Gene:	Socs3 ( Rattus norvegicus ) suppressor of cytokine signaling 3
Description:	involved in insulin and leptin signaling, organ regeneration, and aging; associated with arthritis, cancer, diabetes, and other diseases
Synonyms:	Ssi-3; Cish3; Socs-3; cytokine inducible SH2-containing protein 3;
ArrayIDs:	AF075383_at; 1377092_at; 1369584_at; A_44_P548126; 6416461; 6324051; 6733008; 6414694;  (details...)
Gene Type:	protein-coding
Additional Data
Candidate gene for:	Slep8 - Serum leptin concentration QTL 8 Insul15 - Insulin level QTL 15
Homologs
Homo sapiens: SOCS3     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Socs3     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Socs3 genome assembly 3.1 10 107972971 - 107973834     Rat Celera Assembly 10 101756900 - 101757762     RGSC genome assembly v3.4 10 107958468 - 107959330     Cytogenetic 10 q32.3 Mus musculus Socs3 Mouse genome assembly build 36.1 11 117827393 - 117830476     Cytogenetic 11 11 E2 Homo sapiens SOCS3 human genome assembly 17 73864458 - 73867753     Human genome assembly build 36.2 17 73864454 - 73867753     Cytogenetic 17 q25.3   View comparative maps:      NCBI MapViewer
Genome
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Annotation
Molecular Function	Gene Ontology protein binding (details...)
Biological Process	Note Reference may play a role in the initiation of luteolysis via rapid suppression of luteotropic support from placental lactogen (PL) 625667 inhibits JAK activity and may mediate hypothalamic leptin resistance in aged Wistar rats. 625538 Gene Ontology response to cytokine stimulus,  response to glucocorticoid stimulus,  regulation of protein amino acid phosphorylation ...  (details...)
Cellular Component	Gene Ontology cytoplasm (details...)
Disease	Ontology HIV Infections,  Insulin Resistance,  Fatty Liver ...  (details...)
Expression	Note Reference expressed in mammary galnd with increases during the initial stages of mammary gland involution caused by pup withdrawal 625667 expression increases in the hypothalamus with aging 625538
Pathway	Ontology Jak-Stat signaling pathway,  leptin system pathway,  insulin signaling pathway (details...)
Product	Note Reference member of the suppressor-of-cytokine-signaling family 625538
Regulation	Note Reference cloprostenol, a PGF2 analog, rapidly increases mRNA level and is also strongly induced by STAT3 625667 transcription is induced by 15-deoxy-Delta12,14-prostaglandin J(2) and rosiglitazone 632385
External Links
Databases	DATABASE ID SOURCE Ensembl Protein: ENSRNOP00000003940 IPI SMART: SOCS IPI SMART: SH2 IPI IPI: IPI00210797 IPI PROSITE: SOCS IPI PROSITE: SH2 IPI Gene3D-CATH: SH2 IPI Entrez Gene: Socs3 ENTREZGENE UNIPARC: UPI0000135B67 IPI KEGG Report: rno:89829 ENTREZGENE Ensembl Genes: ENSRNOG00000002946 IPI UniProt: SOCS3_RAT IPI HomoloGene Group ID: 2941 ENTREZGENE Germonline: 621087 Pfam: SH2 IPI Pfam: SOCS_box IPI KEGG Pathway: 04930 ENTREZGENE KEGG Pathway: 04920 ENTREZGENE KEGG Pathway: 04910 ENTREZGENE KEGG Pathway: 04630 ENTREZGENE KEGG Pathway: 04120 ENTREZGENE InterPro: SOCS_C. IPI InterPro: SH2. IPI
Sequences	Nucleotide: NM_053565 Get FASTA Search GEO Profiles Nucleotide: AF075383 Get FASTA Search GEO Profiles (View all 2 Nucleotide Accessions) Protein: O88583 Get FASTA Protein: AAC26223 Get FASTA Protein: NP_446017 Get FASTA (View all 3 Protein Accessions)
Clusters	UniGene: 127801
References
Curated References	44 references in RGD related to Socs3
Other References	38 other references at PubMed related to Socs3
Database Information
RGD ID	621087
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-SEP-04: Socs3 suppressor of cytokine signaling 3 Cish3 cytokine inducible SH2-containing protein 3 APPROVED Symbol and Name updated 1299863 07-AUG-02: Cish3 cytokine inducible SH2-containing protein 3 PROVISIONAL Symbol and Name status set to provisional 70820