENTREZGENE KEGG Pathway: 05218 ENTREZGENE KEGG Pathway: 05223 ENTREZGENE KEGG Pathway: 05212 ENTREZGENE KEGG Pathway: 05200 ENTREZGENE KEGG Pathway: 05222 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 04530 ENTREZGENE InterPro: Protein_kinase_ATP_BS. IPI InterPro: Kinase-like_dom. IPI InterPro: Prot_kinase_cat_dom. IPI InterPro: Se/Thr_prot_kinase-like_dom. IPI InterPro: Ser/Thr_prot_kinase_dom. IPI InterPro: Ser/Thr_prot_kinase_AS. IPI IPI: IPI00198608 IPI Ensembl Protein: ENSRNOP00000034754 IPI Entrez Gene: Cdk4 ENTREZGENE IMAGE_CLONE: IMAGE:6921199 IMAGE-MGC_LOAD IMAGE_CLONE: IMAGE:7104124 IMAGE-MGC_LOAD MGC_CLONE: MGC:91543 IMAGE-MGC_LOAD MGC_CLONE: MGC:72728 IMAGE-MGC_LOAD UniProt: Q71VC8_RAT IPI UniProt: CDK4_RAT IPI Ensembl Genes: ENSRNOG00000025602 IPI Superfamily-SCOP: Kinase_like IPI
Sequences	Nucleotide: CH473950 Get FASTA Search GEO Profiles Nucleotide: BC070956 Get FASTA Search GEO Profiles Nucleotide: BC063158 Get FASTA Search GEO Profiles Nucleotide: L11007 Get FASTA Search GEO Profiles Nucleotide: AF016245 Get FASTA Search GEO Profiles Nucleotide: NM_053593 Get FASTA Search GEO Profiles (View all 6 Nucleotide Accessions) Protein: Q71VC8 Get FASTA Protein: P35426 Get FASTA Protein: AAA40903 Get FASTA Protein: NP_446045 Get FASTA Protein: AAB68843 Get FASTA Protein: AAH70956 Get FASTA Protein: EDM16502 Get FASTA (View all 7 Protein Accessions)
Clusters	UniGene: 6115
References
Curated References	43 references in RGD related to Cdk4
Other References	26 other references at PubMed related to Cdk4
Database Information
RGD ID	621120
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-SEP-04: Cdk4 cyclin-dependent kinase 4 APPROVED Symbol and Name status set to approved 1299863 07-AUG-02: Cdk4 cyclin-dependent kinase 4 PROVISIONAL Symbol and Name status set to provisional 70820