Socs3 (suppressor of cytokine signaling 3) - Rat Genome Database

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Gene: Socs3 (suppressor of cytokine signaling 3) Rattus norvegicus
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Symbol: Socs3
Name: suppressor of cytokine signaling 3
RGD ID: 621087
Description: Predicted to enable several functions, including miRNA binding activity; phosphotyrosine residue binding activity; and protein tyrosine kinase inhibitor activity. Involved in several processes, including cell surface receptor signaling pathway via JAK-STAT; cellular response to thyrotropin-releasing hormone; and cellular response to type II interferon. Predicted to be active in cytoplasmic side of plasma membrane. Biomarker of obesity; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SOCS3 (suppressor of cytokine signaling 3); PARTICIPATES IN erythropoietin signaling pathway; insulin signaling pathway; interleukin-2 signaling pathway; INTERACTS WITH (S)-nicotine; 1-naphthyl isothiocyanate; 15-deoxy-Delta(12,14)-prostaglandin J2.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cish3; cytokine inducible SH2-containing protein 3; cytokine-inducible SH2 protein 3; Socs-3; Ssi-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Slep8 Insul15
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810103,692,579 - 103,695,975 (-)NCBIGRCr8
mRatBN7.210103,193,909 - 103,197,322 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,193,537 - 103,197,787 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10108,296,539 - 108,297,401 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010107,759,666 - 107,760,528 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010103,115,997 - 103,116,859 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010106,973,863 - 106,976,969 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,975,178 - 106,976,040 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010106,611,459 - 106,616,694 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410107,958,468 - 107,959,330 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110107,972,971 - 107,973,834 (-)NCBI
Celera10101,756,900 - 101,757,762 (-)NCBICelera
Cytogenetic Map10q32.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Socs3RatBurns  IEP 730264mRNA and protein:increased expression:hepatocyteRGD 
Socs3Ratcholangiocarcinoma severityISOSOCS3 (Homo sapiens)11250478protein:decreased expression:bile duct (human)RGD 
Socs3Ratductal carcinoma in situ  ISOSOCS3 (Homo sapiens)2298909mRNA:increased expression:breastRGD 
Socs3RatEndotoxemia  IEP 625688 RGD 
Socs3RatEndotoxemia  ISOSocs3 (Mus musculus)2298923mRNA:increased expression:liver and skeletal muscleRGD 
Socs3RatExperimental Arthritis  IEP 1625684mRNA:increased expression:mononuclear cellRGD 
Socs3RatExperimental Colitis treatmentIEP 152995414 RGD 
Socs3RatExperimental Diabetes Mellitus susceptibilityISOSocs3 (Mus musculus)2313787 RGD 
Socs3RatExperimental Diabetes Mellitus  IEP 2298911mRNA and protein:increased expression:retinaRGD 
Socs3RatExperimental Mammary Neoplasms  ISOSocs3 (Mus musculus)2298899mRNA:increased expression:mammary glandRGD 
Socs3RatFibrosis  IEP 1625686 RGD 
Socs3RatHelicobacter Infections  IEP 1625683mRNA and protein:increased expressionRGD 
Socs3Rathuman immunodeficiency virus infectious disease  ISOSOCS3 (Homo sapiens)2298904mRNA:decreased expression:uterine cervixRGD 
Socs3RatHypertriglyceridemia  ISOSocs3 (Mus musculus)1625677associated with ObesityRGD 
Socs3RatInsulin Resistance susceptibilityISOSocs3 (Mus musculus)2313789associated with ObesityRGD 
Socs3RatInsulin Resistance  ISOSocs3 (Mus musculus)1625677associated with Diabetes MellitusRGD 
Socs3Ratinvasive ductal carcinoma  ISOSOCS3 (Homo sapiens)2298909mRNA:increased expression:breastRGD 
Socs3RatLymphatic Metastasis  ISOSOCS3 (Homo sapiens)2298901associated with Breast NeoplasmsRGD 
Socs3Ratobesity  IEP 2298920mRNA and protein:increased expression:white fatRGD 
Socs3Ratobesity  ISOSOCS3 (Homo sapiens)405650675DNA:SNP:utr (rs4969170) (human)RGD 
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Original Reference(s)
Socs3RatIdiopathic Generalized Epilepsy  ISOSOCS3 (Homo sapiens)8554872ClinVar Annotator: match by term: Idiopathic generalized epilepsyClinVarPMID:28492532
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Original Reference(s)
Socs3Ratatherosclerosis  ISOSOCS3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19330073
Socs3RatEndometrial Neoplasms  ISOSOCS3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16804899
Socs3Rathepatocellular carcinoma  ISOSOCS3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16831601
Socs3Ratliver disease  ISOSOCS3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19784758
Socs3RatMyocardial Ischemia  ISOSOCS3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16214533

