Socs3 (suppressor of cytokine signaling 3) - Rat Genome Database

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Gene: Socs3 (suppressor of cytokine signaling 3) Rattus norvegicus
Analyze
Symbol: Socs3
Name: suppressor of cytokine signaling 3
RGD ID: 621087
Description: Predicted to enable several functions, including miRNA binding activity; phosphotyrosine residue binding activity; and protein tyrosine kinase inhibitor activity. Involved in several processes, including cell surface receptor signaling pathway via JAK-STAT; cellular response to thyrotropin-releasing hormone; and cellular response to type II interferon. Predicted to be active in cytoplasmic side of plasma membrane. Biomarker of obesity; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SOCS3 (suppressor of cytokine signaling 3); PARTICIPATES IN erythropoietin signaling pathway; insulin signaling pathway; interleukin-2 signaling pathway; INTERACTS WITH (S)-nicotine; 1-naphthyl isothiocyanate; 15-deoxy-Delta(12,14)-prostaglandin J2.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cish3; cytokine inducible SH2-containing protein 3; cytokine-inducible SH2 protein 3; Socs-3; Ssi-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Slep8 Insul15
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810103,692,579 - 103,695,975 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10103,690,976 - 103,704,825 (-)EnsemblGRCr8
mRatBN7.210103,193,909 - 103,197,322 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,193,537 - 103,197,787 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10108,296,539 - 108,297,401 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010107,759,666 - 107,760,528 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010103,115,997 - 103,116,859 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010106,973,863 - 106,976,969 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,975,178 - 106,976,040 (-)Ensemblrn6Rnor6.0
Rnor_5.010106,611,459 - 106,616,694 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410107,958,468 - 107,959,330 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10101,756,900 - 101,757,762 (-)NCBICelera
RGSC_v3.110107,972,971 - 107,973,834 (-)NCBI
Cytogenetic Map10q32.2NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (EXP,ISO)
3-phenylprop-2-enal  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
5-formyltetrahydrofolic acid  (ISO)
8-Br-cAMP  (ISO)
AACOCF3  (ISO)
acetic acid  (EXP)
acrolein  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
aristolochic acids  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atropine  (ISO)
avobenzone  (ISO)
azoxystrobin  (EXP)
Bardoxolone methyl  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
berberine  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
bortezomib  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGS-21680  (EXP)
chenodeoxycholic acid  (ISO)
chloroethene  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
cisplatin  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
dapagliflozin  (EXP)
DDE  (ISO)
delta-tocotrienol  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimercaprol  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
entinostat  (ISO)
erlotinib hydrochloride  (EXP)
estriol  (ISO)
ethanol  (EXP)
fenofibrate  (EXP)
fenthion  (ISO)
fipronil  (EXP)
flavone  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
galanthamine  (EXP)
gardiquimod  (ISO)
gemfibrozil  (ISO)
genistein  (ISO)
gentamycin  (EXP)
ginsenoside Re  (ISO)
glucose  (ISO)
glyphosate  (EXP)
GSK-J4  (ISO)
GW 3965  (EXP)
hesperetin  (EXP)
hexachlorobenzene  (EXP)
hexaconazole  (ISO)
hexadecanoic acid  (ISO)
hexamethylene diisocyanate  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
imidacloprid  (EXP)
isoeugenol  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
ketamine  (ISO)
KT 5720  (ISO)
L-methionine  (ISO)
Licochalcone B  (ISO)
linagliptin  (EXP)
linderalactone  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
malathion  (ISO)
melittin  (ISO)
mesalamine  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
naled  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP)
nitrobenzenes  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oleic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
PF-3758309  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphane  (EXP)
pirinixic acid  (EXP,ISO)
poly(I:C)  (ISO)
potassium cyanide  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
prostaglandin F2alpha  (EXP)
protein kinase inhibitor  (ISO)
pyrimethamine  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (EXP)
rofecoxib  (ISO)
rolipram  (ISO)
rotenone  (ISO)
rutin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
Salinomycin  (ISO)
sarin  (EXP)
SB 431542  (ISO)
selumetinib  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP,ISO)
stattic  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sulfasalazine  (EXP)
sulpiride  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tofacitinib  (ISO)
topotecan  (EXP)
trans-isoeugenol  (ISO)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. SOCS3 was induced by hypoxia and suppressed STAT3 phosphorylation in pulmonary arterial smooth muscle cells. Bai L, etal., Respir Physiol Neurobiol. 2006 May;152(1):83-91. Epub 2005 Aug 24.
