RGD Reference Report - In situ detection of SOCS and cytokine expression in the uterine cervix from HIV/HPV coinfected women. - Rat Genome Database

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In situ detection of SOCS and cytokine expression in the uterine cervix from HIV/HPV coinfected women.

Authors: Nicol, AF  Nuovo, GJ  Wang, Y  Grinsztejn, B  Tristao, A  Russomano, F  Perez, MA  Lapa e Silva, JR  Fernandes, AT  Gage, JR  Martinez-Maza, O  Bonecini-Almeida, MG 
Citation: Nicol AF, etal., Exp Mol Pathol. 2006 Aug;81(1):42-7.
RGD ID: 2298904
Pubmed: PMID:16878360   (View Abstract at PubMed)

The purpose of this study was to look for associations between a newly described class of suppressors of cytokine signaling (SSI/SOCS) and cytokine expression in the uterine cervix from HIV/HPV coinfected women. We examined the pro-inflammatory cytokines TNF-alpha and IL-6 since their expressions are linked and responsible for many aspects of both localized and systemic inflammatory responses. Further, expression of SSI/SOCS has been implicated in the negative feedback regulation of cytokine receptor signaling. PCR-amplified HIV-1 cDNA was noted mainly in the stroma, showing a perivascular distribution, and most of the infected cells colabeled with the macrophage marker CD68. The distribution of IL-6 and TNF-alpha was in the same area to HIV-1 and much greater than normal cervices from women with no evidence of viral infection. SOCS/SSI-1 and -3 mRNA positive cells in the uterine cervix were commonly detected in these noninfected cervical tissues; however, very few cells that contained SOCS were evident in areas where HIV-1, TNF-alpha, and IL-6 expressing cells were found. This suggests that viral-related suppression of SOCS/SSI-1-3 expression may be a factor in the marked local enhancement of TNF-alpha and IL-6 production which, in turn, may help facilitate viral spread; however, further studies should be done in order to elucidate the exact mechanisms of SOCS in the cervix.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
human immunodeficiency virus infectious disease  IEP 2298904; 2298904mRNA:decreased expression:uterine cervixRGD 
human immunodeficiency virus infectious disease  ISOSOCS1 (Homo sapiens)2298904; 2298904mRNA:decreased expression:uterine cervixRGD 
human immunodeficiency virus infectious disease  ISOSOCS3 (Homo sapiens)2298904; 2298904mRNA:decreased expression:uterine cervixRGD 

Objects Annotated

Genes (Rattus norvegicus)
Socs1  (suppressor of cytokine signaling 1)
Socs3  (suppressor of cytokine signaling 3)

Genes (Mus musculus)
Socs1  (suppressor of cytokine signaling 1)
Socs3  (suppressor of cytokine signaling 3)

Genes (Homo sapiens)
SOCS1  (suppressor of cytokine signaling 1)
SOCS3  (suppressor of cytokine signaling 3)


Additional Information