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Socs3Rat(-)-demecolcine increases expressionISOSOCS3 (Homo sapiens)6480464Demecolcine results in increased expression of SOCS3 mRNACTDPMID:23649840
Socs3Rat(1->4)-beta-D-glucan multiple interactionsISOSocs3 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SOCS3 mRNACTDPMID:36331819
Socs3Rat(S)-naringenin increases expressionISOSOCS3 (Homo sapiens)6480464naringenin results in increased expression of SOCS3 mRNACTDPMID:23782265
Socs3Rat(S)-naringenin increases expressionISOSocs3 (Mus musculus)6480464naringenin results in increased expression of SOCS3 mRNACTDPMID:23782265
Socs3Rat(S)-nicotine increases expressionEXP 6480464Nicotine results in increased expression of SOCS3 mRNACTDPMID:29155039
Socs3Rat1,1-dichloroethene increases expressionISOSocs3 (Mus musculus)6480464vinylidene chloride results in increased expression of SOCS3 mRNACTDPMID:26682919
Socs3Rat1,2-dimethylhydrazine multiple interactionsISOSocs3 (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of SOCS3 mRNA]CTDPMID:22206623
Socs3Rat1,2-dimethylhydrazine increases expressionISOSocs3 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of SOCS3 mRNACTDPMID:22206623
Socs3Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expressionISOSocs3 (Mus musculus)64804641-Methyl-4-phenyl-1 more ...CTDPMID:28801915
Socs3Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of SOCS3 mRNACTDPMID:12832660
Socs3Rat1-naphthyl isothiocyanate increases expressionISOSocs3 (Mus musculus)64804641-Naphthylisothiocyanate results in increased expression of SOCS3 mRNACTDPMID:36460194
Socs3Rat1-naphthyl isothiocyanate multiple interactionsISOSocs3 (Mus musculus)64804643-(5-(4-(cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-hydroxy-1 more ...CTDPMID:30352267 and PMID:36460194
Socs3Rat15-deoxy-Delta(12,14)-prostaglandin J2 increases expressionEXP 648046415-deoxy-delta(12 and 14)-prostaglandin J2 results in increased expression of SOCS3 mRNACTDPMID:12584205
Socs3Rat17alpha-ethynylestradiol affects expressionISOSocs3 (Mus musculus)6480464Ethinyl Estradiol affects the expression of SOCS3 mRNACTDPMID:17555576
Socs3Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of SOCS3 mRNACTDPMID:17351261
Socs3Rat17alpha-ethynylestradiol increases expressionISOSocs3 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of SOCS3 mRNACTDPMID:17942748
Socs3Rat17alpha-ethynylestradiol multiple interactionsISOSocs3 (Mus musculus)6480464Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of SOCS3 mRNA]CTDPMID:12072388
Socs3Rat17beta-estradiol increases expressionISOSocs3 (Mus musculus)6480464Estradiol results in increased expression of SOCS3 mRNACTDPMID:25210133 more ...
Socs3Rat17beta-estradiol multiple interactionsISOSocs3 (Mus musculus)6480464Estradiol promotes the reaction [sodium arsenite results in increased expression of SOCS3 mRNA] and Estradiol promotes the reaction [sodium arsenite results in increased expression of SOCS3 protein]CTDPMID:26631322
Socs3Rat17beta-estradiol decreases expressionISOSOCS3 (Homo sapiens)6480464Estradiol results in decreased expression of SOCS3 mRNACTDPMID:23373633 and PMID:31646340