2. Suppressor of cytokine signaling 3 is induced by angiotensin II in heart and isolated cardiomyocytes, and participates in desensitization. Calegari VC, etal., Endocrinology 2003 Oct;144(10):4586-96. Epub 2003 Jun 26.
3. Expression of suppressors of cytokine signaling-3 in Helicobacter pylori-infected rat gastric mucosal RGM-1cells. Cha B, etal., Ann N Y Acad Sci. 2007 Jan;1096:24-8.
4. A prostaglandin f(2alpha) analog induces suppressors of cytokine signaling-3 expression in the corpus luteum of the pregnant rat: a potential new mechanism in luteolysis. Curlewis JD, etal., Endocrinology 2002 Oct;143(10):3984-93.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Caffeic acid phenethyl ester modifies the Th1/Th2 balance in ileal mucosa after gamma-irradiation in the rat by modulating the cytokine pattern. Gremy O, etal., World J Gastroenterol. 2006 Aug 21;12(31):4996-5004.
8. Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation. Hong-Brown LQ, etal., Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E63-72. Epub 2003 Mar 18.
9. Attenuation of leptin and insulin signaling by SOCS proteins. Howard JK and Flier JS, Trends Endocrinol Metab. 2006 Nov;17(9):365-71. Epub 2006 Sep 28.
10. Insulin attenuates the systemic inflammatory response in endotoxemic rats. Jeschke MG, etal., Endocrinology. 2004 Sep;145(9):4084-93. Epub 2004 Jun 10.
11. Differential expression of suppressors of cytokine signalling genes in response to nutrition and growth hormone in the septic rat. Johnson TS, etal., J Endocrinol 2001 May;169(2):409-15.
12. Signaling through the JAK/STAT pathway, recent advances and future challenges. Kisseleva T, etal., Gene 2002 Feb 20;285(1-2):1-24.
13. Thermal injury-induced increases of hepatocyte SOCS3 lead to decreases in STAT3. Kong F, etal., Shock 2002 Oct;18(4):374-9.
14. Regulation of the acid-labile subunit in sustained endotoxemia. Kong SE, etal., Am J Physiol Endocrinol Metab 2002 Oct;283(4):E692-701.
15. Genetic association analysis of 30 genes related to obesity in a European American population. Li P, etal., Int J Obes (Lond). 2014 May;38(5):724-9. doi: 10.1038/ijo.2013.140. Epub 2013 Jul 31.
16. Acute induction of inflammatory cytokine expression after gamma-irradiation in the rat: effect of an NF-kappaB inhibitor. Linard C, etal., Int J Radiat Oncol Biol Phys. 2004 Feb 1;58(2):427-34.
17. Suppressors of cytokine-signaling proteins induce insulin resistance in the retina and promote survival of retinal cells. Liu X, etal., Diabetes. 2008 Jun;57(6):1651-8. Epub 2008 Mar 20.
18. Unique expression of suppressor of cytokine signaling 3 is essential for classical macrophage activation in rodents in vitro and in vivo. Liu Y, etal., J Immunol. 2008 May 1;180(9):6270-8.
19. Momordica charantia extracts ameliorate insulin resistance by regulating the expression of SOCS-3 and JNK in type 2 diabetes mellitus rats. Ma C, etal., Pharm Biol. 2017 Dec;55(1):2170-2177. doi: 10.1080/13880209.2017.1396350.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. 1Alpha,25-dihydroxyvitamin D3 inhibits GH-induced expression of SOCS-3 and CIS and prolongs growth hormone signaling via the Janus kinase (JAK2)/signal transducers and activators of transcription (STAT5) system in osteoblast-like cells. Morales O, etal., J Biol Chem 2002 Sep 20;277(38):34879-84.
22. Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes. Mori H, etal., Biochem Biophys Res Commun. 2007 Aug 10;359(4):952-8. Epub 2007 Jun 4.
23. Decreased expression of SOCS-3 mRNA in breast cancer with lymph node metastasis. Nakagawa T, etal., Oncol Rep. 2008 Jan;19(1):33-9.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. In situ detection of SOCS and cytokine expression in the uterine cervix from HIV/HPV coinfected women. Nicol AF, etal., Exp Mol Pathol. 2006 Aug;81(1):42-7.
26. Type 2 diabetes impairs insulin receptor substrate-2-mediated phosphatidylinositol 3-kinase activity in primary macrophages to induce a state of cytokine resistance to IL-4 in association with overexpression of suppressor of cytokine signaling-3. O'Connor JC, etal., J Immunol. 2007 Jun 1;178(11):6886-93.
27. 15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia. Park EJ, etal., J Biol Chem 2003 Apr 25;278(17):14747-52. Epub 2003 Feb 12.
28. Thyrotropin induces SOCS-1 (suppressor of cytokine signaling-1) and SOCS-3 in FRTL-5 thyroid cells. Park ES, etal., Mol Endocrinol. 2000 Mar;14(3):440-8. doi: 10.1210/mend.14.3.0433.
29. Regulation of expression of the rat SOCS-3 gene in hepatocytes by growth hormone, interleukin-6 and glucocorticoids mRNA analysis and promoter characterization. Paul C, etal., Eur J Biochem. 2000 Oct;267(19):5849-57.
30. Leptin receptor expression and suppressor of cytokine signaling transcript levels in high-fat-fed rats. Peiser C, etal., Life Sci. 2000 Nov 3;67(24):2971-81.
31. Ageing increases SOCS-3 expression in rat hypothalamus: effects of food restriction. Peralta S, etal., Biochem Biophys Res Commun 2002 Aug 16;296(2):425-8.
32. Ageing increases SOCS-3 expression in rat hypothalamus: effects of food restriction. Peralta S, etal., Biochem Biophys Res Commun 2002 Aug 16;296(2):425.
33. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
34. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
35. Suppressor of cytokine signalling gene expression is elevated in breast carcinoma. Raccurt M, etal., Br J Cancer. 2003 Aug 4;89(3):524-32.
36. Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia. Raghavendra Rao VL, etal., J Neurochem 2002 Dec;83(5):1072-86.
37. GOA pipeline RGD automated data pipeline
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. Suppressor of cytokine signaling 3 expression and insulin resistance in skeletal muscle of obese and type 2 diabetic patients. Rieusset J, etal., Diabetes. 2004 Sep;53(9):2232-41.
40. Differential expression of suppressors of cytokine signaling-1, -2, and -3 in the rat hippocampus after seizure: implications for neuromodulation by gp130 cytokines. Rosell DR, etal., Neuroscience. 2003;122(2):349-58.
41. Activation of signal transducer and activator transcription 3 and expression of suppressor of cytokine signal 1 during liver regeneration in rats. Sakuda S, etal., J Hepatol. 2002 Mar;36(3):378-84.
42. Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women. Seron K, etal., Biochem Biophys Res Commun. 2006 Oct 6;348(4):1232-8. Epub 2006 Jul 24.
43. Identification of blood biomarkers of rheumatoid arthritis by transcript profiling of peripheral blood mononuclear cells from the rat collagen-induced arthritis model. Shou J, etal., Arthritis Res Ther. 2006;8(1):R28. Epub 2006 Jan 10.
44. Hormonal regulation of suppressors of cytokine signaling (SOCS) messenger ribonucleic acid in the arcuate nucleus during late pregnancy. Steyn FJ, etal., Endocrinology. 2008 Jun;149(6):3206-14. Epub 2008 Mar 6.
45. Growth hormone reduces the severity of fibrosis associated with chronic intestinal inflammation. Theiss AL, etal., Gastroenterology. 2005 Jul;129(1):204-19.
46. The dual function of hepatic SOCS3 in insulin resistance in vivo. Torisu T, etal., Genes Cells. 2007 Feb;12(2):143-54.