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Biological Process
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Original Reference(s)
Socs3Ratanimal organ regeneration  IEP 2298919 RGD 
Socs3Ratbranching involved in labyrinthine layer morphogenesis acts_upstream_of_or_withinISOSocs3 (Mus musculus)1624291MGI:2180861 PMID:11481489RGDPMID:11481489
Socs3Ratcell differentiation acts_upstream_ofISOSocs3 (Mus musculus)1624291MGI:96787 PMID:15358627RGDPMID:15358627
Socs3Ratcell surface receptor signaling pathway via JAK-STAT  IDA 625667 RGD 
Socs3Ratcell surface receptor signaling pathway via JAK-STAT  TAS 625538 RGD 
Socs3Ratcellular response to interleukin-17 involved_inISOSocs3 (Mus musculus)1624291 PMID:30294880RGDPMID:30294880
Socs3Ratcellular response to leukemia inhibitory factor acts_upstream_of_or_withinISOSocs3 (Mus musculus)1624291 PMID:20439489RGDPMID:20439489
Socs3Ratcellular response to thyrotropin-releasing hormone  IEP 151232287 RGD 
Socs3Ratcellular response to type II interferon  IEP 151232287 RGD 
Socs3Ratcytokine-mediated signaling pathway involved_inIBAMGI:1354910 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Socs3Ratintracellular signal transduction  IDA 625667 RGD 
Socs3Ratintracellular signal transduction involved_inIEAInterPro:IPR0360361600115GO_REF:0000002InterProGO_REF:0000002
Socs3Ratnegative regulation of inflammatory response acts_upstream_of_or_withinISOSocs3 (Mus musculus)1624291MGI:1933533 PMID:20530874RGDPMID:20530874
Socs3Ratnegative regulation of insulin receptor signaling pathway acts_upstream_of_or_withinISOSocs3 (Mus musculus)1624291 PMID:15169905RGDPMID:15169905
Socs3Ratnegative regulation of receptor signaling pathway via JAK-STAT involved_inISOSOCS3 (Homo sapiens)1624291 PMID:25019494RGDPMID:25019494
Socs3Ratnegative regulation of receptor signaling pathway via JAK-STAT involved_inIBAMGI:1201787 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Socs3Ratnegative regulation of signal transduction involved_inIEAUniProtKB-KW:KW-07341600115GO_REF:0000043UniProtGO_REF:0000043
Socs3Ratnegative regulation of signal transduction acts_upstream_of_or_withinISOSocs3 (Mus musculus)1624291MGI:96787 PMID:15358627RGDPMID:15358627
Socs3Ratplacenta blood vessel development acts_upstream_of_or_withinISOSocs3 (Mus musculus)1624291MGI:2180861 PMID:11481489RGDPMID:11481489
Socs3Ratpositive regulation of cell differentiation acts_upstream_of_or_withinISOSocs3 (Mus musculus)1624291MGI:96787 PMID:15358627RGDPMID:15358627
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Cellular Component

  
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Original Reference(s)
Socs3Ratcytoplasmic side of plasma membrane is_active_inISOSOCS3 (Homo sapiens)1624291 PMID:9727029RGDPMID:9727029

Molecular Function

  

RGD Manual Annotations


  
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Original Reference(s)
Socs3Ratinsulin signaling pathway   ISOSocs3 (Mus musculus)1625125 RGD 
Socs3RatJak-Stat signaling pathway   ISS 1357935 RGD 
Socs3Ratleptin system pathway   ISOSocs3 (Mus musculus)1625125 RGD 

Imported Annotations - KEGG (archival)

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Original Reference(s)
Socs3Rathepatitis C pathway  IEA 6907045 KEGGrno:05160
Socs3Ratinfluenza A pathway  IEA 6907045 KEGGrno:05164
Socs3Ratinsulin signaling pathway   IEA 6907045 KEGGrno:04910
Socs3RatJak-Stat signaling pathway   IEA 6907045 KEGGrno:04630
Socs3Rattype 2 diabetes mellitus pathway   IEA 6907045 KEGGrno:04930
Socs3Ratubiquitin/proteasome degradation pathway  IEA 6907045 KEGGrno:04120

Imported Annotations - PID (archival)


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#
Reference Title
Reference Citation
1. SOCS3 was induced by hypoxia and suppressed STAT3 phosphorylation in pulmonary arterial smooth muscle cells. Bai L, etal., Respir Physiol Neurobiol. 2006 May;152(1):83-91. Epub 2005 Aug 24.
2. Suppressor of cytokine signaling 3 is induced by angiotensin II in heart and isolated cardiomyocytes, and participates in desensitization. Calegari VC, etal., Endocrinology 2003 Oct;144(10):4586-96. Epub 2003 Jun 26.
3. Expression of suppressors of cytokine signaling-3 in Helicobacter pylori-infected rat gastric mucosal RGM-1cells. Cha B, etal., Ann N Y Acad Sci. 2007 Jan;1096:24-8.
4. A prostaglandin f(2alpha) analog induces suppressors of cytokine signaling-3 expression in the corpus luteum of the pregnant rat: a potential new mechanism in luteolysis. Curlewis JD, etal., Endocrinology 2002 Oct;143(10):3984-93.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Caffeic acid phenethyl ester modifies the Th1/Th2 balance in ileal mucosa after gamma-irradiation in the rat by modulating the cytokine pattern. Gremy O, etal., World J Gastroenterol. 2006 Aug 21;12(31):4996-5004.
8. Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation. Hong-Brown LQ, etal., Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E63-72. Epub 2003 Mar 18.
9. Attenuation of leptin and insulin signaling by SOCS proteins. Howard JK and Flier JS, Trends Endocrinol Metab. 2006 Nov;17(9):365-71. Epub 2006 Sep 28.
10. Insulin attenuates the systemic inflammatory response in endotoxemic rats. Jeschke MG, etal., Endocrinology. 2004 Sep;145(9):4084-93. Epub 2004 Jun 10.
11. Differential expression of suppressors of cytokine signalling genes in response to nutrition and growth hormone in the septic rat. Johnson TS, etal., J Endocrinol 2001 May;169(2):409-15.
12. Signaling through the JAK/STAT pathway, recent advances and future challenges. Kisseleva T, etal., Gene 2002 Feb 20;285(1-2):1-24.
13. Thermal injury-induced increases of hepatocyte SOCS3 lead to decreases in STAT3. Kong F, etal., Shock 2002 Oct;18(4):374-9.
14. Regulation of the acid-labile subunit in sustained endotoxemia. Kong SE, etal., Am J Physiol Endocrinol Metab 2002 Oct;283(4):E692-701.
15. Genetic association analysis of 30 genes related to obesity in a European American population. Li P, etal., Int J Obes (Lond). 2014 May;38(5):724-9. doi: 10.1038/ijo.2013.140. Epub 2013 Jul 31.
16. Acute induction of inflammatory cytokine expression after gamma-irradiation in the rat: effect of an NF-kappaB inhibitor. Linard C, etal., Int J Radiat Oncol Biol Phys. 2004 Feb 1;58(2):427-34.
17. Suppressors of cytokine-signaling proteins induce insulin resistance in the retina and promote survival of retinal cells. Liu X, etal., Diabetes. 2008 Jun;57(6):1651-8. Epub 2008 Mar 20.
18. Unique expression of suppressor of cytokine signaling 3 is essential for classical macrophage activation in rodents in vitro and in vivo. Liu Y, etal., J Immunol. 2008 May 1;180(9):6270-8.
19. Momordica charantia extracts ameliorate insulin resistance by regulating the expression of SOCS-3 and JNK in type 2 diabetes mellitus rats. Ma C, etal., Pharm Biol. 2017 Dec;55(1):2170-2177. doi: 10.1080/13880209.2017.1396350.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
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PMID:10579313   PMID:11108838   PMID:11481489   PMID:15118263   PMID:15358627   PMID:15514089   PMID:15578154   PMID:15893771   PMID:15998644   PMID:16185683   PMID:16258063   PMID:16289836  
PMID:16300827   PMID:16302975   PMID:16306356   PMID:16484300   PMID:16956890   PMID:16971535   PMID:17223256   PMID:17986523   PMID:18421861   PMID:18586073   PMID:19080716   PMID:19176113  
PMID:19272793   PMID:19293294   PMID:19386987   PMID:19408656   PMID:19639229   PMID:19643162   PMID:19693688   PMID:19862646   PMID:20185635   PMID:20193756   PMID:20303731   PMID:20439489  
PMID:20530874   PMID:20816823   PMID:20819948   PMID:20848345   PMID:21145973   PMID:21168220   PMID:21255014   PMID:21364493   PMID:21521717   PMID:21545521   PMID:22253420   PMID:22982470  
PMID:23007031   PMID:23222907   PMID:23401297   PMID:23669042   PMID:23948778   PMID:24078776   PMID:24088176   PMID:24091940   PMID:24142708   PMID:24463741   PMID:24660535   PMID:24685947  
PMID:24959867   PMID:25019494   PMID:25086044   PMID:25352752   PMID:25847945   PMID:26384335   PMID:27118613   PMID:28036111   PMID:28111888   PMID:28129651   PMID:28326931   PMID:29550470  
PMID:30763670   PMID:31799684   PMID:31857078   PMID:32030968   PMID:32438059   PMID:32630102   PMID:32989761   PMID:33255404   PMID:33300076   PMID:33522063   PMID:35702948   PMID:36793115  
PMID:37154979   PMID:37856074  