47. Peroxisome proliferator-activated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents. Tureyen K, etal., J Neurochem. 2007 Apr;101(1):41-56.
48. Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Ueki K, etal., Mol Cell Biol. 2004 Jun;24(12):5434-46.
49. Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Ueki K, etal., Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10422-7. Epub 2004 Jul 6.
50. The Prognostic Role of SOCS3 and A20 in Human Cholangiocarcinoma. Wang Y, etal., PLoS One. 2015 Oct 20;10(10):e0141165. doi: 10.1371/journal.pone.0141165. eCollection 2015.
51. Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling. Wang Z, etal., Biochem Biophys Res Commun. 2000 Oct 14;277(1):20-6.
52. Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p-AKT/Bcl-2 pathways. Wazea SA, etal., Sci Rep. 2018 Mar 23;8(1):5110. doi: 10.1038/s41598-018-23359-6.
53. Signatures associated with rejection or recurrence in HER-2/neu-positive mammary tumors. Worschech A, etal., Cancer Res. 2008 Apr 1;68(7):2436-46.
Additional References at PubMed
PMID:10579313   PMID:11108838   PMID:11481489   PMID:15118263   PMID:15358627   PMID:15514089   PMID:15578154   PMID:15893771   PMID:15998644   PMID:16185683   PMID:16258063   PMID:16289836  
PMID:16300827   PMID:16302975   PMID:16306356   PMID:16484300   PMID:16956890   PMID:16971535   PMID:17223256   PMID:17986523   PMID:18421861   PMID:18586073   PMID:19080716   PMID:19176113  
PMID:19272793   PMID:19293294   PMID:19386987   PMID:19408656   PMID:19639229   PMID:19643162   PMID:19693688   PMID:19862646   PMID:20185635   PMID:20193756   PMID:20303731   PMID:20439489  
PMID:20530874   PMID:20816823   PMID:20819948   PMID:20848345   PMID:21145973   PMID:21168220   PMID:21255014   PMID:21364493   PMID:21521717   PMID:21545521   PMID:22253420   PMID:22982470  
PMID:23007031   PMID:23222907   PMID:23401297   PMID:23669042   PMID:23948778   PMID:24078776   PMID:24088176   PMID:24091940   PMID:24142708   PMID:24463741   PMID:24660535   PMID:24685947  
PMID:24959867   PMID:25019494   PMID:25086044   PMID:25352752   PMID:25847945   PMID:26384335   PMID:27118613   PMID:28036111   PMID:28111888   PMID:28129651   PMID:28326931   PMID:29550470  
PMID:30763670   PMID:31799684   PMID:31857078   PMID:32030968   PMID:32438059   PMID:32630102   PMID:32989761   PMID:33255404   PMID:33300076   PMID:33522063   PMID:35702948   PMID:36793115  
PMID:37154979   PMID:37856074  


Genomics

Comparative Map Data
Socs3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810103,692,579 - 103,695,975 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10103,690,976 - 103,704,825 (-)EnsemblGRCr8
mRatBN7.210103,193,909 - 103,197,322 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,193,537 - 103,197,787 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10108,296,539 - 108,297,401 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010107,759,666 - 107,760,528 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010103,115,997 - 103,116,859 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010106,973,863 - 106,976,969 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,975,178 - 106,976,040 (-)Ensemblrn6Rnor6.0
Rnor_5.010106,611,459 - 106,616,694 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410107,958,468 - 107,959,330 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10101,756,900 - 101,757,762 (-)NCBICelera
RGSC_v3.110107,972,971 - 107,973,834 (-)NCBI
Cytogenetic Map10q32.2NCBI
SOCS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381778,356,778 - 78,360,925 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1778,356,778 - 78,360,930 (-)Ensemblhg38GRCh38
GRCh371776,352,859 - 76,357,006 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361773,864,454 - 73,867,753 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341773,864,458 - 73,867,753NCBI
Celera1772,946,889 - 72,950,188 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1771,775,516 - 71,778,779 (-)NCBIHuRef
CHM1_11776,416,767 - 76,420,069 (-)NCBICHM1_1
T2T-CHM13v2.01779,250,300 - 79,254,447 (-)NCBIT2T-CHM13v2.0
Socs3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911117,856,905 - 117,860,192 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11117,856,905 - 117,860,873 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811117,966,079 - 117,970,336 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11117,966,079 - 117,970,047 (-)Ensemblmm10GRCm38