Socs3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810103,692,579 - 103,695,975 (-)NCBIGRCr8
mRatBN7.210103,193,909 - 103,197,322 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,193,537 - 103,197,787 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10108,296,539 - 108,297,401 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010107,759,666 - 107,760,528 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010103,115,997 - 103,116,859 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010106,973,863 - 106,976,969 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,975,178 - 106,976,040 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010106,611,459 - 106,616,694 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410107,958,468 - 107,959,330 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110107,972,971 - 107,973,834 (-)NCBI
Celera10101,756,900 - 101,757,762 (-)NCBICelera
Cytogenetic Map10q32.2NCBI
SOCS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381778,356,778 - 78,360,925 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1778,356,778 - 78,360,077 (-)EnsemblGRCh38hg38GRCh38
GRCh371776,352,859 - 76,357,006 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361773,864,454 - 73,867,753 (-)NCBINCBI36Build 36hg18NCBI36
Build 341773,864,458 - 73,867,753NCBI
Celera1772,946,889 - 72,950,188 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1771,775,516 - 71,778,779 (-)NCBIHuRef
CHM1_11776,416,767 - 76,420,069 (-)NCBICHM1_1
T2T-CHM13v2.01779,250,300 - 79,254,447 (-)NCBIT2T-CHM13v2.0
Socs3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911117,856,905 - 117,860,192 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11117,856,905 - 117,860,873 (-)EnsemblGRCm39 Ensembl
GRCm3811117,966,079 - 117,970,336 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11117,966,079 - 117,970,047 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711117,827,393 - 117,830,680 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611117,782,169 - 117,785,252 (-)NCBIMGSCv36mm8
Celera11129,709,800 - 129,713,087 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1182.96NCBI
Socs3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555064,222,455 - 4,225,563 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555064,222,455 - 4,225,563 (+)NCBIChiLan1.0ChiLan1.0
SOCS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21994,406,250 - 94,409,543 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11799,235,744 - 99,239,041 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01772,433,206 - 72,436,500 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11777,981,752 - 77,985,059 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1777,983,389 - 77,984,066 (-)Ensemblpanpan1.1panPan2
SOCS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.192,859,267 - 2,859,944 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha93,516,096 - 3,516,773 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.093,509,383 - 3,512,579 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl93,510,193 - 3,510,870 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.193,533,406 - 3,534,083 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.093,657,845 - 3,658,522 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.093,738,946 - 3,739,623 (+)NCBIUU_Cfam_GSD_1.0
Socs3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056023,476,572 - 3,479,692 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365942,933,747 - 2,934,451 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365942,932,297 - 2,935,358 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOCS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl123,643,929 - 3,647,009 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1123,643,832 - 3,647,015 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap12p15NCBI
SOCS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11670,353,099 - 70,356,401 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1670,354,746 - 70,355,423 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607741,479,311 - 41,482,614 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Socs3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248017,840,889 - 7,843,860 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248017,841,230 - 7,843,912 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Socs3
14 total Variants


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
10 106975923 106975924 A T snv MR/N (MCW) View more Information

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:84
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000003940
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 54 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat

1 to 10 of 54 rows
PMC148819P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210103,195,568 - 103,196,081 (+)MAPPERmRatBN7.2
Rnor_6.010106,975,511 - 106,976,023NCBIRnor6.0
Rnor_5.010106,613,107 - 106,613,619UniSTSRnor5.0
RGSC_v3.410107,958,801 - 107,959,313UniSTSRGSC3.4
Celera10101,757,233 - 101,757,745UniSTS
Cytogenetic Map10q32.3UniSTS
PMC148819P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210103,195,944 - 103,196,081 (+)MAPPERmRatBN7.2
Rnor_6.010106,975,887 - 106,976,023NCBIRnor6.0
Rnor_5.010106,613,483 - 106,613,619UniSTSRnor5.0
RGSC_v3.410107,959,177 - 107,959,313UniSTSRGSC3.4
Celera10101,757,609 - 101,757,745UniSTS
Cytogenetic Map10q32.3UniSTS
PMC22025P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr810103,695,217 - 103,696,093 (+)Marker Load Pipeline
Rnor_6.010106,976,490 - 106,977,356NCBIRnor6.0
Rnor_5.010106,614,086 - 106,614,754UniSTSRnor5.0
RGSC_v3.410107,959,780 - 107,960,863UniSTSRGSC3.4
Celera10101,758,212 - 101,759,056UniSTS
Cytogenetic Map10q32.3UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000003940   ⟹   ENSRNOP00000003940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl10106,975,178 - 106,976,040 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118098   ⟹   ENSRNOP00000097273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10103,193,537 - 103,197,787 (-)Ensembl
RefSeq Acc Id: NM_053565   ⟹   NP_446017
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,693,906 - 103,694,768 (-)NCBI
mRatBN7.210103,195,236 - 103,196,098 (-)NCBI
Rnor_6.010106,975,178 - 106,976,040 (-)NCBI
Rnor_5.010106,611,459 - 106,616,694 (-)NCBI
RGSC_v3.410107,958,468 - 107,959,330 (-)RGD
Celera10101,756,900 - 101,757,762 (-)RGD
Sequence:
RefSeq Acc Id: XM_008768398   ⟹   XP_008766620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,692,579 - 103,695,975 (-)NCBI
mRatBN7.210103,193,909 - 103,197,322 (-)NCBI
Rnor_6.010106,973,863 - 106,976,969 (-)NCBI
Sequence:
Protein RefSeqs NP_446017 (Get FASTA)   NCBI Sequence Viewer  
  XP_008766620 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC26223 (Get FASTA)   NCBI Sequence Viewer  
  CAB56083 (Get FASTA)   NCBI Sequence Viewer  
  EDM06745 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000111511
GenBank Protein O88583 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446017   ⟸   NM_053565
- UniProtKB: Q9QYV5 (UniProtKB/Swiss-Prot),   O88583 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008766620   ⟸   XM_008768398
- Peptide Label: isoform X1
- UniProtKB: G3V6D2 (UniProtKB/TrEMBL),   A6HL40 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003940   ⟸   ENSRNOT00000003940
Ensembl Acc Id: ENSRNOP00000097273   ⟸   ENSRNOT00000118098
SH2   SOCS box

Name Modeler Protein Id AA Range Protein Structure
AF-O88583-F1-model_v2 AlphaFold O88583 1-225 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 33 of 33 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-22526 BioCyc
Ensembl Genes ENSRNOG00000002946 Ensembl
  ENSRNOG00000063373 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000145627 ENTREZGENE
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot
  SOCS box UniProtKB/Swiss-Prot
InterPro SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SOCS3 UniProtKB/Swiss-Prot
  SOCS3_SH2 UniProtKB/Swiss-Prot
  SOCS_box UniProtKB/Swiss-Prot
  SOCS_box-like_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:89829 UniProtKB/Swiss-Prot
NCBI Gene 89829 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT UniProtKB/Swiss-Prot
  PTHR10155:SF11 UniProtKB/Swiss-Prot
Pfam SH2 UniProtKB/Swiss-Prot
PhenoGen Socs3 PhenoGen
PROSITE SH2 UniProtKB/Swiss-Prot
  SOCS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002946 RatGTEx
  ENSRNOG00000063373 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot
  SOCS UniProtKB/Swiss-Prot
  SOCS_box UniProtKB/Swiss-Prot
Superfamily-SCOP SSF158235 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
UniProt A6HL40 ENTREZGENE, UniProtKB/TrEMBL
  G3V6D2 ENTREZGENE, UniProtKB/TrEMBL
  O88583 ENTREZGENE
  Q9QYV5 ENTREZGENE
  SOCS3_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9QYV5 UniProtKB/Swiss-Prot
1 to 33 of 33 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Socs3  suppressor of cytokine signaling 3  Cish3  cytokine inducible SH2-containing protein 3  Symbol and Name updated 1299863 APPROVED
2002-08-07 Cish3  cytokine inducible SH2-containing protein 3      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression expression increases in the hypothalamus with aging 625538
gene_expression expressed in mammary galnd with increases during the initial stages of mammary gland involution caused by pup withdrawal 625667
gene_process inhibits JAK activity and may mediate hypothalamic leptin resistance in aged Wistar rats. 625538
gene_process may play a role in the initiation of luteolysis via rapid suppression of luteotropic support from placental lactogen (PL) 625667
gene_product member of the suppressor-of-cytokine-signaling family 625538
gene_regulation transcription is induced by 15-deoxy-Delta12,14-prostaglandin J(2) and rosiglitazone 632385
gene_regulation cloprostenol, a PGF2 analog, rapidly increases mRNA level and is also strongly induced by STAT3 625667