MGSCv3711117,827,393 - 117,830,680 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611117,782,169 - 117,785,252 (-)NCBIMGSCv36mm8
Celera11129,709,800 - 129,713,087 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1182.96NCBI
Socs3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555064,222,455 - 4,225,563 (+)Ensembl
ChiLan1.0NW_0049555064,222,455 - 4,225,563 (+)NCBIChiLan1.0ChiLan1.0
SOCS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21994,406,250 - 94,409,543 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11799,235,744 - 99,239,041 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01772,433,206 - 72,436,500 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11777,981,752 - 77,985,059 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1777,983,389 - 77,984,066 (-)EnsemblpanPan2panpan1.1
SOCS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.192,859,267 - 2,859,944 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha93,516,096 - 3,516,773 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.093,509,383 - 3,512,579 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl93,510,193 - 3,510,870 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.193,533,406 - 3,534,083 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.093,657,845 - 3,658,522 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.093,738,946 - 3,739,623 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Socs3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056023,476,572 - 3,479,692 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365942,933,747 - 2,934,451 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365942,932,297 - 2,935,358 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOCS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl123,643,929 - 3,647,009 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1123,643,832 - 3,647,015 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap12p15NCBI
SOCS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11670,353,099 - 70,356,401 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1670,354,746 - 70,355,423 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607741,479,311 - 41,482,614 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Socs3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248017,840,889 - 7,843,860 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248017,841,230 - 7,843,912 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Socs3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1966,089,076 - 66,092,476 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Socs3
20 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:84
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000003940
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat

Markers in Region
PMC148819P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210103,195,568 - 103,196,081 (+)MAPPERmRatBN7.2
Rnor_6.010106,975,511 - 106,976,023NCBIRnor6.0
Rnor_5.010106,613,107 - 106,613,619UniSTSRnor5.0
RGSC_v3.410107,958,801 - 107,959,313UniSTSRGSC3.4
Celera10101,757,233 - 101,757,745UniSTS
Cytogenetic Map10q32.3UniSTS
PMC148819P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210103,195,944 - 103,196,081 (+)MAPPERmRatBN7.2
Rnor_6.010106,975,887 - 106,976,023NCBIRnor6.0
Rnor_5.010106,613,483 - 106,613,619UniSTSRnor5.0
RGSC_v3.410107,959,177 - 107,959,313UniSTSRGSC3.4
Celera10101,757,609 - 101,757,745UniSTS
Cytogenetic Map10q32.3UniSTS
PMC22025P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr810103,695,217 - 103,696,093 (+)Marker Load Pipeline
Rnor_6.010106,976,490 - 106,977,356NCBIRnor6.0
Rnor_5.010106,614,086 - 106,614,754UniSTSRnor5.0
RGSC_v3.410107,959,780 - 107,960,863UniSTSRGSC3.4
Celera10101,758,212 - 101,759,056UniSTS
Cytogenetic Map10q32.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000003940   ⟹   ENSRNOP00000003940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl10106,975,178 - 106,976,040 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118098   ⟹   ENSRNOP00000097273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10103,692,579 - 103,704,825 (-)Ensembl
mRatBN7.2 Ensembl10103,193,537 - 103,197,787 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000142846   ⟹   ENSRNOP00000109646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10103,690,976 - 103,696,562 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000145627   ⟹   ENSRNOP00000111511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10103,692,134 - 103,700,254 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000145772   ⟹   ENSRNOP00000108465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10103,693,154 - 103,696,179 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000161353   ⟹   ENSRNOP00000108489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10103,693,115 - 103,695,400 (-)Ensembl
RefSeq Acc Id: NM_053565   ⟹   NP_446017
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,693,906 - 103,694,768 (-)NCBI
mRatBN7.210103,195,236 - 103,196,098 (-)NCBI
Rnor_6.010106,975,178 - 106,976,040 (-)NCBI
Rnor_5.010106,611,459 - 106,616,694 (-)NCBI
RGSC_v3.410107,958,468 - 107,959,330 (-)RGD
Celera10101,756,900 - 101,757,762 (-)RGD
Sequence:
RefSeq Acc Id: XM_008768398   ⟹   XP_008766620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,692,579 - 103,695,975 (-)NCBI
mRatBN7.210103,193,909 - 103,197,322 (-)NCBI
Rnor_6.010106,973,863 - 106,976,969 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_446017 (Get FASTA)   NCBI Sequence Viewer  
  XP_008766620 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC26223 (Get FASTA)   NCBI Sequence Viewer  
  CAB56083 (Get FASTA)   NCBI Sequence Viewer  
  EDM06745 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000111511
GenBank Protein O88583 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446017   ⟸   NM_053565
- UniProtKB: Q9QYV5 (UniProtKB/Swiss-Prot),   O88583 (UniProtKB/Swiss-Prot),   A6HL40 (UniProtKB/TrEMBL),   G3V6D2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766620   ⟸   XM_008768398
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000003940   ⟸   ENSRNOT00000003940
Ensembl Acc Id: ENSRNOP00000097273   ⟸   ENSRNOT00000118098
Ensembl Acc Id: ENSRNOP00000111511   ⟸   ENSRNOT00000145627
Ensembl Acc Id: ENSRNOP00000108465   ⟸   ENSRNOT00000145772
Ensembl Acc Id: ENSRNOP00000109646   ⟸   ENSRNOT00000142846
Ensembl Acc Id: ENSRNOP00000108489   ⟸   ENSRNOT00000161353
Protein Domains
SH2   SOCS box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88583-F1-model_v2 AlphaFold O88583 1-225 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621087 AgrOrtholog
BioCyc Gene G2FUF-22526 BioCyc
Ensembl Genes ENSRNOG00000002946 Ensembl
  ENSRNOG00000063373 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000145627 ENTREZGENE
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot
  SOCS box UniProtKB/Swiss-Prot
InterPro SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SOCS3 UniProtKB/Swiss-Prot
  SOCS3_SH2 UniProtKB/Swiss-Prot
  SOCS_box UniProtKB/Swiss-Prot
  SOCS_box-like_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:89829 UniProtKB/Swiss-Prot
NCBI Gene 89829 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT UniProtKB/Swiss-Prot
  PTHR10155:SF11 UniProtKB/Swiss-Prot
Pfam SH2 UniProtKB/Swiss-Prot
PhenoGen Socs3 PhenoGen
PROSITE SH2 UniProtKB/Swiss-Prot
  SOCS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002946 RatGTEx
  ENSRNOG00000063373 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot
  SOCS UniProtKB/Swiss-Prot
  SOCS_box UniProtKB/Swiss-Prot
Superfamily-SCOP SSF158235 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
UniProt A6HL40 ENTREZGENE, UniProtKB/TrEMBL
  G3V6D2 ENTREZGENE, UniProtKB/TrEMBL
  O88583 ENTREZGENE
  Q9QYV5 ENTREZGENE
  SOCS3_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9QYV5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Socs3  suppressor of cytokine signaling 3  Cish3  cytokine inducible SH2-containing protein 3  Symbol and Name updated 1299863 APPROVED
2002-08-07 Cish3  cytokine inducible SH2-containing protein 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression increases in the hypothalamus with aging 625538
gene_expression expressed in mammary galnd with increases during the initial stages of mammary gland involution caused by pup withdrawal 625667
gene_process inhibits JAK activity and may mediate hypothalamic leptin resistance in aged Wistar rats. 625538
gene_process may play a role in the initiation of luteolysis via rapid suppression of luteotropic support from placental lactogen (PL) 625667
gene_product member of the suppressor-of-cytokine-signaling family 625538
gene_regulation transcription is induced by 15-deoxy-Delta12,14-prostaglandin J(2) and rosiglitazone 632385
gene_regulation cloprostenol, a PGF2 analog, rapidly increases mRNA level and is also strongly induced by STAT3 625667